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NIH funding notice PA-18-575

PHS 2018-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)

Closed on April 5, 2019.

Posted
January 16, 2018
Close date
April 5, 2019
Activity codes
R41, R42
Institutes taking part
NCI, NEI, NHLBI, NHGRI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDCD, NIDCR, NIDDK, NIDA, NIEHS, NIGMS, NIMH, NINDS, NINR, NIMHD, NLM, NCCIH, NCATS, ORIP

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

  1. Reissues: PA-17-303 PHS 2017-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  2. 2 steps back: PA-16-303 PHS 2016-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  3. 3 steps back: PA-15-270 PHS 2015-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  4. 4 steps back: PA-14-072 PHS 2014-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42]
  5. 5 steps back: PA-13-235 Reissue PHS 2013-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  6. 6 steps back: PA-13-089 PHS 2013-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  7. 7 steps back: PA-12-089 PHS 2012-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  8. 8 steps back: PA-11-097 PHS 2011-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  9. 9 steps back: PA-10-051 PHS 2010-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  10. 10 steps back: PA-09-081 PHS 2009-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])

Replaced by PA-19-270.

Who won it before

1,178 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $373,294,982 in first-year total cost, median $225,000.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 SBIB-T (10)]82
  2. Special Emphasis Panel[ZRG1 OTC-T (10)]65
  3. Special Emphasis Panel[ZRG1 ETTN-G (12)]59
  4. Special Emphasis Panel[ZRG1 ETTN-M (11)]55
  5. Special Emphasis Panel[ZRG1 BCMB-G (10)]34

Most frequent institutions

  1. FOX CHASE CHEMICAL DIVERSITY CENTER, INC11
  2. L2 DIAGNOSTICS, LLC10
  3. MEDOSOME BIOTEC, LLC9
  4. MICROBIOTIX, INC7
  5. FIREBIRD BIOMOLECULAR SCIENCES, LLC6
Competing awards under PA-18-575 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2020A small molecule integrin activator to enhance cord blood transplant2R42HL129612-02MARATHI, UPENDRAVANDERSLICE, PETER7 HILLS PHARMA, LLC, TX$935,957ZRG1
2020Caduceus Quest: An interactive digital media resource to promote knowledge of reproductive health and STEM2R44GM133290-02A1GILLIAM, MELISSA L.PARSONS, TIMOTHYRESILIENT GAMES STUDIO, LLC, IL$781,659ZRG1
2020Clinical Text Automatic De-Identification to Support Large Scale Data Reuse and Sharing2R42GM116479-02A1MEYSTRE, STEPHANECLINACUITY,INC., SC$759,330ZRG1
2020A Novel Polymeric Valve for Transcatheter Aortic Valve Replacement2R42HL134418-03A1BLUESTEIN, DANNYPOLYNOVA CARDIOVASCULAR, INC, NY$719,175ZRG1
2020Integrated Platform for Mass-Spectrometric Studies of Protein Structure2R42GM121133-02BERN, MARSHALL WAYNEPROTEIN METRICS, LLC, CA$613,930ZRG1
2020Inhaled Fasudil and DETA NONOate CAR-Targeted Liposomes for PAH1R42HL151045-01AHSAN, FAKHRULVASCULAR BIOSCIENCES, CA$330,004ZRG1
2020Optimizing a Stapled-Peptide That Specifically Targets HSV-1 to Treat Herpes Ocular Keratitis1R41EY030391-01A1RICCIARDI, ROBERT PAULFOX CHASE CHEMICAL DIVERSITY CENTER, INC, PA$309,102ZRG1
2020Multivalent Adjuvant Immunization to Prevent Hospital Acquired Infections1R41AI145759-01A1SPELLBERG, BRAD JEXBAQ LLC, MD$300,000ZRG1
2020Tumor bed implant for simultaneous heat and radiation of resectable brain tumors1R41CA239815-01A1STAUFFER, PAUL RATHMAE CONSULTING GROUP LLC, NH$300,000ZRG1
2020Development of Broad Spectrum Antifungal Agents1R41AI149960-01WRIGHT, DENNIS L.QUERCUS MOLECULAR DESIGN, LLC, CT$300,000ZRG1
2020Antimetabolites for Acute Myeloid Leukemias1R41CA247113-01WRIGHT, DENNIS L.QUERCUS MOLECULAR DESIGN, LLC, CT$300,000ZRG1
2020Regenerative Therapy for Corneal Endothelial Dystrophies and Injuries1R42EY031196-01DAS, HIRANMOYRASHMIVU, LLC, OH$300,000ZRG1
2020Developing high throughput measurement of thiopurine in DNA by mass spectrometry1R41GM136093-01TAO, W. ANDYTYMORA ANALYTICAL OPERATIONS, LLC, IN$299,975ZRG1
2020Biodegradability and Biocompatibility of a Shape Memory Polymer Wrap to Improve Saphenous Vein Graft Patency in Peripheral and Coronary Artery Bypass Grafting Surgeries1R41HL151025-01BOIRE, TIMOTHY CVENOSTENT, INC., TX$299,910ZRG1
