Barnes Maze citations

Maze Engineers, part of ConductScience, makes this product. Each study below names the product or its maker in the sentence quoted under its title.

35 papers and theses as of

Acetyl-carnitine improves hyperactivity and learning deficits in KAT6A haploinsufficient mice.

Samantha Eccles, Hannah K Vanyai, Maria I Bergamasco et al. · Life Science Alliance · 2026

From the methods
...to seek and enter a target hole. The operator was located behind a curtain. The Barnes maze (MazeEngineers) was comprised of a white circular platform 92 cm in diameter and 95 cm high with 20 circular...
Altered physiology and ensemble recruitment of dentate gyrus semilunar granule cells in a mouse model of epilepsy

Laura Dovek, Andrew Huang, Vijayalakshmi Santhakumar · Neurobiology of Disease · 2026

From the methods
The Barnes maze table (Maze Engineers, https://conductscience.com/maze/) was 92cm in diameter and consisted of 20 holes that are 5cm in diameter.
Impact of chronic alcohol and stress on midlife cognition and locus coeruleus integrity in mice

O. Revka, S. J. Belculfine, L. Fitts et al. · Alcohol, Clinical and Experimental Research · 2026

From the methods
Barnes maze apparatus consisted of a circular gray platform (92 cm in diameter) with 20 evenly spaced holes (5 cm in diameter) along the perimeter, mounted on the round table 68.5 cm above the ground (Maze Engineers, Old Orchard Towers, IL).
Indigenous gut microbes modulate neural cell state and neurodegenerative disease susceptibility

Lisa Blackmer-Raynolds, Lyndsey D. Lipson, Anna Kozlov et al. · Cell Systems · 2026

From the methods
Testing was performed over a 6-day period using a 92cm diameter, 20-hole, Barnes maze (MazeEngineers) with consistent extra-maze cues throughout.
Neuronal toll-like receptor-4 regulation of matrix metalloproteinase-9 activity mediates dentate circuit dysfunction after traumatic brain injury

Deepak Subramanian, Erick M Contreras, Laura Dovek et al. · Journal of Neuroinflammation · 2026

From the methods
The Barnes maze table (Maze Engineers, https://conductscience.com/maze/) was 122 cm in diameter with 20 holes (10 cm each).
Persistent hypersensitivity after repeat concussion is associated with chronic cognitive dysfunction

Janel E. Le Belle, Michelle Zhong, Carmel Al-Sheikh et al. · Frontiers in Neurology · 2026

From the methods
These tests were conducted on a 40-hole table (Maze Engineers) that is 122 cm diameter circular light gray platform with 5 cm diameter holes, a single dark escape tunnel, and two wall-mounted spatial cues.
Stable neuronal representations underlie cognitive resilience to Alzheimer's disease pathology

Keying Chen, Emma Pineau, Margaret Koletar et al. · Alzheimer's & Dementia · 2026

From the methods
Barnes Maze (Maze Engineers, Boston, MA) testing was conducted in a behavioral suite equipped with spatial cues, using an aversive light in all trials except during training (Figure 1B).
Synergistic Neuroprotection of Fe3O4 Nanoparticles Combined with Intermittent Theta Burst Stimulation in Ischemic Stroke via Nrf2-Mediated Ferroptosis Regulation

Ying-Ying Huang, Li-Hong Gui, Wen-Xi Yu et al. · International Journal of Nanomedicine · 2026

From the methods
In a variation of the earlier Barnes maze setup, a customized apparatus featured a circular platform 92 cm in width, elevated and made of PVC (Maze Engineers, Skokie, IL, USA).
Targeted senotherapy improves electrographic and behavioral outcomes in a mouse model of temporal lobe epilepsy

David J. McFall, Abbas I. Hussain, Michelle Cho et al. · Epilepsia · 2026

From the methods
Animals were tested using a mouse Barnes maze (BM) (92 cm diameter with 20, 5 cm diameter holes, evenly spaced along the perimeter of the maze; Maze Engineers).
An AIM2 inflammasome biomimetic mineralization inhibitor for vascular dementia therapy

Yueqi Zhang, Lixian Jiang, Rongrong Wu et al. · Theranostics · 2025

From the methods
Barnes maze (Maze Engineers, Boston, MA, USA) testing was conducted in a behavioral suite equipped with spatial cues and an aversive light source, except training trials.
Autophagic impairment in sleep-wake circuitry is linked to sleep loss at the early stages of Alzheimer's disease

Christopher Daniel Morrone, Arielle A Tsang, W Haung Yu · Molecular Neurodegeneration · 2025

From the methods
...a circular field was utilized with 20 holes (1 escape box) along the outside (92 cm diameter, Maze Engineers), and an overhead camera acquired trials in EthoVision XT (Noldus) software.
Cellular and circuit features distinguish mouse dentate gyrus semilunar granule cells and granule cells activated during contextual memory formation

Laura Dovek, Mahboubeh Ahmadi, Krista Marrero et al. · eLife · 2025

From the key resources table
Other · Barnes maze table · Maze Engineers · https://conductscience.com/maze/
Complementary roles of dorsal and ventral hippocampus in the flexible adaptation of goal-directed behavior.

