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NIH funding notice PA-19-270

PHS 2019-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed

Closed on July 6, 2020.

Posted
May 7, 2019
Close date
July 6, 2020
Activity codes
R41, R42
Institutes taking part
NCI, NEI, NHLBI, NHGRI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDCD, NIDCR, NIDDK, NIDA, NIEHS, NIGMS, NIMH, NINDS, NINR, NIMHD, NLM, NCCIH, NCATS, ORIP

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

  1. Reissues: PA-18-575 PHS 2018-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)
  2. 2 steps back: PA-17-303 PHS 2017-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  3. 3 steps back: PA-16-303 PHS 2016-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  4. 4 steps back: PA-15-270 PHS 2015-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  5. 5 steps back: PA-14-072 PHS 2014-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42]
  6. 6 steps back: PA-13-235 Reissue PHS 2013-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  7. 7 steps back: PA-13-089 PHS 2013-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  8. 8 steps back: PA-12-089 PHS 2012-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  9. 9 steps back: PA-11-097 PHS 2011-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  10. 10 steps back: PA-10-051 PHS 2010-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  11. 11 steps back: PA-09-081 PHS 2009-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])

Replaced by PA-20-265.

Who won it before

1,360 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $440,802,024 in first-year total cost, median $226,684.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 SBIB-T (10)]97
  2. Special Emphasis Panel[ZRG1 OTC-T (10)]75
  3. Special Emphasis Panel[ZRG1 ETTN-G (12)]62
  4. Special Emphasis Panel[ZRG1 ETTN-M (11)]55
  5. Special Emphasis Panel[ZRG1 CVRS-C (10)]42

Most frequent institutions

  1. FOX CHASE CHEMICAL DIVERSITY CENTER, INC13
  2. L2 DIAGNOSTICS, LLC11
  3. MEDOSOME BIOTEC, LLC9
  4. ARREVUS, INC.7
  5. MICROBIOTIX, INC7
Competing awards under PA-19-270 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2021Epigenetic Markers and Sustained Cytoprotection for Stroke Treatment2R42NS098918-02A1BOOHER, KEITHGUO, WEIHUANG, SHAOLINGZYMO RESEARCH CORPORATION, CA$1,082,714ZRG1
2021Aminoglycosides with reduced ototoxicity2R42AI126874-03ARYA, DEV PRIYANUBAD, LLC, SC$999,986ZRG1
2021Development of peptide nucleic acid antibiotics2R42AI114114-03ARYA, DEV PRIYANUBAD, LLC, SC$999,985ZRG1
2021Multi-Institutional Implementation of Quality Decisions: a Clinical Decision Support Analytics Tool to Drive Outcomes2R42LM013317-02ORENSTEIN, EVAN WILLIAMPHRASE HEALTH, INC., PA$872,808ZRG1
2021Imaging biomarkers of severe respiratory infections in premature infants Phase II2R42HL145669-02A1ENQUOBAHRIE, ANDINET ASMAMAWLINGURARU, MARIUS GEORGENINO, GUSTAVOKITWARE, INC., NY$852,101ZRG1
2021VAL-0914 Decreases PAO to Protect Against Cardiac Proteinopathies1R41HL152919-01A1SHAFFER, ROBERTWANG, XUEJUNENABLE THERAPEUTICS LLC, MA$450,022ZRG1
2021A New Anti-inflammatory Therapy for Ischemic Stroke1R41HL156322-01LIANG, BRUCECORNOVUS PHARMACEUTICALS, INC., CT$433,483ZRG1
2021Development of a Therapeutic Monoclonal Antibody Against EGFL6, a Mediator of Tumor Growth and Metastasis1R41CA250757-01A1ALLEN, THADDEUS DAVIDTRADEWIND BIOSCIENCE, INC., CA$405,552ZRG1
2021Engineered adipokine receptor inhibitor for the treatment of triple negative breast cancer in obese patients1R41CA257425-01KRAUS, CARL NEILARREVUS, INC., NC$400,000ZRG1
2021Development of a biomarker panel for screening and early detection of gynecological cancers1R41CA257115-01MARTIGNETTI, JOHN AMDDX, INC., NY$399,972ZRG1
2021A novel polymer-metal nanocomplex for ovarian cancer treatment1R41CA254500-01A1XU, PEISHENGACEPRE, LLC, SC$392,803ZRG1
2021Identifying novel targets for cardioprotection with non-traditional animal models1R41HG011577-01GOODMAN, LINDA BOETTGERFAUNA BIO INCORPORATED, CA$373,434ZRG1
2021A Transparent Surgical Mask to Improve Patient/Caregiver Communication, Minimize Errors and Increase Patient Satisfaction2R42NR017124-02HAHNE, JEANNEFACEVIEW MASK, LLC, OR$359,907ZRG1
2021Single molecule DNA/RNA transport and Raman scattering readout in a coupled nanochannel/nanopore sequencing system.1R43HG011608-01BRUECK, STEVENARMONICA TECHNOLOGIES, INC., NM$349,200ZRG1
