Y Maze citations

Maze Engineers, part of ConductScience, makes this product. Each study below names the product or its maker in the sentence quoted under its title.

34 papers and preprints as of

Catestatin ameliorates tauopathy and amyloidogenesis via adrenergic inhibition

Suborno Jati, Satadeepa Kal, Daniel Munoz-Mayorga et al. · Preprint on bioRxiv · 2026

From the methods
Mice were tested in the Y-Maze (ConductScience) following a previously published method 74, with some modifications.
Chronic cocaine exposure negatively impacts Long-COVID-like outcomes produced by the SARS-CoV-2 spike protein in the rat

Sarah E. Davis, Danielle R. Stern, Saadet Inan et al. · Preprint on bioRxiv · 2026

From the methods
Rats were placed in the center of the Y-maze (Maze Engineers, Skokie, IL) and allowed to freely explore for 5 minutes.
Engineered nanosponges mitigate peripheral stress-induced neuroinflammation and restore cognitive function

Sajeeshkumar Madhurakkat Perikamana, Biswanath Maity, Rokas Dargis et al. · Preprint on bioRxiv · 2026

From the methods
The maze consists of three identical arms positioned at 120° angles (Maze Engineers).
Effects of the Quinone Analog Ubiquinone-5 on Murine Mitochondria and Hypnosis

Yash R. Somnay, Aili Wang, Haeun Lim et al. · Anesthesiology · 2025

From the methods
The test was conducted in a Y maze apparatus (3 arms of equal length (35 cm), width (5 cm), and height (10 cm)(Maze Engineer, Skokie, IL) 1-week post-injection of Ubiquinone-5 (100 mg/kg) or vehicle.
Elevated maternal testosterone induces sex-specific neurodevelopmental changes and ASD-related behavioral phenotypes in rat offspring

Jay S. Mishra, Sai Krishna Bhamidipati, Jordan Ronald Ross et al. · Pediatric Research · 2025

From the methods
The Y-maze apparatus (Maze Engineers, Skokie, IL) consisted of three identical arms (11 cm wide × 50 cm long) surrounded by distal spatial cues (e.g., geometric patterns, contrasting visual markers).
Inhibition tunes prefrontal circuit dynamics to promote sociosexual behavior in female mice

Elizabeth A. Amadei, Pau Vilimelis Aceituno, Reinhard Loidl et al. · Preprint on bioRxiv · 2025

From the methods
The setup consisted of a custom Y-shaped arena (Maze Engineers), with three rectangular arms (35 cm length x 7 cm width x 20 cm height) and a triangular center chamber (7 cm edges).
Opposing roles of microglial and macrophagic C3ar1 signaling in stress-induced synaptic and behavioral changes

Ashutosh Tripathi, Alona Bartosh, Dania Jose et al. · Molecular Psychiatry · 2025

From the methods
We used Y-maze (Maze Engineers) to perform a continuous spontaneous alternation test measuring spatial working memory deficits.
Reversal of early-life high fat diet prevents spatial discrimination deficits corresponding with altered brain inflammatory and metabolic profiles in male C57BL/6J mice

Caleb S. Bailey, McKenna C. Green, Meggie J. Coleman et al. · Nutritional Neuroscience · 2025

From the methods
On the second day of the behavioral battery, the novel spatial recognition (NSR) assay was performed using a clear polycarbonate 3-armed mouse Y-maze (Maze Engineers; Boston, MA, USA) with distinct visual cues at the distal wall of each Y-maze arm as previously described.
Vasoactive neuropeptide dysregulation: A novel mechanism of microvascular dysfunction in vascular cognitive impairment.

Willians Tambo, Keren Powell, Steven Wadolowski et al. · Alzheimer's & Dementia · 2025

From the methods
The testing apparatus consisted of a symmetrical Y‐shaped maze (MazeEngineers, USA) with three identical arms (40 cm length × 8 cm width × 15 cm height) positioned at equiangular intervals (120° separation) and constructed of blue, opaque polyvinyl chloride to ensure consistent visual cues while minimizing extraneous environmental influences.
Early-life obesogenic environment integrates immunometabolic and epigenetic signatures governing neuroinflammation

Perla Ontiveros-Ángel, Julio David Vega-Torres, Timothy B. Simon et al. · Brain, Behavior, & Immunity - Health · 2024

From the methods
The Social Y-Maze (MazeEngineers, Stokie, IL) is a plexiglass Y-maze with a triangular center (8 cm sides) and three identical arms (50 cm × 9 cm × 10 cm; length × width × height).
In Vivo Evaluation of Nose-to-Brain Delivery of Liposomal Donepezil, Memantine, and BACE-1 siRNA for Alzheimer's Disease Therapy

