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NIH funding notice PA-19-130

NIH Pathway to Independence Award (Parent K99/R00 - Independent Clinical Trial Not Allowed)

Closed on May 7, 2020.

Posted
December 20, 2018
Close date
May 7, 2020
Activity codes
K99, R00
Institutes taking part
NCI, NEI, NHLBI, NHGRI, NIA, NIAAA, NIAMS, NIAID, NIBIB, NCCIH, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NIMH, NINDS, NINR, NLM, ORIP, NIMHD

Read the notice on Grants.gov ยท NIH Guide page

The notices it replaced

  1. Reissues: PA-18-398 NIH Pathway to Independence Award (Parent K99/R00 - Independent Clinical Trial Not Allowed)
  2. 2 steps back: PA-16-193 NIH Pathway to Independence Award (Parent K99/R00)
  3. 3 steps back: PA-16-077 NIH Pathway to Independence Award (Parent K99/R00)
  4. 4 steps back: PA-15-083 NIH Pathway to Independence Award (Parent K99/R00)
  5. 5 steps back: PA-14-042 NIH Pathway to Independence Award (Parent K99/R00)
  6. 6 steps back: PA-11-197 NIH Pathway to Independence Award (Parent K99/R00)
  7. 7 steps back: PA-10-063 NIH Pathway to Independence Award (Parent K99/R00)
  8. 8 steps back: PA-09-036 NIH Pathway to Independence Award (K99/R00)
  9. 9 steps back: PA-07-297 NIH Pathway to Independence (PI) Award (K99/R00)
  10. 10 steps back: PA-06-133

Replaced by PA-20-188.

Who won it before

1,732 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $194,186,212 in first-year total cost, median $106,776.

Most frequent study sections

  1. Transition to Independence Study Section (I)[NCI-I]246
  2. NST-2 Study Section [NST-2]97
  3. Basic Neuroscience of Aging Study Section[NIA-N]68
  4. NHLBI Mentored Transition to Independence Study Section[MTI (JA)]62
  5. Biological Aging Study Section[NIA-B]52

Most frequent institutions

  1. STANFORD UNIVERSITY133
  2. UNIVERSITY OF CALIFORNIA, SAN FRANCISCO75
  3. MASSACHUSETTS GENERAL HOSPITAL56
  4. UNIVERSITY OF CALIFORNIA, SAN DIEGO46
  5. COLUMBIA UNIVERSITY HEALTH SCIENCES42
Competing awards under PA-19-130 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2021Arousal-induced noradrenergic signaling modulates cortical astrocyte-neuron circuits during ethanol consumption1K99AA028579-01A1SIPE, GRAYSON ORENMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$184,409AA
2021Neurometabolic profile of tobacco smoking in HIV-infected Individuals1K99DA051315-01A1SALEH, MUHAMMAD GUNIVERSITY OF MARYLAND BALTIMORE, MD$173,298ZDA1
2021A universal genome editing strategy to develop an airway stem cell therapy for cystic fibrosis1K99HL151900-01A1VAIDYANATHAN, SRIRAMSTANFORD UNIVERSITY, CA$166,536MTI
2021Identifying how alcohol-evoked changes in neural firing affect systems level computations during decision-making1K99AA028265-01A1TIMME, NICHOLAS MINDIANA UNIVERSITY INDIANAPOLIS, IN$162,936AA
2021Statistical Methods to Integrate Rich Functional and Phenotypic Data in Whole Genome Sequencing Analyses1K99HL151877-01A1GAYNOR, SHEILAHARVARD SCHOOL OF PUBLIC HEALTH, MA$162,864MTI
2021Sources and Regulation of Epithelial Stem/Progenitor Cells in Alveolar Regeneration1K99HL155785-01KATHIRIYA, JAYMIN JUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$157,680MTI
2021Cancer misinformation on social media and its correction1K99CA248720-01A1SWIRE-THOMPSON, BRIONYNORTHEASTERN UNIVERSITY, MA$154,223NCI
2021Epigenetic-metabolic aspects of alcohol use disorder and early developmental alcohol exposure1K99AA028577-01A1EGERVARI, GABORUNIVERSITY OF PENNSYLVANIA, PA$145,400AA
2021Functional Characterization of HER Family Variant Biology and Resistance in Cancer1K99CA248836-01A1HAYES, TIKVAH KDANA-FARBER CANCER INST, MA$142,992NCI
2021Systematic identification of RNA sequences and protein components regulating circular RNA translation1K99HG011475-01CHEN, CHUN-KANSTANFORD UNIVERSITY, CA$137,184GNOM
2021Direct Nanopore Sequencing and Structural Profiling of Non-Polyadenylated RNA1K99HG011492-01SHAW, ALANUNIVERSITY OF CALIFORNIA BERKELEY, CA$133,834GNOM
2021An ELSI-Integrated Evaluation of the Family-Level Utility of Pediatric Genomic Sequencing1K99HG011491-01SMITH, HADLEY STEVENSBAYLOR COLLEGE OF MEDICINE, TX$133,631GNOM
2021Development, validation and assessment of an automated, topographic structure-function approach to the detection of glaucoma and its progression1K99EY032182-01TSAMIS, EMMANOUILCOLUMBIA UNIV NEW YORK MORNINGSIDE, NY$130,054ZEY1
2021Roles of allele-specific chromatin interactions in transcription regulation during development1K99HG011542-01KIM, MINJIJACKSON LABORATORY, ME$129,622GNOM
