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NIH funding notice PA-16-160

NIH Research Project Grant (Parent R01)

Closed on January 23, 2018.

Posted
March 31, 2016
Close date
January 23, 2018
Activity codes
R01
Institutes taking part
NCI, NEI, NHLBI, NHGRI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDCD, NIDCR, NIDDK, NIDA, NIEHS, NIGMS, NIMH, NINDS, NINR, NIMHD, NLM, NCCIH, ORIP

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

  1. Reissues: PA-13-302 Research Project Grant (Parent R01)
  2. 2 steps back: PA-11-260 Research Project Grant (Parent R01)
  3. 3 steps back: PA-10-067 Research Project Grant (Parent R01)
  4. 4 steps back: PA-07-070 Research Project Grant (Parent R01)

Replaced by PA-18-484.

Who won it before

23,344 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $10,847,074,916 in first-year total cost, median $398,749.

Most frequent study sections

  1. Diseases and Pathophysiology of the Visual System Study Section[DPVS]259
  2. Surgery, Anesthesiology and Trauma Study Section[SAT]246
  3. Biology of the Visual System Study Section[BVS]231
  4. Molecular Genetics A Study Section[MGA]200
  5. Auditory System Study Section[AUD]193

Most frequent institutions

  1. JOHNS HOPKINS UNIVERSITY568
  2. UNIVERSITY OF PITTSBURGH AT PITTSBURGH542
  3. UNIVERSITY OF MICHIGAN AT ANN ARBOR539
  4. UNIVERSITY OF PENNSYLVANIA507
  5. UNIVERSITY OF CALIFORNIA, SAN FRANCISCO479
Competing awards under PA-16-160 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2019Rat Genome Database2R01HL064541-20SHIMOYAMA, MARY EMEDICAL COLLEGE OF WISCONSIN, WI$2,232,697GCAT
2019Characterizing the therapeutic efficacy of CD8 T cell responses induced by the IL-15 superagonist ALT-8032R01AI108415-06OCONNOR, SHELBY LUNIVERSITY OF WISCONSIN-MADISON, WI$761,196VACC
2019Using genetics to discover mechanisms of myocardial infarction2R01HL109946-06A1CHEN, YUQING EUGENEUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$754,912ZRG1
2019Neurobiological Markers of Rhythm: Risk and Resilience for Language Acquisition1R01DC016977-01A1GORDON, REYNA LEIGHVANDERBILT UNIVERSITY MEDICAL CENTER, TN$750,810LCOM
2019Pathogenic Wnt-beta catenin target genes in macrophages and fibrosis1R01AR073270-01HINCHCLIFF, MONIQUE EVANGELINEYALE UNIVERSITY, CT$702,976ACTS
2019Interventions Against the Molecular Etiology of BMPR2-induced PAH2R01HL095797-10WEST, JAMES DVANDERBILT UNIVERSITY MEDICAL CENTER, TN$662,881RIBT
2019Reprogramming of mature smooth muscle cells to vascular progenitor cells2R01HL121877-05MAJESKY, MARK W.WEISER-EVANS, MARY CM.UNIVERSITY OF COLORADO DENVER, CO$651,434AICS
2019Validation of Novel Pathogenic Post-Translational Modifications of Huntingtin, and of Modifying Enzymes as Therapeutic Targets for Huntington's Disease2R01NS086452-06ROSS, CHRISTOPHER AJOHNS HOPKINS UNIVERSITY, MD$639,103CMND
2019Transformation of Paraplegic Paralysis to Overground Stepping in Humans1R01NS102920-01A1EDGERTON, REGGIEGERASIMENKO, YURYUNIVERSITY OF LOUISVILLE, KY$589,515BNVT
2019Conjunctival Goblet Cell Mucin Secretion in Inflammation and Its Resolution2R01EY019470-10DARTT, DARLENE ASCHEPENS EYE RESEARCH INSTITUTE, MA$579,629ZRG1
2019Linking metabolism, neural function, and aging2R01AG046400-06ASHRAFI, KAVEHUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$538,582CMAD
2019Voltage-dependent ion channels controlling firing patterns of central neurons2R01NS036855-22BEAN, BRUCE PHARVARD MEDICAL SCHOOL, MA$536,783NTRC
2019Clonal hematopoiesis and accelerated metabolic dysfunction in obesity1R01HL139819-01A1WALSH, KENNETHUNIVERSITY OF VIRGINIA, VA$534,760IPOD
2019Auditory Processing of Complex Sounds2R01DC001641-28CARNEY, LAUREL H.UNIVERSITY OF ROCHESTER, NY$517,656AUD
2019Dorsal horn circuits for mechanical allodynia1R01NS107364-01SEAL, REBECCA PUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$516,068ZRG1
2019Neurogenetic Approaches to Study Directed Behavior in Drosophilla2R01NS086859-06GALLIO, MARCONORTHWESTERN UNIVERSITY, IL$460,861MNG
2019Spinal muscular atrophy: Mechanisms & treatment strategies.1R01NS104218-01A1MONANI, UMRAOCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$460,303MNG
2019Animal Models of Addiction1R01DA044204-01A1ROBINSON, TERRY E.UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$449,063BRLE
2019Early Detection and Treatment of Emerging Cognitive-Linguistic Impairment in Minority Cognitive Aging and Primary Progressive Aphasia2R01DC013063-06REILLY, JAMES JOSEPHTEMPLE UNIV OF THE COMMONWEALTH, PA$438,611ZRG1
