← Capabilities

Unsupervised Discovery

Identify behavioral patterns your scoring rubric doesn't include

Unsupervised clustering reveals behavioral structure you didn't define in advance — find phenotypes, drug effects, and strain differences in unbiased fashion.

Unsupervised Discovery
UMAP
Embedding method
0
Predefined labels required
p<0.001
Density permutation test
Markov
Transition analysis
The problem

Predefined ethograms restrict what you can find

Supervised behavioral scoring only detects behaviors you define in advance. Subtle phenotypes, unexpected drug effects, and novel behavioral states are invisible when observers score only what their rubric includes. This confirmation bias limits discovery and can cause meaningful behavioral differences to go unreported.

  • Observers only score behaviors listed in the ethogram — unlisted patterns go unrecorded
  • Subtle behavioral variants (e.g., partial rearing, interrupted grooming sequences) are collapsed into coarse categories
  • Cross-condition differences in behavioral microstructure are invisible to standard scoring rubrics
The solution

Unsupervised clustering reveals behavioral structure without categories

ConductVision embeds behavioral features into a low-dimensional space using UMAP and identifies clusters without any predefined labels. Novel behavioral states are flagged automatically. Cross-condition comparisons reveal phenotypic differences that standard ethograms would miss.

  • Behavioral features embedded into UMAP space without predefined categories or training labels
  • Clusters identified automatically — each represents a distinct behavioral motif or state
  • Novel behavior flagging detects patterns that fall outside the distribution of control animals
Endpoints

Unbiased behavioral structure variables

Behavioral cluster assignments per frame

Behavioral cluster assignments per frame

Each frame assigned to a behavioral cluster without predefined labels. Cluster identities are consistent within and across sessions for direct comparison.

CSV
UMAP embeddings and visualization

UMAP embeddings and visualization

Low-dimensional embedding coordinates for each frame, color-coded by cluster, condition, or time. Publication-ready UMAP visualizations exported as images.

CSVPNG
Transition probabilities between clusters

Transition probabilities between clusters

Markov transition matrix between behavioral clusters. Reveals sequential structure — which behavioral states follow which — and how transitions differ across conditions.

CSVJSON
Density-difference mapping

Density-difference mapping

Group-level kernel density estimates over the UMAP manifold with permutation testing. Reveals localized regions where one condition occupies behavioral microstates more frequently than another.

CSVPNG
Applications

Discovery-oriented experimental designs

Drug discovery

Phenotype-first drug screening

Screen compounds for behavioral effects without specifying which behaviors to look for. Unsupervised clustering detects any behavioral shift relative to vehicle control.

Measures
  • Cluster occupancy distribution
  • Behavioral state entropy
  • Effect size vs vehicle
Biomarker identification

Novel behavioral biomarker identification

Discover behavioral signatures that discriminate disease model from control without prior hypotheses. Identified clusters can be characterized post-hoc and validated in independent cohorts.

Measures
  • Discriminative cluster identity
  • Classification accuracy
  • Biomarker sensitivity/specificity
Genetic phenotyping

Strain comparison without prior hypotheses

Compare behavioral repertoires across strains or genotypes using unbiased embedding. Detect strain-specific behavioral motifs that standard ethograms do not include.

Measures
  • Strain-specific cluster occupancy
  • Behavioral repertoire overlap
  • Novel motif frequency
Mechanism of action

Drug effect discovery

Characterize the full behavioral profile of a novel compound. Identify which behavioral clusters are expanded, compressed, or newly introduced relative to control.

Measures
  • Cluster shift magnitude
  • New cluster emergence
  • Transition structure alteration
Neurotrauma

Post-injury behavioral assessment

Detect subtle behavioral shifts following traumatic brain injury without predefined endpoints. Unsupervised embedding reveals injury-associated behavioral microstates that conventional motor scoring misses.

Measures
  • Microstate occupancy shift
  • Density-difference significance
  • Kinematic effect sizes
Compared to typical systems

How ConductVision differs

FeatureConductVisionTypical systems
Discovery modeUnsupervised — no predefined labelsSupervised — scores only predefined behaviors
Observer biasEliminated — data-driven clusteringPresent — scorer selects what to score
Novel behavior detectionAutomatic flaggingNot possible with fixed ethogram
Ethogram requiredNo — categories emerge from dataYes — must define behaviors in advance
Cross-condition comparisonUMAP overlay with statistical testingLimited to predefined measures
Density mappingKernel density estimation with permutation testingNot available

Discover behaviors your rubric doesn't include

Upload recordings from two conditions and see unsupervised clustering reveal behavioral differences you did not define.