2021Elucidating the causal associations underlying Alzheimer's disease1K99AG070109-01ANDREWS, SHEA JICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$128,639NIA
2021Language Input as a Mechanism Underlying Socioeconomic Disparities in Neurocognitive Development1K99HD103873-01ROMEO, RACHEL RENEHARVARD UNIVERSITY, MA$128,007CHHD
2021Wearable multifunctional optical device for early detection of postpartum hemorrhage1K99HD103954-01O'BRIEN, CHRISTINE MWASHINGTON UNIVERSITY, MO$127,701CHHD
2021Controlling oscillations to treat Alzheimers disease targeting the basal forebrain parvalbuminsystem1K99AG066819-01A1SCHIFFINO, FELIPE LOPESHARVARD MEDICAL SCHOOL, MA$126,792NIA
2021Host defense mechanisms of resident peritoneal macrophages1K99AI151198-01A1ZHANG, NANWASHINGTON UNIVERSITY, MO$126,401AITC
2021Resolving the AUD Phenotype: Unique and Transdiagnostic Features and Genetic Heterogeneity1K99AA028306-01A1WATTS, ASHLEY L.UNIVERSITY OF MISSOURI-COLUMBIA, MO$125,926AA
2021Action-specific dissecting of basal ganglia: from the classical model to diverse action-specific subcircuits1K99NS119788-01GU, ZIRONGCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$125,442NST
2021Interpretable machine learning for understanding the neural control of movement1K99NS119787-01GLASER, JOSHUA ICOLUMBIA UNIV NEW YORK MORNINGSIDE, NY$125,442NST
2021A new animal model to examine nervous system function, development, and regeneration1K99NS119749-01WEISSBOURD, BRANDONCALIFORNIA INSTITUTE OF TECHNOLOGY, CA$125,280NST
2021Examining the role of the neighborhood environment on muscle function in older adults1K99AG066846-01A1DUCHOWNY, CATHERINEUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$124,971NIA
2021The role of central amygdala somatostatin signaling in binge ethanol drinking1K99AA028268-01A1ROBINSON, STACEYUNIV OF NORTH CAROLINA CHAPEL HILL, NC$123,942AA
2021Interactions of Environmental Chemical Mixtures, Genetics, and Immune Pathways in Autism Spectrum Disorder1K99ES032481-01AMES, JENNIFER LISAKAISER FOUNDATION RESEARCH INSTITUTE, CA$122,801ZES1
2021Molecular basis of glutamatergic synapse function in inhibitory interneurons1K99MH124920-01BYGRAVE, ALEXEI MANSFIELDJOHNS HOPKINS UNIVERSITY, MD$122,526ZMH1
2021Dissecting roles of microbiome-host interactions in colorectal neoplasia etiology using multi-omics data1K99CA248822-01A1YANG, YAOHUAVANDERBILT UNIVERSITY MEDICAL CENTER, TN$121,203NCI
2021Role of myeloid-derived suppressor cells in local and systemic immunosuppression in glioblastoma1K99CA248611-01A1BAYIK WATSON, DEFNECLEVELAND CLINIC LERNER COM-CWRU, OH$120,450NCI
2021Machine learning for brain and epigenetic aging in neurodegenerative diseases1K99AG066947-01A1LE, TRANG THAOUNIVERSITY OF PENNSYLVANIA, PA$119,508NIA
2021Development and application of new tools to identify repeat expansions in human diseases1K99HG011467-01ERWIN, GRAHAM SCOTTSTANFORD UNIVERSITY, CA$119,096GNOM
2021Characterizing Population Differences between Clinical Trial and Real World Populations1K99NS114850-01A1BEAULIEU-JONES, BRETT KHARVARD MEDICAL SCHOOL, MA$118,759NST
2021Representation and utilization of sensory uncertainty in the primate visual system1K99EY032102-01ZIEMBA, COREY MUNIVERSITY OF TEXAS AT AUSTIN, TX$118,471ZEY1
2021Implication of Galectin-3 to regulate Graft vs. Host Disease (GvHD) and Graft vs. Tumor (GvT) Responses1K99HL155792-01MOHAMMADPOUR, HEMNROSWELL PARK CANCER INSTITUTE CORP, NY$117,864MTI
2021Neural mechanisms of active vision in the fovea1K99EY032179-01YATES, JACOB LUNIV OF MARYLAND, COLLEGE PARK, MD$116,969ZEY1
2021Computational Methods for Inferring Single-cell DNA Methylation and its Spatial Landscape1K99HG011468-01HOU, WENPINJOHNS HOPKINS UNIVERSITY, MD$115,909GNOM
2021Comprehensive mapping of multimodal chromatin state in single cells1K99HG011489-01STUART, TIMNEW YORK GENOME CENTER, NY$115,628GNOM
2021Mechanistic insights into lysosomal nutrient efflux in cancer1K99CA255926-01ROGALA, KACPERWHITEHEAD INSTITUTE FOR BIOMEDICAL RES, MA$115,080NCI
2021Quantitative and Spectroscopic Imaging of Skeletal Muscle Changes in Sarcopenia at High Field1K99AG066815-01A1SVEINSSON, BRAGIMASSACHUSETTS GENERAL HOSPITAL, MA$114,480NIA
2021Presenilin Knock-in Rat Model of Neurodegeneration1K99AG065441-01A1TAMBINI, MARC DRBHS-NEW JERSEY MEDICAL SCHOOL, NJ$113,884NIA
2021Reversing Skeletal Aging by Restoring Functional Skeletal Stem Cell Diversity1K99AG066963-01A1AMBROSI, THOMAS HANSSTANFORD UNIVERSITY, CA$113,696NIA