2021Mitigation of Ionizing Irradiation-Induced Intestinal Damage by Second-Generation Probiotics LR-IL-22 and LR-IFN-β1R41AI157357-01GREENBERGER, JOEL SROGERS, CLAUDE J.CHROMOLOGIC, LLC, CA$300,000ZRG1
2021Use novel natural compound Sparstolonin B to treat bacterial sepsis1R41AI157378-01FAN, HONGKUANACEPRE, LLC, SC$300,000ZRG1
2021Biomimetic size-adaptable heart valve for prosthesis-patient mismatch1R41HL156563-01DEL NIDO, PEDRO J.AUTUS VALVE TECHNOLOGIES, INC., MA$299,994ZRG1
2021Memory-promoting Ad vaccine for long-lived protection against SARS-CoV-21R41AI157626-01HARTIGAN-O'CONNOR, DENNIS J.TENDEL THERAPIES INC., CA$299,983ZRG1
2021Multiplexed CRISPR-based immune cell RNA profiling by flow and mass cytometry1R41AI157717-01O'CONNELL, MITCHELLDAHLIA BIOSCIENCES, INC., CA$299,978ZRG1
2021A Novel Broad-spectrum Antiviral Agent1R41AI157527-01BOTTEN, JASON W.MURAD, JOANA MCELDARA MEDICAL, LLC, NH$299,916ZRG1
2021Furopyrimidines as novel inhibitors of henipaviruses1R41AI157095-01RONG, LIJUNCHICAGO BIOSOLUTIONS, INC., IL$299,595ZRG1
2021Establishing the market-readiness of an in vivo technology for assessing drug toxicity-induced tissue damage1R41GM140538-01JOHNSON, STEVEN EDWARDDURAMETRIX LLC, WI$257,175ZRG1
2021Computer-aided design for improved lantibiotics1R41GM136034-01A1HANDFIELD, MARTINORAGENICS, INC., FL$256,654ZRG1
2021An Innovative Screener for Reading and SLI targeting Kindergarten through 3rd Grade Students1R43DC018766-01A1ANGEL, MARKRICE, MABEL LAMIRA LEARNING, INC., CA$256,580ZRG1
2021Novel Ophthalmic Product for Corneal Infections and Injuries1R41EY032437-01PEREIRA, HELOISE ANNEBIOLYTX PHARMACEUTICALS CORP, OK$256,580ZRG1
2021PHMB-Impregnated Acellular Biologic Grafts for Treatment of Third-Degree Burns1R41GM140660-01PASHOS, NICHOLASBIOAESTHETICS CORPORATION, NC$256,069ZRG1
2021A Peptide-Based Polyplex Platform for Nucleotides Delivery to the Sites of Inflammation1R41TR003244-01A1WICKLINE, SAMUEL ATRASIR THERAPEUTICS, INC., FL$254,092ZRG1
2021Developing a RPN13 inhibitor for the treatment of Quadruple Negative Breast Cancer1R41CA257110-01ANCHOORI, RAVI KUMARUP THERAPEUTICS, INC., MD$253,516ZRG1
2021X-ray Visualized Interbody Spacer Indicating Biomechanical Load (X-VISIBL) Fusion Device1R41AR078137-01A1DESJARDINS, JOHN DAVIDLORE, VITOSPINEFRONTIER, INC., MA$252,127ZRG1
2021Pediatric Heart Valve with Expansion Capability1R41HL154972-01A1SIERAD, LESLIE NEILAPTUS, LLC, SC$252,127ZRG1
2021A Chemiluminescent Assay and Device for Monitoring Vascular Endogenous Nitric Oxide1R41GM140575-01LIPPERT, ALEXANDER RYANBIOLUM SCIENCES, LLC, TX$251,943ZRG1
2021Multi-stable Compliant-Mechanism-based Mattress for Bedsore Prevention1R41NR019721-01HOPKINS, JONATHANK MEDICAL LLC, CA$251,440ZRG1
2021Milling with Ultraviolet Excitation for Whole Organ Cellular-Level Phenotyping1R41GM140586-01WOMACK, TASHASWIFT FRONT, LLC, TX$251,417ZRG1
2021Imaging Bacterial Infections in Vivo: First in Man Studies1R42AI157552-01GOODMAN, MARK MYRONMICROBIAL IMAGING, LLC, GA$228,484ZRG1
2021BandPass: A Remote Monitoring System for Sarcopenia and Functional Decline1R41AG071290-01HALTER, RYAN JOSEPHSYNCHROHEALTH LLC, NH$224,700ZRG1
2021HB-EGF regeneration to treat oral aphthous ulcers1R41DE030043-01MCGRAW, BENJAMIN FRANKLINSANTA MARIA, PETER LUKEAURATION BIOTECH, INC., NC$200,240ZRG1
2021Intravenous ivermectin for sepsis1R41AI156935-01HASKO, GEORGEPURINE PHARMACEUTICALS, INC., NJ$193,829ZRG1
2021Developing a novel drug for neurobehavioral deficits in FASD1R41AA029025-01TORII, MASAAKICOGTHERA, LLC, MD$164,683ZRG1
2020Enabling self-reported outcomes for youth with developmental disabilities: The Pediatric Evaluation of Disability Inventory - Patient Reported Outcome (PEDI-PRO) - Phase II2R42HD090772-03A1DAVIES, DANIEL KKRAMER, JESSICA MARVELLEABLELINK TECHNOLOGIES, INC., CO$1,520,155ZRG1
2020Omniphobic cerebral shunt to eliminate clogging and dysfunction2R42NS103704-02A1BANDYOPADHYAY, SAIBALHARRIS, CAROLYN AMCALLISTER, JAMES PATTERSONCERULEAN SCIENTIFIC INC., PA$1,384,382ZRG1
2020Catheter Based Cardiovascular Device Retrieval System2R42HL139309-02GORMAN, JOSEPH HONOCOR, LLC, PA$1,270,287ZRG1
2020Multi-Modality Image Data Fusion and Machine Learning Approaches for Personalized Diagnostics and Prognostics of MCI due to AD2R42AG053149-02A1LI, JINGLURE, FLEMING Y. M.MS TECHNOLOGIES CORPORATION, MD$1,252,970ZRG1
