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NIH funding notice PA-20-265

PHS 2020-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)

Closed on April 5, 2021.

Posted
July 14, 2020
Close date
April 5, 2021
Activity codes
Not stated on the notice page
Institutes taking part
NCI, NEI, NHLBI, NHGRI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDCD, NIDCR, NIDDK, NIDA, NIEHS, NIGMS, NIMH, NINDS, NINR, NIMHD, NLM, NCCIH, NCATS, ORIP

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

  1. Reissues: PA-19-270 PHS 2019-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed
  2. 2 steps back: PA-18-575 PHS 2018-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)
  3. 3 steps back: PA-17-303 PHS 2017-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  4. 4 steps back: PA-16-303 PHS 2016-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  5. 5 steps back: PA-15-270 PHS 2015-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  6. 6 steps back: PA-14-072 PHS 2014-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42]
  7. 7 steps back: PA-13-235 Reissue PHS 2013-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  8. 8 steps back: PA-13-089 PHS 2013-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  9. 9 steps back: PA-12-089 PHS 2012-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  10. 10 steps back: PA-11-097 PHS 2011-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  11. 11 steps back: PA-10-051 PHS 2010-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  12. 12 steps back: PA-09-081 PHS 2009-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])

Replaced by PA-21-262.

Who won it before

1,563 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $518,999,501 in first-year total cost, median $251,344.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 SBIB-T (10)]101
  2. Special Emphasis Panel[ZRG1 OTC-T (10)]81
  3. Special Emphasis Panel[ZRG1 ETTN-G (12)]62
  4. Special Emphasis Panel[ZRG1 ETTN-M (11)]55
  5. Special Emphasis Panel[ZRG1 BCMB-G (10)]48

Most frequent institutions

  1. FOX CHASE CHEMICAL DIVERSITY CENTER, INC15
  2. L2 DIAGNOSTICS, LLC13
  3. MEDOSOME BIOTEC, LLC10
  4. ARREVUS, INC.7
  5. MICROBIOTIX, INC7
Competing awards under PA-20-265 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2022Portable Affordable Innovative and Smart Device-Coupled Electronic Fetal Monitoring System to Improve Rural Access to Obstetrics Services and Improve Outcomes in Rural Communities2R42MD015915-02SHAH, SWATIFETAL LIFE, LLC, KY$1,022,015ZRG1
2022Interstitial Chemophototherapy with Light-Activated Nanoparticulate Doxorubicin2R42CA243954-02SHAFIRSTEIN, GALPOP BIOTECHNOLOGIES, INC, NY$1,001,404ZRG1
2022Development of a novel accurate therapy for multiple sclerosis2R42AI141323-02A1GALARZA-MUNOZ, GADDIELAUTOIMMUNITY BIOLOGIC SOLUTIONS, INC., TX$1,000,000ZRG1
2022A method for accurate and sensitive detection of HIV drug-resistant minority variants2R42AI122855-02A1WANG, GARY P.MEDOSOME BIOTEC, LLC, FL$999,999ZRG1
2022Multivalent Adjuvant Immunization to Prevent Hospital Acquired Infections2R42AI145759-03SPELLBERG, BRAD JEXBAQ LLC, MD$995,098ZRG1
2022A novel vaccine against mosquito-borne Zika virus based on mosquito salivary gland protein AgBR12R42AI142846-03FIKRIG, EROLL2 DIAGNOSTICS, LLC, CT$988,360ZRG1
2022Mitofusin Agonists to Treat Neurodegenerative Disease2R42NS113642-03DORN, GERALD W.HAUGER, DEBORAH ANNMITOCHONDRIA IN MOTION, INC., MO$968,715ZRG1
2022Teleconsent: Enabling informed consent for remote care and research2R42TR004277-02WELCH, BRANDON MDOXY.ME, LLC, SC$863,404ZRG1
2022Novel methods to improve nuclease mediated homologous recombination2R42GM122181-02ZHANG, JIFENGATGC, INC., MI$854,843ZRG1
2022VasaPlex-based biologics for treatment of reperfusion injury after myocardial infarction1R41HL162161-01SPEES, JEFFREY LSAMBA BIOLOGICS INCORPORATED, VT$498,271ZRG1
2022Broadly Accessible Technologies for Single-cell Joint Analysis of Transcriptome and Epigenome1R41MH128993-01REN, BINGEPIGENOME TECHNOLOGIES, INC., CA$450,000ZRG1
2022Development of the GlycoHCCTyper for the early detection of HCC1R41CA268268-01CASTELLINO, STEPHENMEHTA, ANAND S.GLYCOPATH, INC, SC$428,443ZRG1
2022Liquid Immunogenic Fiducial Eluter (LIFE) for Cervical Cancer Treatment1R41CA268623-01NGWA, WILFREDSHILLING, ADAMNANOCAN THERAPEUTICS CORPORATION, NJ$400,000ZRG1