2020Evaluation of a peptide that inhibits the activation of NOX2 and the generation of reactive oxygen species in protection against acute lung injury1R41HL145848-01A1FEINSTEIN, SHELDON IFISHER, ARON B.PEROXITECH, LLC, PA$299,866ZRG1
2020Non-Invasive Oropharynx Appliance to Maintain Airway Patency1R41HL150933-01DURAND, DOMINIQUE MANEMED INC, OH$299,743ZRG1
2020Using Targeted Lipid Nanoparticles to Deliver Chemotherapeutic Agents against Pancreatic Cancer1R41CA247009-01LAMBROS, MARIADORICPHARMA LLC, CA$299,559ZRG1
2020Inhibitors of T3SS translocon assembly to combat multi-drug resistant P. aeruginosa1R41AI149922-01HEUCK, ALEJANDRO PABLOMOIR, DONALD TMICROBIOTIX, INC, MA$299,449ZRG1
2020Point-of-care antigen detection assay for early diagnosis of Ebola virus disease (EVD)1R41AI149940-01AUCOIN, DAVID PRAYCHAUDHURI, SYAMAL XINBIOS INTERNATIONAL, INC., WA$299,112ZRG1
2020Next-generation precision medicine for targeting recombination-deficient cancers1R41CA239983-01A1POMERANTZ, RICHARD TRECOMBINATION THERAPEUTICS, LLC, PA$298,959ZRG1
2020Multiplexed Bioassay for Checkpoint Inhibitor Autoimmunity1R41AI149951-01MAMULA, MARK JL2 DIAGNOSTICS, LLC, CT$298,911ZRG1
2020Enhanced MDx: a computational model to optimize pre-analytical pathogen isolation from whole blood.1R41GM136084-01MILLER, CASS TREDBUD LABS, INC., NC$296,954ZRG1
2020Determination of optimal antisense oligonucleotide chemistry for efficient and safe splicing modulation in T cells1R41AI149920-01GALARZA-MUNOZ, GADDIELAUTOIMMUNITY BIOLOGIC SOLUTIONS, INC., TX$283,667ZRG1
2020Development of a vaccine to prevent Pneumocystis pneumonia1R41AI145416-01A1DOWNES, MICHAEL ROBERTNORRIS, KAREN ANXT BIOLOGICS, INC., GA$272,439ZRG1
2020Hemoglobin-based antidotes for the treatment of carbon monoxide poisoning1R42ES031993-01ROSE, JASON JTEJERO BRAVO, JESUSGLOBIN SOLUTIONS, INC., PA$249,993ZRG1
2020Feelix @ Home: Testing and optimization of a smart stethoscope for home use to monitor changes in lung status of individuals with chronic conditions1R42HL147728-01A1BUSCH-VISHNIAC, ILENE JOYELHILALI, MOUNYASONAVI LABS, INC., MD$236,489ZRG1
2020Development of Hsp90 beta-selective inhibitors as safer anti-cancer agents1R41CA247058-01MISHRA, SANKETGRANNUS THERAPEUTICS LLC, IN$233,195ZRG1
2020Novel QcrB Inhibitors for the Treatment of Tuberculosis1R41AI145514-01A1HIPSKIND, PHILIP ARTHURLGENIA, INC., IN$225,343ZRG1
2020A new generation, enhanced, corneal-birefringence-independent retinalscanning device for pediatric vision disorders using polarization modulation1R41EY030382-01A1GRAMATIKOV, BORISSHAKA, JUSTINREBISCAN, LLC, MA$225,000ZRG1
2020A platform for engineering peptide ligase for building next generation peptide therapeutics.1R41GM136037-01ABATE, ADAM R.SCRIBE BIOSCIENCES, INC., CA$225,000ZRG1
2020Novel Nanosecond Laser and Ultrasound to Selectively Treat Eye Blood Vessels1R41EY031219-01PAULUS, YANNIS MANTASPHOTOSONOX LLC, MI$225,000ZRG1
2020Pharmacological chaperones for the treatment of Open-Angle Glaucoma1R41EY031203-01MAKLEY, LEAH NICOLEVIEWPOINT THERAPEUTICS, INC., CA$225,000ZRG1
2020Portable, affordable, quantitative microchip electrophoresis system for integrated anemia and hemoglobin variant testing1R41HL151015-01GALEN, PETERHEMEX HEALTH, INC., OR$225,000ZRG1
2020Photodynamic Therapy to Prevent Arteriovenous Fistula Maturation Failure1R41HL151235-01ROY-CHAUDHURY, PRABIRRYCHNOVSKY, STEVENADGERO BIOPHARMACEUTICALS HOLDINGS, INC., CA$225,000ZRG1
2020Development of EFTX-001 to target KRAS mutations in cancer1R41CA246848-01PECOT, CHAD VENFUEGO THERAPEUTICS INC., NC$224,995ZRG1
2020Non-invasive Detection of Cerebral Aneurysm Recurrence after Endovascular Treatment Using Automated Image Processing1R41NS115253-01CHEN, PENG ROCLEE, TOMMEDICAL INNOVATORS COMPANY, LLC, TX$224,981ZRG1
2020A Mobile/Web-based Training Curriculum for Disseminating Best Practices for the Care of Newborns with Neonatal Opioid Withdrawal Syndrome1R41DA050408-01KONG, ALBERTA SUM-YUPRATT-CHAVEZ, HEATHER ASMITH, DAVID RANDOLPHOREGON RES BEHAVIORAL INTERVENTION STRAT, OR$224,919ZRG1
2020Application of TNFRSF25 agonists for prophylaxis and treatment of graft versus host disease1R41AI149916-01SEAVEY, MATTHEWPELICAN THERAPEUTICS, INC., TX$224,713ZRG1
2020Programming Metabolically Fit TILs for Immunotherapy1R41CA239952-01A1MEHROTRA, SHIKHARLIPO-IMMUNO TECH, LLC, SC$224,559ZRG1