2020A Sparse-readout Quantitative PET scanner for breast cancer therapy optimization2R42CA213909-02A1HUNTER, WILLIAM COULIS JASONPET/X, LLC, WA$1,231,107ZRG1
2020Robust Predictor of Breast Cancer Risk2R42CA217383-02A1OSTRER, HARRYMORGAN AND MENDEL GENOMICS, INC., DE$991,797ZRG1
2020A small molecule integrin activator to enhance cord blood transplant2R42HL129612-02 · under PA-18-575MARATHI, UPENDRAVANDERSLICE, PETER7 HILLS PHARMA, LLC, TX$935,957ZRG1
2020Development of novel Amadorins for Diabetic Peripheral Neuropathy2R42DK120063-02KHALIFAH, RAJA GPRAETEGO, INC., NC$874,423ZRG1
2020EpiZode: Noninvasive Seizure Screening in Preclinical Models of Epilepsy2R42NS107148-02SUNDERAM, SRIDHARSIGNAL SOLUTIONS, LLC, KY$852,320ZRG1
2020Novel Algorithms for Reducing Radiation Dose of CT Perfusion2R44EB024438-03ALGER, JEFFRY RWANG, DANNY JJHURA IMAGING, INC, CA$820,709ZRG1
2020Broad Spectrum Bitter Taste Antagonists Discovery2R42DC017693-02A1RAWSON, NANCY ELLENREED, DANIELLE RENEESCHWIEBERT, ERIK MILLSDISCOVERYBIOMED, INC., AL$816,655ZRG1
2020A Deep Learning Model to Improve Pathologist Interpretation of Donor Kidney Biopsies2R42DK120253-02GAUT, JOSEPH PNEWVENTUREIQ, LLC, MO$811,695ZRG1
2020Wearable shear-wave tensiometry for tracking tendon load during dynamic movement2R42AR074897-02ADAMCZYK, PETER GTHELEN, DARRYL GDESIGN CONCEPTS, INC, WI$805,387ZRG1
2020Magnetic levitation motor for pediatric cardiac and cardiopulmonary therapies - Phase II2R42HL134455-04CAHALAN, PATRICK THOMASENSION, INC., PA$798,861ZRG1
2020Caduceus Quest: An interactive digital media resource to promote knowledge of reproductive health and STEM2R44GM133290-02A1 · under PA-18-575GILLIAM, MELISSA L.PARSONS, TIMOTHYRESILIENT GAMES STUDIO, LLC, IL$781,659ZRG1
2020Clinical Text Automatic De-Identification to Support Large Scale Data Reuse and Sharing2R42GM116479-02A1 · under PA-18-575MEYSTRE, STEPHANECLINACUITY,INC., SC$759,330ZRG1
2020Development of Drug Delivery Technology for Stem Cell Based TMJ Regeneration2R42DE028215-02A1CHEN, MOEMBREE, MILDRED CHRISTINEWNT SCIENTIFIC, LLC, NY$752,047ZRG1
2020Single application thixotropic antibiotic delivery systems for otitis externa2R42DC017641-02A1SERBAN, MONICA ANDREAPROMILIAD BIOPHARMA, INC., MT$751,069ZRG1
2020A Novel Polymeric Valve for Transcatheter Aortic Valve Replacement2R42HL134418-03A1 · under PA-18-575BLUESTEIN, DANNYPOLYNOVA CARDIOVASCULAR, INC, NY$719,175ZRG1
2020Image Analysis Tools for mpMRI Prostate Cancer Diagnosis Using PI-RADS2R42CA224888-03A1ONOFREY, JOHN AARONEIGEN HEALTH SERVICES LLC, CA$700,836ZRG1
2020Integrated Platform for Mass-Spectrometric Studies of Protein Structure2R42GM121133-02 · under PA-18-575BERN, MARSHALL WAYNEPROTEIN METRICS, LLC, CA$613,930ZRG1
2020A youth-specific helmet for preventing traumatic brain injury1R43NS119134-01CAMARILLO, DAVIDGRANT, GERALD ARTHURSAVIOR BRAIN INC., VA$587,742ZRG1
2020CNS Gene Therapy for CLN2 Disease Using Parallel Multiple Routes of Administration1R41NS117265-01CRYSTAL, RONALD GLEXEO THERAPEUTICS, LLC, NY$499,916ZRG1
2020Salmonella typhimurium-based Bacteriotherapy for Orphan Benign Tumors: Neurofibromatosis Type II (NF2)1R41NS120338-01BRENNER, GARY JAYLUO, SUSAN XMULBERRY BIOTHERAPEUTICS, INC., MA$499,527ZRG1
2020Recombinant Fc fusions for treatment of uropathogenic E. coli1R41DK122933-01A1SOKURENKO, EVGENI VENIAMINOVICWYCOFF, KEITHPLANET BIOTECHNOLOGY, INC., CA$486,870ZRG1
2020Transposon Engineered B Cell Therapy for Hunter Syndrome1R43NS120264-01A1HAMPE, CHRISTIANE SMCIVOR, R. SCOTTIMMUSOFT CORPORATION, WA$466,804ZRG1
2020Chemical-based Nitric Oxide Gas-generating Drug Device for the Treatment of Pulmonary Hypertension1R41HL152921-01ENIKA, NAGABABUTECHNOLOGY COMMERCIALIZATION PARTNERS, LLC, AL$465,219ZRG1
2020Microbial Synthesis of Therapeutic Bile Acids1R41NS113732-01A1LIAO, DEZHILOW, WALTER CSMANSKI, MICHAEL JMETSELEX, INC., MN$450,234ZRG1
2020A novel role for Reelin therapeutics in inflammatory bowel disease1R41DK126520-01GONIAS, STEVEN L.KOUNNAS, MARIA ZREELIN THERAPEUTICS, INC., CA$400,032ZRG1
2020Oleocanthal functional food products for breast cancer recurrence control1R41CA247025-01A1EL SAYED, KHALID AOLEOLIVE, INC., LA$399,999ZRG1
2020Efficacy of a novel small-molecule splicing modulator in chronic lymphocytic leukemia (CLL)1R41CA254498-01A1MORRIS, STEPHAN WADESHI, HUIDONGWEBB, THOMAS ROYWILDFLOWER BIOPHARMA INC, CA$399,999ZRG1