2022Development of a novel personalized medicine platform using apheretically isolated circulating tumor cells to assess drug responsiveness in prostate cancer1R41CA268344-01DRAKE, JUSTIN MICHAELPARTHASARATHY, JAYANTASTRIN BIOSCIENCES, INC., MN$399,678ZRG1
2022Development of Natural Killer (NK) Cell Line-Derived Extracellular Vesicles as a New Treatment for Cancer1R41CA268300-01KORNBLUTH, JACKIVANQUISH BIO LLC, FL$399,580ZRG1
2022Development of a small-molecule immunomodulator for the treatment of melanoma1R41CA261311-01A1VAN DROSS, RUKIYAHCLARADELE PHARMACEUTICALS, INC., NC$398,242ZRG1
2022High-speed, portable reflectance confocal microscope (pRCM) for imaging skin cancer1R41CA261214-01A1KANG, DONGKYUNARGOSMD, INC., CA$398,209ZRG1
2022Development of Novel CD180-Based Cancer Immunotherapeutics1R41CA257531-01A1CLARK, EDWARD AFULLER, DEBORAH H.ABACUS BIOSCIENCE INC, WA$398,040ZRG1
2022Development of Therapeutic Cancer Vaccine1R41CA265459-01SHEN, HAIFAIMMUNOQ THERAPEUTICS INC., TX$395,738ZRG1
2022Development of novel pharmacotherapies for AUD1R41AA029365-01A1ANDERSON, ETHAN MICHAELCOWAN, CHRISTOPHER WNEUROEPIGENIX, LLC, SC$392,942ZRG1
2022Profiling circulating metabolites for the diagnosis of pulmonary hypertension1R41HL158296-01A1RAFIKOVA, OLGAMETFORA LLC, AZ$373,684ZRG1
2022Preclinical testing of a 3D printed external scaffold device to prevent vein graft failure after coronary bypass graft surgery1R41HL162397-01MARSDEN, ALISON LWILSON, NATHAN MARSHALLBIOGRAFT, INC., CA$345,103ZRG1
2022Improved Diagnosis of Shunt Malfunction with Automatic Quantification of Ventricular Space1R41NS125874-01FENG, XUECARINA MEDICAL, LLC, VA$339,999ZRG1
2022Rusalatide Acetate (TP508) Mitigation of Genotoxic Radiation Damage in Human Lens Epithelial Cells1R41EY033583-01ANDLEY, USHA PFRANK, STEVEN JAYAFFIRMED PHARMA, LLC, TX$327,510ZRG1
2022Implementation and validation of a lung x-ray interferometry imaging system, with applications to COPD, COVID-19 and other lung diseases1R41HL158414-01A1MATTHEWS, KENNETH LREFINED IMAGING, LLC, LA$322,996ZRG1
2022Development of a Gectosome Therapy for Cardiovascular Diseases1R41HL162212-01LIU, XUEDONGVESICLE THERAPEUTICS INC., CO$316,823ZRG1
2022Real-Time Quantitation of Transport Across Vascular-Tissue Interfaces in Organ-On-Chip Models Using In Situ Mass Spectrometry1R41GM145196-01GERMAN, CARRIECFD RESEARCH CORPORATION, AL$314,215ZRG1
2022Rapid Drug Susceptibility Test for Tuberculosis1R41AI167101-01CIRILLO, JEFFREY D.PULMONESCENCE DIAGNOSTICS, INC., TX$306,500ZRG1
2022Design and Engineering of Biodegradable 3D Nanoprinted Microcarriers for HIV Drug Delivery1R41AI167166-01FLANK, SHARONSOCHOL, RYAN DANIELINFRATRAC, INC., MD$303,714ZRG1
2022A capsule-based bioconjugate vaccine to prevent Klebsiella pneumoniae infections1R41AI167078-01HARDING, CHRISTIANVAXNEWMO, LLC, MO$300,000ZRG1
2022Novel Peptide Fusion Inhibitors for the Treatment of COVID-191R41AI162083-01A1TARRAN, ROBERTELDEC PHARMACEUTICALS, INC., NC$300,000ZRG1
2022Anti-inflammatory Activity of a Systemic STING Inhibitory Non-Nucleotide1R41AI167270-01A1BARBER, GLEN NSTINGINN, LLC, FL$300,000ZRG1
2022The re-activatable Yb-169 radiation source: a therapeutic medical device to reduce the risk of brachytherapy and increase adoption1R41CA268293-01FLYNN, RYAN THOMASPXALPHA, LLC, IA$300,000ZRG1
2022Treatment of Inflammatory Complications of Viral Pneumonia1R41AI162590-01A1AGRAWAL, ANDYRESPANA THERAPEUTICS, INC., PA$300,000ZRG1
2022Developing Hepatoselective Hepatitis B Therapeutic Dihydroquinolizinone (DHQ) Molecules with Better Safety Profiles for Efficient HBsAg Reduction1R41AI167172-01DU, YANMINGHARLINGENE LIFE SCIENCES LLC, PA$300,000ZRG1
2022CCR5 immunotoxins as components of HIV cure regimens1R41AI165350-01A1HARTIGAN-O'CONNOR, DENNIS J.TENDEL THERAPIES INC., CA$300,000ZRG1
2022Simple Method for Screening of HIV Drug Resistance in Resource-Limited Settings1R41AI162258-01A1STEVENSON, MARIODISCIDIUM BIOSCIENCES, LLC, FL$299,999ZRG1
2022AIDen: An AI-empowered detection and diagnosis system for jaw lesions using CBCT1R41DE031485-01LI, JINGLURE, FLEMING Y. M.SETZER, FRANK CARSTEN MARTINMS TECHNOLOGIES CORPORATION, MD$299,987ZRG1
2022Non-catalytic FAK inhibitors as novel therapeutics for lung fibrosis1R41HL162392-01KNOX, KENNETH SMARLOWE, TIMOTHY AFAKNOSTICS, LLC, AZ$299,905ZRG1
2022A rapid test for congenital syphilis screening1R41HD107895-01FRALEY, STEPHANIE IRENESINHA, MRIDUMELIOLABS INC., CA$299,891ZRG1
