Dissolution Tester
Three-basket dissolution tester with dual-function electric lifting, high-precision rotation control, and integrated temperature management for USP pharmacopeial dissolution testing of solid dosage forms.
Louise Corscadden, PhD
Director of Science · ConductScience
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Key Specifications
Full details →- Model fit
- 4 selectable configurations
- SKU family
- BIO-BRC-3
- Shipping box
- 42.0 x 43.6 x 38.0 cm
- Ordering
- Online checkout and quote request available
- Category
- Dissolution Testing
- Build notes
- Confirm accessories, station layout, and support needs before purchase
Advanced dissolution tester designed for pharmaceutical research and quality assurance. Provides precise control and accurate measurement of drug dissolution rates. Available in multiple vessel configurations for flexible testing requirements.
How It Works
Dissolution testing operates on the principle of controlled hydrodynamic conditions to simulate gastrointestinal drug release. The BIO-BRC-3 system uses rotating baskets or paddles to create standardized fluid motion patterns around the dosage form, ensuring consistent mass transfer conditions. The high-precision rotation control maintains specified RPM values to generate reproducible hydrodynamic environments that influence boundary layer thickness and dissolution rate.
Temperature control systems rapidly heat and maintain dissolution media at physiological temperatures (typically 37°C), while the dual-function lifting mechanism allows precise positioning of test heads and automated sampling protocols. The three-basket configuration enables simultaneous testing of multiple units or different formulations under identical conditions, improving statistical power and experimental efficiency.
Independent timer functions coordinate test initiation, sampling timepoints, and protocol termination, while automated parameter storage ensures method consistency across testing sessions. The system maintains sink conditions through media volume control and stirring optimization, preventing precipitation and ensuring accurate dissolution kinetics measurement.
Features & Benefits
Shipping weight
- 11.0 lb
Shipping box
- L: 42.0 cm
- W: 43.6 cm
- H: 38.0 cm
| Model | SKU | Listed price | Status | Shipping box |
|---|---|---|---|---|
| 8-Vessel | BK-RC8 | $4,390.00 | Available | 42.0 x 43.6 x 38.0 cm |
| 6-Vessel | BK-RC6 | $3,190.00 | Available | 42.0 x 43.6 x 38.0 cm |
| 3-Vessel | BK-RC3 | $2,490.00 | Available | 42.0 x 43.6 x 38.0 cm |
| 1-Vessel | BK-RC1 | $1,490.00 | Available | 42.0 x 43.6 x 38.0 cm |
Practical Tips
Verify temperature accuracy at multiple points within each vessel using calibrated thermometers before initiating dissolution testing.
Why: Temperature uniformity directly affects dissolution kinetics and must meet USP calibration requirements for method validation.
Check rotation speed accuracy monthly using a calibrated tachometer at all vessel positions to ensure consistent hydrodynamic conditions.
Why: Rotation speed variations alter boundary layer thickness and can significantly impact dissolution rate measurements.
Clean all wetted surfaces with appropriate solvents after each test and inspect baskets for wear or deformation that could affect flow patterns.
Why: Residual drug deposits or damaged apparatus components introduce variability in subsequent dissolution measurements.
Allow sufficient equilibration time after media addition before dosage form introduction to ensure stable thermal and hydrodynamic conditions.
Why: Temperature fluctuations during test initiation can cause dissolution artifacts and affect early timepoint accuracy.
Use consistent dosage form placement techniques within baskets to minimize position-dependent dissolution variability between replicates.
Why: Dosage form positioning affects local hydrodynamics and can introduce systematic bias in dissolution rate measurements.
Perform dissolution testing of USP prednisone or salicylic acid reference standards periodically to verify system performance and mechanical calibration.
Why: Reference standard testing provides objective evidence of apparatus suitability and helps identify drift in mechanical performance.
Monitor for air bubble formation on dosage forms or apparatus surfaces, particularly when testing poorly soluble compounds or using degassed media.
Why: Air bubbles alter local hydrodynamics and can cause artificially slow dissolution rates or increased measurement variability.
Ensure adequate ventilation around heating elements and verify overheat protection functionality during initial system qualification.
Why: Proper thermal management prevents equipment damage and maintains safe operating conditions during extended dissolution protocols.
Setup Guide
Complete installation support and operator training included. System includes heating apparatus, vessel holders, paddle assemblies, and temperature control unit.What’s in the Box
- BIO-BRC-3 main dissolution testing unit
- Three dissolution baskets with mounting hardware
- Paddle attachments for USP Apparatus 2 testing
- Temperature calibration probe
- Power cord and electrical connections
- User manual and operation guide
- Method parameter setup documentation
- Safety and maintenance instructions
Warranty
ConductScience provides a one-year manufacturer warranty covering defects in materials and workmanship, with technical support for method development and troubleshooting assistance.
Compliance
Comprehensive operation manuals, calibration procedures, maintenance schedules, and technical documentation included. Technical support available.References
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