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A Tasquinomod-loaded dopamine-modified pH sensitive hydrogel is effective at inhibiting the proliferation of KRAS mutant lung cancer cells
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METHODS. Bovine ilia were used in the simulations because their histological structure (a fibrolamellar cortex overlying cancellous bone26) was found to match that of the Triceratops ilium. Bone sections 10 x 50 x 縠 3.0 cm with cortices ranging from 0.5 to 5.5 mm in depth (the range of initial cortical-thickness estimates based on gross morphology) were mounted on a servohydraulic mechanical loading frame (MTS Bionix, Minneapolis) and penetrated with an aluminium-bronze T. rex tooth replica. The replica was cast from an actual adult T. rex maxillary tooth, after casts made from some ofthe deeper bite marks revealed the size and shape of the teeth that had impacted the pelvis8 • The replica was penetrated into the ilia sections at 1 mm s-1 to a depth of 11.5 mm, equivalent to the maximum depth of the deepest ilium bite mark8 • Forces were measured with an MTS 25 N strain-gauge-based axial load cell accurate to 0.2%. The forces increased with increasing penetration depth even after the cortical layer had been perforated and the underlying cancellous bone was being crushed. The increase in force with penetration depth is attributed to a greater cortical surface area coming into contact with the semi-conical penetrator tooth as it descended through the ilia. in Bite-force estimation for Tyrannosaurus rex from tooth-marked bones
METHODS. Bovine ilia were used in the simulations because their histological structure (a fibrolamellar cortex overlying cancellous bone26) was found to match that of the Triceratops ilium. Bone sections 10 x 50 x 縠 3.0 cm with cortices ranging from 0.5 to 5.5 mm in depth (the range of initial cortical-thickness estimates based on gross morphology) were mounted on a servohydraulic mechanical loading frame (MTS Bionix, Minneapolis) and penetrated with an aluminium-bronze T. rex tooth replica. The replica was cast from an actual adult T. rex maxillary tooth, after casts made from some ofthe deeper bite marks revealed the size and shape of the teeth that had impacted the pelvis8 • The replica was penetrated into the ilia sections at 1 mm s-1 to a depth of 11.5 mm, equivalent to the maximum depth of the deepest ilium bite mark8 • Forces were measured with an MTS 25 N strain-gauge-based axial load cell accurate to 0.2%. The forces increased with increasing penetration depth even after the cortical layer had been perforated and the underlying cancellous bone was being crushed. The increase in force with penetration depth is attributed to a greater cortical surface area coming into contact with the semi-conical penetrator tooth as it descended through the ilia.
Figure 10 from: Al-Sahlawi F, Al-Ani I, El-Tanani M, Farooq HA (2024) Preparation and evaluation of biological activity of ZSM-5 nanoparticles loaded with gefitinib for the treatment of non-small cell lung carcinoma. Pharmacia 71: 1-12. https://doi.org/10.3897/pharmacia.71.e112449
Figure 10 Normalize of transform of A. ZSM-5 Carrier only; B. Free GEF, and C. GEF-ZSM-5 loaded prepared by kneading method (ratio 1:1).
Figure 7 from: Al-Sahlawi F, Al-Ani I, El-Tanani M, Farooq HA (2024) Preparation and evaluation of biological activity of ZSM-5 nanoparticles loaded with gefitinib for the treatment of non-small cell lung carcinoma. Pharmacia 71: 1-12. https://doi.org/10.3897/pharmacia.71.e112449
Figure 7 Drug release profile of free GEF and GEF from the loaded NPs for 60 min, phosphate buffer pH 6.8, apparatus II (paddle), 50 rpm, and 37 °C.
Figure 11 from: Al-Sahlawi F, Al-Ani I, El-Tanani M, Farooq HA (2024) Preparation and evaluation of biological activity of ZSM-5 nanoparticles loaded with gefitinib for the treatment of non-small cell lung carcinoma. Pharmacia 71: 1-12. https://doi.org/10.3897/pharmacia.71.e112449
Figure 11 Control migration testing Treatment of A-549 cells with: Half-Maximal Inhibitory Concentration (IC50), IC50, 2 IC50, Double-Maximal.
Figure 8 from: Al-Sahlawi F, Al-Ani I, El-Tanani M, Farooq HA (2024) Preparation and evaluation of biological activity of ZSM-5 nanoparticles loaded with gefitinib for the treatment of non-small cell lung carcinoma. Pharmacia 71: 1-12. https://doi.org/10.3897/pharmacia.71.e112449
Figure 8 Drug release profile of free GEF and GEF from the loaded NPs for 12 hr, phosphate buffer pH 6.8, apparatus II(paddle), 50 rpm, and 37 °C.
