ConductScience Syringe Filters 0.22um, PES, Sterile (Pack of 10)
$55.00 per unit | 10 units per pack Bulk pricing: Pack of 10 at $550.00 ($55.00 per unit)
| Automation Level | manual |
The ConductScience Syringe Filters 0.22μm feature polyethersulfone (PES) membrane construction in 33mm diameter sterile format designed for microfiltration applications. The 0.22μm pore size provides effective retention of bacteria and other microorganisms while allowing passage of solutions and small molecules. PES membrane material exhibits low protein binding characteristics, making these filters suitable for biological sample preparation and media sterilization workflows where protein recovery is important.
These sterile syringe filters integrate with standard luer-lock syringes for manual filtration procedures in laboratory settings. The hydrophilic PES membrane provides consistent flow rates and filtration efficiency across a range of aqueous solutions. The 33mm diameter provides adequate filtration area for typical laboratory sample volumes while maintaining reasonable filtration times for routine procedures.
How It Works
Syringe filtration operates through size exclusion separation where the PES membrane acts as a physical barrier with defined pore structure. The 0.22μm pore diameter effectively retains bacteria (typically 0.5-5μm), yeasts, and larger particles while allowing passage of dissolved molecules, salts, and proteins smaller than the pore size. The hydrophilic polyethersulfone membrane material creates consistent wetting characteristics with aqueous solutions, ensuring uniform flow distribution across the filtration area.
During filtration, manual pressure applied through the syringe forces sample liquid through the membrane matrix. The tortuous pore pathway within the PES structure provides depth filtration characteristics, capturing particles through both surface straining and internal adsorption mechanisms. Low protein binding properties of PES minimize non-specific protein adsorption to membrane surfaces, maintaining sample recovery rates for biological applications.
The sterile packaging and construction eliminate introduction of contaminants during filtration procedures. The 33mm membrane diameter provides 8.5 cm² of effective filtration area, balancing throughput capacity with manageable pressure requirements for manual syringe operation.
Features & Benefits
Automation Level
- manual
Research Domain
- Analytical Chemistry
- Cell Biology
- Clinical Diagnostics
- Immunology
- Microbiology
- Pharmaceutical QC
Weight
- 0.22 kg
Dimensions
- L: 8.3 mm
- W: 6.9 mm
- H: 5.5 mm
Comparison Guide
| Feature | This Product | Typical Alternative | Advantage |
|---|---|---|---|
| Pore Size Precision | 0.22μm rated pore size for bacterial retention | Similar products typically offer 0.22μm or 0.45μm options | Precise pore size specification ensures consistent bacterial removal while maintaining solution component passage. |
| Membrane Material | Polyethersulfone (PES) construction with low protein binding | Alternative materials include nylon, cellulose acetate, or PVDF with varying binding characteristics | PES material preserves protein integrity and recovery rates critical for biological applications. |
| Diameter and Area | 33mm diameter providing 8.5 cm² filtration area | Standard sizes range from 13mm to 50mm diameter | Balanced filtration area provides good throughput while maintaining manageable pressure requirements for manual operation. |
| Sterility Assurance | Individual sterile packaging | Some products offer bulk packaging or non-sterile options | Sterile packaging eliminates contamination risk and supports aseptic procedures in controlled environments. |
| Connection Type | Luer-lock compatible connection | Most syringe filters use standard luer connections | Secure luer-lock connection prevents leakage and ensures reliable sample processing. |
This product combines 0.22μm PES membrane technology with sterile packaging and 33mm diameter configuration for reliable bacterial retention in biological applications. The low protein binding characteristics and individual sterile packaging support critical laboratory sterilization workflows where sample integrity and contamination control are essential.
Practical Tips
Pre-wet PES membranes with a small volume of sample or compatible solvent before processing main sample volume.
Why: Membrane wetting ensures uniform flow distribution and removes air bubbles that can create pressure inconsistencies.
Pre-filter heavily particulated samples through larger pore size filters (0.45μm or 0.8μm) before final 0.22μm filtration.
Why: Sequential filtration extends filter life and prevents premature clogging from high particle loads.
Monitor filtration rate throughout procedure and replace filter if flow rate decreases significantly.
Why: Reduced flow indicates membrane clogging that can compromise filtration efficiency and sample processing time.
Use appropriate personal protective equipment and work in laminar flow hood when filtering potentially hazardous biological samples.
Why: Sterile technique and containment protect both sample integrity and operator safety during filtration procedures.
Document lot numbers, filtration dates, and any unusual observations during processing for sample traceability.
Why: Complete documentation supports quality assurance requirements and troubleshooting of downstream analytical issues.
If excessive pressure is required, check for air bubbles in syringe or consider sample dilution for viscous solutions.
Why: High pressure requirements often indicate procedural issues rather than membrane problems and may damage the filter.
Process samples at room temperature unless specific temperature control is required for sample stability.
Why: Temperature affects solution viscosity and can impact filtration rates and membrane performance.
Setup Guide
What’s in the Box
- 100 individually packaged sterile syringe filters (typical)
- Product documentation and specifications (typical)
Warranty
ConductScience provides standard warranty coverage for manufacturing defects and material quality issues. Technical support is available for filtration application guidance and troubleshooting.
Compliance
What particle retention efficiency can be expected with 0.22μm PES filters?
The 0.22μm pore size provides effective retention of bacteria and particles larger than the membrane cutoff, though specific efficiency values depend on particle characteristics and should be verified through product datasheet specifications.
How does PES membrane compare to other filter materials for protein applications?
PES exhibits lower protein binding compared to nylon or cellulose acetate membranes, making it preferred for applications where protein recovery is important, such as antibody purification or enzyme preparations.
What pressure range is suitable for manual syringe filtration?
Apply steady, controlled pressure avoiding excessive force that may damage the membrane. Pressure requirements vary with sample viscosity and should be kept within syringe manufacturer specifications.
Can these filters be used for organic solvents or non-aqueous solutions?
PES membranes are primarily designed for aqueous solutions. Chemical compatibility with specific organic solvents should be verified through membrane compatibility charts before use.
What is the recommended storage condition for sterile filters?
Store in original sterile packaging at room temperature in dry conditions away from direct sunlight. Check expiration dates and package integrity before use.
How much sample volume can typically be processed through one filter?
Volume capacity depends on sample characteristics including particle load and viscosity. Consult product specifications for recommended volumes and expect reduced flow rates with high-particulate samples.
What are the primary causes of membrane clogging during filtration?
High particulate load, cellular debris, or protein aggregates can cause premature clogging. Pre-filtration with larger pore size or sample dilution may be necessary for heavily contaminated samples.
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