Track plasticity. Quantify change.
The first ML-assisted 4D analysis platform for dendritic spine dynamics.
Align, track, and classify spines across days or weeks — automatically.
Longitudinal imaging is an alignment nightmare
Three challenges that make manual spine tracking unsustainable at scale.
The Drift
Brains deform. Samples drift. Rigid alignment tools fail to capture non-linear tissue warping across weeks.
Classification Subjectivity
Is that a “Thin” or a “Mushroom”? Manual classification varies between raters and sessions.
The Manual Slog
Click, click, click. Hundreds of spines per segment per timepoint — manually — is unsustainable.
Rigorous 4D spine analysis
Elastic 4D Registration
Non-rigid alignment corrects tissue drift at sub-micron precision across unlimited timepoints.
Longitudinal Event Tracking
Automatically detect new, stable, and lost spines across imaging sessions.
Morphology & Survival
ML classifies spine types. Survival curves quantify plasticity across conditions.
Plasticity quantification, automated
Drift? What drift?
Elastic 4D registration aligns dendrites across timepoints — even through tissue warping and sample drift.
Birth, death, and stability
Track the full life cycle of every synapse. Generate survival curves and turnover metrics instantly.
Beyond “point and click”
ML classifies spines into Filopodia, Thin, Stubby, and Mushroom based on volumetric geometry — not subjective labeling.
Sub-micron precision
Non-rigid alignment handles non-linear tissue warping that rigid tools miss, so measurements stay comparable across weeks.
Publication-ready statistics
From raw time-lapse stacks to spine density, turnover rate, survival fraction, and head volume — in one pipeline.
Reproducible by construction
Every classification is derived from geometry, not clicks. Reviewers can re-run the same analysis on the same data and get the same answer.
The ConductScience pipeline
ConductSpine sits downstream of ConductTrace, using reconstructed dendrites for automated spine analysis.
Built for 4D data
- 2-Photon / Confocal Time-Lapse
- OME-TIFF, CZI, IMS, LIF
- 3D + Time datasets
- Compatible with any fluorescence microscope
- Elastic Alignment
- Spine Density & Turnover Rate
- Survival Fraction
- Head Volume & Neck Length
- Export: CSV, SWC, JSON
Flexible plans for every lab
From single-workstation licenses to department-wide deployments. No hardware costs, no per-seat dongles.
Individual
Single workstation
- All ConductSpine modules
- Free software updates
- Standard support
Lab
Up to 5 seats
- All ConductSpine modules
- Free software updates
- Priority support
- Volume discount
Department
Unlimited seats + priority support
- All ConductSpine modules
- Free software updates
- Dedicated support
- Custom integration
Quantify your plasticity
Ideal for LTP/LTD research, Alzheimer’s models, and drug discovery studies.
