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NIH funding notice PA-18-484

NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)

Closed on January 7, 2019.

Posted
December 6, 2017
Close date
January 7, 2019
Activity codes
R01
Institutes taking part
NCI, NEI, NHLBI, NHGRI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDCD, NIDCR, NIDDK, NIDA, NIEHS, NIGMS, NIMH, NINDS, NINR, NIMHD, NLM, NCCIH, ORIP

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

  1. Reissues: PA-16-160 NIH Research Project Grant (Parent R01)
  2. 2 steps back: PA-13-302 Research Project Grant (Parent R01)
  3. 3 steps back: PA-11-260 Research Project Grant (Parent R01)
  4. 4 steps back: PA-10-067 Research Project Grant (Parent R01)
  5. 5 steps back: PA-07-070 Research Project Grant (Parent R01)

Replaced by PA-19-056.

Who won it before

27,977 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $13,260,052,210 in first-year total cost, median $404,000.

Most frequent study sections

  1. Diseases and Pathophysiology of the Visual System Study Section[DPVS]304
  2. Surgery, Anesthesiology and Trauma Study Section[SAT]290
  3. Biology of the Visual System Study Section[BVS]267
  4. Molecular Genetics A Study Section[MGA]238
  5. Molecular Genetics B Study Section[MGB]232

Most frequent institutions

  1. JOHNS HOPKINS UNIVERSITY660
  2. UNIVERSITY OF PITTSBURGH AT PITTSBURGH638
  3. UNIVERSITY OF MICHIGAN AT ANN ARBOR630
  4. UNIVERSITY OF PENNSYLVANIA617
  5. UNIVERSITY OF CALIFORNIA, SAN FRANCISCO557
Competing awards under PA-18-484 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2020Biology of Native Alpha-Synuclein Tetramers in Parkinson's Disease2RF1NS083845-06SELKOE, DENNIS JBRIGHAM AND WOMEN'S HOSPITAL, MA$2,884,925CNN
2020Models for Therapy of Hereditary Retinal Degeneration2R01EY006855-34AGUIRRE, GUSTAVO DAVIDMIYADERA, KEIKOUNIVERSITY OF PENNSYLVANIA, PA$750,679DPVS
2020The impact of HIV adaptation to CD8 T cells on infection and viral control1R56AI143482-01GOEPFERT, PAUL A.UNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$662,144AIP
2020Algorithms and Software for the Assembly of Metagenomic Data2R01AI100947-05A1POP, MIHAIUNIV OF MARYLAND, COLLEGE PARK, MD$634,665ZRG1
2020Asthma susceptibility due to environmental programming of innate immunity in utero2R01HL122995-06GORSKA, MAGDALENA MARIANATIONAL JEWISH HEALTH, CO$612,522LCMI
2020EValuation Of Longitudinal outcomes in mild TBI Active-Duty Military and VEterans 10-Year2R01NS091618-06MACDONALD, CHRISTINE LUNIVERSITY OF WASHINGTON, WA$603,141ANIE
2020Mechanism and Uses of Transmembrane Helix Insertion by Soluble Peptides2R01GM073857-13ANDREEV, OLEG AENGELMAN, DONALD M.RESHETNYAK, YANA KYALE UNIVERSITY, CT$595,452BBM
2020Quantitative magnetization transfer MRI for evaluation of renal fibrosis1R01DK122734-01LERMAN, LILACH OMAYO CLINIC ROCHESTER, MN$578,170PBKD
2020Neural Correlates of Recovery from Aphasia After Stroke2R01DC013270-06WILSON, STEPHEN MVANDERBILT UNIVERSITY MEDICAL CENTER, TN$564,226LCOM
2020Relationships between Neuroactive Steroids, GABA and Glutamate MRS and Connectivity of the Default Mode Network in Postpartum Depression1R01MH120313-01DELIGIANNIDIS, KRISTINA MARIEFEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, NY$551,736ZRG1
2020Deciphering the role of a novel micropeptide in cardiac function and dysfunction2R01HL130253-05BASSEL-DUBY, RHONDAOLSON, ERIC NUT SOUTHWESTERN MEDICAL CENTER, TX$544,997CCHF
2020Phasic dopamine and symptom domains of mental illness2R01MH104450-06ZWEIFEL, LARRY SUNIVERSITY OF WASHINGTON, WA$540,999MNPS
2020The 2020 ESPINA study follow-up Exam: Fungicides, Insecticides, Inflammation and Child Development1R01ES030378-01SUAREZ, JOSE RICARDOUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$531,731BGES
2020REPEAT-CONTAINING RNA BINDING PROTEINS OF TRYPANOSOMES2R01AI113157-06AFASIZHEVA, INNABOSTON UNIVERSITY MEDICAL CAMPUS, MA$509,192ZRG1
2020The IL-23/IL-17 Axis in Inflammatory Arthritis2R01AR062173-05A1ADAMOPOULOS, IANNIS ELIASUNIVERSITY OF CALIFORNIA AT DAVIS, CA$483,628ACTS
2020Coordinated Repair and Regeneration of Defective Mitochondria2R37AG047182-06HAYNES, COLE MUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$446,523ZRG1
2020Exposure to Insecticides and Child Growth and Pubertal Development in a South African Population Exposed Through Indoor Residual Spraying1R01ES030411-01CHEVRIER, JONATHANMCGILL UNIVERSITY, QC$441,488KNOD
