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884 results for “Nicotine”
Deidentified public survey data for: Patterns and perceptions of nicotine use among U.S. adolescents and young adults receiving medication treatment for opioid use disorder
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Data from: Positive allosteric modulation of the α7 nicotinic acetylcholine receptor as a treatment for cognitive deficits after traumatic brain injury
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An observational study of nicotine replacement therapy availability through pharmacist prescribing in the California Central Valley
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Data from: Hepatic steatosis induced by nicotine plus Coca-Cola™ is prevented by nicotinamide riboside (NR)
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Functional impact of subunit composition and compensation on Drosophila melanogaster nicotinic receptors: Targets of neonicotinoids
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Gut microbial metabolites reveal diet-dependent metabolic changes induced by nicotine administration
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Central Valley and other California smokers nicotine replacement therapy (NRT) furnishing surveys
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Toxin or medication? Immunotherapeutic effects of nicotine on a specialist caterpillar
<p>1. A core tenant in the field of ecological immunology is that immune responses trade off with other physiological functions due to resource-allocation costs. Caterpillars, for example, tend to exhibit reduced immune responses when reared on more toxic food plants due to a cost from detoxifying or sequestering secondary metabolites, also known as the "vulnerable host hypothesis". However, support for this hypothesis is mixed, and studies have not yet mechanistically isolated the relative contributions of total plant defenses, specific metabolites, or macro-nutritional quality. </p> <p>2. We used the tobacco hornworm (Manduca sexta), a specialist herbivore on plants in the nightshade family (Solanaceae), to investigate tradeoffs in immune response. This system is ideal given the availability of solanaceous plant lines varying in general (i.e., jasmonate-induced) and specific (i.e., nicotine) resistance traits. We also applied a geometric diet stoichiometry approach to examine how phytochemical toxicity and nutritional quality interactively impact insect immunity and performance. We predicted that as plant toxicity increased immune activity and herbivore performance would decrease.</p> <p>3. Increasing food plant toxicity reduced insect growth and development, as predicted, but contrary to our hypothesis, plant toxicity did not trade off with immune parameters. Surprisingly, specific plant chemicals, in this case nicotine, appeared immunotherapeutic, stimulating the phenoloxidase (PO) immune response of M. sexta. Available nutrients in artificial diets, mainly protein, also strongly impacted insect growth, but did not affect PO activity, while diets supplemented with nicotine enhanced the PO and melanization response.</p> <p>4. This work highlights how specific secondary metabolites, and not overall plant toxicity, impact the immune response. Importantly, our data also suggest an alternative mechanism (i.e., immune enhancement) for reduced parasitoid performance when reared from hosts on toxic plants via tri-trophic interactions.</p>
The prenatal hypoxic pathology associated with maternal stress predisposes to dysregulated expression of the chrna7 gene and the subsequent development of nicotine addiction in adult offspring (Supplementary)
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Chronic nicotine exposure alters sperm small RNA content in a C57BL/6J mouse model: Implications for epigenetic inheritance
<p>Raw small RNA sequencing data files to accompany manuscript</p>
Complete NMR data set for Quinidine, Nicotine and m-Xylene
<p>NMR Data set for Quinidine, Nicotine and m-Xylene at 500 MHz, 80MHz and 43 MHz</p>
Tobacco consumption and nicotine dependence in Bengo Province, Angola: a community-based survey - dataset.