2022F plus G RSV VLP Vaccine for Improved Safety and Efficacy1R41AI167226-01ANDERSON, LARRY JRAZI PHARMA LLC, GA$299,791ZRG1
2022Developing Vertebrate-Specific Replication-Defective Dengue Virus as Novel Single-CycleDengue Vaccine Candidate1R41AI162366-01A1PANG, XIAOWUTENGEN BIOMEDICAL CO., MD$298,530ZRG1
2022Targeted delivery of novel miRNA-based therapeutics for pneumonia-induced acute lung injury1R41AI155327-01A1AKERLEY, BRIANADVAC THERAPEUTIC, LLC, PA$296,926ZRG1
2022Solving Sepsis: Early Identification and Prompt Management Using Machine Learning1R42GM144999-01PATEL, MANESH RCOHERE-MED, INC., CA$275,766ZRG1
2022Novel platform for optimizing AAV transgene expression to improve efficacy of ocular gene therapies1R41EY033603-01HIRSCH, MATTHEW LOUISEPIGENOS BIOSCIENCE, INC., NC$263,372ZRG1
2022Cell permeant peptidomimetics to prevent delayed vasospasm and neurological deficits after subarachnoid hemorrhage1R41NS122656-01A1BROPHY, COLLEEN MVASAMETRIX LLC, TN$261,863ZRG1
2022Microfluidic Technology for Concurrent Assessment of Red Blood Cell Adhesion and Deformability1R42HL162214-01FEDERICI, CHIARAGURKAN, UMUT A.BIOCHIP LABS, INC., OH$259,611ZRG1
2022Point-of-care microdevices for simultaneous detection of multiple pertussis-like respiratory diseases from Bordetella species1R41AI162477-01A1LI, XIUJUNMICROBIOCHIP DIAGNOSTICS LLC, TX$259,565ZRG1
2022Increasing efficiency of sdFv production in a tobacco-based system for synthetic platelet design1R41HL162242-01NANDI, SEEMASELSYM BIOTECH, INC., NC$258,501ZRG1
2022Reduction of Pigmentation Dependent Errors using Spectroscopic Pulse Oximetery1R41GM142406-01A1KHURANA, VIKASPATIL, CHETAN AAIMLOXY LLC, PA$256,571ZRG1
2022Assessment of mobile application-delivered lighting interventions for reducing circadian disruption in shift workers1R41HL163783-01A1CHENG, PHILIPWALCH, OLIVIAARCASCOPE, INC, VA$254,877ZRG1
2022Optimal adjuvant/antigen formulation toward a Staphylococcus aureus human vaccine1R41AI167268-01MISSIAKAS, DOMINIQUE M.IMMUNARTES LLC, IL$253,925ZRG1
2022Development and Evaluation of Rosette Array Technology for HumanNeurodevelopmental Toxicity Screening1R42ES033912-01ASHTON, RANDOLPH SCOTTNEUROSETTA LLC, WI$199,800ZRG1
2022The BioGradMatch Program1R41GM145182-01JOSH, LEVINEWARRICK, CYNTHIA AADMIT ACADEMY LLC, TX$149,957ZRG1
2021Epigenetic Markers and Sustained Cytoprotection for Stroke Treatment2R42NS098918-02A1 · under PA-19-270BOOHER, KEITHGUO, WEIHUANG, SHAOLINGZYMO RESEARCH CORPORATION, CA$1,082,714ZRG1
2021Mitofusin agonists to prevent Charcot-Marie-Tooth disease 2A2R42NS115184-02DORN, GERALD W.MITOCHONDRIA IN MOTION, INC., MO$1,059,214ZRG1
2021SnapCap: a device to decontaminate central venous catheters (CVC) with 5 snaps2R42HD097831-02KHEIR, JOHN NAGICONTECH MEDICAL, INC., RI$1,036,191ZRG1
2021Development of a treatment for the durable remission of HIV using autologous human CAR T cells that target B cell follicles2R42AI155031-02ATHANASIOU, MARIA CONSTANCESKINNER, PAMELA JMARPAM PHARMA, LLC, MN$1,018,997ZRG1
2021Development of Small Molecule Therapeutics Targeting Hemorrhagic Fever Viruses2R42AI138630-03HARTY, RONALD NFOX CHASE CHEMICAL DIVERSITY CENTER, INC, PA$1,017,000ZRG1
2021Preclinical Development of ACXT-3102 for the Treatment of Pancreatic Adenocarcinoma (PDAC)2R42CA239853-02A1HAWKINS, WILLIAM GKELLER, BRADLEY T.ACCURONIX THERAPEUTICS, INC., MO$1,014,729ZRG1
2021Small-molecule therapy for metastatic castration-resistant prostate cancer2R42CA217491-02A1WU, DAQINGMETCURE THERAPEUTICS, LLC, GA$1,007,817ZRG1
2021Development of a ZIKA viral pseudoinfectious virus as ZIKA vaccine candidate (STTR Phase II)2R42AI129119-03PANG, XIAOWUTENGEN BIOMEDICAL CO., MD$1,000,000ZRG1
2021Phase II STTR development of an intranasal/oral Spirulina-based PfCSP malaria vaccine.2R42AI138623-03A1KHUONG, NHIMURPHY, SEAN CLUMEN BIOSCIENCE, INC., WA$1,000,000ZRG1
2021Aminoglycosides with reduced ototoxicity2R42AI126874-03 · under PA-19-270ARYA, DEV PRIYANUBAD, LLC, SC$999,986ZRG1
2021Development of peptide nucleic acid antibiotics2R42AI114114-03 · under PA-19-270ARYA, DEV PRIYANUBAD, LLC, SC$999,985ZRG1
2021Isovolumetric Multimodal Venous Thrombectomy System2R42HL150963-02A1LIEKWEG, STACEYZAYED, MOHAMED A.CAELI VASCULAR, LLC, MO$981,043ZRG1
2021A Novel Therapeutic that Harnesses Microtubules to Promote Cavernous Nerve Regeneration after Radical Prostatectomy2R42DK117684-02A1BAKER, LISA ANNDAVIES, KELVIN PSHARP, DAVID JAMESMICROCURES, INC., CA$941,635ZRG1