2019Visible Light Photocatalysis2R01GM095666-09YOON, TEHSHIK PUNIVERSITY OF WISCONSIN-MADISON, WI$424,343SBCB
2019Mechanisms of Dopamine Action in Learning: Implications for Addiction2R01DA035943-06JANAK, PATRICIA H.JOHNS HOPKINS UNIVERSITY, MD$422,717NMB
2019Intraflagellar Transport Proteins in Mice2R01GM060992-18PAZOUR, GREGORY JUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$422,527NCSD
2019Exploiting metabolic vulnerabilities of CD4 T cell subsets to control inflammatory disease2R01DK105550-07RATHMELL, JEFFREY C.VANDERBILT UNIVERSITY MEDICAL CENTER, TN$389,203CMIB
2019Origins, properties, and therapeutic potential of cells that repopulate the microglia-depleted adult brain2R01NS083801-06GREEN, KIMWOOD, MARCELO ANDRESUNIVERSITY OF CALIFORNIA-IRVINE, CA$373,512CNBT
2019Role of Asxl1 in normal hematopoiesis and pathogenesis of myeloid malignancies2R01CA172408-06XU, MINGJIANGYANG, FENG-CHUNUNIVERSITY OF MIAMI SCHOOL OF MEDICINE, FL$364,563MONC
2019The Circadian Molecular Clock is a Biomarker for Epilepsy in Focal Cortical Dysplasia1R01NS104428-01A1LIU, JUDY SHIH-HWABROWN UNIVERSITY, RI$361,270ZRG1
2019A role for the complement system in seizure induced neuronal and dendritic injury1R01NS096234-01A1BREWSTER, AMY L.PURDUE UNIVERSITY, IN$333,979CNNT
2019Biosynthetic Models of Heteronuclear Metalloenzymes in Multi-electron Processes2R01GM062211-17LU, YIUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$292,854MSFA
2018Wisconsin Registry for Alzheimer's Prevention2RF1AG027161-11A1JOHNSON, STERLING CUNIVERSITY OF WISCONSIN-MADISON, WI$18,783,802ZRG1
2018Subclinical vascular disease and AD pathology in the transition from midlife to old age1RF1AG052525-01A1LOPEZ, OSCAR L.REIS, STEVEN EUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$9,322,123CNN
2018Early Onset AD Consortium - the LEAD Study (LEADS)1U01AG057195-01A1APOSTOLOVA, LIANA GCARRILLO, MARIA CDICKERSON, BRADFORD CRABINOVICI, GIL DANINDIANA UNIVERSITY INDIANAPOLIS, IN$8,285,753ZRG1
2018Study of Muscle, Mobility and Aging (SOMMA)1R01AG059416-01CUMMINGS, STEVEN RONHEPPLE, RUSSELL TKRITCHEVSKY, STEPHEN B.NEWMAN, ANNE B.CALIFORNIA PACIFIC MED CTR RES INSTITUTE, CA$6,456,826NAME
2018VCID and Stroke in a Bi-racial National Cohort2U01NS041588-17CUSHMAN, MARYHOWARD, GEORGEMANLY, JENNIFER JAIEUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$5,949,596NAME
2018API A4 Alzheimer's Prevention Trial1R01AG058468-01AISEN, PAUL S.JOHNSON, KEITH A.LANGBAUM, JESSICA BROOKEREIMAN, ERIC MICHAELSPERLING, REISA A.TARIOT, PIERRE N.BANNER HEALTH, AZ$5,670,134NIA
2018Genetics of CSF Metabolites in Alzheimer Disease and other Brain Disorders1RF1AG058484-01A1OPHOFF, ROEL AUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$3,811,778NAME
2018Translating SHIP1 genetics to generate a novel Alzheimer's pharmacologic agent1RF1AG059717-01ESTUS, STEVENHUMPHREY, MARY BETHKERR, WILLIAM GARROWUNIVERSITY OF KENTUCKY, KY$3,791,020CMND
2018Integrative biobehavioral and psychosocial risk for cognitive decline in the elderly1RF1AG056487-01A1ENGELAND, CHRISTOPHER GGRAHAM-ENGELAND, JENNIFER ELISEPENNSYLVANIA STATE UNIVERSITY, THE, PA$3,781,840ZRG1
2018Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD)2U01NS038455-16A1MAY, RYANMEADOR, KIMFORD JPENNELL, PAGE BUCKHANNANSTANFORD UNIVERSITY, CA$3,599,894DBD
2018Exosome-mediated propagation of disease linked poly-dipeptides in C9orf72-FTD/ALS1RF1AG057882-01TROTTI, DAVIDEYANG, YONGJIETHOMAS JEFFERSON UNIVERSITY, PA$3,560,090CMND
2018GENETIC MODIFIERS OF CEREBROSPINAL FLUID TREM2 IN ALZHEIMER'S DISEASE1RF1AG058501-01CRUCHAGA, CARLOSPICCIO, LAURAWASHINGTON UNIVERSITY, MO$3,509,903NAME
2018Dynamics of synaptic connectivity in a mouse model of alpha-synuclein transmission1RF1AG059686-01DAWSON, TED M.DAWSON, VALINA L.JOHNS HOPKINS UNIVERSITY, MD$3,459,933CMND
2018Novel Inducible Complement C3 Conditional KO Mouse Models to Investigate Neurodegeneration in AD1RF1AG060057-01LEMERE, CYNTHIA ABRIGHAM AND WOMEN'S HOSPITAL, MA$3,441,150CDIN
2018Multiple Approaches to Abeta Vaccination in Animal Models2RF1AG020241-16AGADJANYAN, MICHAEL GCRIBBS, DAVID HASTINGSINSTITUTE FOR MOLECULAR MEDICINE, CA$3,340,325ZRG1
2018The Role of Inflammation and NGF Dysfunction in the Evolution of AlzheimerDisease Pathology in Down syndrome1RF1AG056850-01A1BUSCIGLIO, JORGE ACUELLO, A CLAUDIOFORTEA, JUANWISNIEWSKI, THOMAS MUNIVERSITY OF CALIFORNIA-IRVINE, CA$3,260,720CNN
