Rotarod Test citations

Maze Engineers, part of ConductScience, makes this product. Each study below names the product or its maker in the sentence quoted under its title.

18 papers and preprints as of

See the Rotarod TestAll citations
Impact of impaired endogenous neurosteroidogenesis on outcomes following chronic alcohol exposure

Katrina Blandino, Yingchu He, Lifen Htet et al. · Alcohol · 2026

From the methods
Upon removal from vapor chambers, animals were placed on a rotor rod (Maze Engineers) to assess coordination after vapor exposure (Blum et al. 1971, Krahe et al. 2017).
Nicotinamide Riboside Enhances Mitochondrial Bioenergetics and Dopaminergic Signaling Independent of Neuron Survival in a Double-Hit Parkinson’s Model

Sukanya Saha, Chengbo Meng, Jie Dong et al. · Preprint on Research Square · 2026

From the methods
Motor coordination was assessed using an accelerating rotarod (4–40 rpm; Maze Engineers model 5703).
A novel CD71 Centyrin:Gys1 siRNA conjugate reduces glycogen synthesis and glycogen levels in a mouse model of Pompe disease.

Bryce D Holt, Samuel J Elliott, Rebecca Meyer et al. · Molecular Therapy · 2025

From the methods
Mice were tested on a six-lane rotarod (Maze Engineers) set to accelerate from 4 to 40 rpm over 180 s.
CRISPR activation of the ribosome-associated quality control factor ASCC3 ameliorates fragile X syndrome phenotypes in mice

Ji Geng, Xiying Wang, Jie Pan et al. · Science Translational Medicine · 2025

From the methods
Rotarod was used to evaluate motor performance in mice. The experiment was performed using Maze engineers according to the protocol provided by vendor.
Experimental Galactose-1-Phosphate Uridylyltransferase (GALT) mRNA Therapy Improves Motor-Related Phenotypes in a Mouse Model of Classic Galactosemia-A Pilot Study.

Olivia Bellagamba, Aaron J Guo, Xinhua Yan et al. · Biomedicines · 2025

From the methods
...rotarod and accompanying software (Conductor Science SA102) used in this study was purchased from Maze Engineers (Skokie, IL, USA).
Inhibition of Rho-Associated Kinases ROCK1 and ROCK2 as a Therapeutic Strategy to Reactivate the Repressed FXN Gene in Friedreich Ataxia.

Minggang Fang, Shahid Banday, Sara K Deibler et al. · The Journal of Neuroscience · 2025

From the methods
For the rotarod test, mice were trained to walk on a rotating rod (Maze Engineers) in a dimly lit environment and then tested for their ability to maintain balance as the rod accelerated from 4 to 40 rpm over 300 s.
MICU2 controls mitochondrial calcium signaling and migration in neurons during development.

Elena Berezhnaya, Benjamín Cartes-Saavedra, Raghavendra Singh et al. · Cell Reports · 2025

From the methods
Sensorimotor coordination and balance were assessed using a Rotarod device (Maze Engineers).
Short-lived Niemann-Pick type C mice with accelerated brain aging as a novel model for Alzheimer’s disease research

Vikas Anil Gujjala, Morteza Abyadeh, Isaiah Klimek et al. · Neural Regeneration Research · 2025

From the methods
Finally, following the coat hanger test and a 10-minute rest period, the animal was placed on the Rotarod (Maze Engineers, Skokie, IL, USA) to determine the animal’s ability to maintain balance on a 3 cm motor-driven drum rotating at 15 revolutions per minute.
Targeting microRNA-dependent control of X chromosome inactivation improves the Rett Syndrome phenotype

Song Lou, Rachisan DJiake Tihagam, Urszula N. Wasko et al. · Nature Communications · 2025

From the methods
Briefly, the mice were tested on a commercial rotarod apparatus (MAZE Engineers) by placing a mouse on rotating drums (3.9 cm diameter).
Therapeutic Treatment With OLX-07010 Inhibited Tau Aggregation and Ameliorated Motor Deficits in an Aged Mouse Model of Tauopathy

E J Davidowitz, P Lopez, D Patel et al. · Journal of Neurochemistry · 2025

From the methods
Motor function was assayed with MazeEngineers 6‐Lane rotarod for mice (Deacon 2013; Koppel et al. 2019).
ATP1A1-linked diseases require a malfunctioning protein product from one allele

Kerri Spontarelli, Victoria C. Young, Ryan Sweazey et al. · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · 2024

From the methods
All data included here were obtained with a six lane rotarod from Maze Engineers with are 3 cm diameter rod.
Inhibition of GSK3α,β rescues cognitive phenotypes in a preclinical mouse model of CTNNB1 syndrome

Jonathan M Alexander, Leeanne Vazquez-Ramirez, Crystal Lin et al. · EMBO Molecular Medicine · 2024

From the key resources table
Rotarod · Maze Engineers - Conduct Science
Small-molecule inhibition of glycogen synthase 1 for the treatment of Pompe disease and other glycogen storage disorders

Julie C. Ullman, Kevin T. Mellem, Yannan Xi et al. · Science Translational Medicine · 2024

From the methods
All experiments were performed on a 6-lane rotarod (Maze Engineers, Skokie IL) in the morning between 8am-12pm.
A deep-learning-based screening platform in aging-relevant human motor neurons to identify therapeutic compounds for amyotrophic lateral sclerosis

Bhagawati Jalnapurkar, David Le, William Shainin et al. · Preprint on bioRxiv · 2023

From the methods
In order to track changes in motor coordination, we tested animals in the rotarod test (Maze Engineers).
AJ76 and UH232 as potential agents for diagnosing early-stage Parkinson's disease

Jingheng Zhou, Jicheng Li, Amy B. Papaneri et al. · Neuropharmacology · 2023

From the methods
Mice were placed on a rotating rod (Mouse 6 Lane, Maze Engineers) with rotation speed gradually increasing from 4 to 40 RPM with an acceleration of 20 rpm2 over a...
Generation and characterization of a knock-in mouse model for spastic tetraplegia, thin corpus callosum, and progressive microcephaly (SPATCCM)

Megan L. Ratz-Mitchem, Greg Leary, Andrea Grindeland et al. · Mammalian Genome · 2023

From the methods
For the Rotarod test, mice from the same cage were placed on the apparatus (Maze Engineers) facing forward at a speed of 4 rpm.
Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints

Eric Vallabh Minikel, Hien T Zhao, Jason Le et al. · Nucleic Acids Research · 2020

From the methods
Mice were seated on a rod rotating at 4 rpm in a six-lane Rotarod apparatus (Maze Engineers).
TDP-43 mediated blood-brain barrier permeability and leukocyte infiltration promote neurodegeneration in a low-grade systemic inflammation mouse model

Frank Zamudio, Anjanet R. Loon, Shayna Smeltzer et al. · Journal of Neuroinflammation · 2020

From the methods
...and learning performance were assessed by placing mice onto an accelerating circular rod (Maze Engineers, Boston, MA, USA). The time until falling was recorded for each mouse.