2020An adjuvanted influenza vaccine platform for dose sparing, multiplexing, and rapid deployment1R41AI149954-01DAVIDSON, BRUCE A.KUTSCHER, HILLIARDPOP BIOTECHNOLOGIES, INC, NY$223,797ZRG1
2020Rifampin potentiation in NTM1R41AI145461-01A1TIMMINS, GRAHAM SSPINCEUTICA, INC., NM$205,299ZRG1
2019A Novel Probiotic Platform to Treat Necrotizing Enterocolitis2R44GM122130-02BAILEY, MICHAEL TBESNER, GAIL EGOODMAN, STEVEN DTREBLEY, JOESCIOTO BIOSCIENCES, INC., IN$1,150,153ZRG1
2019The Bumps: A Device for Rapid, Non-Invasive Quantification of Touch Sensation2R42TR000462-04A1KENNEDY, WILLIAM RSIMONE, DONALDNEURO DEVICES, INC., MN$1,011,590ZRG1
2019Drug-eluting Brachytherapy Implants for Chemo-radiation Therapy2R42CA224646-02SRIDHAR, SRINIVASTHERANANO, LLC, MA$1,007,156ZRG1
2019Developing a Small Peptide to Control Autoimmune Inflammation In Type 1 Diabetes2R42AI131784-02WAGNER, DAVID H.OP-T-MUNE, INC., CO$1,000,000ZRG1
2019IND enabling development of LGM2605 as adjuvant treatment for asthma2R42AI132012-02HACZKU, ANGELASIELECKI, THAIS MOTRIALIGNAMED, LLC, PA$1,000,000ZRG1
2019Infection Site Targeted Antitoxin Antibody (ISTAb) against Bacillus anthracis2R42AI122666-03ADHIKARI, RAJAN PHAKAMI, RAMIN M.NELSON, DANIEL C.INTEGRATED BIOTHERAPEUTICS, INC., MD$999,997ZRG1
2019Preclinical Development of OCF001 for Treatment of Yeast Infections2R42AI131792-02A1SMITH, JAMES LEIFSANO CHEMICALS, INC, TX$983,345ZRG1
20194-(Aminomethyl) benzamides as novel anti-Ebola agents2R42AI126971-03A1RONG, LIJUNCHICAGO BIOSOLUTIONS, INC., IL$972,475ZRG1
2019Visual biofeedback to reduce head motion during MRI scans1R44MH122066-01DECKARD, TODD WILLIAMDOSENBACH, NICOFAIR, DAMIEN ATURING MEDICAL TECHNOLOGIES INC, MO$966,084ZRG1
2019Non-Invasive Physiologic Evaluation of Peripheral Arterial Disease2R42HL133633-02A1FERGUSON, THOMAS BRUCERFPI, LLC, NC$963,313ZRG1
2019An Automated Patient Chart Error Detection System for Radiation Therapy2R42CA195819-02A1XIA, JUNYIINFONDRIAN, LLC, IA$894,987ZRG1
2019Stem Cells for Treating Acute Stroke1R42NS112070-01GRANDE, ANDREW WKUZMIN-NICHOLS, NICOLE A.LOW, WALTER CSANERON CCEL THERAPEUTICS, INC., FL$843,689ZRG1
2019Application of PPODA-QT for embolization of aneurysms2R42NS097069-02A1BECKER, TIMANEUVAS TECHNOLOGIES, INC., AZ$763,805ZRG1
20193D-Printed Superhydrophobic-Tipped Optical Fiber for Targeted Periodontal Photodynamic Therapy2R44DE026083-03XU, QIANFENGSINGLETO2 THERAPEUTICS, LLC, NJ$761,878ZRG1
2019Next Generation Tools for Onsite Monitoring and Treatment of Drug of Abuse-Dependent Persons2R42DA041959-02MEHALSO, ROBERTSENSODX II, LLC, NY$760,245ZRG1
2019Production and Characterization of Human Immunoglobulin Producing Goats for Diagnostic Reagents and Therapeutics2R42AI131823-02POLEJAEVA, IRINA A.WU, HUASAB CAPRA, LLC, UT$758,090ZRG1
2019Automated Intestinal Electrical Stimulation for Diabetes2R42DK100212-02A1CHEN, JIANDETRANSTIMULATION RESEARCH, INC., OK$749,185ZRG1
2019Novel antibacterial agents derived from natural products2R42AI118104-02PRIESTLEY, NIGEL DPROMILIAD BIOPHARMA, INC., MT$746,516ZRG1
2019BlueBox: A Complete Code Blue Data Recorder, Phase II2R42GM113463-02CHANG, RUEY-KANGNEOVATIVE, INC., CA$723,986ZRG1
2019Ultrasound-Based Device to Guide Treatment of Graft-Versus-Host-Disease using Skin Elasticity as a Biomarker2R42CA228159-02CARDONES, ADELA RAMBIHOLLENDER, PETERPALMERI, MARK L.MICROELASTIC ULTRASOUND SYSTEMS, INC., NC$721,226ZRG1
2019Personalized Neural Stem Cell Therapy for Cancer2R42TR001789-02A1NICHOLS, SUSANFALCON THERAPEUTICS, INC., NC$716,643ZRG1
2019Novel sanitizer/disinfectants against viral infections with long-lasting effect2R42AI124738-02DICKINSON, DOUGLAS PETERHSU, STEPHENCAMELLIX, LLC, GA$705,771ZRG1
2019Wireless, implantable optofluidic systems for programmed pharmacology and optogenetics2R42MH116525-02GHAFFARI, ROOZBEHNEUROLUX, INC., IL$694,703ZRG1
2019Preventing Vascular Complications in Type 1 Diabetes: Muscle Metabolic Monitoring2R42DK112497-02MCCULLY, KEVIN K.INFRARED RX, INC., GA$676,698ZRG1
2019Targeting lipid rafts for treatment of migraine1R41NS113705-01BACON, KEVINSORKIN, LINDA SRAFT PHARMACEUTICALS, LLC, CA$665,674ZRG1
2019Pre-clinical evaluation of DT-001, a small molecule antagonist of MD2-TLR4 for utility in the treatment of pain.1R41NS113717-01CHAKRAVARTHY, KRISHNANYAKSH, TONY L.DOULEUR THERAPEUTICS, INC., CA$646,527ZRG1