2018Inhibition of BACE1 for benefiting Alzheimer's patients2RF1AG046929-06YAN, RIQIANGUNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT$3,255,415CDIN
2018ALZHEIMER'S DISEASE PATHWAYS AND BIOMARKER DISCOVERY BY INTEGRATIVE PROTEOMICS, GLYCOPROTEOMICS, AND GLYCOMICS1RF1AG057965-01A1LI, LIANEMORY UNIVERSITY, GA$3,232,393CNN
2018The Role of PGC-1alpha and Mitochondrial Biogenesis in the Pathogenesis of Alzheimer's Disease1RF1AG056363-01A1ZHU, XIONGWEICASE WESTERN RESERVE UNIVERSITY, OH$3,192,507NOMD
2018Role of Tau Cleavage and Phosphorylation in Tauopathy1RF1AG060766-01ASHE, KAREN HUNIVERSITY OF MINNESOTA, MN$3,014,543ZRG1
2018Decision making and basolateral amygdala dysfunction in aging1RF1AG060778-01BIZON, JENNIFER LYNNFRAZIER, CHARLES JSETLOW, BARRYUNIVERSITY OF FLORIDA, FL$3,004,660ZRG1
2018Vascular Inflammation and Exosomes as Mediators in Aging and Dementia1RF1AG056710-01A1GELLI, ANGIEKNOWLTON, ANNE ALEIN, PAMELA JUNIVERSITY OF CALIFORNIA AT DAVIS, CA$2,991,750ASG
2018Targeting Cerebrovascular TGF Signaling in Alzheimer's Disease1RF1AG059694-01LUO, JIANWYSS-CORAY, TONYPALO ALTO VETERANS INSTIT FOR RESEARCH, CA$2,978,965BINP
2018Restoring Blood-Brain Function to Improve Cognition in Alzheimer's Disease2RF1AG039621-06HARTZ, ANIKA M.S.UNIVERSITY OF KENTUCKY, KY$2,870,472BINP
2018Molecular and cellular mechanisms of the UNC5C netrin receptor in Alzheimer's disease pathogenesis1RF1AG057727-01A1VASSAR, ROBERT JNORTHWESTERN UNIVERSITY AT CHICAGO, IL$2,840,176CDIN
2018Epigenetics of the Aging Astrocyte: Implications for Stroke2RF1AG042189-06SOHRABJI, FARIDATEXAS A&M UNIVERSITY, TX$2,815,194ZRG1
2018Effects of PS1FAD mutations on PS1-NMDAR association, necroptosis and electrophysiology.2RF1AG008200-29ROBAKIS, NIKOLAOS KICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$2,754,170NOMD
2018Convergence of myeloid susceptibility protein function in Alzheimer's disease1RF1AG058852-01BRADSHAW, ELIZABETH MCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$2,747,409CMND
2018Neuronal/Glial exosome signaling and beta-amyloid propagation in Alzheimer's Disease (AD)1RF1AG059610-01TESCO, GIUSEPPINAYANG, YONGJIETUFTS UNIVERSITY BOSTON, MA$2,743,520CDIN
2018Clinical, Imaging, and Pathological Studies in the Oldest Old: The 90+ Study2R01AG021055-16CORRADA, MARIAKAWAS, CLAUDIA H.UNIVERSITY OF CALIFORNIA-IRVINE, CA$2,738,885NAME
2018Are multiple tau species toxic in Alzheimer's Disease?1RF1AG059789-01HYMAN, BRADLEY T.MASSACHUSETTS GENERAL HOSPITAL, MA$2,738,635CMND
2018Microglia are necessary for cortical plaque formation in Alzheimer's disease1RF1AG056768-01A1GREEN, KIMUNIVERSITY OF CALIFORNIA-IRVINE, CA$2,728,590CMBG
2018Novel mechanistic link between metabolic changes and dementia - potential role of miRNAs1RF1AG058467-01A1LIAO, FRANCESCA-FANGYUE, JUNMINGUNIVERSITY OF TENNESSEE HEALTH SCI CTR, TN$2,662,493ZRG1
2018Synergy between amyloid and tau in Alzheimer's Disease1RF1AG058674-01HYMAN, BRADLEY T.MASSACHUSETTS GENERAL HOSPITAL, MA$2,624,185CMND
2018Characterizing neuroprotective roles for SNX27 signaling pathways in AD and DS2RF1AG044420-06HUANG, TIMOTHY YIKAISANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, CA$2,437,500CDIN
2018Di-Leu-enabled multiplexed quantitation for biomarker discovery and validation in Alzheimer's disease1RF1AG052324-01A1LI, LINGJUNUNIVERSITY OF WISCONSIN-MADISON, WI$2,424,837EBIT
2018Calcineurin and inflammatory signaling processes in aging and Alzheimer's Disease2RF1AG027297-11A1NORRIS, CHRISTOPHER MARKUNIVERSITY OF KENTUCKY, KY$2,338,540ZRG1
2018A Longitudinal MRI Study Characterizing Very Early Brain Development in Infants with Down Syndrome1R01HD088125-01A1 · under PA-13-302BOTTERON, KELLY NWASHINGTON UNIVERSITY, MO$2,297,205ZRG1
2018Preeclampsia to cardiovascular disease: Life course analysis of biomarkers and risk1R01HL139844-01A1HLATKY, MARK A.WINN, VIRGINIA DSTANFORD UNIVERSITY, CA$2,267,445CICS
2018New Approaches for Empowering Studies of Asthma in Populations of African Descent2R01HL104608-06BARNES, KATHLEEN CKENNY, EIMEAR ELIZABETHMATHIAS, RASIKA ANNUNIVERSITY OF COLORADO DENVER, CO$2,202,931ZRG1
2018Genomic and Proteomic Architecture of Atherosclerosis2R01HL111362-05A1HERRINGTON, DAVID MCLEODWAKE FOREST UNIVERSITY HEALTH SCIENCES, NC$2,158,706CHSB
2018Substrate Feedback Mechanism of gamma-Secretase1RF1AG057593-01LI, YUEMINGSLOAN-KETTERING INST CAN RESEARCH, NY$2,146,250CMND