2021Studying the mammalian regulatory circuits by developing single-cell multi-omics technologies1K99HG011483-01ZHU, CHENXULUDWIG INSTITUTE FOR CANCER RES LTD, CA$113,415GNOM
2021Functional genomics of hypothetical genes in Gram-positive bacteria1K99AI151080-01A1WILLETT, JULIAUNIVERSITY OF MINNESOTA, MN$112,326MID
2021Gasdermin E-mediated pyroptosis in promoting antitumor immunity and cancer treatment1K99CA255841-01ZHANG, YINGBOSTON CHILDREN'S HOSPITAL, MA$112,242NCI
2021Mechanisms of translational output control in pancreatic cancer1K99CA255936-01HAUSMANN, SIMONE CHRISTINEUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$111,828NCI
2021Unpacking the Multi-level Drivers of Cardiotoxicity Disparities in Breast Cancer Survivors1K99CA256038-01SUTTON, ARNETHEA LA'SHAUNVIRGINIA COMMONWEALTH UNIVERSITY, VA$111,052NCI
2021Modeling Reciprocal Genomic Disorders in Neuronal Cells and Cerebral Organoids1K99MH121577-01A1NUTTLE, XANDERMASSACHUSETTS GENERAL HOSPITAL, MA$110,380ZMH1
2021The Development of Face-Processing Abilities in Infants: Structural and Functional Brain Changes During the First Year of Life1K99HD102566-01A1CONTE, STEFANIAUNIVERSITY OF SOUTH CAROLINA AT COLUMBIA, SC$108,401CHHD
2021Molecular mechanisms of Werner syndrome helicase in genome stability and aging1K99AG066938-01A1SONIAT, MICHAELUNIVERSITY OF TEXAS AT AUSTIN, TX$108,000NIA
2021Investigating whole-body innate immune activation in Alzheimer's disease using PET imaging and immune profiling1K99AG070105-01CHANEY, AISLINGSTANFORD UNIVERSITY, CA$107,546NIA
2021Mesenchymal Stem Cells can Restore and Maintain Corneal Endothelial Function1K99EY031373-01A1ISLAM, MOHAMMAD MIRAZULSCHEPENS EYE RESEARCH INSTITUTE, MA$106,339ZEY1
2021Perilipin 5: Linking lipid droplets to nutrient sensing and healthy aging1K99AG070104-01NAJT, CHARLES PUNIVERSITY OF MINNESOTA, MN$102,600NIA
2021Epigenomic mechanisms regulating RGC survival and axon regeneration1K99EY032181-01TIAN, FENGBOSTON CHILDREN'S HOSPITAL, MA$101,698ZEY1
2021Childhood fluoride exposure and sleep patterns1K99ES031676-01A1MALIN, ASHLEYUNIVERSITY OF SOUTHERN CALIFORNIA, CA$101,628ZES1
2021Elucidating the molecular and cellular mechanisms underlying cone survival in the peripheral retina in mouse models of Retinitis Pigmentosa1K99EY032110-01AMAMOTO, RYOJIHARVARD MEDICAL SCHOOL, MA$100,570ZEY1
2021Identification of genetic and environmental suppressors of mitochondrial dysfunction1K99GM140217-01MEISEL, JOSHUA DANIELMASSACHUSETTS GENERAL HOSPITAL, MA$100,000ZGM1
2021Evolutionary adaptation and spatial organization of signaling in the Mitotic Exit Network1K99GM140212-01ZHOU, XIAOXUEMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$100,000ZGM1
2021Electrocatalysis for the synthesis of chiral and PET imaging pharmaceuticals1K99GM140249-01MALAPIT, CHRISTIANUNIVERSITY OF UTAH, UT$100,000ZGM1
2021Identifying genetic barriers to animal virus replication in human cells: Insights into zoonosis1K99AI151256-01A1WARREN, CODY JAYUNIVERSITY OF COLORADO, CO$100,000MID
2021Selfish meiotic drive and the role of RNAi in defending intragenomic conflict1K99GM137077-01A1VEDANAYAGAM, JEFFREYSLOAN-KETTERING INST CAN RESEARCH, NY$100,000ZGM1
2021Biophysical Determinants of Physiological and Pathological alpha-Synuclein Membrane Interactions1K99NS116679-01A1NEWBERRY, ROBERT WILLIAMUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$99,943NST
2021Contextual Representation of Tactile Information in Mouse Primary Somatosensory Cortex1K99NS119739-01EMANUEL, ALAN JOSEPHHARVARD MEDICAL SCHOOL, MA$99,104NST
2021Molecular impediments to fate-specifying pioneer factor activity during development1K99GM140251-01MEERS, MICHAEL PFRED HUTCHINSON CANCER RESEARCH CENTER, WA$97,999ZGM1
2021Deep-learning based profiling of patient-derived cells as a tool for genomic and translational medicine1K99HG011488-01PERNICE, WOLFGANG MAXIMILIAN ANTONCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$97,780GNOM
2021Bridging gap in comparative biology using the tree shrew visual system1K99EY032119-01ROY, SUVADUKE UNIVERSITY, NC$97,059ZEY1
2021Effects of light exposure on amygdala plasticity during adolescence: implications for anxiety and well-being1K99AT010903-01A1PORCU, ALESSANDRAUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$96,576ZAT1
2021A cross-national comparative study on cardiometabolic risk, education, and cognitive aging1K99AG070274-01ZHANG, YUAN SUNIV OF NORTH CAROLINA CHAPEL HILL, NC$95,409NIA
