Primary Assay — Naked Mole-Rat
Pain Insensitivity
Heterocephalus glaber
Naked mole-rats are uniquely insensitive to capsaicin pain and acid pain — adaptations to their high-CO2 tunnel environment. Absent capsaicin and acid responses, and reduced formalin responses, make them a unique pain research model.
Quantitative Output
Measured Parameters
Every parameter is automatically tracked frame-by-frame in the ConductVision pipeline for Heterocephalus glaber.
| Parameter | Unit | Description |
|---|---|---|
| Capsaicin response | latency to lick/s | Absent in NMR (unique) |
| Acid response | withdrawal latency/s | Insensitive to acid pain |
| Formalin response | licking time/s | Reduced vs mice |
References
Citations for Pain Insensitivity
- Park TJ, et al. (2017). Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat. Science, 356(6335), 307-311. PMID: 28428423
Compatible Equipment
Hardware for Naked Mole-Rat Research
Transparent Tunnel System
Cooperative digging observation
Colony Observation Setup
Caste behavior monitoring
Pain Testing Apparatus
Nociception assays
Thermal Gradient Chamber
Temperature preference
Food Transport Arena
Cooperative behavior quantification
Related Assays
Other Naked Mole-Rat Primary Assays
06
Cooperative Tunnel Digging
Heterocephalus glaber
Naked mole-rats cooperatively excavate tunnel systems using a chain-gang relay system. Dig rate, bout duration, caste co…
06
Cooperative Food Transport
Heterocephalus glaber
Colony members cooperatively transport food items to central stores. Transport frequency, group vs individual effort, an…
06
Caste-Specific Behavioral Repertoire
Heterocephalus glaber
Like eusocial insects, naked mole-rats show caste-specific behavior. Work time budgets, behavioral diversity, and queen-…
Run Pain Insensitivity on ConductVision
Our team will configure the protocol, camera rig, and analysis pipeline for your naked mole-rat facility.