2018Assessing Brain Microstructure in Alzheimer's Disease with Advanced Diffusion MRI1RF1AG057602-01FALANGOLA, MARIA FJENSEN, JENS HMEDICAL UNIVERSITY OF SOUTH CAROLINA, SC$2,071,501MEDI
2018National Social Life and Aging Project: Wave 42R01AG043538-06WAITE, LINDA JNATIONAL OPINION RESEARCH CENTER, IL$2,066,157SSPB
2018Targeting Senescence pathways in Alzheimer's disease1RF1AG059712-01CLARKE, MICHAELSTANFORD UNIVERSITY, CA$2,065,131ASG
2018The role of methylation-sensitive PP2A isoforms in regulating the pathological response to tau1RF1AG055125-01A1ARANCIO, OTTAVIOCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$2,025,000CDIN
2018Posttranslational Protein Modification in Alzheimer Pathology1RF1AG057197-01A1AXELSEN, PAUL HUNIVERSITY OF PENNSYLVANIA, PA$2,012,500ZRG1
2018The Immune Cell Atlas – A Robust Framework to Map the Entire Human Immune System1R56AI137244-01BENOIST, CHRISTOPHE O.HACOHEN, NIRMERAD, MIRIAMICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$1,997,997CMIA
2018Early Life Adversity, Biological Embedding, and Risk for Developmental Precursors of Mental Disorders1R01MH113883-01A1LUBY, JOAN L.SMYSER, CHRISTOPHER DANIELWARNER, BARBARA BWASHINGTON UNIVERSITY, MO$1,996,238CPDD
2018Design and evolution of polyvalent domain antibodies specific for tau aggregates1RF1AG059723-01KANE, RAVI S.TESSIER, PETER MUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$1,991,468BPNS
2018Chemical design of amyloid targeting fluorescent probes1RF1AG062362-01A1THEODORAKIS, EMMANUEL AYANG, JERRYUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$1,969,999SBCB
2018Short-term estradiol use in middle-age: implications for female cognitive aging2RF1AG041374-06DANIEL, JILL MTULANE UNIVERSITY OF LOUISIANA, LA$1,893,125NNRS
2018HDL Mimetic Peptide-Mediated Enhancement of Neurovascular Function to Mitigate Cerebral Amyloid Angiopathy and Alzheimer's Disease1RF1AG058081-01LI, LINGUNIVERSITY OF MINNESOTA, MN$1,884,326CNN
2018Therapeutic targeting of TREM2 for Alzheimer's disease1RF1AG057754-01WILCOCK, DONNA MUNIVERSITY OF KENTUCKY, KY$1,878,315CDIN
2018Natural History of Viral Induced Airway Dysfunction and Asthma in Minority Children1U01HL138626-01A1BURCHARD, ESTEBAN GONZALEZRODRIGUEZ-SANTANA, JOSESEIBOLD, MAX AUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$1,826,642IRAP
2018Molecular structures of tau aggregates studied by solid-state NMR1RF1AG059661-01HONG, MEIMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$1,803,825MSFB
2018Integrating Common and Rare Variation to Discover Genes Associated with Tourette Syndrome1R01NS102371-01A1MATHEWS, CAROL ASCHARF, JEREMIAH MSUL, JAE HOONMASSACHUSETTS GENERAL HOSPITAL, MA$1,783,370GHD
2018Protecting Privacy and Facilitating Shared Access of Clinical and Genetic Data of Special Populations1R01HL136835-01A1OHNO-MACHADO, LUCILAUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$1,656,557BCHI
2018Play & Learning Across a Year (PLAY)1R01HD094830-01ADOLPH, KAREN EGILMORE, RICK OTAMIS-LEMONDA, CATHERINE SNEW YORK UNIVERSITY, NY$1,451,445ZRG1
2018Improving Mitral Compensation In Ischemic Regurgitation1R01HL141917-01AIKAWA, ELENABISCHOFF, JOYCE E.LEVINE, ROBERT AMASSACHUSETTS GENERAL HOSPITAL, MA$1,413,244CICS
2018A comparative effectiveness study of speech and surgical treatments using a Cleft Palate Registry/Research Outcomes Network.1R01DE027493-01CHAPMAN, KATHY LKEAN, JACOB T.UNIVERSITY OF UTAH, UT$1,401,200NRCS
2018Decrypting Variants of Uncertain Significance in Long-QT Syndrome2R01HL122010-05GEORGE, ALFRED L.SANDERS, CHARLES RNORTHWESTERN UNIVERSITY AT CHICAGO, IL$1,304,594ZRG1
2018Functionally Assessing Transcriptional Enhancers In Vivo2R01HG003988-13PENNACCHIO, LEN ALEXANDERUNIVERSITY OF CALIF-LAWRENC BERKELEY LAB, CA$1,286,578GCAT
2018Low Level Laser Therapy in Alzheimer's Disease1RF1AG058603-01ZHANG, QUANGUANGAUGUSTA UNIVERSITY, GA$1,258,998CDIN
2018Prenatal Genetic Diagnosis by Genomic Sequencing: A Prospective Evaluation2R01HD055651-11CHUNG, WENDY KCLIFTON, REBECCA GERSNOVIEZVAN DEN VEYVER, IGNATIA BWAPNER, RONALDCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$1,228,546BCHI
2018Virologic Correlates of Heterosexual Transmission2R01AI051231-17ALLEN, TODD MHUNTER, ERICEMORY UNIVERSITY, GA$1,185,704AIP
2018Leukotriene modifying agents in the prevention of excess morbidity and mortality from influenza1R01AI136526-01A1BRACIALE, THOMAS JHARTERT, TINA VVANDERBILT UNIVERSITY MEDICAL CENTER, TN$1,126,149ZRG1