2020Targeted transcriptional activation of HIV1R56AI147684-01MORRIS, KEVIN VBECKMAN RESEARCH INSTITUTE/CITY OF HOPE, CA$440,000ZRG1
2020Development of an Animal Model of Task Specific Dystonia1R01NS109227-01A1DAUER, WILLIAM T.UT SOUTHWESTERN MEDICAL CENTER, TX$429,791CDIN
2020Novel insights into nutrient-dependent regulation of beta cell proliferation2R01DK078803-11SANDER, MAIKEUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$429,370CADO
2020Cell-Contact Mediated Mechanisms Assembling Synapses2R01DA022727-12A1DALVA, MATTHEW BTHOMAS JEFFERSON UNIVERSITY, PA$424,077ZRG1
2020Determinants of Rod and Cone Response Characteristics2R01EY006641-34HURLEY, JAMES BRYANTUNIVERSITY OF WASHINGTON, WA$423,515ZRG1
2020High Resolution Characterization of Receptor Signaling and Regulation2R01GM117552-36BAIRD, BARBARA AHOLOWKA, DAVID ACORNELL UNIVERSITY, NY$408,584ZRG1
2020Surface Proteins of Gram-Positive Bacteria2R01AI038897-25MISSIAKAS, DOMINIQUE M.UNIVERSITY OF CHICAGO, IL$405,000PCMB
2020Structure and Dynamics of the Telomerase Ribonucleoprotein2R01GM095850-10STONE, MICHAEL DUNIVERSITY OF CALIFORNIA SANTA CRUZ, CA$396,895MSFB
2020Osteoblasts Role in Dysfunction of Body Adiposity and Bone Metabolism1R56AG065129-01JAVED, AMJADUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$392,627SBDD
2020Functional characterization of prostate cancer risk loci by high throughput sequencing1R01CA250018-01WANG, LIANGH. LEE MOFFITT CANCER CTR & RES INST, FL$386,114GHD
2020Brain tumor recurrence via signals from vascular endothelial cells1R01NS113631-01NAKANO, ICHIROUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$385,704MCT1
2020Genetic dissection of Cardiac Conduction System homeostasis and regeneration1R01HL142704-01A1WANG, JUNUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$366,188CDD
2020Identifying SREBP-1 activation mechanism in glioblastoma and its new role in regulating glutamine metabolism1R01NS112935-01GUO, DELIANGOHIO STATE UNIVERSITY, OH$359,493TCB
2020The role of weak multivalent interactions and phase separation in SPOP tumor suppressor function2R01GM112846-06MITTAG, TANJAST. JUDE CHILDREN'S RESEARCH HOSPITAL, TN$359,000MSFC
2020Alarmin-mediated control of CNS infection1R01NS112516-01HARRIS, TAJIE H.UNIVERSITY OF VIRGINIA, VA$349,296CNBT
2020Selective galactosylceramidase ablation to study the pathogenesis of Krabbe leukodystrophy1R01NS112327-01SHIN, DAESUNGSTATE UNIVERSITY OF NEW YORK AT BUFFALO, NY$348,906DBD
2020Mechanisms of Oligodendrocyte Fate Specification in the Developing Neocortex1R01NS109239-01FRANCO, SANTOS JOEUNIVERSITY OF COLORADO DENVER, CO$329,473CMBG
2020New Computational Methods for Data-driven Protein Structure Prediction2R01GM089753-10XU, JINBOTOYOTA TECHNOLOGICAL INSTITUTE / CHICAGO, IL$319,222MSFD
2020Elucidating the relationship between lipid droplets, lipid metabolism, and lipotoxicity2R01GM112948-06OLZMANN, JAMES AUNIVERSITY OF CALIFORNIA BERKELEY, CA$313,586MBPP
2020Computational methods for detecting patterns of complex genomic variation2R01GM114362-05BAFNA, VINEETUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$289,446BDMA
2019Neural network and immune cell dysfunctions in Alzheimer's disease pathogenesis1RF1AG063519-01MUCKE, LENNARTJ. DAVID GLADSTONE INSTITUTES, CA$4,538,275ZRG1
2019Fibrinogen and vascular cognitive impairment: mechanisms, imaging, therapeutics1RF1AG064926-01AKASSOGLOU, KATERINAELLISMAN, MARK HPALOP, JORGE JJ. DAVID GLADSTONE INSTITUTES, CA$4,523,685ZRG1
2019Attention and Semantic Evaluation as Predictors of Empathy in Healthy Aging and Frontotemporal Dementia2RF1AG029577-11RANKIN, KATHERINE PUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$4,022,337ZRG1
2019Microglial apoE in neuroinflammation and Alzheimer's disease1RF1AG062110-01FRYER, JOHN DAVIDMAYO CLINIC ARIZONA, AZ$4,000,570CDIN
2019Development of novel therapies for FAD1RF1AG063520-01A1SHEN, JIEBRIGHAM AND WOMEN'S HOSPITAL, MA$3,927,945ZRG1
2019Systems Approaches to Novel Molecular Mechanism in Alzheimer's Disease1RF1AG064909-01PENG, JUNMINYU, GANGUT SOUTHWESTERN MEDICAL CENTER, TX$3,869,330ZRG1
2019Novel Strategies and Mechanisms to Target APOE and Alzheimer's Disease2RF1AG047644-06HOLTZMAN, DAVID M.HYMAN, BRADLEY T.WASHINGTON UNIVERSITY, MO$3,760,149CDIN
2019Age-related cognitive decline and myelin pathology: A comprehensive study of oligodendroglia, microglia and myelin homeostasis in the normal aging monkey1RF1AG062831-01ROSENE, DOUGLAS LBOSTON UNIVERSITY MEDICAL CAMPUS, MA$3,743,250LAM