2021Analyzing the role of cAMP and STAT3 signaling in cartilage homeostasis and osteoarthritis development1K99AR077090-01A1LIU, ZHAOYANGUNIVERSITY OF TEXAS AT AUSTIN, TX$92,610AMS
2021Sensory mechanisms underlying metabolic regulation1K99DK127210-01BAI, LINGUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$91,500DDK
2021Role of CTRP1 in Renal Sodium Handling in Obesity-Related Hypertension1K99HL155850-01WANG, FEIUNIVERSITY OF UTAH, UT$90,000MTI
2021Molecular Mechanisms of Co-Transcriptional Ribonucleoprotein Assembly1K99GM140204-01RODGERS, MARGARET LOUISEJOHNS HOPKINS UNIVERSITY, MD$89,829ZGM1
2021Exploring Common Biological Pathways Underlying Insulin Resistance and Alzheimer Disease using Genetic and Omic Tools1K99AG066849-01A1SARNOWSKI, CHLOร‰UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$89,564NIA
2021Leveraging human evolutionary history to improve our understanding of complex disease architecture1K99GM137076-01A1ZAIDI, SYED ARSLAN ABBASUNIVERSITY OF PENNSYLVANIA, PA$89,558ZGM1
2021Genetically harmonized dietary intake and causal relationships with diabetes-related outcomes1K99DK127196-01COLE, JOANNE BURNETTEMASSACHUSETTS GENERAL HOSPITAL, MA$89,520DDK
2021Epstein-Barr Virus nuclear antigen leader protein in transcription regulation1K99DE030215-01WANG, CHONGBRIGHAM AND WOMEN'S HOSPITAL, MA$86,916DSR
2021Single-molecule Measurements of Membrane-protein Folding and Ligand-Interaction Energetics in Bacteriorhodopsin and the Diabetes-insipidus-involved Vasopressin Receptor 21K99GM140439-01JACOBSON, DAVID RUNIVERSITY OF COLORADO, CO$86,615ZGM1
2021Assessment of EEG Responses to Spinal Cord Stimulation Waveforms in Chronic Pain Patients1K99NS119672-01TELKES ERGUN, ILKNURALBANY MEDICAL COLLEGE, NY$83,009NST
2021Using the literature to build causal models of retrospective observational data1K99LM013367-01A1MALEC, SCOTT ALEXANDERUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$76,101ZLM1
2020Reducing racial disparities in the treatment of opioid use disorder using machine learning-based causal analysis1K99DA051534-01KIANG, MATHEW VINHHOASTANFORD UNIVERSITY, CA$179,582ZDA1
2020Exploiting metabolic reprogramming to target IDH1 mutated cholangiocarcinoma1K99CA245194-01SHI, LEIMASSACHUSETTS GENERAL HOSPITAL, MA$178,200NCI
2020Circuit-specific molecular mechanisms in fentanyl use and relapse1K99DA050575-01FOX, MEGAN ELIZABETHUNIVERSITY OF MARYLAND BALTIMORE, MD$175,792ZDA1
2020A Simulation Model-based Framework to Support Oncology Guidelines and Practice1K99CA241397-01A1JAYASEKERA, JINANIGEORGETOWN UNIVERSITY, DC$175,392NCI
2020Investigating the novel role of acetylation in cardiac mitochondrial bioenergetics and function in the aging heart1K99HL146905-01A1THAPA, DHARENDRAUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$173,001MTI
2020Discovery of novel pharmacotherapeutic targets for opioid addiction1K99DA048119-01A1SMITH, ALEXANDER WANLESSICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$171,504ZDA1
2020Influence of sleep on hematopoietic stem cell diversity and clonality in cardiovascular disease1K99HL151750-01MCALPINE, CAMERON STUARTMASSACHUSETTS GENERAL HOSPITAL, MA$171,073MTI
2020Joint impacts of local alcohol and cannabis policies and outlet densities on violence1K99AA028256-01MATTHAY, ELLICOTT COLSONUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$170,892ZAA1
2020Characterizing the role of fronto-striatal connectivity in value-based decision-making1K99DA050662-01GORE, FELICITYSTANFORD UNIVERSITY, CA$169,037ZDA1
2020A synthetic hematopoietic stem cell niche to investigate stemness and hematopathologies1K99HL150218-01WILKINSON, ADAM CSTANFORD UNIVERSITY, CA$166,536MTI
2020The role of autophagy in the escape from replicative crisis and tumorigenesis1K99CA252447-01NASSOUR, JOESALK INSTITUTE FOR BIOLOGICAL STUDIES, CA$163,080NCI
2020Age-Related Decrease in Mitofusin 1 Results in Platelet Dysfunction and Thrombosis1K99HL150166-01A1BRAGANZA, ANDREA CATHERINEUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$162,732MTI
2020Identifying Angiocrine Factors for Cardiomyocyte Maturation Using Single-Cell Sequencing1K99HL150216-01PAIK, DAVID TSTANFORD UNIVERSITY, CA$162,432MTI
2020Malondialdehyde-induced Endothelial Dysfunction in Atherosclerosis1K99HL148504-01A1SUN, XIAOLIUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$159,732MTI
2020Microenvironment-driven electrical regulation of primary and secondary brain tumor progression1K99CA252001-01VENKATESH, HUMSASTANFORD UNIVERSITY, CA$158,533NCI