2018Alpha2 adrenergic signaling in AD pathogenesis1RF1AG056815-01A1WANG, QINUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$1,117,224CMND
2018Amyloid Burden among Mexican Americans1R56AG058533-01O'BRYANT, SID ERISSMAN, ROBERTTOGA, ARTHUR WUNIVERSITY OF NORTH TEXAS HLTH SCI CTR, TX$1,113,198APDA
2018Emotion Processing: Risk for Psychopathology in Children2R01MH061285-16POLLAK, SETH DUNIVERSITY OF WISCONSIN-MADISON, WI$1,100,632PDRP
2018A Prospective Study of T cell Immune-phenotype and Disease Outcome in Pulmonary Sarcoidosis1R01HL136681-01A1HAMZEH, NABEELKOTH, LAURA LLEACH, SONIAO'CONNOR, BRIAN PNATIONAL JEWISH HEALTH, CO$1,049,926IRAP
2018Discovery, Biology and Risk of Inherited Variants in Glioma1R01CA217105-01A1BAINBRIDGE, MATTHEW NEILBONDY, MELISSA L.DENEEN, BENJAMINBAYLOR COLLEGE OF MEDICINE, TX$1,043,807CHSB
2018A new high-throughput gastrointestinal tract explant platform for drug formulation discovery and metabolic disease modulation2R01EB000244-39LANGER, ROBERT SAMUELTRAVERSO, CARLO GIOVANNIMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$1,024,309XNDA
2018Subclinical Atrial Fibrillation and Supraventricular Ectopy in the Jackson Heart Study1R01HL142599-01FLOYD, JAMES SUNIVERSITY OF WASHINGTON, WA$1,006,655CHSB
2018HIV Exposed Uninfected Infant Cohort Study1R01HD094650-01A1THEA, DONALD MBOSTON UNIVERSITY MEDICAL CAMPUS, MA$1,004,811ACE
2018PAGE III: Population Architecture using Genomics and Epidemiology1R56HG010297-01BUYSKE, STEVEN GHAIMAN, CHRISTOPHER ALANKOOPERBERG, CHARLES LLOOS, RUTH JFMATISE, TARA C.NORTH, KARI E.RUTGERS, THE STATE UNIV OF N.J., NJ$1,000,000ZRG1
2018The interplay of social, normative, and legal marijuana environments and marijuana and ATOD use from late childhood to young adulthood2R01DA044522-15A1OESTERLE, SABRINAUNIVERSITY OF WASHINGTON, WA$994,467CIHB
2018Antibody-based Protection against Flavivirses2R01AI073755-11DIAMOND, MICHAEL SFREMONT, DAVED H.KUHN, RICHARD J.ROSSMANN, MICHAEL GWASHINGTON UNIVERSITY, MO$988,938VIRB
2018DHODH Inhibitors: A Potential New Class of Antimicrobials for Treatment of the Drug Resistant Gram-Negative Bacillus Acinetobacter baumannii1R56AI129986-01A1PHILLIPS, MARGARET A.RUSSO, THOMAS ASTATE UNIVERSITY OF NEW YORK AT BUFFALO, NY$981,697DDR
2018Longitudinal Molecular Imaging of Neuropathology and Serotonin in Mild Cognitive Impairment1R01AG059390-01SMITH, GWENN SJOHNS HOPKINS UNIVERSITY, MD$975,825CNN
2018Hepatocyte Transplantation for Liver Based Metabolic Disease1R01DK117916-01FOX, IRA J.VOCKLEY, GERARDUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$965,154HBPP
2018Does Dopamine Mediate Effects of Stress on Inhibitory Control and Smoking Lapse?1R01DA045465-01A1MORRIS, EVAN DYALE UNIVERSITY, CT$953,150ZRG1
2018Regulation of Protein C Pathways1R01HL142975-01GRIFFIN, JOHN HMOSNIER, LAURENT OLIVIERSCRIPPS RESEARCH INSTITUTE, THE, CA$944,019HT
2018EMPOWER Study: Promoting BC Screening in Women Who Survived Childhood Cancer2R01CA134722-06A1FORD, JENNIFER SOEFFINGER, KEVIN CHARLESDUKE UNIVERSITY, NC$940,195PRDP
2018Design and testing of germline-targeting and boosting immunogens to elicit 10E8-like broadly neutralizing antibodies against HIV1R56AI134418-01A1SCHIEF, WILLIAM R.SCRIPPS RESEARCH INSTITUTE, THE, CA$929,812ZRG1
2018Identifying Genetic Variants Associated with Opioid Overdose Mortality1R01DA046436-01AGRAWAL, ARPANANELSON, ELLIOT CWASHINGTON UNIVERSITY, MO$928,386GHD
2018Role of Microbiome in Neonatal Lung Maturation and Immune Susceptibility1R01AI138553-01MILLER, LISA AUNIVERSITY OF CALIFORNIA AT DAVIS, CA$928,370LCMI
2018Cervical, Anal & Oral HPV Persistence/Adolescent Girls2R01AI072204-11BURK, ROBERT DDIAZ, ANGELASCHLECHT, NICOLASICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$927,425IRAP
2018Health Care Provider Responses to Receiving Unsolicited Genomic Results1R01HG010004-01A1HOLM, INGRID ADELEBOSTON CHILDREN'S HOSPITAL, MA$922,828ZRG1
2018Dissecting Polyclonal Sera to Reveal Correlates of Productive Immune Responses to HIV1R01AI136621-01A1HANGARTNER, LARS OLIVERWARD, ANDREW BARRETTSCRIPPS RESEARCH INSTITUTE, THE, CA$919,034VACC
2018Assessing measures to eliminate transmission of cholera in Haiti2R01AI099243-06A1HARRIS, JASON BIVERS, LOUISE C.MASSACHUSETTS GENERAL HOSPITAL, MA$918,190CRFS
2018Improving Tissue Engineered Vascular Graft Performance via Computational Modeling1R01HL139796-01BREUER, CHRISTOPHER KANEHUMPHREY, JAY D.MARSDEN, ALISON LRESEARCH INST NATIONWIDE CHILDREN'S HOSP, OH$917,170MABS