2019Mechanisms of myelin damage and cognitive impairment in the aging monkey: Gene Expression, Neurophysiology, Inflammation and Effects of Calorie Restriction2RF1AG043640-06ROSENE, DOUGLAS LBOSTON UNIVERSITY MEDICAL CAMPUS, MA$3,720,029ASG
2019Microglial lipid droplets in Alzheimer's disease1RF1AG064928-01WYSS-CORAY, TONYSTANFORD UNIVERSITY, CA$3,681,800ZRG1
2019Relevance of Abeta N-terminal Truncations for Alzheimer Pathogenesis and Therapy - Resubmission - 11RF1AG059695-01A1GHISO, JORGE ANEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$3,659,909CNN
2019Advancing Analysis of Multi-omics Data in Alzheimer's Disease Research1RF1AG063481-01A1LONG, QIUNIVERSITY OF PENNSYLVANIA, PA$3,635,365ZRG1
2019Lifespan Cardiovascular Risk Exposures and Alzheimer-related brain health: Bogalusa Heart Study2RF1AG041200-06BAZZANO, LYDIACARMICHAEL, OWEN T.TULANE UNIVERSITY OF LOUISIANA, LA$3,599,769CNN
2019Identifying Rare Variants that Increase Risk for Alzheimer's Disease2RF1AG044546-06CRUCHAGA, CARLOSWASHINGTON UNIVERSITY, MO$3,597,538MNG
2019Calcineurin Mediates the Synergistic Toxicity of Tau and Aβ Oligomers1RF1AG060718-01A1KAYED, RAKEZTAGLIALATELA, GIULIOUNIVERSITY OF TEXAS MED BR GALVESTON, TX$3,532,750CDIN
2019Boston Early Adversity and Mortality Study (BEAMS): Linking administrative data to long-term longitudinal studies1RF1AG064006-01LEE, LEWINA ONYIMROCZEK, DANIEL K.NORTHWESTERN UNIVERSITY AT CHICAGO, IL$3,528,185SSPB
2019Identification and characterization of tau seeding and strain composition in tauopathy1RF1AG059689-01A1DIAMOND, MARC IWHITE, CHARLES LEEUT SOUTHWESTERN MEDICAL CENTER, TX$3,442,490CDIN
2019Immunometabolic phenotypes in adult severe asthma and disease progression1U01HL146002-01A1CASTRO, MARIOCOMHAIR, SUZYDENLINGER, LOREN CHOFFMAN, ERIC ALFREDISRAEL, ELLIOTKHATRI, PURVESHKUMARLEVY, BRUCE DMAUGER, DAVID T.MEYERS, DEBORAH A.MOORE, WENDY CPENNINGTON, EMILYWENZEL, SALLY EWOODRUFF, PRESCOTT GBRIGHAM AND WOMEN'S HOSPITAL, MA$3,419,613IRAP
2019Probing Alzheimer synaptopathy in neurons derived from engineered human iPS cells2RF1AG048131-02SUDHOF, THOMAS C.WERNIG, MARIUSSTANFORD UNIVERSITY, CA$3,360,685ZRG1
2019Management of Hypertension among Persons with and without Dementia in Long-Term Care1RF1AG062568-01ODDEN, MICHELLE CHRISTINASTANFORD UNIVERSITY, CA$3,327,236ASG
2019Flexible multivariate models for linking multi-scale connectome and genome data in Alzheimer's disease and related disorders1RF1AG063153-01A1CALHOUN, VINCE DLIU, JINGYUGEORGIA STATE UNIVERSITY, GA$3,319,889BMRD
2019Pin1 Regulation in Evolving Alzheimer’s Disease1RF1AG062653-01MALTER, JAMES SUT SOUTHWESTERN MEDICAL CENTER, TX$3,257,680ZRG1
2019Antimicrobial activities of Abeta in Alzheimer's disease brain1RF1AG061035-01TANZI, RUDOLPH EMILEMASSACHUSETTS GENERAL HOSPITAL, MA$3,229,539CDIN
2019Role of PS1 in neurodegeneration2RF1AG044486-06BEREZOVSKA, OKSANAMASSACHUSETTS GENERAL HOSPITAL, MA$3,188,744CMND
2019AMP-Kinase as a target for neuroprotection in AD1RF1AG062135-01LEE, MICHAEL KTRUSHINA, EUGENIAUNIVERSITY OF MINNESOTA, MN$3,175,735NOMD
2019Opposing Regulation of Sleep-Wake Abeta Fluctuations by Orexin and Dynorphin1RF1AG064902-01CIRRITO, JOHN RWASHINGTON UNIVERSITY, MO$3,142,615ZRG1
2019Novel Therapeutic Approaches to Increase Progranulin Levels in Brain to Treat FTD and AD1RF1AG060765-01A1FINKBEINER, STEVEN MJ. DAVID GLADSTONE INSTITUTES, CA$3,112,016CMND
2019ApoE isoform-specific therapy for Alzheimer disease2RF1AG046205-06ZHAO, NAMAYO CLINIC JACKSONVILLE, FL$3,100,040CDIN
2019Role of arterial stiffness in the decline of cognitive control in aging1RF1AG062666-01FABIANI, MONICAGRATTON, GABRIELEUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$3,024,850CP
2019Characterizing WDR23 in Alzheimer's disease pathology1RF1AG063947-01CURRAN, SEAN PUNIVERSITY OF SOUTHERN CALIFORNIA, CA$2,924,025ASG
2019Defining native proteoform landscape for amyloid-beta in Alzheimers disease1RF1AG063903-01KELLEHER, NEIL LKLEIN, WILLIAM LPATRIE, STEVEN MATTHEWNORTHWESTERN UNIVERSITY, IL$2,909,025EBIT
2019Postmortem validation of novel tau PET tracers1RF1AG061206-01GOMEZ-ISLA, TERESAMASSACHUSETTS GENERAL HOSPITAL, MA$2,887,030CMIP
2019TAM Receptor Signaling in Neurodegenerative Disease1RF1AG060748-01A1LEMKE, GREG ESALK INSTITUTE FOR BIOLOGICAL STUDIES, CA$2,877,690CDIN
2019Pre-clinical efficacy of a selective p38MAPK inhibitor in a model of comorbid Alzheimer/vascular pathology1RF1AG064859-01VAN ELDIK, LINDA JUNIVERSITY OF KENTUCKY, KY$2,872,820ZRG1