Maryam Hasantash, Yifei Li, Arturo Torres-Herraez et al. · Science Advances · 2025

From the methods
Mice were habituated to a Barnes maze (Ø: 92 cm, 20 holes, 95 cm high; MazeEngineers) with spatial cues around the testing room for 10 to 15 min.
Longitudinal characterization reveals behavioral impairments in aged APP knock in mouse models

Lisa Blackmer-Raynolds, Lyndsey D Lipson, Isabel Fraccaroli et al. · Scientific Reports · 2025

From the methods
...assess spatial learning and memory. Testing occurred on a 92 cm diameter, 20 hole, Barnes maze (MazeEngineers) over a 6-day period, with one habituation trial, five 3-minute training trials, and a 72-hour...
Senescent Cell Clearance Ameliorates Temporal Lobe Epilepsy and Associated Spatial Memory Deficits in Mice

Tahiyana Khan, David J. McFall, Abbas I. Hussain et al. · Annals of Neurology · 2025

From the methods
Animals were tested using a standard mouse Barnes maze (92 cm diameter, 20 holes, 5 cm each; Maze Engineers).
Gastrointestinal nematode infection during pregnancy and lactation enhances spatial reference memory and reduces indicators of anxiety-like behaviour in uninfected adult female mouse offspring

Sophia Noel, Ryan LaFrancois, Marilyn E Scott · Parasitology · 2024

From the methods
As previously described (Noel et al., 2022), the Barnes Maze (Maze engineers, 412 Wilmette Ave, Glenview, IL 60025, USA) is an opaque circular platform (diameter: 92 cm, height: 70 cm) with 20 equally spaced holes (diameter: 5 cm) located 2 cm from the edge.
Memory loss and aberrant neurogenesis in mice exposed to patient anti-N-methyl-d-aspartate receptor antibodies

Olga Taraschenko, Howard S. Fox, Priscilla Heliso et al. · Experimental Neurology · 2024

From the methods
In a modification of the previously described Barnes maze paradigm (Attar et al., 2013), the apparatus was comprised of a circular platform with 20 holes of 4.45 cm in diameter positioned 2.54 cm from the edge of the 92 cm wide elevated PVC platform (Maze Engineers, Skokie, IL).
Prophylactic senolytic treatment in aged mice reduces seizure severity and improves survival from Status Epilepticus

Tahiyana Khan, Abbas I Hussain, Timothy P Casilli et al. · Aging Cell · 2024

From the methods
...maze consists of an elevated circular platform (92 cm) with 20 holes (5 cm) around the perimeter (Maze Engineers). The target hole consisted of an escape box, and the remaining holes had a false floor.
An updated Barnes maze protocol for assessing the outcome of controlled cortical impact mouse models of traumatic brain injury

Connor C. Gee, Rylie Steffen, Forrest M. Kievit · Journal of Neuroscience Methods · 2023

From the methods
Both BM protocols utilized a 93 cm diameter blue platform obtained from Maze Engineers (Skokie, IL, USA) with 20 holes equally spaced around the outside of the platform.
Concurrent behavioral and electrophysiological longitudinal recordings for in vivo assessment of aging

Christopher Daniel Morrone, Arielle A. Tsang, Sarah M. Giorshev et al. · Frontiers in Aging Neuroscience · 2023

From the methods
Barnes maze (Maze Engineers): spatial cues, escape box, overhead light (LED; 5000K, 4000 lumen), camera, and computer (Noldus).
Decreased myelin-related gene expression in the nucleus accumbens during spontaneous neonatal opioid withdrawal in the absence of long-term behavioral effects in adult outbred CFW mice

Kristyn N. Borrelli, Kelly K. Wingfield, Emily J. Yao et al. · Neuropharmacology · 2023

From the methods
The apparatus consisted of a circular, wall-less, and elevated platform that is 95 cm tall and 92 cm in diameter with 20 holes (5 cm diameter) equally spaced around the perimeter (2 cm from edge) (MazeEngineers, Skokie, IL).
Compromised Cortical-Hippocampal Network Function From Transient Hypertension: Linking Mid-Life Hypertension to Late Life Dementia Risk

Aaron Y. Lai, Paolo Bazzigaluppi, Christopher D. Morrone et al. · Frontiers in Neuroscience · 2022

From the methods
We conducted all trials except the training of Barnes maze (Maze Engineers) testing in a behavioral suite with spatial cues and an aversive light.
Dendrimer-2PMPA selectively blocks upregulated microglial GCPII activity and improves cognition in a mouse model of multiple sclerosis