2020A mixed-methods approach to understanding stress and hazardous drinking among same-sex female couples1K99AA028049-01A1VELDHUIS, CINDY BCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$158,093ZAA1
2020Role of Gstt1 in metastatic maintenance and self-renewal in PDA1K99CA252600-01FERRER, CHRISTINAMASSACHUSETTS GENERAL HOSPITAL, MA$156,330NCI
2020Defining the metabolic-epigenetic regulation of neuronal chromatin by alcohol1K99AA027839-01A1MEWS, PHILIPPICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$155,576AA
2020microRNA therapies for advanced brain tumors1K99CA245030-01BHERE, DEEPAKBRIGHAM AND WOMEN'S HOSPITAL, MA$155,412NCI
2020Interrogating oncogene-dependency and mutation order in FLT3 mutant AML1K99CA248460-01BOWMAN, ROBERT LYLESLOAN-KETTERING INST CAN RESEARCH, NY$154,697NCI
2020Magnetic Particle Imaging (MPI) for Imaging and Magnetothermal Therapy of Brain Tumors1K99CA234208-01A1ARAMI, HAMEDSTANFORD UNIVERSITY, CA$154,529NCI
2020Targeting mitochondrial dynamics in drug-resistant acute myeloid leukemia1K99CA252602-01GLYTSOU, CHRISTINANEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$153,025NCI
2020Exploring the impact of HSP90 inhibition on antigen presentation and anti-tumor immune responses1K99CA241072-01A1JAEGER, ALEXMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$150,223NCI
2020Insular Cortex-BNST neural circuit regulation of chronic alcohol abstinence-induced negative affect1K99AA027774-01A1CENTANNI, SAMUELVANDERBILT UNIVERSITY, TN$149,685AA
2020Tumor suppressive functions of TET proteins in B cell malignancies: role of G-quadruplex structures1K99CA248835-01SHUKLA, VIPULLA JOLLA INSTITUTE FOR IMMUNOLOGY, CA$144,720NCI
2020Cross-Feature Correlations Define Cell Types, Asymmetric Cell Division, and Variant Networks1K99HG011270-01TYLER, SCOTT RICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$143,212GNOM
2020Physiological and Molecular Mechanisms of Mu Opioid Receptors in Motivation and Affect1K99DA049862-01CASTRO, DANIEL CHARLESUNIVERSITY OF WASHINGTON, WA$141,997ZDA1
2020Delineating the Genetic Susceptibility of Smoking-Induced Vascular Dysfunction1K99HL150319-01A1GUO, HONGCHAOSTANFORD UNIVERSITY, CA$141,420MTI
2020Using a 24-Hour Movement Framework to Improve Pregnancy Outcomes1K99HD100585-01A1BADON, SYLVIA EKAISER FOUNDATION RESEARCH INSTITUTE, CA$139,914CHHD
2020Sex differences in fast-spiking interneurons promote AUD-related PFC dysfunction: remediation by modulating mGlu1 and mGlu51K99AA027806-01A1JOFFE, MAX EVANDERBILT UNIVERSITY, TN$138,165AA
2020Establishment of the meiotic cell cycle program through post-transcriptional regulation by MEIOC and YTHDC21K99HD097285-01A1MIKEDIS, MARIAWHITEHEAD INSTITUTE FOR BIOMEDICAL RES, MA$136,755CHHD
2020Young Infants' Detection of Emotion1K99HD101500-01ZIEBER, NICOLEUNIVERSITY OF KANSAS LAWRENCE, KS$136,110CHHD
2020Diet-microbe interactions modulating host energy balance1K99AI147165-01A1BISANZ, JORDAN ADAMUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$135,824MID
2020ASC oligomerization and transmission as an initiating event for protein aggregation in Synucleinopathy Dementias1K99AG066862-01PANICKER, NIKHILJOHNS HOPKINS UNIVERSITY, MD$135,540NIA
2020Molecular Heterogeneity and Functional Diversity of the Vestibular System1K99DC018574-01SUN, SHUOHAOJOHNS HOPKINS UNIVERSITY, MD$135,540CDRC
2020Biophysical and genetic mechanisms underlying diaphragm morphogenesis and Congenital Diaphragmatic Hernias1K99HD101682-01SEFTON, ELIZABETH MARIEUNIVERSITY OF UTAH, UT$133,920CHHD
2020Sensory processing downstream of primary auditory cortex1K99DC018600-01YAO, JUSTIN DANIELNEW YORK UNIVERSITY, NY$133,110CDRC
2020Paraventricular thalamic control of opioid withdrawal and relapse1K99DA048974-01A1GIANNOTTI, GIUSEPPEUNIVERSITY OF COLORADO DENVER, CO$132,626ZDA1
2020Psychological Responses to the Possibility of Dying: Decision-Making Implications for Advanced Cancer Patients1K99CA241310-01A1GEORGE, LOGINSLOAN-KETTERING INST CAN RESEARCH, NY$132,333NCI
2020The fitness effects of de novo structural variants1K99HG011041-01HSIEH, PINGHSUNUNIVERSITY OF WASHINGTON, WA$132,244GNOM
2020Quantitating, Targeting, and Phenotyping In Vivo Cellular Senescence in Humans1K99AG065484-01A1BASISTY, NATAN BOHDONIVICHBUCK INSTITUTE FOR RESEARCH ON AGING, CA$131,652NIA
2020Dysregulation of Mitochondrial Dynamics in Sepsis Induced Multi-Organ Dysfunction Syndrome (MODS)1K99HD099387-01A1HAILESELASSIE, BEREKETABSTANFORD UNIVERSITY, CA$131,652CHHD
2020Probing the biophysical basis of large-scale brain dynamics using simultaneous PET/fMRI and EEG/PET/fMRI1K99NS118120-01CHEN, JINGYUANMASSACHUSETTS GENERAL HOSPITAL, MA$130,950NST