2021Multi-Institutional Implementation of Quality Decisions: a Clinical Decision Support Analytics Tool to Drive Outcomes2R42LM013317-02 · under PA-19-270ORENSTEIN, EVAN WILLIAMPHRASE HEALTH, INC., PA$872,808ZRG1
2021Chitosan Endoluminal Hemostatic Dressing2R42DK078400-05MCCARTHY, SIMON JOHNXIE, HUATRICOL BIOMEDICAL, INC., OR$853,858ZRG1
2021Imaging biomarkers of severe respiratory infections in premature infants Phase II2R42HL145669-02A1 · under PA-19-270ENQUOBAHRIE, ANDINET ASMAMAWLINGURARU, MARIUS GEORGENINO, GUSTAVOKITWARE, INC., NY$852,101ZRG1
2021STTR Phase II: Advance Early Detection of Lupus Nephritis with ClearGold2R42DK123943-02A1YU, MENGXIAOCLEARNANO, INC., TX$809,923ZRG1
2021Mitigating Injurious Falls in Older Adults Through Non-Injurious Fall and Gait Analysis From Floor Vibrations2R42AG059475-02A1FRITZ, STACY LYNNEADVANCED SMART SYSTEMS/EVALUATION TECHNO, SC$740,205ZRG1
2021Development of microparticle-based topical treatments for treating erectile dysfunction in patients refractory to oral PDE5 inhibitors2R44DK121587-02DRAGANSKI, ANDREW RZYLO THERAPEUTICS, INC., SC$697,168ZRG1
2021Development of Non-Catalytic Peptide Inhibitors of Focal Adhesion Kinase (FAK) for Use in Melanoma2R42CA240124-02MARLOWE, TIMOTHY AFAKNOSTICS, LLC, AZ$674,537ZRG1
2021Affordable sialoglycans and associated reagents for expanded chemoenzymatic production1R42GM143998-01LEE, LIM ANDREWINTEGRATED MICRO-CHROMATOGRAPHY SYSTEMS, INC., SC$640,000ZRG1
2021Enabling rapid and effective stroke thrombectomy procedures from a Transradial approach: Combining introducer sheath, guide catheter, and distal access catheter into a single device.1R41NS122602-01KALLMES, DAVID FCONWAY MEDICAL LLC, MN$490,053ZRG1
2021A GIP Companion Drug for Enhancing Metabolic Benefits of Long-Acting GLP-12R42AG061909-02A1BEINBORN, MARTINKUMAR, KRISHNAVELUM, INC., MA$488,486ZRG1
2021NanO2 as a Cerebroprotectant in a tMCAO Stroke Model in Mice1R41NS124450-01MORRISON, HELENA WILLINGTONUNGER, EVAN CHARLESNUVOX PHARMA, LLC, AZ$478,050ZRG1
2021HBI-002 to Treat Parkinson’s Disease1R41NS122576-01GOMPERTS, EDWARDGOMPERTS, STEPHEN N.HILLHURST BIOPHARMACEUTICALS, INC., CA$453,158ZRG1
2021VAL-0914 Decreases PAO to Protect Against Cardiac Proteinopathies1R41HL152919-01A1 · under PA-19-270SHAFFER, ROBERTWANG, XUEJUNENABLE THERAPEUTICS LLC, MA$450,022ZRG1
2021A New Anti-inflammatory Therapy for Ischemic Stroke1R41HL156322-01 · under PA-19-270LIANG, BRUCECORNOVUS PHARMACEUTICALS, INC., CT$433,483ZRG1
2021Targeting the neuropilin-1 receptor (NRP-1)/VEGF-A axis for neuropathic pain1R41NS122545-01A1KHANNA, RAJESHREGULONIX, LLC, NY$419,470ZRG1
2021Multi-modal cloud based system for detecting early signs of driver cognitive decline and/or high risk driving behaviors1R41AG073222-01MAGULURI, GOPI NPHYSICAL SCIENCES, INC, MA$416,423ZRG1
2021Development of a Therapeutic Monoclonal Antibody Against EGFL6, a Mediator of Tumor Growth and Metastasis1R41CA250757-01A1 · under PA-19-270ALLEN, THADDEUS DAVIDTRADEWIND BIOSCIENCE, INC., CA$405,552ZRG1
2021Engineered adipokine receptor inhibitor for the treatment of triple negative breast cancer in obese patients1R41CA257425-01 · under PA-19-270KRAUS, CARL NEILARREVUS, INC., NC$400,000ZRG1
2021Development of small molecule epigenetic therapeutics for prostate cancer1R41CA261384-01AHN, JUNG-MOHSIEH, JER-TSONGLIU, ZHI-PINGRAPHAEL PHARMACEUTICALS LLC, TX$400,000ZRG1
2021CCR4-IL2 Bispecific Immunotoxin for Targeted Therapy of Cutaneous T-Cell Lymphoma1R42CA261547-01WANG, ZHIRUIROCK IMMUNE LLC, CO$400,000ZRG1
2021Development of a Targeted Radiotherapeuitc for Pancreatic Ductal Adenocarcinoma1R41CA254492-01A1GARRISON, JERED CADDUCTNE, LLC, NE$400,000ZRG1
2021Efficacy of an Electrophile Scavenger in the Prevention of Gastrointestinal Inflammatory Carcinogenesis1R41CA257262-01A1RATHMACHER, JOHN AWILSON, KEITH T.MTI BIOTECH, INC., IA$400,000ZRG1
2021A New Class of Magnetic Nanoparticles for Glioma Targeted Drug Delivery1R41CA261544-01LI, YUANCHENGMAO, HUI5M BIOMED, LLC, GA$400,000ZRG1
2021Development of a radiation-activatable nanoparticle for lung cancer therapy1R41CA257584-01A1LIU, ZHIATHNA BIOTECH, INC., GA$400,000ZRG1
2021Inhibition of CaVα-β interaction with orally available small organic molecules for chronic pain1R41CA257845-01A1KHANNA, RAJESHREGULONIX, LLC, NY$400,000ZRG1