2020Aminonaphthyridine compounds as potential therapeutics for lung and thyroid cancers1R41CA250707-01HOLTSBERG, FREDERICK WAYNESINTIM, HERMAN OKINARX, LLC, MD$399,933ZRG1
2020Interstitial Chemophototherapy with Light-Activated Nanoparticulate Doxorubicin1R41CA243954-01A1SHAFIRSTEIN, GALPOP BIOTECHNOLOGIES, INC, NY$399,917ZRG1
2020Inhibition of breast cancer cell metastases using a connexin43 mimetic peptide1R41CA250874-01LAMOUILLE, SAMYACOMHAL RESEARCH, INC., VA$399,878ZRG1
2020A novel monobody-drug conjugate to treat mutant Ras multiple myeloma1R41CA250616-01A1BAR-SAGI, DAFNAMORGAN, GARETH JOHNRAMIREZ, CRAIG PATRICKTEZCAT LABORATORIES LLC, CT$399,877ZRG1
2020Nucleotide inhibitors as precision medicine in breast cancer1R41CA257002-01POMERANTZ, RICHARD TRECOMBINATION THERAPEUTICS, LLC, PA$399,757ZRG1
2020Modulation of the gut microbiome to enhance efficacy of immunotherapy in pancreatic adenocarcinoma1R41CA250892-01LI, XINSAXENA, DEEPAKPERIOMICS CARE, LLC, NY$399,752ZRG1
2020Development of a Novel Therapeutic Transporter to Treat Metastatic Cancers1R41CA257020-01KLEMKE, RICHARD L.CYTONUS THERAPEUTICS, INC., OH$399,346ZRG1
2020Simplified Transfemoral Carotid Angioplasty and Stenting Under FlowReversal Using a Novel Combination Access Sheath/Balloon System1R41HL152873-01A1KALLMES, DAVID FMARBLEHEAD MEDICAL, LLC, MN$398,081ZRG1
2020Development of gene therapy product for treating MPS IIIB1R41NS115232-01A1FU, HAIYANNEUROGT, INC., NC$397,823ZRG1
2020Examination of a novel potential therapy for autonomic dysreflexia1R41NS117205-01RUPNIAK, NADIA MELANIE JOSEPHINEDIGNIFY THERAPEUTICS, LLC, NC$394,754ZRG1
2020Development of CA-IL-12 for Triple Negative Breast Cancer1R41CA250887-01KLEMKE, RICHARD L.CYTONUS THERAPEUTICS, INC., OH$386,586ZRG1
2020Refinement of a rapid saliva miRNA diagnostic test for concussion1R42NS119119-01LEVITSKIY, DAVIDWRIGHT, FORRESTQUADRANT BIOSCIENCES, INC., NY$380,848ZRG1
2020SciDAP: a next generation universal platform for collaborative data analysis1R41HG011219-01A1BARSKI, ARTEMKARTASHOV, ANDREYDATIRIUM, LLC, OH$374,500ZRG1
2020Developing a clinically relevant radiosensitizer for temozolomide-resistant gliomas1R41CA246902-01A1CHEN, THOMAS C.NEONC TECHNOLOGIES, INC., CA$336,000ZRG1
2020Real-time Multimodal Diffuse Reflectance and Polarization Imaging Based Nerve Identification in Surgical Field of View1R41EB029888-01A1BABA, JUSTINYAYA SCIENTIFIC, LLC, TN$333,355ZRG1
2020Inhaled Fasudil and DETA NONOate CAR-Targeted Liposomes for PAH1R42HL151045-01 · under PA-18-575AHSAN, FAKHRULVASCULAR BIOSCIENCES, CA$330,004ZRG1
2020Decellularized xenograft leaflet patch for pulmonary valve repair in pediatric patients1R41EB031594-01VYAVAHARE, NAREN RANNOVIANT, INC, GA$327,779ZRG1
2020Targeted delivery of amiodarone to the heart for atrial fibrillation utilizing novel cardiac targeting peptides1R41HL150908-01A1ZAHID, MALIHAVIVASC THERAPEUTICS INC., PA$327,289ZRG1
2020Cerenkov Multi-Spectral Imaging (CMSI) for Adaptation and Real-Time Imaging in Radiotherapy1R41CA243722-01A1EL NAQA, ISSAM M.ENDECTRA, LLC, MI$327,240ZRG1
2020Photo-mediated ultrasound therapy for treatment of cutaneous vascular malformations1R41EB030875-01WANG, XUEDINGYANG, XINMAIPHOTOSONOX LLC, MI$325,355ZRG1
2020Engineering probiotic yeast for efficient sulforaphane delivery1R43AT011168-01DENBY, CHARLESBERKELEY FERMENTATION SCIENCE INC., CA$325,000ZRG1
2020RememberStuff: a dyadic-focused technology to support persons with Alzheimer's disease in the community1R41AG066238-01A1FOWLER, NICOLE R.EPERTURE, LLC, IN$316,895ZRG1
2020Contamination resistant interconnection for reducing peritoneal dialysis - associated peritonitis1R41DK126586-01A1VIKER, TOMCEROVATIONS, LLC, MN$314,354ZRG1
2020A novel device for cervical insufficiency in pregnant women1R41HD102268-01A1CRAIGO, SABRINACX THERAPEUTICS, INC, MA$312,578ZRG1
2020Optimizing a Stapled-Peptide That Specifically Targets HSV-1 to Treat Herpes Ocular Keratitis1R41EY030391-01A1 · under PA-18-575RICCIARDI, ROBERT PAULFOX CHASE CHEMICAL DIVERSITY CENTER, INC, PA$309,102ZRG1
2020Optimization of Cannabinoids for Development as FDA-Approved Migraine Therapeutics1R41DA051309-01PAPPAS, GEORGESCHEDULE 1 THERAPEUTICS, INC., IL$308,465ZRG1
2020Soft LXR Agonists for Idiopathic Pulmonary Fibrosis1R41HL154852-01SUMMER, ROSS SFOX CHASE CHEMICAL DIVERSITY CENTER, INC, PA$306,500ZRG1
2020An Economical Point-of-Care Software Solution Prototype for Medication Prior Authorization1R41MH124600-01SALZBRENNER, STEPHENBREEZMED, LLC, NE$301,383ZRG1