2020Investigating Membrane Alterations as a Mechanism of Acid Tolerance in Cariogenic Bacteria1K99DE029228-01A1BAKER, JONATHONJ. CRAIG VENTER INSTITUTE, INC., CA$130,902DSR
2020Factors of Resilience to Alzheimers Disease and Related Dementias among Latinx: The Role of Bilingualism1K99AG066932-01ARCE, MIGUELCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$130,842ZAG1
2020Impacts of Early Life Food Insecurity on Child Obesity and Cognitive Development Trajectories1K99HD101657-01KINSEY, ELIZA W.COLUMBIA UNIVERSITY HEALTH SCIENCES, NY$130,698CHHD
2020Preclinical markers of Alzheimer's disease using psycholinguistic semantic measures1K99AG066934-01VONK, JET M.J.COLUMBIA UNIVERSITY HEALTH SCIENCES, NY$130,698ZAG1
2020A Role of Astrocyte and Microglia Interplay in Alzheimer's Disease1K99AG066960-01JIANG, LU-LINSANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, CA$129,870NIA
2020Neurodegenerative diseases and the role of green space: A deep learning assessment1K99AG066949-01PESCADOR JIMENEZ, MARCIA IXCHELHARVARD SCHOOL OF PUBLIC HEALTH, MA$129,600NIA
2020Characterizing the role of lipid plasticity in ferroptosis sensitivity and evasion in clear-cell carcinomas1K99CA248610-01ZOU, YILONGBROAD INSTITUTE, INC., MA$129,470NCI
2020Immunization strategies to elicit broadly neutralizing antibodies against HCV1K99AI153465-01FLYAK, ANDREW ICALIFORNIA INSTITUTE OF TECHNOLOGY, CA$129,465MID
2020Molecular mechanisms linking epigenetic changes to longevity1K99AG065508-01A1SILVA-GARCIA, CARLOS GIOVANNIHARVARD SCHOOL OF PUBLIC HEALTH, MA$128,898NIA
2020Role of orexin receptors in the abuse- and sleep-related effects of methamphetamine1K99DA049886-01A1BERRO, LAIS FUNIVERSITY OF MISSISSIPPI MED CTR, MS$128,617ZDA1
2020Simulation framework to develop ankle exoskeleton gait assistance for older adults1K99AG065524-01SONG, SEUNGMOONSTANFORD UNIVERSITY, CA$128,574ZAG1
2020Learning-mediated plasticity in cortical feedback projections to the olfactory bulb1K99DC017754-01A1ZAK, JOSEPH DONALDHARVARD UNIVERSITY, MA$128,574CDRC
2020Quantifying the genetic and environmental factors driving avian influenza spillover1K99AI147029-01A1MONCLA, LOUISE HILLIERFRED HUTCHINSON CANCER RESEARCH CENTER, WA$128,574MID
2020Integrating functional proteomics, genome engineering, and live-cell microscopy to the study of ciliopathies1K99HD100554-01VAN DE WEGHE, JULIE CRAFTUNIVERSITY OF WASHINGTON, WA$128,333CHHD
2020Persistent Microvasculature Thrombosis Caused by Fibrinolysis Shutdown Driving Delayed Graft Function in Liver Transplant Recipients1K99HL151887-01MOORE, HUNTER BUNIVERSITY OF COLORADO DENVER, CO$128,282MTI
2020Identifying optimal dynamic strategies for prostate cancer control1K99CA248335-01DICKERMAN, BARBRA ANNEHARVARD SCHOOL OF PUBLIC HEALTH, MA$128,088NCI
2020The neurodevelopmental mechanisms linking environmental experience and executive function1K99HD099203-01A1ROSEN, MAYAHARVARD UNIVERSITY, MA$128,007CHHD
2020Tracking the onset of spatial memory deficits in aging and Alzheimers disease models with single neuron resolution electrophysiology1K99AG068602-01ZWANG, THEODORE JOSEPHMASSACHUSETTS GENERAL HOSPITAL, MA$128,007NIA
2020Targeting aspartate biosynthesis in pancreatic tumors1K99CA248838-01GARCIA BERMUDEZ, JAVIERROCKEFELLER UNIVERSITY, NY$127,990NCI
2020Development and Characterization of 19-Fluorine Magnetic Resonance Spectroscopy False Neurotransmitter Probes1K99MH122659-01POST, MICHAEL ROBERTNEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC, NY$127,710ZMH1
2020Live imaging of neuron circuit assembly in Drosophila olfactory system1K99DC018830-01LI, TONGCHAOSTANFORD UNIVERSITY, CA$127,683CDRC
2020Assessing the impact and implementation of state laws for adolescent intimate partner violence1K99HD102567-01ADHIA, AVANTI BUNIVERSITY OF WASHINGTON, WA$127,359CHHD
2020Mechanisms and Consequences of Tau Internalization and Aggregation in the Central Nervous System1K99AG064116-01A1RAUCH, JENNIFER NICOLEUNIVERSITY OF CALIFORNIA SANTA BARBARA, CA$127,224NIA
2020Mechanisms of Endometrial Innate Immune Responses to Infection and Impact on Placental Interactions1K99HD101653-01A1TONG, MANCYYALE UNIVERSITY, CT$126,967CHHD
2020Multifunctional tough adhesive hydrogels to recruit, expand, and deliver tendon cells during aging and injury1K99AG065495-01FREEDMAN, BENJAMIN ROSSHARVARD UNIVERSITY, MA$126,900NIA