2021Fingerprinting Cancer via Multiparameter Extracellular Vesicle Analysis1R41CA265607-01GERMAN, SEANELECTRONIC BIOSCIENCES, INC., CA$400,000ZRG1
2021An integrated strategy using a serum and imaging biomarker for the early detection of pancreatic cancer.1R41CA265655-01MUKHERJEE, PINKUZHOU, RUONCOTAB, INC, NC$400,000ZRG1
2021SIRPant Technology for anti-Cancer Immunity1R42CA265691-01MCCURLEY, NATHANAELSIRPANT IMMUNOTHERAPEUTICS, INC., PA$400,000ZRG1
2021Non-invasive neurosurgical planning with Random Matrix Theory MRI1R41CA257624-01A1LEMBERSKIY, GRIGORIYMICROSTRUCTURE IMAGING, INC., NY$399,999ZRG1
2021Long-lived Platform Development for Exonuclease-Based Sequencing1R41HG012163-01ERVIN, ERICELECTRONIC BIOSCIENCES, INC., CA$399,999ZRG1
2021Small Molecule CUL4 Inhibitors as Dual Precision Oncology and Immuno-Oncology Drugs1R41CA265583-01ELIASOF, SCOTT DCULNEXIN THERAPEUTICS, INC., NJ$399,999ZRG1
2021Neupron™: A Neuroprotective Agent for Treating Acute Spinal Cord Injury1R41NS122587-01LABHASETWAR, VINOD DAXONEURAL THERAPEUTICS, INC., OH$399,987ZRG1
2021Development of a biomarker panel for screening and early detection of gynecological cancers1R41CA257115-01 · under PA-19-270MARTIGNETTI, JOHN AMDDX, INC., NY$399,972ZRG1
2021Development of Drug Detoxifying Bacteria for Chemotherapy Induced Gut Injury1R41CA261292-01HU, MINGSINGH, RASHIMWANG, XIAOQIANGSANARENTERO LLC, TX$399,955ZRG1
2021A novel monobody-drug conjugate to treat mutant KRas pancreatic cancer.1R41CA265512-01BAR-SAGI, DAFNAKOIDE, SHOHEIRAMIREZ, CRAIG PATRICKTEZCAT LABORATORIES LLC, CT$398,715ZRG1
2021Same-day Breast Pathology Results using Open-Top Light-Sheet Microscopy for Image-guided Core Needle Biopsies1R41CA261263-01REDER, NICHOLASALPENGLOW BIOSCIENCES, INC., WA$398,305ZRG1
2021Cancer Immunotherapy Targeting Tn Antigen1R41CA261408-01A1DEMETRIOU, MICHAELZHOU, RAYMOND WENHOUGLYTR THERAPEUTICS, INC., CA$398,178ZRG1
2021Improved Treatment of Colorectal Cancer with CF101R41CA254834-01A1GMEINER, WILLIAM H.DEEP CREEK PHARMA, LLC, NC$396,429ZRG1
2021A novel polymer-metal nanocomplex for ovarian cancer treatment1R41CA254500-01A1 · under PA-19-270XU, PEISHENGACEPRE, LLC, SC$392,803ZRG1
2021Optimizing Radiosynthetic Yield of [18F]FTT For Wide-Spread Distribution1R41CA261259-01LEE, HSIAOJU SHARONSCHWARZ, SALLY WAGNERTREVARX BIOMEDICAL, INC., PA$390,058ZRG1
2021Structure Based Design of Pol-theta inhibitors1R41CA265430-01POMERANTZ, RICHARD TRECOMBINATION THERAPEUTICS, LLC, PA$385,900ZRG1
2021Identifying novel targets for cardioprotection with non-traditional animal models1R41HG011577-01 · under PA-19-270GOODMAN, LINDA BOETTGERFAUNA BIO INCORPORATED, CA$373,434ZRG1
2021Multi-path DCS as a novel non-invasive treatment for amyotrophic lateral sclerosis1R41NS125872-01AHMED, ZAGHLOULPATHMAKER NEUROSYSTEMS, INC., MA$371,628ZRG1
2021Bispecific T cell engagers for the treatment of pancreatic ductal adenocarcinoma1R41CA265624-01DOLLOFF, NATHAN G.LEUKOGENE THERAPEUTICS, INC., SC$362,118ZRG1
2021Lipid Receptor GPR31 as a Target for Anti-Thrombotic and Stroke Therapy1R41HL160429-01KULIOPULOS, ATHANOASIS PHARMACEUTICALS, MA$361,774ZRG1
2021A Transparent Surgical Mask to Improve Patient/Caregiver Communication, Minimize Errors and Increase Patient Satisfaction2R42NR017124-02 · under PA-19-270HAHNE, JEANNEFACEVIEW MASK, LLC, OR$359,907ZRG1
2021Analyzing the efficacy of MMP-13 inhibitors in the treatment of CIPN1R41CA261451-01A1RIEGER, SANDRAAVANTYX, LLC, FL$355,723ZRG1
2021Site-specific epigenetic activation of TP53 to improve cancer therapy1R41GM146326-01A1HATHAWAY, NATHANIEL A.EPIGENOS BIOSCIENCE, INC., NC$350,000ZRG1
2021Smart, integrated well-plates for ultra-high-throughput screening of excitation-contraction coupling in tissues1R41GM146269-01PUSHKARSKY, IVANTSENG, PETERFORCYTE BIOTECHNOLOGIES, INC., CA$350,000ZRG1
2021The Nanopore-based Ion Selective Electrode Vial1R41GM144015-01GERMAN, SEANELECTRONIC BIOSCIENCES, INC., CA$350,000ZRG1
2021AlgenML: Drug target discovery platform for transcriptional reprogramming of MYCN-driven neuroblastoma1R41GM146327-01HUANG, CHUN-HAOALGEN BIOTECHNOLOGIES INC, CA$350,000ZRG1
2021Treatment of liver fibrosis with oral hepatic stable and non-genotoxic HDAC inhibitors1R41DK130707-01CHOU, CHUNG-JEN JAMESZHONG, ZHILYDEX PHARMACEUTICALS, LLC, SC$349,908ZRG1
2021A novel approach to restricting the spread of neurofibrillary tau1R41AG073080-01A1KOSIK, KENNETH STEPHENSTILES, TRAVIS LEENOVORON BIOSCIENCE, INC., CA$349,580ZRG1