Kristen R. Hollinger, Anjali Sharma, Carolyn Tallon et al. · Nanotheranostics · 2022

From the methods
...approximately 5 weeks post-immunization. Briefly, mice were placed in the center of the maze (Maze Engineers, Glenview, IL) and trained to find a hidden target platform for 2 trials per day over 4...
Distinct Cecal and Fecal Microbiome Responses to Stress Are Accompanied by Sex- and Diet-Dependent Changes in Behavior and Gut Serotonin

Joshua M. Lyte, Lucas R. Koester, Karrie M. Daniels et al. · Frontiers in Neuroscience · 2022

From the methods
In brief, the maze (Maze Engineers; Skokie, IL) consisted of 20 equally spaced holes each 5 cm in diameter with a single black nesting box.
Parvalbumin neuroplasticity compensates for somatostatin impairment, maintaining cognitive function in Alzheimer’s disease

Christopher Daniel Morrone, Aaron Yenhsin Lai, Jossana Bishay et al. · Translational Neurodegeneration · 2022

From the methods
All rats were naïve to behavioral assessment. Barnes maze (Maze Engineers, Boston, MA) testing was conducted in a behavioral suite with spatial cues, with an aversive...
Alterations of GABA B receptors in the APP/PS1 mouse model of Alzheimer's disease

Arnold M. Salazar, Amanda M. Leisgang, Andrew A. Ortiz et al. · Neurobiology of Aging · 2021

From the methods
The maze, made of white, circular plastic (92 cm diameter) with a black false bottom, was purchased from Maze Engineers (IL, USA).
Abrogation of atypical neurogenesis and vascular-derived EphA4 prevents repeated mild TBI-induced learning and memory impairments

Kisha Greer, Erwin Kristobal Gudenschwager Basso, Colin Kelly et al. · Scientific Reports · 2020

From the methods
...for learning and memory utilizing the Barnes Maze (92 cm diameter, 20 holes, 5 cm holes) (Maze Engineers, Boston, MA USA) and the Ethovision XT software (Noldus, Leesburg, VA USA) at the same time each...
Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus

Amir Rattner, Chantelle E Terrillion, Claudia Jou et al. · eLife · 2020

From the methods
Briefly, a brightly lit (1100 lux) Barnes maze with 40 evenly spaced holes and an escape box placed under one of the holes was used (Maze Engineers).
Efficacy of β-amyloid Attenuation Depends on Regional and Temporal Progression of Alzheimer’s Disease

Christopher Daniel Morrone · Thesis at University of Toronto · 2020

From the methods
A circular field (Maze Engineers) was utilized (20 holes, one is the escape box).
Hippocampal cognitive impairment in juvenile rats after repeated mild traumatic brain injury

Cristina Pinar, Juan Trivino-Paredes, Samantha T. Perreault et al. · Behavioural Brain Research · 2020

From the methods
Spatial memory performance after r-mTBI was assessed using the Barnes maze (Maze Engineers, Cambridge, MA).
Regional differences in Alzheimer’s disease pathology confound behavioural rescue after amyloid-β attenuation

Christopher D Morrone, Paolo Bazzigaluppi, Tina L Beckett et al. · Brain · 2020

From the methods
A circular field (Maze Engineers) was used (20 holes, one is the escape box).
Aberrant hippocampal neurogenesis contributes to learning and memory deficits in a mouse model of repetitive mild traumatic brain injury

Kisha Greer · Thesis at Virginia Tech · 2019

From the methods
Mice were evaluated for learning and memory utilizing the Barnes Maze (Maze Engineers, Boston, MA USA) and the Ethovision XT software (Noldus, Leesburg, VA USA).
An Evaluation of Alzheimer's Disease-related Pathology in Two Different Models of Diabetes in Immune-challenged Mice

Andrew Scott Murtishaw · Thesis at University of Nevada, Las Vegas · 2018

From the methods
The maze, made of white, circular plastic (92 cm diameter) with a black false bottom, was purchased from Maze Engineers (Glenview, IL).
Behavioral Phenotyping of an Improved Mouse Model of Phelan-McDermid Syndrome with a Complete Deletion of the Shank3 Gene

Elodie Drapeau, Mohammed Riad, Yuji Kajiwara et al. · eNeuro · 2018

From the methods
...holes evenly spaced around the edge of a brightly-lit 100 cm in diameter circular arena (Maze Engineers).
Repeated mild traumatic brain injury can cause acute neurologic impairment without overt structural damage in juvenile rats

Alicia Meconi, Ryan C. Wortman, David K. Wright et al. · PLOS ONE · 2018

From the methods
The Barnes maze was used to assess spatial memory after injury. The Barnes maze (Maze Engineers, Cambridge, MA) is an elevated circular platform (122 cm diameter) with 20 holes (10cm diameter)...