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Lab Management
September 19, 2019

Fundamentals of Lab Management

Running a lab is not so different from running a business. Like a business, a lab is made up of people with diverse skills who work as a team. A lab needs to be financed so that the required resources can be made available. Generally, a lab should have a…
The light digital microscope can be used to visualize structures as small as ~1 micron
Lab Basics
September 19, 2019

Mastering the Microtome

Description of Microtome Generally, microtomes are involved in the process of preparing samples of biological material to be examined under a microscope. Specifically, they slice material into extremely thin pieces so they can fit in a microscope slide and be studied by researchers. It holds the material in place while…
The light digital microscope can be used to visualize structures as small as ~1 micron
Lab Basics
September 19, 2019

Spectrophotometer

The spectrophotometer is a common optical device that measures the intensity of light relative to color (or wavelength). In the lab, they are used to determine how much light is absorbed by a colored chemical dissolved in solution. This allows us to calculate the concentration or purity of chemicals, analyze…
Protocols
September 14, 2019

Weight Drop Injury Model

Traumatic brain injury (TBI) is one of the most common brain injuries caused by an external impact or pressure, such as rapid acceleration or deceleration, crushing, and projectile penetration. Following TBI, cognitive, physical, and psychosocial functions are impaired depending on the severity of the injury. To investigate TBI, several animal…
Grants and Funding
September 14, 2019

What Reviewers Want to See in Grant Applications

For every grant application for the National Institute of Health (NIH) funding award program, there are several review panels consisting of a group of reviewers with different expertise areas and experience. Grant application reviewers are often regarded as an academic power group. All the hardship and struggle that every applicant…
ProtocolsScience
September 13, 2019

6-OHDA rat models

Parkinson’s disease (PD) is the most common neurological disorder that is characterized by debilitating motor abnormalities, including muscle rigidity, resting tumor, stiffer voluntary movements, and postural instability. Primary neuropathological condition of PD includes progressive degeneration of the dopaminergic neurons in the nigrostriatal area. Experimental models of PD are specifically designed…
ProtocolsScience
September 13, 2019

Animal Models of Traumatic Brain Injury

The use of animal models for studying traumatic brain injury (TBI) has several advantages, including low breeding cost, easy maintenance, and innovative techniques to create genetically modified strains. Rodent models provide powerful tools to screen and characterize putative therapeutic targets in TBI. These models efficiently recapitulate several clinical features of…
ConductGrants and Funding
September 13, 2019

Challenges of Health Investigators

The scientific discourse has been abuzz with the ongoing discussion on young scientists and health investigators and the challenges they face. With the growing unpredictability of the economic climate, the biomedical research budget is shrinking every day. Both early-career investigators and established scientists are facing the worsening funding crisis, the…
ProtocolsScience
September 13, 2019

Rodent Craniotomy Protocol

A craniotomy is a surgical procedure used to temporarily open a part of the skull to expose the brain for experimental manipulations. Research developments over the past two decades have made craniotomy safer, simpler, and more successful. In craniotomy, a bone flap is removed from the skull to reach the…
Protocols
September 13, 2019

Controlled Cortical Impact for Traumatic Brain Injury

Traumatic brain injury (TBI) is referred to as alteration or dysfunctionality in brain function, or brain pathology resulted by external trauma or force. TBI is a serious health condition because of its complexity and wide-reaching effects, including lesions, necrosis, and axon degeneration. Research on traumatic brain injury has been challenging…
Protocols
September 12, 2019

Fluid Percussion Injury

The fluid percussion injury (FPI) model is a widely used study model for traumatic brain injury. FPI model produces an injury through a craniectomy by applying a momentary fluid pressure pulse on to the exposed dura. This pulse is created by a pendulum striking to the piston of the fluid…
Protocols
September 12, 2019

Huntington’s Disease Rodent Models

Huntington’s disease (HD) is an inherited genetic neurological disorder characterized by cognitive dysfunction, abnormal body movements, and progressive cell death and neurodegeneration of the striatum and cerebral cortex. HD is a dominantly inherited disorder caused by a genetic mutation in the IT15 gene. This mutation is an abnormally expanded and…
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