2020eNamptorTM: A Humanized mAb To Reduce the Severity of Radiation Pneumonitis and Fibrosis1R42HL152888-01GARCIA, JOE G. N.AQUALUNG THERAPEUTICS CORP., FL$300,001ZRG1
2020Multivalent Adjuvant Immunization to Prevent Hospital Acquired Infections1R41AI145759-01A1 · under PA-18-575SPELLBERG, BRAD JEXBAQ LLC, MD$300,000ZRG1
2020Tumor bed implant for simultaneous heat and radiation of resectable brain tumors1R41CA239815-01A1 · under PA-18-575STAUFFER, PAUL RATHMAE CONSULTING GROUP LLC, NH$300,000ZRG1
2020Development of Broad Spectrum Antifungal Agents1R41AI149960-01 · under PA-18-575WRIGHT, DENNIS L.QUERCUS MOLECULAR DESIGN, LLC, CT$300,000ZRG1
2020Antimetabolites for Acute Myeloid Leukemias1R41CA247113-01 · under PA-18-575WRIGHT, DENNIS L.QUERCUS MOLECULAR DESIGN, LLC, CT$300,000ZRG1
2020Regenerative Therapy for Corneal Endothelial Dystrophies and Injuries1R42EY031196-01 · under PA-18-575DAS, HIRANMOYRASHMIVU, LLC, OH$300,000ZRG1
2020Engineering a unique antibody for patients with RA1R41AI147697-01A1MARUYAMA, TOSHIAKISHAHRARA, SHIVAABWIZ BIO, INC., CA$300,000ZRG1
2020Development of Natural Product Inspired Adjuvants to Treat Tolerant Infections1R41AI152873-01PIERCE, JOSHUA G.SYNOXA SCIENCES, INC, NC$300,000ZRG1
2020Nucleic acid-based formulation of cytomegalovirus-vectored HIV vaccines1R41AI150232-01A1HARTIGAN-O'CONNOR, DENNIS J.TENDEL THERAPIES INC., CA$300,000ZRG1
2020PROTACS Against Nef as a Functional Cure for HIV Infection1R41AI155054-01SMITHGALL, THOMAS E.FOX CHASE CHEMICAL DIVERSITY CENTER, INC, PA$300,000ZRG1
2020Novel strategy to block AAV neutralizing anitbody activity1R41AI155038-01LI, CHENGWENNABGEN, INC., NC$300,000ZRG1
2020ELD607 Orai1 Antagonist Increases Bacterial Clearance from the Lung1R42AI155107-01TARRAN, ROBERTELDEC PHARMACEUTICALS, INC., NC$300,000ZRG1
2020Development of a treatment for the durable remission of HIV using autologous human CAR T cells that target B cell follicles1R41AI155031-01ATHANASIOU, MARIA CONSTANCESKINNER, PAMELA JMARPAM PHARMA, LLC, MN$300,000ZRG1
2020Prevention of GVHD by a probiotic exopolysaccharide.1R41AI155281-01KNIGHT, KATHERINE L.OSBORNE, BARBARA AHASENTECH, INC., IL$300,000ZRG1
2020Intrapartum Transabdominal Fetal Pulse Oximetry: Demonstration in Ewe Models1R41HD104537-01GHIASI, SOHEILSTORX TECHNOLOGIES, INC., CA$300,000ZRG1
2020Development of a Designer Proline-rich antimicrobial peptide Chaperone protein inhibitor (DPC) for treating sepsis1R41AI149809-01A1KRAUS, CARL NEILARREVUS, INC., NC$299,999ZRG1
2020Enabling comprehensive diagnosis of sub-acute infection in chronic respiratory disease via high sensitivity next generation sequencing1R41AI154380-01FINGERLIN, TASHA E.O'CONNOR, BRIAN PPEAK DIAGNOSTIC PARTNERS LLC, CO$299,999ZRG1
2020Development of Dietary Quercetin to Treat Muscle Wasting Disorders1R43AT011171-01VANDERVEEN, BRANDONVELAZQUEZ, KANDY TACEPRE, LLC, SC$299,998ZRG1
2020Development of a biomarker panel for minimally-invasive screening and diagnosis of gynecological disease1R41HD104402-01REVA, BORISMDDX, INC., NY$299,998ZRG1
2020Developing high throughput measurement of thiopurine in DNA by mass spectrometry1R41GM136093-01 · under PA-18-575TAO, W. ANDYTYMORA ANALYTICAL OPERATIONS, LLC, IN$299,975ZRG1
2020Development of an innovative diabetes therapeutic via GPER targeting1R41DK122856-01A1ELLING, JOHNGPER G-1 DEVELOPMENT GROUP LLC, NM$299,952ZRG1
2020Whispering Gallery Mode Devices for the Rapid Detection of Pan-Filoviruses1R41AI152745-01A1AMARASINGHE, GAYA K.HOLTSBERG, FREDERICK WAYNEINTEGRATED BIOTHERAPEUTICS, INC., MD$299,939ZRG1
2020DFMO Therapy for Polycystic Kidney Disease1R41DK125183-01A1VITEK, MICHAEL PETERRESILIO THERAPEUTICS, LLC, NC$299,934ZRG1
2020Biodegradability and Biocompatibility of a Shape Memory Polymer Wrap to Improve Saphenous Vein Graft Patency in Peripheral and Coronary Artery Bypass Grafting Surgeries1R41HL151025-01 · under PA-18-575BOIRE, TIMOTHY CVENOSTENT, INC., TX$299,910ZRG1
2020Q-GRFT Enema Development Supporting a Multi-Administration Clinical Study1R41AI152919-01TUSE, DANIELGROW BIOMEDICINE LLC, CA$299,874ZRG1
2020Evaluation of a peptide that inhibits the activation of NOX2 and the generation of reactive oxygen species in protection against acute lung injury1R41HL145848-01A1 · under PA-18-575FEINSTEIN, SHELDON IFISHER, ARON B.PEROXITECH, LLC, PA$299,866ZRG1