Figure 12 from: Al-Sahlawi F, Al-Ani I, El-Tanani M, Farooq HA (2024) Preparation and evaluation of biological activity of ZSM-5 nanoparticles loaded with gefitinib for the treatment of non-small cell lung carcinoma. Pharmacia 71: 1-12. https://doi.org/10.3897/pharmacia.71.e112449
Figure 12 Colony test of untreated A-549 cells in a control. utilizing free gefitinib and ZSM- 5-gefitinib-loaded utilizing kneading technique 1:1 w/w, 12 IC50 stands for half dosage of the half maximum inhibitory concentration, IC50 for the half maximum inhibitory concentration, and 2 IC50 for double dose of the half maximum inhibitory concentration. Comparisons between each dosage and the control were made. The findings were shown as mean SD. The signs for statistical significance were *P 0.05, **P 0.01, and ***P 0.001.
Supplementary material 1 from: Sadaqa E, Utami RA, Mudhakir D (2024) In vitro cytotoxic and genotoxic effects of Phyllanthus niruri extract loaded chitosan nanoparticles in TM4 cells and their influence on spermatogenesis. Pharmacia 71: 1-14. https://doi.org/10.3897/pharmacia.71.e112138
Supplementary information
Figure 7 from: Sadaqa E, Utami RA, Mudhakir D (2024) In vitro cytotoxic and genotoxic effects of Phyllanthus niruri extract loaded chitosan nanoparticles in TM4 cells and their influence on spermatogenesis. Pharmacia 71: 1-14. https://doi.org/10.3897/pharmacia.71.e112138
Figure 7 Imaging of cellular morphological change in the presence of ChNP and PNNP. TM4 cells were incubated in the absence of nanoparticles (a) and in the presence of ChNP at 50 µg/mL (b), PNNP at 125 µg/mL (c), and ChNP at 200 µg/mL (d). Images were captured 2 h after transfection using a 20× lens on a CLSM (Olympus FV-1200) and the nucleus was stained with Hoechst 33342 (blue). The bar indicates 50 µm.
Figure 9 from: Sadaqa E, Utami RA, Mudhakir D (2024) In vitro cytotoxic and genotoxic effects of Phyllanthus niruri extract loaded chitosan nanoparticles in TM4 cells and their influence on spermatogenesis. Pharmacia 71: 1-14. https://doi.org/10.3897/pharmacia.71.e112138
Figure 9 Claudin 11 expression in the presence of ChNP and PNNP. TM4 cells were incubated with ChNP 50 µg/mL, PNNP 125 µg/mL and ChNP 200 µg/mL for 24 h. a. Confocal images of claudin 11 expression after cells were incubated with a secondary antibody goat anti-rabbit IgG Alexa Fluor 488 (green) and the nucleus was stained with Hoechst 33342 (blue). The bars indicate 50 µm; b. Histogram of downregulation claudin 11 expression. The results are shown as mean ± SE of two separate studies (n = 50). ns (not significant) p > 0.05. Stars (***) indicate significance when compared with the control group (untreated cells) (p < 0.001). Pound signs (###) demonstrate significance compared with ChNP 50 µg/mL.
Figure 8 from: Sadaqa E, Utami RA, Mudhakir D (2024) In vitro cytotoxic and genotoxic effects of Phyllanthus niruri extract loaded chitosan nanoparticles in TM4 cells and their influence on spermatogenesis. Pharmacia 71: 1-14. https://doi.org/10.3897/pharmacia.71.e112138
Figure 8 Connexin 43 expression in the presence of ChNP and PNNP. TM4 cells were incubated with ChNP 50 µg/mL, PNNP 125 µg/mL and with ChNP 200 µg/mL for 24 h. a. Confocal images of connexin 43 expression after cells were incubated with a secondary antibody goat anti-rabbit IgG Alexa Fluor 488 (green) and the nucleus was stained with Hoechst 33342 (blue). The bars indicate 50 µm. b. Histogram of downregulation of connexin 43 expression. The results are shown as mean ± SEM of two separate studies (n=50). ns (not significant) p > 0.05. Stars (***) indicate significance when compared with the control group (untreated cells) (p < 0.001). Pound signs (###) demonstrate significance compared with ChNP 50 µg/mL.