2018Resolution of Epithelial Cell Hyperplasia in Asthma2R01HL068111-14TESFAIGZI, YOHANNESLOVELACE BIOMEDICAL & ENVIRONMENTAL RESEARCH INSTITUTE, NM$911,262ZRG1
2018Structure-based design of coronavirus subunit vaccines1R01AI139092-01DU, LANYINGNEW YORK BLOOD CENTER, NY$911,083CMIA
2018Structure Analysis of Viral Assembly Mechanisms1R01GM128507-01YEAGER, MARK JAYUNIVERSITY OF VIRGINIA, VA$896,216AMCB
2018Development of the Next Generation of Conjugate Vaccines1R01AI139748-01TEYTON, LUCSCRIPPS RESEARCH INSTITUTE, THE, CA$894,543CMIA
2018Mechanistic insights into asthma pathogenesis through the integration of asthma genes, risk exposures, and metabolomics1R01HL141826-01LASKY-SU, JESSICA ABRIGHAM AND WOMEN'S HOSPITAL, MA$894,230IRAP
2018Decoding chromosome structure with multiplexed super-resolution microscopy1R01GM124401-01YIN, PENGHARVARD UNIVERSITY, MA$894,198ZRG1
2018Optimizing HIV Care in Less Developed Countries2R37AI058736-14A1FREEDBERG, KENNETH ALANMASSACHUSETTS GENERAL HOSPITAL, MA$892,666ACE
2018Patient Level Prediction of Clinical Outcomes and Cost-Effectiveness in SPRINT (Optimize-SPRINT)1R01HL139837-01BRESS, ADAM PMORAN, ANDREW EDWARDWEINTRAUB, WILLIAM SCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$892,656CHSA
2018Airway dual-transcriptomics in bronchiolitis and risk of asthma: MARC-35 cohort1R01AI137091-01HASEGAWA, KOHEIMASSACHUSETTS GENERAL HOSPITAL, MA$887,528ZRG1
2018SANOS (SAlud y Nutricion para todOS)1R01MD012819-01LENG, JENNIFER CFSLOAN-KETTERING INST CAN RESEARCH, NY$887,506HDEP
2018Using Computational Approaches to Optimize Asthma Care Management1R01HL142503-01LUO, GANGUNIVERSITY OF WASHINGTON, WA$883,091BCHI
2018Epsin in Angiogenesis and Vascular Remodeling2R01HL093242-10CHEN, HONGWANG, DA-ZHIBOSTON CHILDREN'S HOSPITAL, MA$883,049ZRG1
2018Harnessing IL-10 in cART treated SIV infected macaques to restore immunity and to eradicate HIV1R37AI141258-01SEKALY, RAFICK PIERRECASE WESTERN RESERVE UNIVERSITY, OH$875,207AIP
2018Lipidomics Biomarkers Link Sleep Restriction to Adiposity Phenotype, Diabetes, and Cardiovascular Risk1R01HL140335-01A1KRISTAL, BRUCE SBRIGHAM AND WOMEN'S HOSPITAL, MA$873,305NPAS
2018Scalable tools and comprehensive maps to interpret structural variation across the neuropsychiatric spectrum1R56MH115957-01TALKOWSKI, MICHAEL EBROAD INSTITUTE, INC., MA$869,805GCAT
2018Airway metagenome & metabolome in bronchiolitis and risk of asthma: MARC-35 cohort1R01AI134940-01HASEGAWA, KOHEIMASSACHUSETTS GENERAL HOSPITAL, MA$869,596IRAP
2018Slowing aging by multiplexing (SLAM)1R56AG058543-01LADIGES, WARREN CUNIVERSITY OF WASHINGTON, WA$866,759ZRG1
2018Autoimmune features of neurodegenerative disorders1R01NS095435-01A1SETTE, ALESSANDROSULZER, DAVIDCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$864,823CNBT
2018Reducing Disparities in Early Intervention Use: The Opening Doors to Early Intervention Study1R01MD011598-01A1GUEVARA, JAMES PCHILDREN'S HOSP OF PHILADELPHIA, PA$862,663HDEP
2018Blocking type I interferon signaling to reverse T cell exhaustion and control HIV-1 reservoirs1R01AI136990-01A1AMARA, RAMA RAOBOSINGER, STEVEN EDWARDSU, LISHANUNIV OF NORTH CAROLINA CHAPEL HILL, NC$862,217ZRG1
2018Parsing ASD Heterogeneity: Neuroendophenotypes of Social Attention and Sensory Responsivity1R01MH117982-01DAPRETTO, MIRELLAPELPHREY, KEVIN AUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$860,901ZRG1
2018Asthma Exacerbations and MicroRNA prediction: Treatment Response in an Underserved Ethnicity (AEM-TRUE)1R01HL139634-01MCGEACHIE, MICHAEL JOHNBRIGHAM AND WOMEN'S HOSPITAL, MA$859,007GHD
2018Sleep Aging and Risk for Alzheimer's disease-Resubmission-12R01AG056031-05A1OSORIO, RICARDO SNEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$858,434CNN
2018Mechanisms of fibrosis in post-surgical lymphedema2R01HL111130-06A1MEHRARA, BABAK JSLOAN-KETTERING INST CAN RESEARCH, NY$858,115SAT
2018Hispanic Latino Lipid Consortium1R01HL142302-01BELOW, JENNIFERHAIMAN, CHRISTOPHER ALANLOOS, RUTH JFMCCORMICK, JOSEPHNORTH, KARI E.ROTTER, JEROME IUNIV OF NORTH CAROLINA CHAPEL HILL, NC$856,812CHSB
2018Development and Testing of a Pediatric Cervical Spine Injury Risk Assessment Tool1R01HD091347-01A1LEONARD, JULIE C.RESEARCH INST NATIONWIDE CHILDREN'S HOSP, OH$856,804HSOD
2018Development of Novel Proteins Synthesis Inhibitors for MDR Tuberculosis2R01AI090810-06LEE, RICHARD E.ST. JUDE CHILDREN'S RESEARCH HOSPITAL, TN$856,731DDR