2020Non-Invasive Oropharynx Appliance to Maintain Airway Patency1R41HL150933-01 · under PA-18-575DURAND, DOMINIQUE MANEMED INC, OH$299,743ZRG1
2020Learning from the Ebola success: Can a mAb also save lives after yellow fever infection?1R42AI155275-01SACHA, JONAH B.WATKINS, DAVID IMABLOC, LLC, DC$299,598ZRG1
2020Using Targeted Lipid Nanoparticles to Deliver Chemotherapeutic Agents against Pancreatic Cancer1R41CA247009-01 · under PA-18-575LAMBROS, MARIADORICPHARMA LLC, CA$299,559ZRG1
2020Inhibitors of T3SS translocon assembly to combat multi-drug resistant P. aeruginosa1R41AI149922-01 · under PA-18-575HEUCK, ALEJANDRO PABLOMOIR, DONALD TMICROBIOTIX, INC, MA$299,449ZRG1
2020Vaccination against Zika virus infection using mosquito NeSt1 protein1R41AI152904-01A1LEDIZET, MICHELL2 DIAGNOSTICS, LLC, CT$299,200ZRG1
2020Point-of-care antigen detection assay for early diagnosis of Ebola virus disease (EVD)1R41AI149940-01 · under PA-18-575AUCOIN, DAVID PRAYCHAUDHURI, SYAMAL XINBIOS INTERNATIONAL, INC., WA$299,112ZRG1
2020Next-generation precision medicine for targeting recombination-deficient cancers1R41CA239983-01A1 · under PA-18-575POMERANTZ, RICHARD TRECOMBINATION THERAPEUTICS, LLC, PA$298,959ZRG1
2020Development of an irreversible covalent inhibitor of FMS-like tyrosine kinase receptor 3 for treating acute myeloid leukemia1R41CA250761-01A1CAO, PINGBRIDGENE BIOSCIENCES, INC., CA$298,928ZRG1
2020Multiplexed Bioassay for Checkpoint Inhibitor Autoimmunity1R41AI149951-01 · under PA-18-575MAMULA, MARK JL2 DIAGNOSTICS, LLC, CT$298,911ZRG1
2020Preclinical proof of concept validation of a novel endoscopic treatment for urethral stricture disease1R41DK125209-01A1GODZICH, CHANYACELEFLUX LLC, MD$298,531ZRG1
2020New Inhibitors of HIV latency reactivation1R41AI152860-01KARN, JONATHANSHORTRIDGE, MATTHEW DEANVARANI, GABRIELEITHAX PHARMACEUTICALS, INC., WA$298,410ZRG1
2020Development of Single Agent Antibiofilm Antibiotics1R41AI155280-01PIERCE, JOSHUA G.SYNOXA SCIENCES, INC, NC$298,326ZRG1
2020Development of a Lighted Infusion Line to Enhance Pediatric Critical Care1R41HD104560-01CALAMARO, CHRISTINA JOYCHS HEALTHCARE VENTURES, INC, GA$298,099ZRG1
2020Novel AMPK Activators for the Treatment of Lithium-Induced Nephrogenic Diabetes Insipidus1R41DK127798-01KLEIN, JANET D.SANDS, JEFF MNEPHRODI THERAPEUTICS, INC., WA$297,609ZRG1
2020Enhanced MDx: a computational model to optimize pre-analytical pathogen isolation from whole blood.1R41GM136084-01 · under PA-18-575MILLER, CASS TREDBUD LABS, INC., NC$296,954ZRG1
2020Selective targeting of high affinity alpha4 integrins as a safe treatment strategy for IBD1R41DK127869-01HOLLAND, GEORGEWOODSIDE, DARREN GAVIARA PHARMACEUTICALS, INC., TX$296,724ZRG1
2020Non-Immunogenic PEG-like Conjugates of Uricase1R41TR003255-01HUCKNALL, ANGUSGATEWAY BIO, INC., NC$288,472ZRG1
2020Determination of optimal antisense oligonucleotide chemistry for efficient and safe splicing modulation in T cells1R41AI149920-01 · under PA-18-575GALARZA-MUNOZ, GADDIELAUTOIMMUNITY BIOLOGIC SOLUTIONS, INC., TX$283,667ZRG1
2020Development of a vaccine to prevent Pneumocystis pneumonia1R41AI145416-01A1 · under PA-18-575DOWNES, MICHAEL ROBERTNORRIS, KAREN ANXT BIOLOGICS, INC., GA$272,439ZRG1
2020Preventing liver fibrosis in alcoholic hepatitis by enhancing liver regenerative capacity via transient telomere extension using lipid nanoparticle-encapsulated TERT mRNA1R41AA028749-01RAMUNAS, JOHNREJUVENATION TECHNOLOGIES, INC., CA$272,403ZRG1
2020Multi NA-based influenza vaccines1R41AI152800-01KANG, SANG-MOOADVAC, LLC, GA$272,223ZRG1
2020Extracellular NAMPT is a Novel Therapeutic Target in Chorioamnionitis-Related Prematurity (ChorP)1R41HD101202-01A1AHMED, MOHAMEDGARCIA, JOE G. N.AQUALUNG THERAPEUTICS CORP., FL$265,096ZRG1
2020Enabling the repurposing of niclosamide for castrate-resistant prostate cancer using a novel formulation technology platform1R41CA243931-01A1WILLIAMS, ROBERT O.VIA THERAPEUTICS, LLC, TX$263,895ZRG1
2020FH-Fc as a Pre-Exposure Prophylactic for Tickborne Disease1R41AI152954-01A1WYCOFF, KEITHPLANET BIOTECHNOLOGY, INC., CA$262,947ZRG1
2020Development of wearable technology to enable therapy personalization of 177Lu DOTATATE for neuroendocrine tumors1R41CA243982-01A1PIERCE, LARRYPRECISION SENSING, LLC, WA$262,921ZRG1
2020Antioxidant enzyme-loaded Pro-NP for treatment of TBI.1R41NS119082-01KIEVIT, FORREST MMADSEN, GARY LEONARDPROTRANSIT NANOTHERAPY, LLC, NE$259,938ZRG1