2021Single molecule DNA/RNA transport and Raman scattering readout in a coupled nanochannel/nanopore sequencing system.1R43HG011608-01 · under PA-19-270BRUECK, STEVENARMONICA TECHNOLOGIES, INC., NM$349,200ZRG1
2021New Treatments for Glaucoma1R41EY033263-01MISHRA, SANKETGRANNUS THERAPEUTICS LLC, IN$346,562ZRG1
2021An automated system to interpret echocardiography to predict adverse outcomes in patients with right ventricular dysfunction in daily hospital practice1R41HL160362-01SCHILLING, JAMES WMPROBE, INC., CA$346,545ZRG1
2021Targeting the Integrated Stress Response effector ATF4 for mitigation of treatment-induced fibrosis1R41CA261378-01A1KOUMENIS, CONSTANTINOSSIELECKI, THAIS MOTRIAVELTION THERAPEUTICS LLC, PA$335,671ZRG1
2021Immunosuppressive Gene Therapy for Ocular Graft vs Host Disease1R41EY033262-01GILGER, BRIAN CHIRSCH, MATTHEW LOUISBEDROCK THERAPEUTICS, INC., NC$328,150ZRG1
2021Computational prediction of gut microbiome-mediated drug metabolism1R41TR003571-01A1MOFRAD, MOHAMMAD RKSHIRAZI, FATEMEHSOHEILYPOUR, MOHAMMADNEXILICO, INC., CA$325,000ZRG1
2021Bioengineering a Novel Therapeutic Transporter that Crosses the Blood Brain Barrier to Treat Brain Disorders1R41TR003960-01A1KLEMKE, RICHARD L.CYTONUS THERAPEUTICS, INC., OH$324,986ZRG1
2021Development of antisense oligonucleotides that enhance sIL7R as novel cancer immunotherapy1R43CA257108-01A1GALARZA-MUNOZ, GADDIELAUTOIMMUNITY BIOLOGIC SOLUTIONS, INC., TX$324,675ZRG1
2021Bronchoscopic lung navigation system for accurately excising lung nodules1R41CA261420-01A1JAGADEESAN, JAYENDERNAVIGATION SCIENCES, INC., MA$324,002ZRG1
2021Engineering a long-acting relaxin agonist to treat liver fibrosis1R41DK131681-01AGOULNIK, ALEXANDER IAGOULNIK, IRINADISTEFANO, PETER SLINDSAY, RONALDZEBRA BIOLOGICS, INC., MA$308,708ZRG1
20213D Printed Silicon Nitride Porous PEEK Composite Spinal Cages for Anti-Infection1R41GM146268-01MCENTIRE, BRYAN J.SINTX TECHNOLOGIES, INC., UT$308,301ZRG1
2021On-chip filtration and fractionation components for high-sensitive POC device to measure Chiral Metabolites in Urine1R41GM143348-01HEJAZI, LEILAZHANG, GUANSHISYGNAMAP, INC., TX$307,230ZRG1
2021Development of a Peptide-Drug Conjugate for Topically Treating the Viral Skin Disease Molluscum Contagiosum1R41AI162385-01RICCIARDI, ROBERT PAULFOX CHASE CHEMICAL DIVERSITY CENTER, INC, PA$306,500ZRG1
2021Removable airway stents that preserve mucociliary function1R41HL158451-01DUPONT, PIERRE EKAZA, ADITYA KDOWN FROM THE DOOR, LLC, NC$303,769ZRG1
2021Mitigation of Ionizing Irradiation-Induced Intestinal Damage by Second-Generation Probiotics LR-IL-22 and LR-IFN-β1R41AI157357-01 · under PA-19-270GREENBERGER, JOEL SROGERS, CLAUDE J.CHROMOLOGIC, LLC, CA$300,000ZRG1
2021Use novel natural compound Sparstolonin B to treat bacterial sepsis1R41AI157378-01 · under PA-19-270FAN, HONGKUANACEPRE, LLC, SC$300,000ZRG1
2021Small molecule inhibitors of influenza virus nucleoprotein1R41AI162408-01ENGEL, DANIEL AALEXANDER BIODISCOVERIES, LLC, VA$300,000ZRG1
2021Development of 4-(aroylamino)piperidine-based entry inhibitors as anti-influenza therapeutics1R42AI155039-01A1RONG, LIJUNCHICAGO BIOSOLUTIONS, INC., IL$300,000ZRG1
2021Targeting Covid-19 with a Therapeutic Interfering Particle1R41AI157129-01A1ANDINO, RAULALEPH THERAPEUTICS, INC., CA$300,000ZRG1
2021Gene therapy to treat glaucoma by reducing intraocular pressure1R41EY033238-01DANIAS, JOHNADVANCED VISION TECHNOLOGIES, NY$300,000ZRG1
2021Pulmonary Surface Irregularity score: A Quantitative CT Biomarker for Idiopathic Pulmonary Fibrosis1R41GM146329-01JACOBUS, ROBERT BAI METRICS, LLC, AL$299,999ZRG1
2021Biomimetic size-adaptable heart valve for prosthesis-patient mismatch1R41HL156563-01 · under PA-19-270DEL NIDO, PEDRO J.AUTUS VALVE TECHNOLOGIES, INC., MA$299,994ZRG1
2021Memory-promoting Ad vaccine for long-lived protection against SARS-CoV-21R41AI157626-01 · under PA-19-270HARTIGAN-O'CONNOR, DENNIS J.TENDEL THERAPIES INC., CA$299,983ZRG1
2021Multiplexed CRISPR-based immune cell RNA profiling by flow and mass cytometry1R41AI157717-01 · under PA-19-270O'CONNELL, MITCHELLDAHLIA BIOSCIENCES, INC., CA$299,978ZRG1
2021A dual-acting small molecule for the treatment of type 1 diabetes1R41DK131839-01BAHAMONDES LORCA, VERONICA ANDREANUNEMAKER, CRAIG SASAKE BIOTECHNOLOGY, LLC, OH$299,974ZRG1
2021Small Intestine Targeted Fast Acting Oral Insulin Formulation1R41DK131761-01LI, YUANCHENGMAO, HUI5M BIOMED, LLC, GA$299,931ZRG1