2019Defining modifiers and mechanisms of RAN translation1RF1AG064690-01GITLER, AARON D.PUGLISI, JOSEPH DSTANFORD UNIVERSITY, CA$2,824,794MGA
2019Molecular mechanisms of PINK1-PRKN directed mitochondrial quality control2RF1NS085070-06SPRINGER, WOLFDIETERMAYO CLINIC JACKSONVILLE, FL$2,822,900NOMD
2019Safe Cardiometabolic Drug Prescribing to Prevent Injury in Nursing Home Residents1RF1AG061221-01A1BERRY, SARAH DYERHEBREW REHABILITATION CENTER FOR AGED, MA$2,812,212ASG
2019Dementia Following Spinal Cord Injury: Mechanism and Therapeutic Targeting1RF1NS110637-01JAY, STEVEN MICHAELWU, JUNFANGUNIVERSITY OF MARYLAND BALTIMORE, MD$2,799,596ANIE
2019Plasma Proteome and Risk of Alzheimer Dementia and Related Endophenotypes in the Framingham Study1RF1AG063507-01GERSZTEN, ROBERT ERAMACHANDRAN, VASAN SSESHADRI, SUDHABOSTON UNIVERSITY MEDICAL CAMPUS, MA$2,730,110NAME
2019Mechanisms of amyloid precursor protein processing: novel regulation of α-secretase activity1RF1AG062671-01SOCKANATHAN, SHANTHINIJOHNS HOPKINS UNIVERSITY, MD$2,726,485CMND
2019Structure and Function of Neuronal Hemichannels1RF1NS113632-01FURUKAWA, HIROYASUCOLD SPRING HARBOR LABORATORY, NY$2,716,377BBM
2019Immunotherapy targeting the HPA axis in Alzheimer’s disease1RF1AG064942-01BIZON, JENNIFER LYNNGOLDE, TODD ELEWIS, JADA MUNIVERSITY OF FLORIDA, FL$2,689,784ZRG1
2019Soluble αSyn is a modulator of AD pathophysiology2RF1AG044342-06A1LESNE, SYLVAIN E.UNIVERSITY OF MINNESOTA, MN$2,689,594CDIN
2019Genetic Architecture of Alzheimer's disease Proteinopathies1R56AG064877-01CRUCHAGA, CARLOSKAMBOH, M. ILYASUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$2,626,839ZRG1
2019THERAPEUTIC STRATEGIES FOR ALZHEIMER'S DISEASE BASED ON TREM2 BIOLOGY1RF1AG059082-01A1COLONNA, MARCOWASHINGTON UNIVERSITY, MO$2,611,246CMBG
2019Control of Gene Expression and Life Span2RF1AG024353-16A1HELFAND, STEPHEN LBROWN UNIVERSITY, RI$2,535,115CMAD
2019Role of Glucosylsphingosine in Parkinson Disease and Dementia with Lewy Bodies1RF1NS110354-01CHANDRA, SREEGANGA SYALE UNIVERSITY, CT$2,480,685ZRG1
2019Elucidating factors that modulate tauopathy and cellular degeneration to guide therapeutic development1RF1AG064914-01GOLDE, TODD ELEWIS, JADA MMCFARLAND, KAREN NUNIVERSITY OF FLORIDA, FL$2,473,595ZRG1
2019Non-alcoholic Fatty Liver Disease and Cardiovascular Disease in Hispanics/Latinos1R01HL144707-01A1KIZER, JORGE RLIMA, JOAO A CNORTHERN CALIFORNIA INSTITUTE/RES/EDU, CA$2,425,096CHSB
2019Combined Cardiopulmonary Failure in COPD: SPIROMICS HF2R01HL093081-09BARR, R GRAHAMCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$2,391,491IRAP
2019Effects of Hypertension and Hypoperfusion on the Brain Vasculome1R01NS110818-01ARAI, KENLO, ENG H.MASSACHUSETTS GENERAL HOSPITAL, MA$2,356,600BINP
2019Rat Genome Database2R01HL064541-20 · under PA-16-160SHIMOYAMA, MARY EMEDICAL COLLEGE OF WISCONSIN, WI$2,232,697GCAT
2019Leveraging multi-omics approaches to examine metabolic challenges of obesity in relation to cardiovascular diseases1R01HL143885-01A1AVERY, CHRISTY LEIGHGORDON-LARSEN, PENNYNORTH, KARI E.SUMNER, SUSAN JUNIV OF NORTH CAROLINA CHAPEL HILL, NC$2,210,843KNOD
2019Post stroke cognitive impairment: mechanism and therapy1RF1NS109583-01YANG, SHAOHUAUNIVERSITY OF NORTH TEXAS HLTH SCI CTR, TX$2,202,500BINP
2019PASOS: Peripheral Artery Disease Study of SOL. An ancillary study of the Hispanic Community Health Study/Study of Latinos1R01HL146132-01KAPLAN, ROBERT CMATSUSHITA, KUNIHIROALBERT EINSTEIN COLLEGE OF MEDICINE, NY$2,182,970CHSA
2019Assessing the effectiveness of oral anticoagulants in patients with atrial fibrillation at high risk of underutilization due to dementia, recurrent falls, or poor anticoagulation quality1RF1AG063381-01LIN, JOSHUA KBRIGHAM AND WOMEN'S HOSPITAL, MA$2,150,379HSOD
2019Molecular Basis of Mitochondrial Dysfunction in Neurodegeneration1RF1AG064175-01NORMAN, KENNETH RALBANY MEDICAL COLLEGE, NY$2,111,031NOMD
2019Risk Factors, Pathology, and Clinical Expressions of AD2R01AG015819-17BENNETT, DAVID ALANRUSH UNIVERSITY MEDICAL CENTER, IL$2,104,828NAME
2019Carboxyl-terminal modulator protein, Aβ and brain aging1RF1AG061047-01A1WENKER, IAN CHRISTOPHERUNIVERSITY OF VIRGINIA, VA$2,018,750ASG
2019Retromer deficiency and Alzheimer's disease pathology2RF1AG045781-06XIONG, WEN-CHENGCASE WESTERN RESERVE UNIVERSITY, OH$2,008,958CDIN