Figure 6 from: Sadaqa E, Utami RA, Mudhakir D (2024) In vitro cytotoxic and genotoxic effects of Phyllanthus niruri extract loaded chitosan nanoparticles in TM4 cells and their influence on spermatogenesis. Pharmacia 71: 1-14. https://doi.org/10.3897/pharmacia.71.e112138
Figure 6 DNA breakage caused by ChNP and PNNP using FHA. TM4 cells were incubated with various concentration of ChNP (25, 50, 200 µg/mL) and PNNP (62.5, 125, 500 µg/mL) for 2 h. Positive control 100 µm H2O2 was used and incubated for 15 min. Photomicrograph obtained by Inverted Microscope Olympus IX73. Single stranded DNA was stained with ethidium bromide of a. NEgative control (untreated cells); b. H2O2; c.ChNP 25 µg/mL; d.ChNP 50 µg/mL; e.ChNP 200 µg/mL; f.PNNP 62.5 µg/mL; g.PNNP 125 µg/mL; h.PNNP 500 µg/mL. The bar indicates 5 µm. i. Histogram showing DNA damage level using NDF from several randomly selected microscope images. The results are shown as mean ± SEM of three independent experiments (n=150). ns (not significant) p > 0.05. ***p < 0.001 when compared to the corresponding control group.
Figure 4 from: Sadaqa E, Utami RA, Mudhakir D (2024) In vitro cytotoxic and genotoxic effects of Phyllanthus niruri extract loaded chitosan nanoparticles in TM4 cells and their influence on spermatogenesis. Pharmacia 71: 1-14. https://doi.org/10.3897/pharmacia.71.e112138
Figure 4 Cell viability percentage after 24 hours of exposure to various concentrations of ChNP and PNNP assessed by CCK8 test. The values are presented as mean ± standard deviation (SD) (n = 3). All data were analyzed using One-way ANOVA. The stars indicate significant difference between control negative (untreated cells) and various treatment groups (P < 0.05 significantly different, p-value ≥ 0.05 was determined as non-significant (ns). A p-value score of between 0.01 and 0.05 was considered significant (*), between 0.01 and 0.001 as very significant (**), and < 0.001 as extremely significant (***).
Figure 3 from: Sadaqa E, Utami RA, Mudhakir D (2024) In vitro cytotoxic and genotoxic effects of Phyllanthus niruri extract loaded chitosan nanoparticles in TM4 cells and their influence on spermatogenesis. Pharmacia 71: 1-14. https://doi.org/10.3897/pharmacia.71.e112138
Figure 3 Illustration of the TGA, DTG, and DTA curves for A.ChNP and B.PNNP. DTA curves are represented in green, DTG curves in red, and TGA curves in blue.
Figure 5 from: Sadaqa E, Utami RA, Mudhakir D (2024) In vitro cytotoxic and genotoxic effects of Phyllanthus niruri extract loaded chitosan nanoparticles in TM4 cells and their influence on spermatogenesis. Pharmacia 71: 1-14. https://doi.org/10.3897/pharmacia.71.e112138
Figure 5 DNA damage caused by ChNP and PNNP using comet assay. TM4 cells were incubated with various concentrations of ChNP and PNNP for 2 h. Positive control 100 µm H2O2 was used and incubated for 15 min. Comet images demonstrating the degree of DNA damage on TM4 cells were captured using Inverted Microscope Olympus IX73. Single stranded DNA was stained with ethidium bromide. Comet images displayed untreated cells as control (a), H2O2-treated cells (b), and ChNP-treated cells at concentrations of 25 µg/mL (c), 50 µg/mL (d), and 200 µg/mL (e), as well as PNNP-treated cells at concentrations of 62.5 µg/mL (f), 125 µg/mL (g), and 500 µg/mL (h). The bar indicates 5 µm. Quantitative assessment of DNA damage was performed by measuring olive tail moment (i) and % tail DNA (j). The data are presented as the mean ± SEM of three independent trials (n=200), ns (not significant) (***p < 0.001, **p < 0.01, *p < 0.05 when compared to the corresponding control group).
Figure 1 from: Sadaqa E, Utami RA, Mudhakir D (2024) In vitro cytotoxic and genotoxic effects of Phyllanthus niruri extract loaded chitosan nanoparticles in TM4 cells and their influence on spermatogenesis. Pharmacia 71: 1-14. https://doi.org/10.3897/pharmacia.71.e112138
Figure 1 Transmission electron microscope (TEM) images showing morphology of A. unloaded ChNP compared to B.PNNP. The scale bar represents 100 nm.
Dendritic Cell (DC)-Based Vaccines Loaded With Allogeneic Prostate Cell Lines in Combination With Androgen Ablation in Patients With Prostate Cancer
ClinicalTrials.gov study NCT00970203. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Transcriptome analysis of human periodontal ligament cells under tensile loading
GEO Series GSE173891. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Single cell data from mechanically-loaded muscle
GEO Series GSE232257. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Let-7b-5p loaded Mesenchymal Stromal Cell Extracellular Vesicles reduce Pseudomonas-biofilm formation and inflammation in CF Bronchial Epithelial Cells
GEO Series GSE295607. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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