David Lee, Andrew M Shen, Milin Shah et al. · International Journal of Molecular Sciences · 2024

From the methods
...20 cm in height. These arms were attached at 120-degree angles, creating a maze-like structure (Maze Engineers, Skokie, IL, USA).
Intrinsic diving reflex enhances cognitive performance by alleviating microvascular dysfunction in vascular cognitive impairment

Willians Tambo, Keren Powell, Steven Wadolowski et al. · Preprint on bioRxiv · 2024

From the methods
The maze is comprised of a Y-shaped structure (MazeEngineers, USA), with three blue, opaque plastic arms that are positioned 120 degrees apart from each other.
Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids

Jiaxiang Wu, Jingliang Zhang, Xiaoling Chen et al. · Molecular Psychiatry · 2024

From the methods
...with three arms of 5 cm wide × 35 cm long with 20 cm tall transparent walls placed 120° apart (Maze Engineers).
Role of the prefrontal cortical protease TACE/ADAM17 in neurobehavioral responses to chronic stress during adolescence

Fransua Sharafeddin, Julio Sierra, Mina Ghaly et al. · Brain and Behavior · 2024

From the methods
The Social Y‐Maze (Conduct Science, Maze Engineers, Skokie, IL) is a plexiglass Y‐maze with a triangular center (8 cm sides) and three identical arms (50 cm × 9 cm × 10 cm, length × width × height).
Shifts in naturalistic behaviors induced by early social isolation stress are associated with adult binge-like eating in female rats

Timothy B. Simon, Julio Sierra, Arianna Williams et al. · Frontiers in Behavioral Neuroscience · 2024

From the methods
The Social Y-Maze (Conduct Science, Maze Engineers, Skokie, IL) is a plexiglass Y-maze with a triangular center (8 cm sides) and three identical arms (50 cm × 9 cm × 10 cm, length × width × height).
Further Characterization of Multi-Organ DEARE and Protection by 16,16 Dimethyl Prostaglandin E2 in a Mouse Model of the Hematopoietic Acute Radiation Syndrome

Tong Wu, Louis M. Pelus, P. Artur Plett et al. · Radiation Research · 2023

From the methods
...memory by spontaneous alternation test in the Y-maze. Mice were placed in one arm of a Y-maze (Maze Engineers, Skokie, IL) and allowed to freely navigate for 10 min.
Influence of RVFV Infection on Olfactory Perception and Behavior in Drosophila melanogaster.

Stella Bergmann, Maja C Bohn, Susann Dornbusch et al. · Pathogens · 2023

From the methods
To evaluate the chemosensory responses, a Y-maze (MazeEngineers, Skokie, IL, USA) after Simonnet et al. (2014) [59] was used at 1 dpi and 7 dpi.
Intergenerational arsenic exposure on the mouse epigenome and metabolic physiology

Mathia L. Colwell, Nicole Flack, Amanda Rezabek et al. · Environmental and Molecular Mutagenesis · 2023

From the methods
Mice were placed in one arm of a standard Y-maze (MazeEngineers, Boston, MA), consisting of a high walled chamber with three arms connected at 120°.
Neurodevelopmental deficits and cell-type-specific transcriptomic perturbations in a mouse model of HNRNPU haploinsufficiency

Sarah A. Dugger, Ryan S. Dhindsa, Gabriela De Almeida Sampaio et al. · PLOS Genetics · 2023

From the methods
The test is conducted in the Y maze (Maze Engineer) consisting of three arms of equal arm lengths (35 cm), arm lane width (5 cm), wall height (10 cm).
PI3K block restores age-dependent neurovascular coupling defects associated with cerebral small vessel disease

Pratish Thakore, Evan Yamasaki, Sher Ali et al. · Proceedings of the National Academy of Sciences · 2023

From the methods
Memory function was assessed using the Y-maze (Maze Engineers, Skokie, IL, USA) using two different configurations.
Protocol for wireless deep brain stimulation in freely behaving mice with infrared light

Xiang Wu, Guosong Hong · STAR Protocols · 2023

From the paper
Y maze · Maze Engineers · 3501
A feature of maternal sleep apnea during gestation causes autism-relevant neuronal and behavioral phenotypes in offspring

Amanda M. Vanderplow, Bailey A. Kermath, Cassandra R. Bernhardt et al. · PLOS Biology · 2022

From the methods
...as animals must maintain and update a mental log of arm entries. The Y-maze was purchased from Maze Engineers (Skokie, IL, USA), with each arm 11-cm wide and 50-cm long.
A gut-derived metabolite alters brain activity and anxiety behaviour in mice