2019Optical photothermal IR (O-PTIR) microscopy for chemical imaging of living cells at sub-micron resolution2R42CA224844-02CHENG, JI-XINPHOTOTHERMAL SPECTROSCOPY CORP., CA$600,000ZRG1
2019Compatibility between Brain-Computer Interface and High-Efficiency Augmentative and Alternative Communication Systems2R42DC015142-02CROSS, RUSSELL THOMASHILL, KATYA JHUGGINS, JANE EPRENTKE ROMICH COMPANY, OH$538,655ZRG1
2019Monochromatic 222 nm UV light: Development of a safe, cost-effective technology for the efficient reduction of bacterial and viral infection and transmission2R42AI125006-02A1BRENNER, DAVID JONATHANPARK, SUNG-JINEDEN PARK ILLUMINATION, INC., IL$500,000ZRG1
2019Minimally Invasive Intercostal Nerve Block Device to Treat Severe Pain and Reduce Usage of Opiates1R41NS115460-01POPIELARSKI, STEPHENTAI, CHANGFENGTHERMAQUIL, INC., PA$499,325ZRG1
2019In Vivo Studies of a Novel HDAC Inhibitor for Treating Hemoglobin Disorders2R42HL136068-02JUNKER, LOUIS HPACE, BETTY SUEWILLIAMS, ROBERT MICHAELCETYA THERAPEUTICS, INC., CO$499,220ZRG1
2019A New Non-Invasive Approach for Accessing Pulmonary Arterial Stiffness in Patients with Pulmonary Hypertension1R41HL145838-01A1DENNEY, THOMAS SARCUS-MED, LLC, NC$488,009ZRG1
2019Novel monoclonal antibody for single dose treatment of acute CNS injury1R41NS115249-01CARBONELL, ANNE-MARIEKILBAUGH, TODD JUSTENONCOSYNERGY, INC., CT$456,047ZRG1
2019Developing an efficient E-cigarette aerosol generation and exposure system for rodent models with aerosol characteristics equivalent to those inhaled by E-cigarette users2R42DA044788-02KEWEKORDES, JOSEFSHAO, XUESI MAXAUTOMATE SCIENTIFIC, INC., CA$453,495ZRG1
2019Developing Insulin-like growth factor binding protein 2(IGFBP2)peptide fragment-based therapeutics to treat functional and behavioral deficits in Phelan-McDermid Syndrome.1R41MH121140-01PENZES, PETERALISBIO, LLC, IL$447,036ZRG1
2019Glioblastoma multiforme therapy via telomerase reverse transcriptase (hTERT) down-regulation. Molecular chaperones redirect quadruplex folding to reverse the effect of hTERT gene promoter mutations.1R41NS110296-01BERENS, MICHAEL E.HURLEY, LAURENCE H.REGLAGENE, LLC, AZ$401,714ZRG1
2019Targeting neurotoxic alpha-synuclein aggregates for Parkinson's disease therapy.1R41NS113694-01LASMEZAS, CORINNE IDAVOVA IDA THERAPEUTICS INC, FL$376,286ZRG1
2019Secure outsourced computation of genomic data1R41HG010978-01BOXWALA, AZIZ AELIMU INFORMATICS, INC., CA$344,948ZRG1
2019Discovery of T-type Calcium Channel Antagonists from Multicomponent Reactions and Their Application in Paclitaxel-induced Peripheral Neuropathy1R41NS116784-01 · under PA-17-303KHANNA, RAJESHREGULONIX, LLC, NY$341,527ZRG1
2019Preventing Neurovascular Matrix Degradation and Hemorrhage in Acute Ischemic Stroke1R41HL147676-01JEONG, SUN YONGREED, GUY LTRANSLATIONAL SCIENCES, INC., AZ$336,200ZRG1
2019Pulmonary valved conduit xenograft with regeneration potential1R41HL147771-01VYAVAHARE, NAREN RANNOVIANT, INC, GA$314,906ZRG1
2019Evaluation of therapeutic efficacy and safety of novel small RNA target delivery platform in vivo.1R41OD028767-01A1DEVENPORT, MARTINTANNO, TOSHIHIKOONCOIMMUNE, INC., MD$312,714ZTR1
2019Discovery of TrkC agonist antibodies for hearing loss1R41DC018250-01DISTEFANO, PETER SGREEN, STEVEN HZEBRA BIOLOGICS, INC., MA$304,258ZRG1
2019PIXUL-FFPE: High throughput platform for chromatin and DNA sample preparation from formalin fixed paraffin embedded (FFPE) tissue samples.1R42HG010855-01A1BOMSZTYK, KAROLMATCHSTICK TECHNOLOGIES, INC., WA$302,399ZRG1
2019Serum Inflammasome proteins: Novel biomarker panel for radiation biodosimetry1R41ES031778-01CHRISTOFIDOU-SOLOMIDOU, MELPOSIELECKI, THAISJT-MESH DIAGNOSTICS, LLC, PA$301,260ZRG1
2019Translational development of specialized NK cells for cancer immunotherapy1R41CA235924-01BIGLEY, AUSTIN BASILINDAPTA THERAPEUTICS, INC., WA$300,000ZRG1
2019Developing a Scalable Manufacturing Process for an Oral Bacteriophage Product that Prevents Cholera1R41AI142960-01CAMILLI, ANDREWYEN, MINMINPHAGEPRO, INC., MA$300,000ZRG1
2019Discovering a Small Molecule that Targets the KSHV Processivity Factor for Treating Oral and Systemic Kaposi Sarcoma1R41DE028489-01RICCIARDI, ROBERT PAULFOX CHASE CHEMICAL DIVERSITY CENTER, INC, PA$300,000ZRG1
2019Development of a bioconjugate vaccine against Group B Streptococcus1R41AI142928-01A1FELDMAN, MARIOVAXNEWMO, LLC, MO$300,000ZRG1