<p>This dataset refers to the specific data on tobacco consumption, extracted from CardioBengo (DOI 10.1186/s12889-016-2759-9) community-based survey. For analysis, age was categorized into five 10-year age groups, 15 to 24; 25 to 34; 35 to 44; 45 to 54; and 55 to 64 years old. Education was categorized according to the number of completed schooling years as none; 1 to 4 years; 5 to 9 years; 10 years or more. Monthly family income in kwanzas was converted into USD, and categorized into groups of no income, under or equal to 150 USD, 151 to 299 USD and greater or equal to 300 USD. Participant’s consumption of alcoholic beverages during the last 12 months was recorded as none, daily, 5–6 days per week, 1–4 days a week, and 1–3 days per month. The area of residence (urban or rural) was classified as described for the area. Individuals were classified as current, ex-, and never users of tobacco. Current users were asked about the type of tobacco used: manufactured, hand-rolled, and smokeless tobacco. Smokers (manufactured and hand-rolled) were further grouped according to the frequency of consumption (≥1 and <6; ≥6 and <20; ≥20 cigarettes/day). Fagerström Test for Nicotine Dependence in Portuguese was used and categorized as 0 to 2 - very low; 3 to 4 - low; 5 - medium; 6 to 7 - high; 8 to 10 - very high.</p>
Supplementary File for: Cannabinoid and nicotine exposure during adolescence induces sex-specific effects on anxiety- and reward-related behaviors during adulthood
<p>Raw data from manuscript.</p>
Dataset of research about Potential of Purwoceng Extract (Pimpinella pruatjan Molkenb.) as Anti-Nicotine Therapy against Viability, Spermatozoa Membrane Integrity, and Organogenesis
<p>The dataset included:</p> <p>1. Ethical test certificate</p> <p>2. Description of ethical clearance</p> <p>3. List of figures of tools and goods used for this study</p> <p>4. Result of active ingredient purwoceng test certificates</p> <p>5. Results of Observation of Viability and Integrity of Spermatozoa Membranes appendices</p>
Fig. 4 in An electrophysiological characterization of naturally occurring tobacco alkaloids and their action on human α4β2 and α7 nicotinic acetylcholine receptors
Fig. 4. Concentration–response curves were obtained by using the whole-cell mode of the patch-clamp technique at a holding potential of −70 mV from CHO cells stably expressing human α4β2 (continuous black lines) or human α7 (dotted grey lines) nAChRs. The lines represent the fits to the Hill equation for nicotine (1) (circles symbols), anabasine (12) (triangles symbols), nornicotine (7) (squared symbols), and S-anatabine (16) (diamonds symbols). The fit parameters are presented (Table 1). The averaged normalized current response is plotted as a function of the maximal current to ACh (ImaxACh). Two backgrounds highlight the concentration range of the tobacco alkaloids levels measured in human plasma (grey background with diagonal lines) and in human cerebrospinal fluid (grey background with horizontal lines). Data are presented as mean ± SD.
Fig. 3 in An electrophysiological characterization of naturally occurring tobacco alkaloids and their action on human α4β2 and α7 nicotinic acetylcholine receptors
Fig. 3. Sequential applications of brief ACh pulses are plotted as a function of time for three ACh concentrations. (a) EC20 = 0.4 μM (circles), EC50 = 1.2 μM (squares), EC90 = 11.1 μM (triangles) for human α4β2 receptors. (b) EC20 = 33.3 μM (circles), EC60 = 300 μM (squares), EC90 = 900 μM (triangles) for human α7 receptors. Experiments were performed by using the whole-cell mode of the patch-clamp technique at a holding potential of −70 mV in CHO cells stably expressing the human α4β2 and α7 nAChRs. EC, effective concentration. Data are presented as mean ± SD.
Fig. 2 in An electrophysiological characterization of naturally occurring tobacco alkaloids and their action on human α4β2 and α7 nicotinic acetylcholine receptors
Fig. 2. Representative traces of currents elicited by using the agonist mode (a and c) and PAM mode (b and d) in the whole-cell mode of the patch-clamp technique at a holding potential of −70 mV in CHO cells stably expressing human α4β2 (a and b) and human α7 (c and d) nAChRs. Agonist mode (a, c): 0.3% DMSO (left); 33.3 μM of the tobacco alkaloid anabasine (middle); 33.3 and 900 μM ACh for α4β2 and α7, respectively (right). PAM mode (b, d): 0.4 and 100 μM ACh for α4β2 and α7, respectively (left); co-application of 33.3 μM of the tobacco alkaloid trans-anatalline (middle); 0.4 or 100 μM ACh for α4β2 and α7, respectively (right). Thick dotted lines represent the pre-application period of the alkaloid (≥2 min). Thin dotted lines represent zero current.; PAM, positive allosteric modulator.
Fig. 1 in An electrophysiological characterization of naturally occurring tobacco alkaloids and their action on human α4β2 and α7 nicotinic acetylcholine receptors
Fig. 1. Representative traces of currents elicited in response to increasing concentrations of ACh. Currents were measured in agonist mode by using the whole-cell mode of the patch-clamp technique at a holding potential of −70 mV in CHO cells stably expressing human α4β2 (a) and human α7 (b) nAChRs. The half-maximal effective concentrations determined by using the Hill equation were 1.02 ± 1.0 μM (a) and 142 ± 16 μM (b) (n = 5–11 cells). Bars indicate (in μM): 0.1 (1), 0.4 (2), 1.2 (3), 3.7 (4), 11.1 (5), 33.3 (6), 100 (7), 300 (8), 900 (9), and 2700 (10). Dotted lines represent zero current.
Effect of Nicotine on Brain Reward Pathways
ClinicalTrials.gov study NCT02346539. IPD Sharing: NO. Countries: 1. Publications: 1.
Examining a New Biomarker of Nicotine Use Among Pregnant Women Who Participated in the New England SCRIPT
ClinicalTrials.gov study NCT00519766. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.