2020Autonomous RNA-Mediated Anti-Influenza A Virus Therapeutics (AMRed Therapeutics)1R41AI147902-01A1HOUSER, BRANDY LYNNTENOEVER, BENJAMIN R.CELDARA MEDICAL, LLC, NH$258,360ZRG1
2020OBJECTIVE HOME MANAGEMENT OF PEDIATRIC ASTHMA EXACERBATION USING MOBILE TECHNOLOGY AND MACHINE LEARNING1R41NR019735-01PATEL, SHILPASHEKHAR, RAJAUSCULTECH DX, LLC, MD$257,878ZRG1
2020A novel non-invasive method of aspiration detection in preterm infants.1R41HD104305-01MCGRATTAN, KATLYN ELIZABETHNUBORN MEDICAL, INC., MN$255,998ZRG1
2020Intraoperative Analytics and Enhanced Patient Outcomes1R41TR003249-01CORR, STUART JAMESMACGILLIVRAY, TOMMECCA, JOSHUAM&S BIOTICS, INC., TX$255,719ZRG1
2020Advancing Small Molecule Read Through Compounds to Prevent and/or Treat Heritable Pulmonary Artery Hypertension1R41HL152915-01REHAN, VIRENDER KADVENT THERAPEUTICS, INC., PA$252,131ZRG1
2020Development of a prototype software for automated PET/CT interpretation and reporting in thoracic cancer1R41CA236492-01A1UDUPA, JAYARAM KQUANTITATIVE RADIOLOGY SOLUTIONS, LLC, PA$252,131ZRG1
2020Novel OCT Technology for Detection of Occult Sperm in the Testes in Non- Obstructed Azoospermia.1R41HD102275-01SWERDLOFF, RONALDUNASPER, INC., CA$252,130ZRG1
2020Preventing outbreaks of foodborne pathogenic bacteria in edible sprouts via novel resistance-conferring seed treatments1R41AI152915-01MANOHAR, MURLIASCRIBE BIOSCIENCE INC., NY$252,130ZRG1
2020Improving data capture in clinical research using a chatbot1R41LM013419-01WELCH, BRANDON MDOKBOT, LLC, NY$252,130ZRG1
2020Targeted Therapies for the Treatment of GI-ARS Diarrhea1R41DK125208-01TIGYI, GABOR JRXBIO, INC., TN$252,128ZRG1
2020Isotopically Labeled Heparan Sulfate Glycosaminoglycan Disaccharides for use as Internal Standards1R41GM139440-01ORLANDO, RONGLYCOSCIENTIFIC, LLC, GA$252,114ZRG1
2020Development and Commercialization of a Sample Preparation System for Time Resolved Cryo-Electron Microscopy1R42GM139495-01FRANK, JOACHIMSALMON, NORMAN JAMESHUMMINGBIRD PRECISION MACHINE COMPANY, WA$252,105ZRG1
2020Determination of circulation factors that mediate the health benefits of exercise in mitochondrial aging1R41AG065131-01A1PROLLA, TOMAS ALBERTOCYTEGEN CORPORATION, CO$252,092ZRG1
2020STING Activators as Therapy for Cancer1R41CA250629-01A1BARBER, GLEN NSTINGINN, LLC, FL$252,064ZRG1
2020Gene Therapy to Treat Ethanol-induced Osteoporosis Associated with Aldehyde Dehydrogenase 2 Deficiency1R41AA028465-01CRYSTAL, RONALD GLEXEO THERAPEUTICS, LLC, NY$252,042ZRG1
2020Nature-inspired Aqueous Biodegradable Adhesives for Abdominoplasty1R41EB030462-01LIU, CHAORAVNIC, DINO JALEO BME, INC., PA$251,989ZRG1
2020Dianomi Therapeutics - Using Mineral Coated Microparticles as an Improved Sustained Delivery Method of Anakinra for Treatment and Prevention of Gout with a Single Injection1R41AR078063-01A1CHAMBERLAIN, CONNIE SCLEMENTS, ANNA ELIZABETHDIANOMI THERAPEUTICS, INC., WI$251,880ZRG1
2020Step UP for STEM and Health Careers: An Intervention to Reduce STEM related biases towards young women and minorities1R41HD103517-01GILLIAM, MELISSA L.PARSONS, TIMOTHYRESILIENT GAMES STUDIO, LLC, IL$251,344ZRG1
2020Chemically controlling chromatin to treat Friedriech's Ataxia1R41TR003245-01HATHAWAY, NATHANIEL A.EPIGENOS BIOSCIENCE, INC., NC$251,236ZRG1
2020A Novel Strategy for Diagnosis of Esophageal Adenocarcinoma.1R41CA250779-01LUNZ, DANIEL GREGORYCAPSULOMICS, LLC, MD$250,764ZRG1
2020High Density Cell Respirator (HDCR) for the production of vectors, viruses and vaccines1R42TR002798-01A1BERGMAN, NICOLECHATTERJEE, SASWATITAI, YU-CHONGXDEMICS CORPORATION, CA$250,241ZRG1
2020A Vaccine for Acute Flaccid Myelitis1R41AI155100-01ANDINO, RAULALEPH THERAPEUTICS, INC., CA$250,215ZRG1
2020Hemoglobin-based antidotes for the treatment of carbon monoxide poisoning1R42ES031993-01 · under PA-18-575ROSE, JASON JTEJERO BRAVO, JESUSGLOBIN SOLUTIONS, INC., PA$249,993ZRG1
2020Develop humanized AAV vectors for liver targeting and neutralizing antibody evasion1R41HL152923-01A1LI, CHENGWENBEDROCK THERAPEUTICS, INC., NC$249,310ZRG1
2020Small molecule inhibitors of oncogenic miR-211R41CA254746-01CALIN, GEORGE A.VARANI, GABRIELEITHAX PHARMACEUTICALS, INC., WA$249,109ZRG1
2020Therapeutic targeting of Nox2 and Nox4 in Duchenne Muscular Dystrophy1R41HL151043-01A1HECKER, LOUISEFIBRONOX, L.L.C., AZ$248,019ZRG1