2019BACE1 as a Therapeutic Target for Alzheimer's Disease2RF1AG022560-16VASSAR, ROBERT JNORTHWESTERN UNIVERSITY AT CHICAGO, IL$1,975,000CDIN
2019PET Imaging agents for a4b2 Nicotinic Receptors2RF1AG029479-10CHRISTIAN, BRADLEY TMUKHERJEE, JOGESHWARUNIVERSITY OF CALIFORNIA-IRVINE, CA$1,957,337CNN
2019Development of inhibitors and diagnostics for amyloid diseases2RF1AG048120-06EISENBERG, DAVIDUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$1,950,000MSFB
2019Examining the role of glycosphingolipids in the progression and heterogeneity of synucleinopathies1RF1NS109157-01MAZZULLI, JOSEPH RNORTHWESTERN UNIVERSITY AT CHICAGO, IL$1,928,426CMND
2019Transcriptional control of proteostasis and aging1RF1AG062593-01SAMUELSON, ANDREW VAUGHNUNIVERSITY OF ROCHESTER, NY$1,925,000CMAD
2019Metabolic Interventions for Enhancing Cognitive Resilience in Aging and Alzheimers Disease1RF1AG060977-01BURKE, SARA NUNIVERSITY OF FLORIDA, FL$1,916,469LAM
2019Investigating the role of transposable element dysregulation as a driver of neurotoxicity in tauopathy1RF1NS112391-01FROST, BESSUNIVERSITY OF TEXAS HLTH SCIENCE CENTER, TX$1,912,681CMND
2019Hyptothalamic autophagy and metabolic regulation in aging2RF1AG043517-08SINGH, RAJATALBERT EINSTEIN COLLEGE OF MEDICINE, NY$1,895,935CMAD
2019Algebraic Formulations for Characterizing Structural Brain Connectivity Changes and Pathology Transmission Networks in Preclinical Alzheimer's Disease1RF1AG059312-01A1BENDLIN, BARBARA BRIGITTASINGH, VIKASUNIVERSITY OF WISCONSIN-MADISON, WI$1,826,486NOIT
2019Plasma proteomics in CHS and population biology1R01HL144483-01A1GERSZTEN, ROBERT EPSATY, BRUCE MTRACY, RUSSELL PUNIVERSITY OF WASHINGTON, WA$1,799,932CHSA
2019Tau pathology in Down syndrome and Alzheimer's1RF1AG061566-01GRANHOLM-BENTLEY, ANN-CHARLOTTE ESTHERMARGITTAI, MARTINMUFSON, ELLIOTT JAYUNIVERSITY OF DENVER (COLORADO SEMINARY), CO$1,720,831CMND
2019Characterization of Sedentary Patterns and Cardiovascular Disease Risk Markers in Hispanics/Latinos1R01HL148463-01CARLSON, JORDAN A.CHILDREN'S MERCY HOSP (KANSAS CITY, MO), MO$1,671,646ZRG1
2019Molecular Assembly and Disassembly of RNA-Protein Complexes Implicated in ALS/FTD1RF1NS113636-01MYONG, SUAJOHNS HOPKINS UNIVERSITY, MD$1,538,408ZRG1
2019Clonal hematopoiesis in humans: determinants of development and progression1R01HL148050-01BALLANTYNE, CHRISTIE MITCHELLNATARAJAN, PRADEEPBAYLOR COLLEGE OF MEDICINE, TX$1,532,120GHD
2019Neurodevelopmental Mechanisms Underlying Stress Vulnerability during Adolescence1R56MH119194-01MCLAUGHLIN, KATIEHARVARD UNIVERSITY, MA$1,509,821CPDD
2019Eating Disorders Genetics Initiative (EDGI)1R01MH120170-01BULIK, CYNTHIA MUNIV OF NORTH CAROLINA CHAPEL HILL, NC$1,504,134BGES
2019Clinical and Molecular Epidemiology of High Risk Coronary Plaque1R01HL146145-01A1DOUGLAS, PAMELA SUSANHOFFMANN, UDOSHAH, SVATI H.DUKE UNIVERSITY, NC$1,485,906CHSA
2019Examining the quality of opioid use disorder treatment in a Medicaid research network1R01DA048029-01DONOHUE, JULIE MARIEUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$1,482,140HSOD
2019SCAN-MP (Screening for Cardiac Amyloidosiswith Nuclear imaging in Minority Populations)1R01HL139671-01A1MAURER, MATHEW SRUBERG, FREDERICK LIEFCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$1,464,981CHSB
2019PAGE III: Population Architecture using Genomics and Epidemiology1R01HG010297-01A1GIGNOUX, CHRISTOPHER RMATISE, TARA C.RUTGERS, THE STATE UNIV OF N.J., NJ$1,447,080GHD
2019Brain Attack Surveillance in Corpus Christi (BASIC) Project2R01NS038916-21LISABETH, LYNDA DMORGENSTERN, LEWIS BUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$1,437,510NAME
2019Molecular Interactions of HIV-1 with the Nuclear Pore Complex1R01AI148382-01MELIKIAN, GREGORY BSARAFIANOS, STEFAN GTORBETT, BRUCE EDWARDEMORY UNIVERSITY, GA$1,435,582ZRG1
2019Exceptional Cognitive Aging: Neuropsychologic, Anatomic and Pathologic Correlates2R56AG045571-06GEULA, CHANGIZMESULAM, MAREK-MARSEL MROGALSKI, EMILY JNORTHWESTERN UNIVERSITY AT CHICAGO, IL$1,380,437CNN
2019Somatic Mutations and Their Etiological Determinants for Breast Cancer in African American Women1R01CA228156-01A1CARPTEN, JOHN D.PALMER, JULIE RYAO, SONGZHENG, WEIROSWELL PARK CANCER INSTITUTE CORP, NY$1,333,797CHSB
2019Long-term fracture risk in older men: the MrOS study1R56AG061085-01BOUXSEIN, MARY LCAWTHON, PEGGY MANNENORWOLL, ERIC S.CALIFORNIA PACIFIC MED CTR RES INSTITUTE, CA$1,319,737NAME
2019National Social Life, Health and Aging Project: Baby Boom Cohort Wave 22R01AG048511-06WAITE, LINDA JNATIONAL OPINION RESEARCH CENTER, IL$1,291,423SSPA