2020Deep learning approaches to decipher the impact of mobile element insertion on alternative splicing in neurological disorders1K99NS118109-01GAO, DADIMASSACHUSETTS GENERAL HOSPITAL, MA$126,866NST
2020Connectome-based spread of neurodegenerative processes in Alzheimer's disease1K99AG065501-01LA JOIE, RENAUD CHARLESUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$126,630NIA
2020Alcohol-induced alterations in orbitofrontal cortex serotonin signaling1K99AA028298-01PINA, MELANIE MUNIV OF NORTH CAROLINA CHAPEL HILL, NC$126,357AA
2020Hippocampal-subcortical interactions underlying social memory1K99MH122582-01OLIVA GONZALEZ, AZAHARACOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$125,442ZMH1
2020Revealing the organization and functional significance of neural timescales in auditory cortex1K99DC018051-01A1NORMAN-HAIGNERE, SAMUEL VCOLUMBIA UNIV NEW YORK MORNINGSIDE, NY$125,442CDRC
2020Coordination of Structure and Function in Corticospinal and Corticostriatal Pathways1K99NS118053-01NELSON, ANDERSCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$125,442NST
2020Understanding and Predicting High-Need, High-Cost Patients among Older Adults1K99AG064030-01A1ZHANG, YONGKANGWEILL MEDICAL COLL OF CORNELL UNIV, NY$125,185NIA
2020Dynamic neural systems underlying socioemotional function1K99AG065457-01A1PASQUINI, LORENZOUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$125,010NIA
2020Determining the molecular organization of TDP-43 in liquid spherical annuli and establishing a designer gene therapeutic strategy to degrade TDP-43 aggregates1K99NS114162-01YU, HAIYANGLUDWIG INSTITUTE FOR CANCER RES LTD, CA$124,794NST
2020Measuring treatment response and residual disease in leukemia with personalized, sensitive, and quantitative genomic methods1K99CA252616-01MOFFITT, ANDREACOLD SPRING HARBOR LABORATORY, NY$124,738NCI
2020Plasma Cell-Free RNA as Non-invasive Biomarker for Neurodegeneration1K99AG062723-01A1IBANEZ, LAURAWASHINGTON UNIVERSITY, MO$124,680NIA
2020Sensory Mechanisms of Cadmium-Induced Behavioral Disorders Across Generations1K99ES030398-01A1SHELTON, DELIA SOREGON STATE UNIVERSITY, OR$124,537ZES1
2020Reinforcement learning and action sequencing in subcortical and cortical circuits1K99NS114194-01MURRAY, JAMESCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$124,157NST
2020Engineered alveolar organoids to understand ECM signaling1K99HL151670-01LOEBEL, CLAUDIAUNIVERSITY OF PENNSYLVANIA, PA$123,850MTI
2020Investigating the contributions of neural crest to adult regeneration1K99HD100587-01A1MARTIK, MEGAN LEECALIFORNIA INSTITUTE OF TECHNOLOGY, CA$123,768CHHD
2020Discovery of small molecule-mediated protein degradation pathways in human cancer1K99CA248715-01ZHANG, XIAOYUSCRIPPS RESEARCH INSTITUTE, THE, CA$123,655NCI
2020Bone Marrow Functions of Novel Pro-Resolving Mediators1K99HL153673-01LIBREROS, STEPHANIABRIGHAM AND WOMEN'S HOSPITAL, MA$123,397MTI
2020Molecular and functional characterization of the cells and circuits underlying the fever response1K99NS114107-01OSTERHOUT, JESSICA ALLISONHARVARD UNIVERSITY, MA$123,174NST
2020Brainwide Computations Underlying Future Action Plans1K99NS116122-01MACHADO, TIMOTHY ALOYSIUSSTANFORD UNIVERSITY, CA$123,174NST
2020YAP1, neointima formation, and blood pressure regulation1K99HL153896-01OSMAN, ISLAMAUGUSTA UNIVERSITY, GA$122,904MTI
2020Disrupting macrophage metabolism to reduce immunosuppression and enhance therapy in pancreatic cancer1K99CA241357-01A1HALBROOK, CHRISTOPHER J.UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$122,890NCI
2020Executive function in opioid-exposed offspring and subsequent molecular signatures1K99DA049908-01SMITH, BRITTANY LUNIVERSITY OF CINCINNATI, OH$122,864ZDA1
2020Integrative Multi-Scale Systems Analysis of Gene-Expression-Driven Aging Morbidity1K99AG068544-01STOEGER, THOMASNORTHWESTERN UNIVERSITY, IL$122,861NIA
2020Exosomes and Conventional Outflow Homeostasis1K99EY031737-01MCDONNELL, FIONADUKE UNIVERSITY, NC$122,823ZEY1
2020A novel blood-CSF adaptive immune response in Alzheimer's disease1K99NS112458-01A1GATE, DAVIDSTANFORD UNIVERSITY, CA$122,283NST
2020More than just a load control: cytoskeletal form and function during aging1K99AG065200-01A1HIGUCHI-SANABRIA, RYOUNIVERSITY OF CALIFORNIA BERKELEY, CA$121,770NIA
2020The Role of Sensory Inputs and Cholinergic Modulation for the Coding of Location and Movement Speed in the Entorhinal Cortex1K99NS116129-01DANNENBERG, HOLGERBOSTON UNIVERSITY (CHARLES RIVER CAMPUS), MA$121,607NST
2020Elucidating the Role of SMAD4 in Colorectal Cancer1K99CA245123-01A1TONG, KEVINRUTGERS, THE STATE UNIV OF N.J., NJ$120,264NCI