2020Feasibility Study of HIF2A Inhibitor PT2385 to Treat Muscle Strain Injury1R41OD030519-01YIN, AMELIAYIN, HANGHAWA THERAPEUTICS LLC, GA$245,050ZRG1
2020Development of Melanocortin-3 Receptor Peptide Antagonists for the Treatment of Obesity and Maintenance of Weight Loss1R41DK127817-01SAWYER, TOMI KCOURAGE THERAPEUTICS, INC., MA$244,905ZRG1
2020Development of a Rapid Low-Cost Fecal-based TB Diagnostic for Children1R41AI155206-01CIRILLO, JEFFREY D.PULMONESCENCE DIAGNOSTICS, INC., TX$243,960ZRG1
2020Developing Real-time Interaction and Motion Tracking in Immersive Virtual Reality for Telerehabilitation1R41MD015689-01SMITH, DEREK T.TODD, RUSSELL NATHANZHU, QINMOVE, LLC, WY$242,114ZRG1
2020Development of a New Treatment for Diabetic Wounds1R41DK125213-01A1NAIR, SREEJAYANNUTRIWYO, LLC, WY$241,148ZRG1
2020Hybrid nanoparticles as highly efficient photosensitizers for the treatment of topical bacterial infections1R41AI150075-01A1ZHANG, PENGALPH TECHNOLOGIES, LLC, OH$241,018ZRG1
2020Enabling membrane protein structural analysis: Tools for capillary diffusion crystallization and remote in situ diffraction experiments1R41GM139420-01HOWELLS, RICHARD WILLIAMELK VALLEY ENTERPRISES, INC., PA$239,206ZRG1
2020Feelix @ Home: Testing and optimization of a smart stethoscope for home use to monitor changes in lung status of individuals with chronic conditions1R42HL147728-01A1 · under PA-18-575BUSCH-VISHNIAC, ILENE JOYELHILALI, MOUNYASONAVI LABS, INC., MD$236,489ZRG1
2020Development of Hsp90 beta-selective inhibitors as safer anti-cancer agents1R41CA247058-01 · under PA-18-575MISHRA, SANKETGRANNUS THERAPEUTICS LLC, IN$233,195ZRG1
2020A Novel Therapeutic Agent for the Treatment of Gram-positive Infections1R41AI149803-01A1SMITH, JAMES LEIFSANO CHEMICALS, INC, TX$233,066ZRG1
2020Portable Affordable Innovative and Smart Device-Coupled Electronic Fetal Monitoring System to Improve Rural Access to Obstetrics Services and Improve Outcomes in Rural Communities1R41MD015915-01SHAH, SWATIFETAL LIFE, LLC, KY$232,315ZRG1
2020Novel QcrB Inhibitors for the Treatment of Tuberculosis1R41AI145514-01A1 · under PA-18-575HIPSKIND, PHILIP ARTHURLGENIA, INC., IN$225,343ZRG1
2020A new generation, enhanced, corneal-birefringence-independent retinalscanning device for pediatric vision disorders using polarization modulation1R41EY030382-01A1 · under PA-18-575GRAMATIKOV, BORISSHAKA, JUSTINREBISCAN, LLC, MA$225,000ZRG1
2020A platform for engineering peptide ligase for building next generation peptide therapeutics.1R41GM136037-01 · under PA-18-575ABATE, ADAM R.SCRIBE BIOSCIENCES, INC., CA$225,000ZRG1
2020Novel Nanosecond Laser and Ultrasound to Selectively Treat Eye Blood Vessels1R41EY031219-01 · under PA-18-575PAULUS, YANNIS MANTASPHOTOSONOX LLC, MI$225,000ZRG1
2020Pharmacological chaperones for the treatment of Open-Angle Glaucoma1R41EY031203-01 · under PA-18-575MAKLEY, LEAH NICOLEVIEWPOINT THERAPEUTICS, INC., CA$225,000ZRG1
2020Portable, affordable, quantitative microchip electrophoresis system for integrated anemia and hemoglobin variant testing1R41HL151015-01 · under PA-18-575GALEN, PETERHEMEX HEALTH, INC., OR$225,000ZRG1
2020Photodynamic Therapy to Prevent Arteriovenous Fistula Maturation Failure1R41HL151235-01 · under PA-18-575ROY-CHAUDHURY, PRABIRRYCHNOVSKY, STEVENADGERO BIOPHARMACEUTICALS HOLDINGS, INC., CA$225,000ZRG1
2020CD73 for sepsis1R41AI149789-01A1HASKO, GEORGEPURINE PHARMACEUTICALS, INC., NJ$225,000ZRG1
2020MR Virtual Pathology of the Prostate1R41CA244056-01A1KARCZMAR, GREGORY S.MUSTAFI, DEVKUMAROTO, AYTEKINQMIS, LLC, IL$225,000ZRG1
2020Stress forces huESC differentiation; confirmation as an accurate DevTox HTS1R41ES031451-01A1ABDULHASAN, MOHAMMEDRAPPOLEE, DANIEL ALLENREPRODUCTIVE STRESS; MEASUREMENT, MECHANISMS AND MANAGEMENT, CORPORATION, MI$225,000ZRG1
2020The MICELI Aggregometer: a Point-of-Care Platelet Function Analyzer1R41HL147807-01A1LADUCA, FRANKSLEPIAN, MARVIN JPLAKDX, LLC, AZ$225,000ZRG1
2020MITOCHONDRIAL RESPIROMETRY IN FROZEN BIOLOGICAL SAMPLES1R41ES031043-01A1SHIRIHAI, ORIAN SWANG, AMYENSPIRE BIO, INC., CA$225,000ZRG1
2020HIV Research Social and Behavioral Instruments (SABI) Library and Project Management Software System1R41MH123287-01A1STELTER, REBECCA LYNNINNOVATION RESEARCH AND TRAINING, INC., NC$224,999ZRG1
2020Development of EFTX-001 to target KRAS mutations in cancer1R41CA246848-01 · under PA-18-575PECOT, CHAD VENFUEGO THERAPEUTICS INC., NC$224,995ZRG1

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