2019Dementia care in nursing homes: does race matter?1RF1AG063811-01CAI, SHUBINGUNIVERSITY OF ROCHESTER, NY$1,258,255HSOD
2019The EcoCyc Model Organism Database for Escherichia coli2R01GM077678-28KARP, PETER DSRI INTERNATIONAL, CA$1,160,384BDMA
2019Enhancing Retrospective Life History Data in the Health and Retirement Study- Renewal2R01AG051142-05SMITH, JACQUIUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$1,155,294SSPB
2019Depression and accelerated brain aging: A PET imaging study1R01MH118728-01A1ESTERLIS, IRINAPIETRZAK, ROBERT HYALE UNIVERSITY, CT$1,103,740NPAS
2019Scarring and Arrhythmia in Infarcted Aged Hearts: Role of Senescent Fibroblasts1R01HL139467-01A1KOREN, GIDEONSEDIVY, JOHN MRHODE ISLAND HOSPITAL, RI$1,066,467ESTA
2019Prebiotics Intervention to Reduce Alzheimer's Disease Risk via Brain-Gut Axis in an APOE4 Mouse Model1RF1AG062480-01LIN, AI-LINGUNIVERSITY OF KENTUCKY, KY$1,060,292CNN
2019Fragile Families and the Transition to Adulthood2R01HD036916-16A1EDIN, KATHRYNWALDFOGEL, JANEPRINCETON UNIVERSITY, NJ$1,029,901SSPB
2019Long-term Outcomes after Interventions for Congenital Heart Disease2R01HL122392-06A1KOCHILAS, LAZAROS K.EMORY UNIVERSITY, GA$1,012,489CHSA
2019National Neuropsychological Network (NNN)1R01MH118514-01BAUER, RUSSELL MBILDER, ROBERT MDRANE, DANIEL LLORING, DAVID W.SABSEVITZ, DAVID SUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$1,010,364APDA
2019The MetaCyc & BioCyc Pathway/Genome Databases2R01GM080746-13CASPI, RONKARP, PETER DSRI INTERNATIONAL, CA$1,005,713BDMA
2019Uncleaved prefusion-optimized trimers on nanoparticles as HIV vaccines1R01AI140844-01A1ZHU, JIANGSCRIPPS RESEARCH INSTITUTE, THE, CA$992,504VACC
2019SPECT Imaging of Peripheral Vascular Disease1R01HL145786-01A1LIU, CHIMENG, LING-JIANMETZLER, SCOTT DEANSINUSAS, ALBERT JUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$990,046ZRG1
2019Neurodegenerative mechanisms in Christianson syndrome and NHE6-related disorders1R01NS113141-01MORROW, ERIC MBROWN UNIVERSITY, RI$963,816MNG
2019Primate model of deep brain stimulation for Alzheimers and age-related cognitive decline1RF1AG060754-01A1BLAKE, DAVID TCONSTANTINIDIS, CHRISTOSWAKE FOREST UNIVERSITY HEALTH SCIENCES, NC$963,552ZRG1
2019Tracking longitudinal change in presymptomatic genetic prion disease (TLC-Pre-gPrD)1R01AG062562-01GESCHWIND, MICHAEL DUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$962,633CNN
2019Design and testing of germline-targeting and boosting immunogens to elicit 10E8-like broadly neutralizing antibodies against HIV1R01AI147826-01SCHIEF, WILLIAM R.SCRIPPS RESEARCH INSTITUTE, THE, CA$957,981HIVD
2019The functional significance of CTL escape2R01AI052056-17A1WATKINS, DAVID IUNIVERSITY OF MIAMI SCHOOL OF MEDICINE, FL$948,180VACC
2019Engineer Immune Cells via Chemoenzymatic Glycan Editing1R01AI143884-01TEIJARO, JOHN ROSSWU, PENGSCRIPPS RESEARCH INSTITUTE, THE, CA$944,319SBCA
2019Novel vaccine strategies to induce V2 apex-directed broad neutralizing antibodies1R01AI141338-01A1VERKOCZY, LAURENT KARLSAN DIEGO BIOMEDICAL RESEARCH INSTITUTE, CA$943,932HIVD
2019"A Novel Role for the UPR Component, ATF6 in AD-associated Neuroprotective Pathways"1R01AG062190-01KAUFMAN, RANDAL J.XU, HUAXISANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, CA$941,795CDIN
2019Interplay Between ER Associated Degradation (ERAD) Mechanisms and Alzheimer's Disease Pathogenesis1R01AG062203-01FLAJOLET, MARCXU, HUAXISANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, CA$939,910CDIN
2019A systems approach to manipulate microbial adaptation to structured environments1R01AI141953-01A1BALIGA, NITIN SINSTITUTE FOR SYSTEMS BIOLOGY, WA$927,560MABS
2019Fusion peptide directed immunogens that elicit neutralizing and protective antibodies in non-human primates1R01AI145629-01CROTTY, SHANE PWARD, ANDREW BARRETTSCRIPPS RESEARCH INSTITUTE, THE, CA$920,094HIVD
2019JAK-STAT Control of Zika Virus-Induced Fetal Injury1R01AI143265-01A1ADAMS WALDORF, KRISTINA M.GALE, MICHAELUNIVERSITY OF WASHINGTON, WA$919,950ZRG1
2019Functional Redundancy of Human Microbiome and its Implication in Fecal Microbiota Transplantation1R01AI141529-01LIU, YANG-YUBRIGHAM AND WOMEN'S HOSPITAL, MA$919,386MABS
2019Antigen recognition and activation of B-cell receptors of HIV-1 broadly neutralizing antibodies1R01AI145656-01ALAM, S. MUNIRDUKE UNIVERSITY, NC$917,944HIVD