2020Identifying drug synergistic with cancer immunotherapy1K99CA248953-01SAHU, AVINASH DASDANA-FARBER CANCER INST, MA$120,038NCI
2020Characterizing the biological function and therapeutic potential of mitochondrial NADP(H)1K99CA248711-01ZHU, JIAJUNSLOAN-KETTERING INST CAN RESEARCH, NY$119,836NCI
2020Conformational properties of misfolded protein aggregates in cases involving the co-occurrence of prion disease and Alzehimer's disease or prion disease and CTE1K99AG068359-01CALI, IGNAZIOCASE WESTERN RESERVE UNIVERSITY, OH$119,664ZAG1
2020Exploring new roles of Robo2 in synaptic development, plasticity and hippocampal circuit function1K99NS115984-01BLOCKUS, HEIKE MANUELACOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$119,523NST
2020Genetics of Tumor Suppression by p531K99CA241367-01A1BARNOUD, THIBAUTWISTAR INSTITUTE, PA$119,031NCI
2020Targeting HSP70 in CARM1-expressing epithelial ovarian cancer1K99CA241395-01A1KARAKASHEV, SERGEYWISTAR INSTITUTE, PA$119,031NCI
2020Circuit mechanisms of functional diversity of dopamine neurons during complex behavior1K99MH122657-01ENGELHARD, BENPRINCETON UNIVERSITY, NJ$118,941ZMH1
2020Synthetic recording and in situ readout of cell lineage and molecular history in mammalian retina1K99EY031782-01ASKARY, AMJADCALIFORNIA INSTITUTE OF TECHNOLOGY, CA$118,665ZEY1
2020Regulatory mechanisms of rare non-coding variation in neurodegeneration-associated loci1K99AG068271-01COCHRAN, JESSE NHUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY, AL$118,335NIA
2020Articulating the presynaptic input structure to functionally defined, learning-related synaptic clusters1K99NS114175-01HEDRICK, NATHAN GUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$117,843NST
2020Understanding the molecular mechanisms and biological functions of a novel bleach-sensing bacterial receptor in shaping host-associated bacterial populations in response to host inflammation1K99AI148587-01BAYLINK, ARDENUNIVERSITY OF OREGON, OR$117,420MID
2020Deep Learning Approaches to Detect Glaucoma and Predict Progression from Spectral Domain Optical Coherence Tomography1K99EY030942-01A1CHRISTOPHER, MARKUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$117,347ZEY1
2020Ultralong-term single-molecule imaging of amyloid precursor protein (APP) processing in Alzheimer's disease1K99AG065516-01PENG, CHUNTESTANFORD UNIVERSITY, CA$116,385NIA
2020Regulation of Lymphangiogenesis by Thrombospondin 11K99HL146954-01A1SINGLA, BHUPESHAUGUSTA UNIVERSITY, GA$116,100MTI
2020Dual-modal ultrasound velocimetry and photoacoustic oximetry of entire rodent brain for Alzheimer's Disease study1K99AG063762-01A1TANG, JIANBOBOSTON UNIVERSITY (CHARLES RIVER CAMPUS), MA$115,236NIA
2020Realistic quantification of potential privacy loss from genomic summary results1K99HG010909-01A1GURSOY, GAMZEYALE UNIVERSITY, CT$115,020GNOM
2020Neurodevelopmental profiles related to transdiagnostic and disorder-specific symptoms of anxiety and depression1K99MH121518-01A1MAREK, SCOTTWASHINGTON UNIVERSITY, MO$113,963ZMH1
2020Dissecting the cis-regulatory roles of transposable elements in human cancers1K99CA252020-01ZHANG, YANXIAOLUDWIG INSTITUTE FOR CANCER RES LTD, CA$113,716NCI
2020Assessment of murine retinal acuity ex vivo by machine learning of multielectrode array recordings1K99EY031333-01BABINO, DARWINUNIVERSITY OF WASHINGTON, WA$113,080ZEY1
2020Cell Cycle Regulation in Fetal Alcohol Spectrum Disorders1K99AA028273-01BOSCHEN, KAREN ELIZABETHUNIV OF NORTH CAROLINA CHAPEL HILL, NC$112,405AA
2020Development and regeneration of retinal ganglion cells in the vertebrate retina1K99EY031403-01WOODWORTH, MOLLIE BURGOONSTANFORD UNIVERSITY, CA$112,162ZEY1
2020Defining the transcriptional, phenotypic, and functional heterogeneity of virus-specific CD4 T cells during chronic viral infection1K99AI153537-01ZANDER, RYANVERSITI WISCONSIN, INC., WI$112,127AITC
2020Sarcomeric Regulation of Signal Transduction and Cardiomyopathy1K99HL148309-01A1GUO, YUXUANBOSTON CHILDREN'S HOSPITAL, MA$111,603MTI
2020A pipeline for identifying disease-causing variants in transmembrane proteins1K99HG010904-01GLAZER, ANDREW M.VANDERBILT UNIVERSITY MEDICAL CENTER, TN$111,596GNOM
2020Development of direction selectivity maps1K99EY030909-01A1TIRIAC, ALEXANDREUNIVERSITY OF CALIFORNIA BERKELEY, CA$111,444ZEY1
2020Role of regulatory T cells in adverse pregnancy outcomes after ischemia reperfusion injury1K99HL150281-01GILLIS, ELLEN EAUGUSTA UNIVERSITY, GA$110,938MTI

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