2019IRE1beta Inhibitors: Novel Therapeutics to Manage Excess Mucus in Asthma1R41AI142847-01A1HULL-RYDE, EMILY ARTHURRIBEIRO, CARLA MARIA PEDROSAIREX PHARMA, LLC, NC$300,000ZRG1
2019Aminoglycosides with reduced ototoxicity via miRNA targeting1R41AI142856-01A1ARYA, DEV PRIYANUBAD, LLC, SC$300,000ZRG1
2019Fully Human Antibodies for the Prevention of Respiratory Syncytial Virus1R41AI140945-01A1HAINES, CHARLES FIDBIOLOGICS, LLC, TN$300,000ZRG1
2019Monoclonal antibodies targeting novel sites of vulnerability in marburg virus glycoprotein1R41AI147929-01AMAN, M JAVADLI, YUXINGINTEGRATED BIOTHERAPEUTICS, INC., MD$300,000ZRG1
2019Development of a Stem Cell-derived Cell-free Therapeutic for Stress Urinary Incontinence1R41DK122904-01COLEMAN, MICHAEL ELMOTHERATOME BIO, INC., IN$300,000ZRG1
2019A New Small-Molecule Kinase Inhibitor for Airway Disease1R41HL149523-01HOLTZMAN, MICHAEL JNUPEAK THERAPEUTICS, INC., MO$300,000ZRG1
2019Oncolytic virus-mediated target delivery of a therapeutic antibody fragment in glioblastoma1R41CA247044-01CARBONELL, ANNE-MARIEKAUR, BALVEENONCOSYNERGY, INC., CT$300,000ZRG1
2019Development of group 2 influenza A virus entry inhibitors1R41AI145727-01RONG, LIJUNCHICAGO BIOSOLUTIONS, INC., IL$299,999ZRG1
2019Targets of Acquired Tick-Resistance As Anti-Tick Vaccines1R41AI145778-01A1NARASIMHAN, SUKANYAL2 DIAGNOSTICS, LLC, CT$299,999ZRG1
2019Development of a vault nanovaccine for pancreatic cancer immunotherapy1R43CA221602-01A1BOXX, GAYLEAUKERA, INC., CA$299,979ZRG1
2019Novel Flexible Access Port for Extra-Cardiac Beating Heart Repair1R41HL147694-01DEL NIDO, PEDRO J.NIDO SURGICAL, INC., MA$299,948ZRG1
2019Targeting lipid rafts for treatment of asthma1R41AI147879-01BACON, KEVINBROIDE, DAVID HRAFT PHARMACEUTICALS, LLC, CA$299,940ZRG1
2019Rapid Development of a Highly Specific Dengue Diagnostic Test1R41AI141273-01A1WATKINS, DAVID IZ-QUICK, LLC, FL$299,938ZRG1
2019A novel vaccine against mosquito-borne Zika virus based on mosquito salivary gland protein AgBR11R41AI142846-01FIKRIG, EROLL2 DIAGNOSTICS, LLC, CT$299,888ZRG1
2019microRNA-21 Blockade of Triple Negative Breast Cancer1R41CA235707-01A1CASTRO, MIGUELJIN, YUAN-YUANWICKSTROM, ERICBOUND THERAPEUTICS, LLC, NJ$299,774ZRG1
2019A Novel Combination Therapy to Treat Biofilm-based Pneumonia Infections1R41AI143098-01A1LIPKA, ELKETSRL, INC., MI$299,733ZRG1
2019Noninvasive biomarkers for gastrointestinal disease in preterm infants1R41HD095779-01A1BUCKLEY, REBECCA SKIM, SUNYOUNGCHOSEN DIAGNOSTICS, INC., LA$299,641ZRG1
2019DRα1-MOG as a Next-Generation Immunotherapy for Methamphetamine Use Disorder1R41DA047865-01A1HUCKANS, MARILYNLOFTIS, JENNIFER MVIROGENOMICS BIODEVELOPMENT, INC., OR$299,560ZRG1
2019Development of a predictive moderate throughput assay to screen novel Designer Proline-rich antimicrobial peptide Chaperone protein inhibitors (DPCs) against multi-drug resistant pathogen1R41AI142829-01KRAUS, CARL NEILARREVUS, INC., NC$299,248ZRG1
2019Immunization with mosquito AgTRIO protein to prevent malaria1R41AI145779-01FIKRIG, EROLL2 DIAGNOSTICS, LLC, CT$298,944ZRG1
2019Microneedle Based Targeted Allergen Specific Immunotherapy for Treatment of Peanut Allergies1R42AI143011-01A1PATEL, SAMIRKUMARMOONLIGHT THERAPEUTICS, INC., GA$298,359ZRG1
2019Design and Development of Targeted-Liposome for drug delivery to lung cancer by exploiting a vulnerability induced by radiotherapy1R41CA233020-01A1DEORE, SAPNAMEDICAL GUIDANCE SYSTEMS, LLC, MO$296,606ZRG1
2019Detection of HIV proteins in urine to diagnose infection1R41MH122980-01LILLARD, JAMES WNEWMARK DIAGNOSTICS, LLC, GA$296,230ZRG1
2019Next generation HDAC inhibitors with superior potency, selectivity, and pharmacokinetic profiles for the treatment of liver ischemia-reperfusion injury1R41DK120247-01A1CHOU, CHUNG-JEN JAMESZHONG, ZHILYDEX PHARMACEUTICALS, LLC, SC$295,364ZRG1
2019Fully Human Antibody Combinations for the Prevention of Seasonal Influenza Infection1R41AI148019-01HAINES, CHARLES FIDBIOLOGICS, LLC, TN$294,700ZRG1
2019Granulocyte/Monocyte Precursors to Treat Neutropenia after Cancer Chemotherapy1R41CA244011-01DENNER, LARRYCORD BLOOD PLUS, INC., TX$294,634ZRG1
2019Use of a Designer Proline-rich antimicrobial peptide Chaperone protein inhibitor (DPC) for treating antibiotic resistant pneumonia1R41AI142726-01A1KRAUS, CARL NEILARREVUS, INC., NC$294,501ZRG1
2019Discovery of Novel Peptidic Inhibitors of the Non-Catalytic Function of Focal Adhesion Kinase (FAK)1R41CA240124-01A1CANCE, WILLIAM GMARLOWE, TIMOTHY AFAKNOSTICS, LLC, AZ$289,594ZRG1