Brittany D. Needham, Masanori Funabashi, Mark D. Adame et al. · Nature · 2022

From the methods
Y-maze alternations test was performed in a white Y-maze (Maze Engineers, Boston, MA) video-taped from above.
A Pitx3-deficient developmental mouse model for fine motor, olfactory, and gastrointestinal symptoms of Parkinson's disease

Bin Song, Jacob W. Feldmann, Shibo Cao et al. · Neurobiology of Disease · 2022

From the methods
The Y-maze was purchased from Maze Engineers (Cambridge, MA, USA)
C1q deletion exacerbates stress-induced learned helplessness behavior and induces neuroinflammation in mice

Amit Kumar Madeshiya, Carl Whitehead, Ashutosh Tripathi et al. · Translational Psychiatry · 2022

From the methods
A Y-maze apparatus (Maze Engineers) was used to score the continuous and spontaneous alternation in mice.
Chronic allergic lung inflammation negatively influences neurobehavioral outcomes in mice

Akihiro Kanaya, Mu Yang, Charles Emala et al. · Journal of Neuroinflammation · 2022

From the methods
The test was conducted in the Y-maze apparatus (Maze Engineer, Skokie, IL, USA), which consists of three arms of equal length (35 cm), arm lane width (5 cm), and wall height (10 cm).
Impaired intracellular Ca 2+ signaling contributes to age-related cerebral small vessel disease in Col4a1 mutant mice

Evan Yamasaki, Pratish Thakore, Sher Ali et al. · Preprint on bioRxiv · 2022

From the methods
Memory function was assessed using the Y-maze (Maze Engineers, Skokie, IL, USA) using two different configurations.
Pathological tau and reactive astrogliosis are associated with distinct functional deficits in a mouse model of tauopathy

Henika Patel, Pablo Martinez, Abigail Perkins et al. · Neurobiology of Aging · 2022

From the methods
Mice were subjected to the Y-Maze (MazeEngineers) test described in (Cisternas et al., 2020), with modifications.
Developmental cannabidiol exposure increases anxiety and modifies genome-wide brain DNA methylation in adult female mice

Nicole M. Wanner, Mathia Colwell, Chelsea Drown et al. · Clinical Epigenetics · 2021

From the methods
Mice were placed at the end of one arm facing the center in a standard Y-maze (MazeEngineers, Boston, MA) consisting of a high-walled chamber with three arms connected at 120°.
Downregulating carnitine palmitoyl transferase 1 affects disease progression in the SOD1 G93A mouse model of ALS

Michael Sloth Trabjerg, Dennis Christian Andersen, Pam Huntjens et al. · Communications Biology · 2021

From the methods
The y-maze test was constructed according to Maze Engineers (USA). The mice were placed in the y-maze for 5 min to freely explore the three arms.
Type 1 interferon mediates chronic stress-induced neuroinflammation and behavioral deficits via complement component 3-dependent pathway

Ashutosh Tripathi, Carl Whitehead, Katelyn Surrao et al. · Molecular Psychiatry · 2021

From the methods
Y-maze (Maze Engineers) was used to perform a continuous spontaneous alternation test.
(S)-5-(2′-Fluorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine, a Serotonin Receptor Modulator, Possesses Anticonvulsant, Prosocial, and Anxiolytic-like Properties in an Fmr1 Knockout Mouse Model of Fragile X Syndrome and Autism Spectrum Disorder

Jessica L. Armstrong, Austen B. Casey, Tanishka S. Saraf et al. · ACS Pharmacology & Translational Science · 2020

From the methods
Mice were placed in the center of a Y-maze (Maze Engineers, single arm dimensions 2.75 in. × 13.75 in. × 8 in.)
Autophagy protein NRBF2 has reduced expression in Alzheimer’s brains and modulates memory and amyloid-beta homeostasis in mice

Véronik Lachance, Qian Wang, Eric Sweet et al. · Molecular Neurodegeneration · 2019

From the methods
The Y-Maze (Maze Engineers) consisted of three gray acrylic closed arms measuring 35 cm L × 5 cm W × 20 cm H. Mice were placed in the center of the maze and were free to explore for 10 min.
Effects of the second-generation "bath salt" cathinone alpha-pyrrolidinopropiophenone (α-PPP) on behavior and monoamine neurochemistry in male mice

Azizi Ray, Neha Milind Chitre, Cedrick Maceo Daphney et al. · Psychopharmacology · 2019

From the methods
...lasted for 10 minutes. Performance in the Y-maze was assessed by both automated quantitation (Maze Engineers; Cambridge, MA) and manual observation.