2021A Novel Broad-spectrum Antiviral Agent1R41AI157527-01 · under PA-19-270BOTTEN, JASON W.MURAD, JOANA MCELDARA MEDICAL, LLC, NH$299,916ZRG1
2021HBI-002 to Treat Diabetic Retinopathy1R41EY033264-01GOMPERTS, EDWARDJADEJA, RAVIRAJSINHMARTIN, PAMELA MHILLHURST BIOPHARMACEUTICALS, INC., CA$299,899ZRG1
2021Combined Cardiomyopathy, e.g., of Cancer Chemotherapeutics, and Proarrhythmia for Cardiotoxicity Clinical Trials-in-a-Dish (CTiD) with iPSC-Derived Cardiomyocytes1R42HL158510-01PRICE, JEFFREY H.VALA SCIENCES, INC., CA$299,871ZRG1
2021Phospholipid antimetabolite lipid ether amines for topical treatment of chronic wounds and associated biofilms.1R41DK127900-01A1GIBSON, DANIEL JSVETLOV, ARTEM SINTEGUMED, LLC, FL$299,749ZRG1
2021Preventing Post-Thrombotic Syndrome after Deep Vein Thrombosis with Perivascular Anti-Inflammatory Agent Delivery1R41HL160434-01JAFFER, FAROUC AMINSEWARD, KIRKMERCATOR MEDSYSTEMS, INC., CA$299,678ZRG1
2021Translation of Interferometric-based Free-solution Assay Methodology1R41GM139497-01A1BORNHOP, DARRYL J.RODENHAVER, DANIELMERU BIOTECHNOLOGIES, INC., VA$299,661ZRG1
2021Translational imaging tools to nondestructively measure nephron mass1R41DK129138-01A1BENNETT, KEVIN MXN BIOTECHNOLOGIES, LLC, MO$299,633ZRG1
2021Furopyrimidines as novel inhibitors of henipaviruses1R41AI157095-01 · under PA-19-270RONG, LIJUNCHICAGO BIOSOLUTIONS, INC., IL$299,595ZRG1
2021A therapeutic for Lyme disease based on Peptidoglycan Recognition Protein 11R41AI157014-01A1NARASIMHAN, SUKANYAL2 DIAGNOSTICS, LLC, CT$299,514ZRG1
2021Development of Novel Therapeutic Molecules for Treatment of Squamous Head and Neck Cancers1R41CA261407-01A1LEOPOLD, JUDITH SWHITEHEAD, CHRISTOPHER EMILMEKANISTIC THERAPEUTICS, LLC, MI$299,503ZRG1
2021Pn3Pase as an Effective Enzyme Therapeutic for Streptococcus Pneumoniae type 3 Infection1R41AI157287-01A1AVCI, FIKRI YPNEUMOTACTIX, LLC, GA$299,450ZRG1
2021Thermostable Inactivated Potent Yellow Fever Vaccine1R41AI165205-01AGUILAR, PATRICIA VERONICABRONSHTEIN, VICTORUNIVERSAL STABILIZATION TECHNOLOGIES, CA$299,380ZRG1
2021Rapid Genetic Fingerprinting of SARS-Cov-2 Variants1R41AI162575-01A1SAMADPOUR, MANSOURSOKURENKO, EVGENI VENIAMINOVICIDGENOMICS, INC., WA$299,200ZRG1
2021Novel therapeutic target to combat cutaneous lupus1R41TR003929-01A1ASTRUC DIAZ, FANNYDERMAXON, LLC, MT$298,132ZRG1
2021Selective Androgen Receptor Degraders (SARDs) as new therapeutics for spinal and bulbar muscular atrophy (SBMA)1R41NS122647-01KAUFMANN, GUNNAR JOERG FLORISONCTERNAL THERAPEUTICS, INC., CA$297,671ZRG1
2021Development of Small Molecule Antagonists of PAR-2 for treatment of asthma1R41HL160424-01BOITANO, SCOTTDEFEA, KATHRYN ANNEPARMEDICS, INC., CA$283,387ZRG1
2021COVID-19: High Efficiency SARS-CoV-2 Virus Aerosol Sampling and Sensing1R41AI157347-01A1KEADY, PATRICIA BEAAEROSOL DEVICES, INC., CO$262,802ZRG1
2021The use of tMUC1/CD3 bispecific antibody to control pancreatic ductal adenocarcinoma1R41CA265619-01MUKHERJEE, PINKUZHOU, RUONCOTAB, INC, NC$260,588ZRG1
2021Triagonist Peptide Therapeutics for Neuroprotection1R41GM142448-01A1KUMAR, KRISHNAVELUM, INC., MA$259,613ZRG1
2021Diamond NMR spectrometer for microfluidic metabolite profiling1R41GM145129-01ACOSTA, VICTOR MARCELJARMOLA, ANDREJSODMR TECHNOLOGIES, INC., CA$259,000ZRG1
2021Development of a Vaccine for Staphylococcal Infections1R41AI157087-01A1MISSIAKAS, DOMINIQUE M.IMMUNARTES LLC, IL$257,842ZRG1
2021Antibacterial nanoparticles as insecticide synergists and insect growth regulators for improved control of cockroach infestations1R41AI162017-01PIETRI, JOSE ENRIQUEAPEX BAIT TECHNOLOGIES, INC., CA$257,554ZRG1
2021Establishing the market-readiness of an in vivo technology for assessing drug toxicity-induced tissue damage1R41GM140538-01 · under PA-19-270JOHNSON, STEVEN EDWARDDURAMETRIX LLC, WI$257,175ZRG1
2021Designing an Adolescent Centered Cards on the Table Toolkit1R41HD104324-01A1CHOR, JULIEPARSONS, TIMOTHYRESILIENT GAMES STUDIO, LLC, IL$256,937ZRG1
2021Computer-aided design for improved lantibiotics1R41GM136034-01A1 · under PA-19-270HANDFIELD, MARTINORAGENICS, INC., FL$256,654ZRG1
2021Heteroduplex thermostable ligation assembly: a new platform to rapidly generate large DNA molecules1R41GM145048-01BIEBERICH, CHARLES J.CHESAPEAKE GENOMIC SYSTEMS LLC, MD$256,645ZRG1
2021Enabling Next Generation Machine Learning for Large Scale Image Analysis1R41EB032722-01SABIN, GERALDRNET TECHNOLOGIES, INC., OH$256,581ZRG1
