Research data · Disease model
Multiple sclerosis and demyelination
From 2021 to 2025, 223 animal research papers on multiple sclerosis and demyelination mentioned at least one behavioral test, most often the rotarod.
That is 3.4 times the 66 papers of 2011 to 2015. Between the same two periods, all the animal research papers that mention any of the 90 tests we count grew more slowly, to 1.2 times as many.
The tests these papers mention
The rotarod appears in 30% of the papers on multiple sclerosis and demyelination and in 5.7% of all 32,277 papers that mention a test. That makes it 5.2 times as common in this research. Each bar is one test, with how many of the 223 papers from 2021 to 2025 on multiple sclerosis and demyelination mention it, and what share that is. A paper that mentions two tests counts under both.
The 15 tests these papers mention most
All 41 tests these papers mention
| Test | Papers | Share of the 223 papers on multiple sclerosis and demyelination | Share of all 32,277 papers that mention a test |
|---|---|---|---|
| Rotarod | 66 | 30% | 6% |
| Morris water maze | 34 | 15% | 17% |
| Open field | 27 | 12% | 12% |
| Y-maze | 24 | 11% | 6% |
| Grip strength | 22 | 10% | 4% |
| Beam walking | 17 | 8% | 2% |
| Novel object recognition | 16 | 7% | 9% |
| Treadmill running | 15 | 7% | 6% |
| Elevated plus maze | 15 | 7% | 9% |
| Wire hang and inverted grid | 14 | 6% | 1% |
| Von Frey test | 12 | 5% | 4% |
| Tail suspension test | 11 | 5% | 4% |
| Gait analysis | 11 | 5% | 3% |
| Forced swim test | 8 | 4% | 9% |
| Passive avoidance | 7 | 3% | 4% |
| Wheel running | 6 | 3% | 3% |
| Fear conditioning | 5 | 2% | 6% |
| Sucrose preference test | 5 | 2% | 5% |
| Hot plate | 5 | 2% | 2% |
| Pole test | 4 | 2% | under 1% |
| Prepulse inhibition and acoustic startle | 4 | 2% | 2% |
| Nest building | 3 | 1% | 1% |
| Grid walking (foot fault) | 3 | 1% | under 1% |
| Radial arm maze | 2 | 1% | 1% |
| Barnes maze | 2 | 1% | 2% |
| Ladder rung walking | 2 | 1% | under 1% |
| Negative geotaxis and climbing assays | 2 | 1% | 1% |
| Tail flick | 2 | 1% | 2% |
| Paw pressure test | 2 | 1% | under 1% |
| Touchscreen operant tasks | 1 | under 1% | under 1% |
| Operant conditioning | 1 | under 1% | 3% |
| Three-chamber sociability test | 1 | under 1% | 1% |
| Predator odor exposure | 1 | under 1% | 1% |
| Resident-intruder test | 1 | under 1% | under 1% |
| Self-grooming | 1 | under 1% | 1% |
| Elevated zero maze | 1 | under 1% | under 1% |
| Active place avoidance | 1 | under 1% | under 1% |
| Hargreaves plantar test | 1 | under 1% | 1% |
| Formalin test | 1 | under 1% | 2% |
| Attentional set shifting | 1 | under 1% | under 1% |
| Olfactory tests | 1 | under 1% | under 1% |
Papers by year
Animal research papers on multiple sclerosis and demyelination that mention a behavioral test, by year, 2001 to 2026
The 2026 bar counts papers added to PubMed by November 8, 2026.
- Papers in a full year
- 2026 so far
Show the counts for each year
| Year | Papers |
|---|---|
| 2001 | 0 |
| 2002 | 2 |
| 2003 | 4 |
| 2004 | 5 |
| 2005 | 5 |
| 2006 | 6 |
| 2007 | 4 |
| 2008 | 5 |
| 2009 | 13 |
| 2010 | 5 |
| 2011 | 6 |
| 2012 | 9 |
| 2013 | 19 |
| 2014 | 12 |
| 2015 | 20 |
| 2016 | 20 |
| 2017 | 19 |
| 2018 | 32 |
| 2019 | 37 |
| 2020 | 34 |
| 2021 | 44 |
| 2022 | 49 |
| 2023 | 41 |
| 2024 | 43 |
| 2025 | 46 |
| 2026 (part year) | 45 |
Which species the papers used
Each bar is a share of the 223 papers from 2021 to 2025. A paper can use more than one species, so the shares can add to more than 100%.
Species
“Other animals” counts papers that use none of the species this chart names.
Which papers count
A paper counts here when it is animal research, mentions at least one of the 90 tests and studies multiple sclerosis and demyelination.
MeSH terms are the subject headings the National Library of Medicine adds when it indexes a paper. A paper counts under multiple sclerosis and demyelination when its MeSH terms include one of these.
- Multiple Sclerosis, with the headings under it
- Encephalomyelitis, Autoimmune, Experimental
- Demyelinating Diseases
For a paper without MeSH terms, PubTator 3, NCBI's text-mining service, supplies the disease model when it finds the disease in the title or abstract. A paper can count under more than one disease model.
Our main page, Behavioral tests in published research, has the full method and each source's terms of use. Its downloads list each paper and its disease models.
More disease models
These disease models also have a page, with their papers from 2021 to 2025 that mention a test. Each disease model with 100 or more such papers gets one.
- Cognitive impairment and dementia 4,961 papers
- Anxiety 3,041 papers
- Depression 2,827 papers
- Pain conditions 2,617 papers
- Alzheimer disease 2,445 papers
- Substance use disorders 1,599 papers
- Psychological stress 1,484 papers
- Stroke and brain ischemia 1,278 papers
- Parkinson disease 918 papers
- Brain injury 841 papers
- Diabetes 795 papers
- Obesity and high-fat diet 761 papers
- Aging 700 papers
- Epilepsy and seizures 572 papers
- Autism spectrum disorder 484 papers
- Schizophrenia and psychosis 401 papers
- Sleep loss and sleep disorders 400 papers
- Post-traumatic stress 392 papers
- Spinal cord injury 382 papers
- Amyotrophic lateral sclerosis 108 papers
- Attention deficit hyperactivity disorder 107 papers
How to cite
APA
ConductScience. (2026, November 10). Behavioral tests in multiple sclerosis and demyelination research [Data set]. https://conductscience.com/resources/data/behavioral-tests/models/multiple-sclerosis
BibTeX
@misc{conductscience_multiple_sclerosis_2026,
author = {{ConductScience}},
title = {Behavioral tests in multiple sclerosis and demyelination research},
year = {2026},
month = nov,
url = {https://conductscience.com/resources/data/behavioral-tests/models/multiple-sclerosis},
note = {Data set, released November 10, 2026},
}Shop apparatus by test
Our store sells apparatus for nine of the 10 tests these papers mention most, all but wire hang and inverted grid.
- Rotarod
- Morris water maze
- Open field
- Y-maze
- Grip strength
- Beam walking
- Novel object recognition
- Treadmill running
- Elevated plus maze