2018Modifiable cardiovascular factors linking type 2 diabetes and Alzheimer's disease1R01AG055624-01A1CONVIT, ANTONIONEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$854,023CNN
2018Smartwatch Monitoring for Atrial Fibrillation After Stroke1R01HL137734-01A1CHON, KI HMCMANUS, DAVID D.UNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$853,336BCHI
2018Reverse Genetics To Forward The Pan-Lassa Fever Vaccine Lead Candidate ML291R56AI135770-01A1DE LA TORRE, JUAN C.LUKASHEVICH, IGOR S.PAESSLER, SLOBODANUNIVERSITY OF TEXAS MED BR GALVESTON, TX$851,962ZRG1
2018Detecting bleeding events using EHRs for prediction in Afib1R01HL137794-01A1MCMANUS, DAVID D.YU, HONGUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$851,576HSOD
2018TRAF6 Nanoimmunotherapy to resolve plaque inflammation1R01HL144072-01FAYAD, ZAHI A.MULDER, WILLEMICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$851,576AICS
2018Quantifying cardiac structure and function to define the progression to hear failure in African Americans1R01HL143224-01SHAH, AMIL MBRIGHAM AND WOMEN'S HOSPITAL, MA$851,075CHSB
2018Statistical methods to localize disease heritability and identify biological mechanisms2R01MH107649-04NEALE, BENJAMIN MICHAELBROAD INSTITUTE, INC., MA$849,495BGES
2018Structure and Function of C. Difficile Toxins1R01AI139087-01DONG, MINJIN, RONGSHENGBOSTON CHILDREN'S HOSPITAL, MA$848,063BACP
2018Understanding Unconventional CD8+ T cell Responses in Protection from HIV1R01AI140888-01HANSEN, SCOTT GSACHA, JONAH B.OREGON HEALTH & SCIENCE UNIVERSITY, OR$847,205AIP
2018Genetic Drivers of Resilience to Alzheimer's Disease1R01AG059716-01HOHMAN, TIMOTHY JVANDERBILT UNIVERSITY MEDICAL CENTER, TN$846,913ZRG1
2018Oxidation-mediated structural degeneration of bioprosthetic heart valves1R01HL143008-01FERRARI, GIOVANNILEVY, ROBERT JCHILDREN'S HOSP OF PHILADELPHIA, PA$846,165BTSS
2018Rational design and evaluation of novel mRNA vaccines against MERS-CoV1R01AI137472-01DU, LANYINGNEW YORK BLOOD CENTER, NY$844,900VMD
2018Assessment of Policies through Prediction of Long-term Effects on Cardiovascular Disease Using Simulation (APPLE CDS)1R01HL141427-01A1LI, YANYI, STELLA SNEW YORK ACADEMY OF MEDICINE, NY$843,937CIHB
2018Elucidation of Genetic Effects on Sleep and Circadian Traits1R01HL143790-01GEHRMAN, PHILIP RICHARDGRANT, STRUAN F AKEENE, ALEX CUNIVERSITY OF PENNSYLVANIA, PA$843,912CHSA
2018Mapping the role of long noncoding RNAs in gene regulatory networks in schizophrenia1R01MH109715-01A1PINTO, DALILAICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$843,811GHD
2018Next generation in-vivo diffusion imaging at submillimeter resolution1R01MH116173-01RATHI, YOGESHSETSOMPOP, KAWINMASSACHUSETTS GENERAL HOSPITAL, MA$843,728BMIT
2018Obstructive Sleep Apnea and Subclinical Lung Injury in Health and Disease1R01HL137234-01A1GOTTLIEB, DANIEL JLEDERER, DAVID J.COLUMBIA UNIVERSITY HEALTH SCIENCES, NY$841,918ZRG1
2018Image Guided Delivery of Bioresponsive Hydrogels1R01HL137365-01A1BURDICK, JASON ADUNCAN, JAMES SSINUSAS, ALBERT JYALE UNIVERSITY, CT$841,093ZRG1
2018SigH based attenuated, efficacious Mtb vaccines to protect against lethal TB1R01AI138587-01JAGANNATH, CHINNASWAMYKAUSHAL, DEEPAKTULANE UNIVERSITY OF LOUISIANA, LA$837,967VMD
2018Striatin, Aldosterone and Hypertension2R56HL114765-05A1WILLIAMS, GORDON HBRIGHAM AND WOMEN'S HOSPITAL, MA$837,928CICS
2018Understanding Diverging Profiles of Academic and Physical Health Outcomes in African American Youth1R01HD093718-01CHEN, EDITHNORTHWESTERN UNIVERSITY, IL$837,843PDRP
2018Mechanism and Effects of Manipulating Chloride Homeostasis in Heart Failure1R01HL139629-01TESTANI, JEFFREY MYALE UNIVERSITY, CT$837,163CICS
2018PET radiotracers to image the enzyme 11beta-hydroxysteroid dehydrogenase-1 (11beta-HSD1)1R56MH116941-01HUANG, YIYUN HENRYYALE UNIVERSITY, CT$836,039NPAS
2018Mapping Dimensional Aspects of Biobehavioral Threat Reactivity in Young, Violence-Exposed Children: Linkages to Fear and Distress1U01MH113390-01A1BRIGGS-GOWAN, MARGARET JGRASSO, DAMION JOSEPHUNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT$834,637CPDD
2018Novel Mechanisms of Hepatopulmonary Syndrome1R01HL142269-01KAWUT, STEVEN MUNIVERSITY OF PENNSYLVANIA, PA$834,604IRAP
2018Wood Smoke and Chronic Mucous Hypersecretion1R01HL140839-01TESFAIGZI, YOHANNESLOVELACE BIOMEDICAL & ENVIRONMENTAL RESEARCH INSTITUTE, NM$833,288ZRG1
2018Imaging the Atherosclerosis Cascade in Sleep Apnea1R01HL143221-01SHAH, NEOMI AICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$832,642CHSA