2019A Tissue Support Structure (Macular O-Rings) for Reconstructing, Translocating or Transplanting Three-Dimensional Submacular Tissue Organoids in Age Related Macular Degeneration (AMD)1R41EY028803-01A1OLSEN, TIMOTHY WAYNEIMAC REGEN, MN$289,064ZRG1
2019Advance Early Detection of Lupus Nephritis with ClearGold1R41DK123943-01YU, MENGXIAOCLEARNANO, INC., TX$288,365ZRG1
2019Improving HSV-2 vaccine efficacy by focusing antibody epitope coverage.1R41AI142940-01A1BAILEY-KELLOGG, CHRISBROOKS, BENJAMIN DELBERTCOHEN, GARY HFRIEDMAN, HARVEY MICHAELSTEALTH BIOLOGICS, LLC, NH$284,815ZRG1
2019Rapid high-resolution typing of Human Leukocyte Antigen genes by nanopore sequencing for transplantation1R41AI142919-01LIU, CHANGNEWVENTUREIQ, LLC, MO$284,282ZRG1
2019Targeted Chelation for Reversal of Vascular Calcification1R41HL147653-01A1VYAVAHARE, NAREN RELASTRIN THERAPEUTICS, INC., SC$283,980ZRG1
2019Direct-read monitor for airborne viral pathogens1R41AI141047-01A1KEADY, PATRICIA BEAAEROSOL DEVICES, INC., CO$279,307ZRG1
2019Novel, Potent and Metabolically Stable Oxytocin Analogues to Treat Obesity1R41DK120236-01A1ROTH, CHRISTIAN LUDWIGOXT THERAPEUTICS, INC., MO$278,866ZRG1
2019Pudendal neuromodulation for incontinence and sphincter dyssynergia after spinal injury1R41NS115169-01THOR, KARL BDIGNIFY THERAPEUTICS, LLC, NC$269,371ZRG1
2019Targeted Therapy for Myasthenia Gravis1R41NS110331-01A1KAMINSKI, HENRY JARC BIOTECHNOLOGY, LLC, DC$268,669ZRG1
2019Development of an M Protein-Deficient Respiratory Syncytial Virus Vaccine for Aerosolized Vaccination of the Lung1R41AI147787-01WELLIVER, ROBERT C.HEARTLAND VACCINES, LLC, OK$267,672ZRG1
2019Automated CRISPR Screening Using the CellRaft Technology1R41GM131475-01BUCHSER, WILLIAM JCELL MICROSYSTEMS, INC., NC$267,489ZRG1
2019Beyond the pump: a novel shape memory alloy penile prosthesis1R41DK121625-01A1COLOMBO, ALBERTOMCVARY, KEVIN T.URONEXT, LLC, IL$266,922ZRG1
2019Development of mitoNEET agonists for the treatment of stroke1R41NS110070-01GELDENHUYS, WERNERHAZLEHURST, LORIMODULATION THERAPEUTICS, INC., WV$258,700ZRG1
2019Nanoentrapped polyphenol coatings for sustained release from angioplasty balloons1R41HL142403-01A1DUGAS, TAMMY RSABLIOV, CRISTINA MREQUISITE BIOMEDICAL, LLC, LA$257,732ZRG1
2019A recombinant matrix to improve autologous tissue grafts1R41CA244110-01A1HOLLENBECK, SCOTT THOMASROBERTS, STEFANINSOMA BIO, INC., NC$254,627ZRG1
2019Mitofusin agonists to prevent Charcot-Marie-Tooth disease 2A1R41NS115184-01DORN, GERALD W.MITOCHONDRIA IN MOTION, INC., MO$254,379ZRG1
2019MITOFUSIN AGONISTS TO TREAT NEURODEGENERATIVE DISEASE1R41NS113642-01DORN, GERALD W.MITOCHONDRIA IN MOTION, INC., MO$254,062ZRG1
2019Preclinical studies to validate the efficacy of novel mechanism-of-action small molecule inhibitors to treat Duchenne muscular dystrophy1R41AR076871-01NEELAKANTAN, HARSHINIRIDGELINE THERAPEUTICS, LLC, TX$252,131ZRG1
2019A high-efficiency, low-cost, single-use purification technology for therapeutic antibody manufacturing1R41GM134776-01BONDOS, SARAH EBONDWELL TECHNOLOGIES, INC., TX$248,762ZRG1
2019Pharmacologic Suppression of Reperfusion Injury Following Endovascular Thrombectomy In Stroke.1R41NS110252-01A1WARNER, DAVIDBIOMIMETIX JV, LLC, CO$247,352ZRG1
2019Integrin Activation as a Treatment for Leukocyte Adhesion Deficiencies1R41AI145507-01MARATHI, UPENDRAWOODSIDE, DARREN G7 HILLS PHARMA, LLC, TX$243,282ZRG1
2019Urocortin-2 Gene Transfer for Type 1 Diabetes and Associated LV Dysfunction1R42HL144299-01A1HAMMOND, H. KIRKRENOVA THERAPEUTICS, INC., CA$241,698ZRG1
2019Biosensor and Eyedrop Bottle Technologies for Glaucoma Adherence Monitoring1R41EY030403-01MAJID, MANITOROMEDES, INC., CA$240,588ZRG1
2019The first commercial rapid diagnostic test to detect Paragonimus infections1R41AI147875-01BALDWIN, RICHARD KIMOBIAMONTE, MARCO ANTONIOFISCHER, PETER UWENANOCOMPOSIX, INC., CA$238,810ZRG1
2019Development of a tracheal sound sensor for early detection of hypoventilation due to opioid overdose.1R41DA047779-01JOSEPH, JEFFREY IRTM VITAL SIGNS, LLC, PA$236,381ZRG1
2019Establishing a mechanistic foundation for drug discovery: The ABCA4 transporter in Stargardt Disease and other retinopathies1R41EY030401-01MOORE, JONATHANRECTIFY PHARMACEUTICALS, LLC, MA$230,686ZRG1