2019Genetic Prediction for Treatment Resistance in Kawasaki Disease1R01HL146130-01PORTMAN, MICHAEL ASHRESTHA, SADEEPSEATTLE CHILDREN'S HOSPITAL, WA$917,552CHSA
2019Software for Practical Annotation and Exchange of Virtual Anatomy1R01EB025212-01A1ENQUOBAHRIE, ANDINET ASMAMAWERDEMIR, AHMETCLEVELAND CLINIC LERNER COM-CWRU, OH$917,045BTSS
2019Systemic and dietary advanced glycation end products in type 2 diabetes-related cognitive decline and incident dementia: effects on Alzheimer's pathology and cerebrovascular disease1R01AG061093-01SCHNAIDER BEERI, MICHALICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$910,096NAME
2019CD180 targeted immunotherapeutic for chronic HBV in HIV infected patients1R56AI141494-01A1FULLER, DEBORAH H.UNIVERSITY OF WASHINGTON, WA$907,661ZRG1
2019Novel nanoparticulate adjuvants to enhance HIV-1 Env specific mucosal antibody responses1R01AI145640-01A1KASTURI, SUDHIR PAIEMORY UNIVERSITY, GA$904,894HIVD
2019Interstitial Lung Abnormalities: Defining the Phenotype, Causes, and Consequences.2R01HL111024-06HUNNINGHAKE, GARY MATTHEWBRIGHAM AND WOMEN'S HOSPITAL, MA$903,043RIBT
2019Pesticides, Olfaction, and Neurodegeneration Among US Farmers1R01ES029227-01A1CHEN, HONGLEIMICHIGAN STATE UNIVERSITY, MI$902,103NAL
2019Neuroprotective Effects of Vascular Endothelial Growth Factor in Alzheimer's Disease1R01AG061518-01HOHMAN, TIMOTHY JVANDERBILT UNIVERSITY MEDICAL CENTER, TN$900,827CNN
2019Improving Pediatric Cardiac Arrest Survival and Neurologic Outcome1R01HL141386-01A1KILBAUGH, TODD JUSTENCHILDREN'S HOSP OF PHILADELPHIA, PA$897,005CICS
2019Familial hypercholesterolemia screening in children: population impact of phenotype, genotype, and cascade approaches1R01HL141823-01A1DE FERRANTI, SARAH DMORAN, ANDREW EDWARDCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$894,544CHSB
2019Development and validation of an electronic health record prediction tool for first-episode psychosis1R01MH116042-01A1REIS, BEN YSMOLLER, JORDAN WMASSACHUSETTS GENERAL HOSPITAL, MA$892,010BCHI
2019Neural substrates of diffusion imaging in cognitively aging rhesus monkeys2R01AG042512-06KUBICKI, MAREKMAKRIS, NIKOLAOSROSENE, DOUGLAS LBRIGHAM AND WOMEN'S HOSPITAL, MA$891,796ASG
2019Regulation of y-secretase activity by modulatory proteins1R01AG061350-01LI, YUEMINGSLOAN-KETTERING INST CAN RESEARCH, NY$890,974CMND
2019A dual-beta-lactam strategy for treating multidrug resistant M abscessus1R01AI141805-01A1KREISWIRTH, BARRY NEALHACKENSACK UNIVERSITY MEDICAL CENTER, NJ$890,074DDR
2019True 4DCT for Quantifying LV Dyssynchrony and Function for Targeting LV Lead Location in CRT1R01HL144678-01MCVEIGH, ELLIOT RUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$888,993MEDI
2019Arterial Inflammation and Coronary Microvascular Dysfunction among Women with HIV: Missing Pieces to the MI Risk Puzzle1R01HL146267-01A1ZANNI, MARKELLA V.MASSACHUSETTS GENERAL HOSPITAL, MA$886,634HCCS
2019Genetic and Functional Dissection of a Cluster of COPD GWAS Signals on Chromosome 4q1R01HL147148-01CHO, MICHAEL H.SILVERMAN, EDWIN KZHOU, ANNY XIAOBOBRIGHAM AND WOMEN'S HOSPITAL, MA$886,191GHD
2019Linking Endotypes and Outcomes in Pediatric Acute Respiratory Distress Syndrome1R01HL148054-01YEHYA, NADIRCHILDREN'S HOSP OF PHILADELPHIA, PA$885,825IRAP
2019Decoding neural systems underlying anosognosia for memory loss in aging and Alzheimer's disease1R01AG061083-01A1VANNINI, PATRIZIABRIGHAM AND WOMEN'S HOSPITAL, MA$885,481APDA
2019Clonal hematopoiesis in the Women's Health Initiative1R01HL148565-01REINER, ALEXANDER PWHITSEL, ERIC A.FRED HUTCHINSON CANCER RESEARCH CENTER, WA$884,044CHSB
2019MicroRNA Predictors of HIV Risk in Reproductive Age Women1R01HD099091-01FICHOROVA, RAINA N.BRIGHAM AND WOMEN'S HOSPITAL, MA$883,063ZRG1
2019Molecular Regulation of Atherosclerosis1R01HL146134-01CHEN, HONGSRIVASTAVA, SANJAYBOSTON CHILDREN'S HOSPITAL, MA$880,438ZRG1
2019Nanoparticle CT Contrast Agent for New Capabilities in Tumor Detection, Staging, and Therapy Planning and Response1R01CA226868-01A1JOHNSON, BRUCE FYEH, BENJAMIN MUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$878,060CMIP
2019NEIGHBORHOOD Consortium for POAG Genetics2R01EY022305-08WIGGS, JANEY LMASSACHUSETTS EYE AND EAR INFIRMARY, MA$872,775GHD
2019Clinical, Genetic, and Proteomic Risk Factors for Pulmonary Hypertension in Heart Failure1R01HL146588-01BRITTAIN, EVAN LFREIBERG, MATTHEW SVANDERBILT UNIVERSITY MEDICAL CENTER, TN$871,041CHSA
2019Mechanisms of Cell-Based Heart Regeneration1R01HL146868-01MURRY, CHARLES EUNIVERSITY OF WASHINGTON, WA$870,813MIM