2018Biopsychosocial Mechanisms of Superaging1R56AG058745-01BARRETT, LISA FELDMANDICKERSON, BRADFORD CMASSACHUSETTS GENERAL HOSPITAL, MA$832,369ZRG1
2018The Genetic and Molecular Basis of Cholesterol Efflux1R01HL136724-01A1ROHATGI, ANAND KUMARUT SOUTHWESTERN MEDICAL CENTER, TX$831,391CHSB
2018MEKK3 signaling in hemogenic endothelium1R01HL142976-01KAHN, MARK LUNIVERSITY OF PENNSYLVANIA, PA$829,654MCH
2018IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL2R01HL092577-10BENJAMIN, EMELIA J.ELLINOR, PATRICK THOMASLUNETTA, KATHRYN LMASSACHUSETTS GENERAL HOSPITAL, MA$829,096CICS
2018Eicosanoid Profiles as Determinants of HFpEF1R01HL140224-01HO, JENNIFER EMASSACHUSETTS GENERAL HOSPITAL, MA$828,655CHSB
2018Imaging Histone Deacetylase in the Heart and Bone Marrow1R01HL141563-01SOSNOVIK, DAVID EMASSACHUSETTS GENERAL HOSPITAL, MA$827,290CMIP
2018Patterns of Sleep Restriction and Recovery: The Inflammatory Resolution Pathways1R01HL136310-01A1HAACK, MONIKABETH ISRAEL DEACONESS MEDICAL CENTER, MA$827,228MESH
2018Genetic, Environmental & Histologic Basis for Kidney Disease Risk among Persons Living with HIV1R01DK117675-01LOCKE, JAYME ELIZABETHSAWINSKI, DEIRDREUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$826,947ACE
2018Role of cellular senescence in cardiovascular aging1R01AG055822-01A1CAMPISI, JUDITHMELOV, SIMONSEALS, DOUGLAS RBUCK INSTITUTE FOR RESEARCH ON AGING, CA$826,376ASG
2018Machine learning for the automated identification and tracking of rare myocardial diseases1R01HL140731-01A1DEO, RAHUL CHANDRAKANTSHAH, SANJIV JUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$826,025CHSB
2018FHFs and Cardiac Electrophysiology1R01HL142498-01FISHMAN, GLENN INEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$825,967ZRG1
2018Dynamics of antigen specific B and Tfh responses during acute and chronic HCV1R01AI136533-01GRAKOUI, ARASHEMORY UNIVERSITY, GA$825,277ZRG1
2018PediaTrac: Web-based measure to screen and track early developmental trajectories1R01HD095957-01HUTH-BOCKS, ALISSALAJINESS-O'NEILL, RENÉE ROCHELLETAYLOR, HUDSONWARSCHAUSKY, SETH AEASTERN MICHIGAN UNIVERSITY, MI$824,291CPDD
2018Biomarker of Lung Disease in African Americans1R01HL137995-01A1BOWLER, RUSSELL PAULKECHRIS-MAYS, KATHERINANATIONAL JEWISH HEALTH, CO$824,217IRAP
2018Contact Pathway Activation on Vascular Devices1R01HL144113-01HINDS, MONICA TMCCARTY, OWEN JOREGON HEALTH & SCIENCE UNIVERSITY, OR$823,936ZRG1
2018Joint genomic and statistical analyses of schizophrenia and bipolar to decipher genetic susceptibility1R01MH115676-01A1OPHOFF, ROEL APASANIUC, BOGDANUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$823,755BGES
2018The Gut Microbiota and Graft versus Host Disease (GVHD)1R01AI134808-01FREDRICKS, DAVID NEALFRED HUTCHINSON CANCER RESEARCH CENTER, WA$823,701CRFS
2018Characterizing the broad antibody response to HIV superinfection1R01AI138709-01OVERBAUGH, JULIE M.FRED HUTCHINSON CANCER RESEARCH CENTER, WA$821,274AIP
2018Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections1R01AI139032-01FISHER, BRIAN TSTEINBACH, WILLIAM JDUKE UNIVERSITY, NC$820,854CRFS
2018SZ-associated loci: Functional consequences and treatment opportunities1R01MH113215-01A1AVRAMOPOULOS, DIMITRIOSJOHNS HOPKINS UNIVERSITY, MD$820,754GHD
2018Kids SIPsmartER: A multi-level behavioral and health literacy intervention to reduce sugar-sweetened beverages among Appalachian middle-school students1R01MD012603-01ZOELLNER, JAMIEUNIVERSITY OF VIRGINIA, VA$820,221CLHP
2018JUSTice-Involved Individuals Cardiovascular Disease Epidemiology (JUSTICE)1R01HL137696-01A1WANG, EMILY AI-HUAYALE UNIVERSITY, CT$820,080CHSB
2018Perfusable 3D human cardiac constructs for heart regeneration1R01HL141570-01MURRY, CHARLES EZHENG, YINGUNIVERSITY OF WASHINGTON, WA$819,938BTSS
2018Understanding the structural basis of T cell receptor (TCR) and preTCR mechanosensing: single molecule, NMR and molecular dynamics studies1R01AI136301-01A1LANG, MATTHEW J.VANDERBILT UNIVERSITY, TN$817,267MSFC
2018Ambulatory blood pressure and falls in older treated patients with hypertension1R01HL136445-01A1REYNOLDS, KRISTISHIMBO, DAICHIKAISER FOUNDATION RESEARCH INSTITUTE, CA$817,125ASG
2018IMPROVE 2: Inhaled Mometasone to Promote Reduction in Vaso-occlusive Events1R01HL142671-01GLASSBERG, JEFFREY AVINSICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$816,930MCH

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