2019Use of mimotope vaccine technology to develop vaccines against bacterial pathogens1R41AI145611-01ZHANG, GUOQUANZENVAX, LLC, MO$230,244ZRG1
2019Noregen(TM), a regenerative medicine ocular therapeutic1R41EY030807-01MITTON, KENNETH PATRICKRETINAL SOLUTIONS LLC, MI$227,051ZRG1
2019Automation and Performance-Based Selection to Improve the Reproducibility of MSCs1R44GM133291-01LUANGPHAKDY, VIVIANECELL X TECHNOLOGIES, INC., OH$226,638ZRG1
2019Visual acuity and functional measurements in the aging eye1R41EY030829-01ELSNER, ANN EAEON IMAGING, LLC, IN$225,856ZRG1
2019LystaMab Immunotherapy to Inhibit Pericardial Adhesions1R41HL145827-01A1BREUER, CHRISTOPHER KANELYST THERAPEUTICS, LLC, OH$225,342ZRG1
2019Software for Determining Proteoform Heterogeneity and Protein Expression Fidelity1R41GM131533-01WEINBERGER, SCOT RANDYGENNEXT TECHNOLOGIES, INC., CA$225,285ZRG1
2019Resveratrol as a Corneal Pain Therapeutic1R41EY030804-01AICHER, SUE ATED'S BRAIN SCIENCE, INC., TX$225,005ZRG1
2019Medications for Synthetic Cannabinoid Abuse1R41DA044048-01A1 · under PA-17-303MAKRIYANNIS, ALEXANDROSPAFOSPHARMA, LLC, MA$225,000ZRG1
2019Novel and potent SHIP1 inhibitors for improving hematologic recovery following myelosuppressive therapies1R41HL142451-01A1KERR, WILLIAM GARROWALTERNA THERAPEUTICS, INC., NC$225,000ZRG1
2019Mobile Peer Support for Opioid Use Disorders: Refinement of an Innovative Machine Learning Tool1R41DA047837-01BEAUDOIN, FRANCESCABEACON TECH, INC., MA$225,000ZRG1
2019Novel Therapeutic Antibody Targeting of Extracellular NAMPT in Ventilator-Induced Lung Injury (VILI)1R42HL145930-01GARCIA, JOE G. N.AQUALUNG THERAPEUTICS CORP., FL$225,000ZRG1
2019Optimization of microparticle-based topical treatments for treating erectile dysfunction in patients refractory to oral PDE5 inhibitors1R41DK121587-01DAVIES, KELVIN PDRAGANSKI, ANDREW RZYLO THERAPEUTICS, INC., SC$225,000ZRG1
2019Development of a novel accurate therapy for Multiple Sclerosis1R41AI141323-01A1GALARZA-MUNOZ, GADDIELAUTOIMMUNITY BIOLOGIC SOLUTIONS, INC., TX$225,000ZRG1
2019Regenerative rotator cuff repair in a clinically relevant chronic disease model1R41AR074837-01A1EASLEY, JEREMIAHCYTEX THERAPEUTICS INC., NC$225,000ZRG1
2019The CRIT-ICU Biomarker Panel for Stratification of Mortality Risk in ARDS Patients1R41HL147769-01GARCIA, JOE G. N.AQUALUNG THERAPEUTICS CORP., FL$225,000ZRG1
2019Rapid High-Fidelity Assembly of Challenging Peptide Sequences1R41GM133272-01A1KUMAR, KRISHNAVELUM, INC., MA$225,000ZRG1
2019Bone Metastasis Specific 18F PET Imaging Probe for Breast Cancer1R41CA235996-01A1CHEN, KAIEBETINO, FRANK H.BIOVINC, LLC, CA$225,000ZRG1
2019Oral Enzymatic Management of Phenylketonuria1R41DK122897-01D'MELLO, ANIL PMALONE, KENNETH GEORGEABRI SCIENCE, LLC, MD$225,000ZRG1
2019Gallium 68 Tilmanocept for PET Imaging of Atherosclerosis Plaques1R41HL147640-01A1LAPI, SUZANNE ELIZABETHRALPH, DAVID ALLENNAVIDEA BIOPHARMACEUTICALS, INC., OH$225,000ZRG1
2019Development of a novel mobile application to assist in the diagnosis of Fetal Alcohol Syndrome (FAS)1R41AA028142-01CHOCKALINGAM, GANZBLUE RESONANCE, LLC, CA$225,000ZRG1
2019Development of a Novel Therapeutic for Hyperthyroidism1R41DK123953-01RIVKEES, SCOTT A.MEDOSOME BIOTEC, LLC, FL$225,000ZRG1
2019An Integrative and Collaborative Genomic Data Analysis Service with Galaxy1R41HG010982-01AFGAN, ENISGALAXYWORKS, LLC, MD$225,000ZRG1
2019STTR Phase I Development of Novel Antibacterial and Antifungal Bioadhesive Biomaterials for Diabetic Skin Wound Healing1R41DK123949-01FENG, MAOQI MARKYANG, JIANDYNAMIC ENTROPY TECHNOLOGY, LLC, TX$225,000ZRG1
2019Associating Clinical Decision Support Use with Clinical Outcomes in a Visual Analytics Display1R41LM013317-01ORENSTEIN, EVAN WILLIAMPHRASE HEALTH, INC., PA$224,995ZRG1
2019Gene Therapy to Prevent Esophageal Cancer Associated with Aldehyde Dehydrogenase Deficiency1R41AA027739-01CRYSTAL, RONALD GLEXEO THERAPEUTICS, LLC, NY$224,970ZRG1
2019Nanoparticle-based Intraperitoneal Delivery of Combined Chemo-brachytherapy for Treatment of Ovarian Cancer Metastases1R41CA239989-01A1LU, XIULINGNAMI THERAPEUTICS CORP., CT$224,946ZRG1
2019Translating an In-Person Brief, Bystander Bullying Intervention (STAC) to a Technology-Based Intervention1R41MD014943-01MIDGETT, AIDAKLEIN BUENDEL, INC., CO$224,938ZRG1
2019Correction of Splicing Defects in Cystic Fibrosis with Peptide-Oligonucleotide Conjugates and Small Molecule Enhancing Compounds1R41TR002692-01JULIANO, RUDOLPHINITOS PHARMACEUTICALS, LLC, NC$224,931ZRG1