2021An Innovative Screener for Reading and SLI targeting Kindergarten through 3rd Grade Students1R43DC018766-01A1 · under PA-19-270ANGEL, MARKRICE, MABEL LAMIRA LEARNING, INC., CA$256,580ZRG1
2021Novel Ophthalmic Product for Corneal Infections and Injuries1R41EY032437-01 · under PA-19-270PEREIRA, HELOISE ANNEBIOLYTX PHARMACEUTICALS CORP, OK$256,580ZRG1
2021Use of polymer-peptide system to deliver cells for intervertebral disc regeneration1R41AR079324-01SILVA, FRANCISCO JBIORESTORATIVE THERAPIES, INC., NY$256,580ZRG1
2021Development of Safe in Utero Gene Editing Technology in Mice1R41TR003752-01RABUKA, DAVIDACRIGEN BIOSCIENCES, INC., CA$256,580ZRG1
20212-HOBA for Treatment of Pulmonary Hypertension1R41HL158393-01RATHMACHER, JOHN AWEST, JAMES DMTI BIOTECH, INC., IA$256,580ZRG1
2021Allosteric Drug Discovery using Quantum Cascade Laser based Anisotropic THz Microscope (QCL-ATM)1R41GM140587-01A1LEE, ALANLONGWAVE PHOTONICS, LLC, CA$256,580ZRG1
2021Noninvasive challenge-free widely-accessible oxygen extraction fraction mapping1R41NS122675-01A1DORFMAN, GARYWANG, YIMEDIMAGEMETRIC, LLC, NY$256,580ZRG1
2021A Biliary Tract-Specific Fluorescence Image-guided Surgery1R41EB032284-01CHA, RICHARD JAEPYEONGOPTOSURGICAL, LLC, DE$256,579ZRG1
2021Dye-free, multimodal, quantitative imaging to assess bowel perfusion during laparoscopic colorectal resection1R41DK131650-01CHA, RICHARD JAEPYEONGOPTOSURGICAL, LLC, DE$256,579ZRG1
2021Endothelialized microfluidic assays for emerging therapies in sickle cell disease1R42HL160384-01FEDERICI, CHIARAGURKAN, UMUT A.BIOCHIP LABS, INC., OH$256,578ZRG1
2021Universal affinity membrane chromatography for rapid, one-step purification of proteins1R41GM142336-01HUSSON, SCOTT MTRIALTUS BIOSCIENCE, LLC, AL$256,576ZRG1
2021Multistage LC-MSn for automated glycan isomer assignment of glycopeptides1R41GM142363-01GUTTMAN, MIKLOSPROTEIN METRICS, LLC, CA$256,570ZRG1
2021Synthetic Antimicrobial Peptoids for Treatment of Chronic Suppurative Otitis Media1R41DC020077-01BARRON, ANNELISE EMILYKIRSHENBAUM, KENT WSANTA MARIA, PETER LUKEMAXWELL BIOSCIENCES, INC., TX$256,538ZRG1
2021MiGo: wearable sensors that combine actionable data with a behavioral intervention to improve function after stroke1R41HD104296-01A1ROWE, JUSTINWINSTEIN, CAROLEE JFLINT REHABILITATION DEVICES, CA$256,519ZRG1
2021Polymer use in Preservation of Tissue Perfusion to Address Sepsis1R41GM143995-01MANGINO, MARTIN J.PERFUSION MEDICAL, LLC, VA$256,492ZRG1
2021Therapeutic Strategy for NASH1R41DK130765-01SELTZMAN, HERBERT HARTIAM BIO INC., NC$256,475ZRG1
2021Improved Methods and Commercialization of Native Mass Spectrometry by Capillary Vibrating Sharp-edge Spray Ionization (cVSSI)1R41GM142379-01VALENTINE, STEPHENINVIBRAGEN INC., WV$256,452ZRG1
2021Nitazoxanide as a Novel Therapy for Rare Disease Lymphangioleiomyomatosis and Tuberous Sclerosis1R41HL156767-01A1KRYMSKAYA, VERA PPLEIMES, DIRKBIOSPUTNIK LLC, NY$256,400ZRG1
2021Low Cost Spectroscopic OCT for GI Applications1R41EB032693-01BROWN, WILLIAMLUMEDICA, INC., NC$256,323ZRG1
2021Protective film-forming disinfectant based on chitosan/water/ethanol tertiary solutions1R41AI157565-01A1VERTEGEL, ALEXEY AVRM LABS INC, SC$256,321ZRG1
2021Development of Innovative Medical Device Technology for Quantifying Forces during Soft Tissue Manipulation Assessment and Intervention1R41AT011494-01ANWAR, SOHELLOGHMANI, MARY TERRYHEALTH SMART TECHNOLOGIES, INC., IN$256,129ZRG1
2021A Framework for mHealth App Security and Privacy Analysis1R41GM146313-01AHAMED, SHEIKH IQBALUBITRIX INTERNATIONAL, INC., WI$256,079ZRG1
2021PHMB-Impregnated Acellular Biologic Grafts for Treatment of Third-Degree Burns1R41GM140660-01 · under PA-19-270PASHOS, NICHOLASBIOAESTHETICS CORPORATION, NC$256,069ZRG1
2021A Smart Assistant for MRI Technologists1R41EB031739-01A1MACY, ALANWARFIELD, SIMON KBIOPAC SYSTEMS, INC., CA$256,015ZRG1
2021Transient Gene Therapy as Broad Spectrum Antiviral1R41AI164999-01BOGUNOVIC, DUSANLAB11 THERAPEUTICS, LLC, NY$255,932ZRG1
2021Development of an integrated smartphone/resistive nanosensor for onsite biomonitoring of exposure to pesticides1R41ES032388-01A1WANG, JUNNANODIAGNOSTIC TECHNOLOGY, LLC, NC$255,880ZRG1
2021Development of low-cost, field-ready nanobodies against snake venom1R41GM146314-01A1CHANG, GEOFFREY ADEMPSEY, DANIEL THOMASVENOMYX, INC., CA$255,869ZRG1

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