2019Scalable tool and comprehensive maps to interpret structural variation across the neuropsychiatric spectrum1R01MH115957-01A1TALKOWSKI, MICHAEL EBROAD INSTITUTE, INC., MA$869,456GCAT
2019Linking Sleep Disruption to Tau Accumulation and Network Dysregulation in Early Alzheimer's Disease1R01AG062667-01A1CHHATWAL, JASMEER PMASSACHUSETTS GENERAL HOSPITAL, MA$868,210CNN
2019Mediators of Systemic Inflammation and Heart Failure Risk in the Community1R01HL143227-01A1CHENG, SUSANCEDARS-SINAI MEDICAL CENTER, CA$868,069CHSB
2019Depression in Older Asthmatics: Understanding Inflammatory and Behavioral Pathways1R01HL142749-01A1BUSSE, PAULA JFELDMAN, JONATHAN M.WISNIVESKY, JUAN PICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$867,332BMIO
2019Role of impaired cognitive states & risk factors in conversion to mixed dementias2R01AG038651-06A1ABNER, ERINKRYSCIO, RICHARD J.YU, LEIUNIVERSITY OF KENTUCKY, KY$864,464NAME
2019Innate Immune Regulation of Zika Virus Infection1R01AI145296-01COYNE, CAROLYN BDIAMOND, MICHAEL SGALE, MICHAELUNIVERSITY OF WASHINGTON, WA$863,742ZRG1
2019A Single-Cell Resolution Enhancer Atlas of Craniofacial Development1R01DE028599-01VISEL, AXELUNIVERSITY OF CALIF-LAWRENC BERKELEY LAB, CA$857,527GCAT
2019A general mechanism of persister formation1R01AI141966-01LEWIS, KIMPAULSSON, JOHANNORTHEASTERN UNIVERSITY, MA$857,014DDR
2019Elucidating the Role of Adipokines in Mediating and Predicting HF Associated with Obesity1R01HL146907-01NDUMELE, CHIADI EJOHNS HOPKINS UNIVERSITY, MD$856,837CHSB
2019PsycheMERGE: Leveraging electronic health records and genomics for mental health research1R01MH118233-01DAVIS, LEA KSMOLLER, JORDAN WMASSACHUSETTS GENERAL HOSPITAL, MA$855,687BGES
2019Omics Analyses of HIV and Substance Use Disorder1R01DA048882-01REPUNTE-CANONIGO, VEZSCRIPPS RESEARCH INSTITUTE, THE, CA$855,649ZRG1
2019HIV-1 Env structure and function assessed by parallel smFRET and cryoET1R01AI150560-01BLANCHARD, SCOTT CLIU, JUNMOTHES, WALTHER HYALE UNIVERSITY, CT$854,998HVCD
2019Clonal Hematopoiesis in Healthy Individuals from Families with Early OnsetCoronary Artery Disease1R01HL143818-01A1BECKER, LEWIS CRESAR, LINDA M SJOHNS HOPKINS UNIVERSITY, MD$851,405CHSA
2019Molecular Aspects of Tsetse and Trypanosome Transmission1R01AI139525-01A1AKSOY, SERAPYALE UNIVERSITY, CT$849,625VB
2019Genome-wide sieve analysis and immunological validation to identify targets of protective efficacy in field trials of a whole-organism malaria vaccine1R01AI141900-01CARNEIRO DA SILVA, JOANAUNIVERSITY OF MARYLAND BALTIMORE, MD$848,727CRFS
2019Genetic analysis of toxinogenesis of Vibrio cholerae2R37AI018045-39MEKALANOS, JOHN JOSEPHHARVARD MEDICAL SCHOOL, MA$847,498BACP
2019Immunophenotyping for precision medicine for cardiovascular disease in people living with HIV1R01HL148094-01KAPLAN, ROBERT CLEY, KLAUS F.ALBERT EINSTEIN COLLEGE OF MEDICINE, NY$846,562ZRG1
2019Risk Factors for CVD in Women2R01HL034594-32A1MANSON, JOANN ELISABETHQI, LUBRIGHAM AND WOMEN'S HOSPITAL, MA$845,852CHSB
2019Host-pathogen interactions during hospital adaptation of MRSA1R01AI137336-01A1SHOPSIN, BOTORRES, VICTOR J.YANAI, ITAINEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$845,624ZRG1
2019Development of a pre-erythrocytic P. vivax vaccine to prevent clinical relapse1R01AI137234-01A1SATHER, D. NOAHSEATTLE CHILDREN'S HOSPITAL, WA$844,617VMD
2019Harmonizing multi-site diffusion MRI acquisitions for neuroscientific analysis across ages and brain disorders1R01MH119222-01O'DONNELL, LAUREN JEANRATHI, YOGESHBRIGHAM AND WOMEN'S HOSPITAL, MA$843,974BDMA
2019Deriving a Clinical Decision Rule for Suicide Risk in the Emergency Department Setting1R01MH118220-01BOUDREAUX, EDWIN DWANG, BOUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$843,783SERV
2019Bioengineering a chimeric human lung2R01HL120046-06A1SNOECK, HANS-WILLEM EVUNJAK-NOVAKOVIC, GORDANACOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$842,444BMBI
2019Studying Atherosclerosis Macrophage Dynamics by Combined PET and Fluorine-MRI1R01HL143814-01A1FAYAD, ZAHI A.ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$841,318CMIP
2019Ventricular-vascular coupling in the elderly: lifecourse determinants, trajectories and prognostic significance1R01HL142983-01A1CHENG, SUSANMITCHELL, GARY FRANKRAMACHANDRAN, VASAN SBOSTON UNIVERSITY MEDICAL CAMPUS, MA$841,114CHSB

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