2019HIGH RECOVERY RATE AND HIGH PURITY ENRICHMENT OF CIRCULATING TUMOR CELLS1R41EB028191-01ZHAO, WUJUNFCS TECHNOLOGY, LLC, GA$224,878ZRG1
2019A Device to Inhibit Heterotopic Ossification1R41AR074337-01A1BAIN, STEVEN DGROSS, JEFFREYIN SITU THERAPEUTIC SOLUTIONS, INC., WA$224,858ZRG1
2019Drug Development for Hearing Loss1R43DC018258-01DHUKHWA, ASMITAMUKHERJEA, DEBASHREENOVEAR THERAPEUTICS LLC, IL$224,829ZRG1
2019Optimizing membrane repair for the treatment of Duchenne muscular dystrophy1R41AR076276-01A1WEISLEDER, NOAHMYOFINITY BIOSCIENCES INC, MA$224,811ZRG1
2019Development of a Functional Assessment for Children and Youth who are Hospitalized1R41HD097844-01A1JETTE, ALAN MAURICEMOED, RICHARDCRECARE, LLC, MA$224,797ZRG1
2019A novel asthma drug candidate targeting the GABAergic system in lung inflammation1R41HL147658-01ARNOLD, ALEXANDERPANTHERICS INCORPORATED, WI$224,756ZRG1
2019Integrated Microbial Screening and Antimicrobial Susceptibility Test on Microfluidic Digital Array for Diagnosis of Urinary Tract Infections1R41AI145604-01LIN, ROBERTYANG, SAMUELCOMBINATI, INC., CA$224,658ZRG1
2019Advanced Multi-Modal Wearable Sensing for the Prediction of Pre-Term Labor1R41HD100284-01XU, SHUAISONICA, LLC, IL$224,650ZRG1
2019PreImplantation Factor plus hypothermia to treat neonatal brain injury1R41HD100269-01BARNEA, EYTAN RBIOINCEPT, LLC, OH$224,648ZRG1
2019Ultrasound-coupled electrical impedance tomography for assessment of neuromuscular disorders1R41AR076912-01HALTER, RYAN JOSEPHRYTEK MEDICAL, INC., NH$224,640ZRG1
2019Gene Therapy to Protect the Lung from Oxidant Stress1R41HL145871-01A1CRYSTAL, RONALD GLEXEO THERAPEUTICS, LLC, NY$224,593ZRG1
2019Micro-endoscopic impedance sensing for surgical margin assessment1R41CA235994-01HALTER, RYAN JOSEPHRYTEK MEDICAL, INC., NH$224,572ZRG1
2019Development of a Novel Bio-Adhesive Mesh System for Abdominal Hernia Repair1R41DK120168-01CHAMPAIGNE, KEVIN DCIRCA BIOSCIENCE, LLC, SC$224,418ZRG1
2019Developing and validating a podocyte cell-based diagnostic assay for identifying recurrent focal and segmental glomerulosclerosis patients1R41DK118999-01A1NIHALANI, DEEPAKINDEPTH PHARMACEUTICALS, LLC, SC$224,281ZRG1
2019Ultra-sensitive Rapid Diagnostic Test to Support the End-Game of the Global Program to Eliminate Lymphatic Filariasis1R41AI143071-01BALDWIN, RICHARD KIMOBIAMONTE, MARCO ANTONIONANOCOMPOSIX, INC., CA$224,246ZRG1
2019A Novel remedy for periodontal bone loss1R41DE028212-01A1LI, XINSAXENA, DEEPAKPERIOMICS CARE, LLC, NY$224,101ZRG1
2019Validation of a Cranial Neurosurgery Simulator and Assessment of Minimally Invasive Techniques1R41NS115308-01STONE, JONATHAN JAYSIMULATED INANIMATE MODELS, LLC, NY$224,026ZRG1
2019Array Based Affinity Selection1R41GM134782-01KAY, BRIAN KENNETHTANGO BIOSCIENCES, INC., IL$224,009ZRG1
2019Dynasore Analogues for Ocular Surface Protection1R41EY030811-01FINI, M ELIZABETHLAZAROVA, TSVETELINA IVANONOVAMEDCHEM PARTNERS, LLC, MA$223,999ZRG1
2019Prevention of White Matter Injury in Premature Infants1R42HD097911-01A1RIVKEES, SCOTT A.MEDOSOME BIOTEC, LLC, FL$223,899ZRG1
2019Improving the Oral Bioavailability and In vivo Efficacy of a Novel TAK1 Inhibitor Targeting Rheumatoid Arthritis1R41AR076772-01HAYSTEAD, TIMOTHY AEYDIS BIO, INC., NC$223,898ZRG1
2019A2A receptor blockade for sepsis1R41AI141279-01A1HASKO, GEORGEPURINE PHARMACEUTICALS, INC., NJ$223,820ZRG1
2019Novel insulin-sensitizing NASH/diabetes drugs.1R42DK121652-01A1FINCK, BRIAN NPETERSON, TIMOTHY RBIOIO, LLC, MO$223,817ZRG1
2019An Advanced Lung Organomimetic to Reproduce Human Airway Pathophysiology1R41ES031639-01A1HAJIPOURAN BENAM, KAMBEZPNEUMAX, LLC, CO$223,426ZRG1
2019A microfluidic device for blood analysis in neonates1R41HD100251-01STYBAYEVA, GULNAZSERSENSE, INC., MN$223,256ZRG1
2019Development of the GlycoFibrotyper for detection of liver fibrosis1R41DK124058-01MEHTA, ANAND S.SCOTT, DANIELLEGLYCOPATH, INC, SC$223,055ZRG1
2019Continuous real-time fentanyl sensor platform based on smart hydrogels for application in anesthesia1R41GM130241-01A1KUCK, KAISENTIOMED, INC., UT$222,921ZRG1
2019Enabling dexterous surgery at the tip of a flexible endoscope: A low-cost, disposable, steerable sheath.1R41EB028229-01A1WEBSTER, ROBERT JAMESENDOTHEIA, INC., TN$222,874ZRG1

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