Research data · Animal model and test
Open field with restraint stress
From 2021 to 2025, 136 animal research papers mentioned restraint stress and the open field in their title or abstract.
That is 2.9 times the 47 papers of 2011 to 2015. Between the same two periods, the papers that mention restraint stress and any of the 90 tests we count grew more slowly, to 1.3 times as many.
Papers by year
Animal research papers that mention restraint stress and the open field, by year, 2001 to 2026
The 2026 bar counts papers added to PubMed by November 8, 2026.
- Papers in a full year
- 2026 so far
Show the counts for each year
| Year | Papers |
|---|---|
| 2001 | 2 |
| 2002 | 7 |
| 2003 | 3 |
| 2004 | 4 |
| 2005 | 4 |
| 2006 | 5 |
| 2007 | 4 |
| 2008 | 5 |
| 2009 | 7 |
| 2010 | 10 |
| 2011 | 4 |
| 2012 | 6 |
| 2013 | 11 |
| 2014 | 9 |
| 2015 | 17 |
| 2016 | 10 |
| 2017 | 15 |
| 2018 | 18 |
| 2019 | 22 |
| 2020 | 16 |
| 2021 | 24 |
| 2022 | 29 |
| 2023 | 20 |
| 2024 | 31 |
| 2025 | 32 |
| 2026 (part year) | 33 |
Papers that mention restraint stress and the open field fell from 24 in 2021 to 20 in 2023, then rose to 32 in 2025. Part of this dip may come from PubMed's indexing rather than from fewer studies. We take a paper's species from PubMed's indexing when the indexing names one. Otherwise PubTator 3, NCBI's text-mining service, has to find a species in the title or abstract, or the paper is not counted. Papers that PubMed indexed under the subject heading Animals also fell and rose, from 200,221 in 2021 to 156,447 in 2023 and 235,479 in 2025.
Which species the papers used
Each bar is a share of the 136 papers from 2021 to 2025. A paper can use more than one species, so the shares can add to more than 100%.
Species
Tests mentioned alongside the open field
Each bar is one test, with how many of the 136 papers also mention it, and what share that is. Of these papers, 18 (13%) mention no other test.
The 12 tests these papers mention most
Which papers count
A paper counts here when it is animal research and its title or abstract mentions restraint stress and the open field.
A paper that mentions either only in its methods is missed, so the count runs low. The search terms are in the list of models and techniques and the test list. The full method, with each source and its terms of use, is on our main page, Behavioral tests in published research.
More pairings
Every pairing of an animal model and a test with 30 or more papers from 2021 to 2025 has a page like this one.
Other tests with restraint stress
The open field with other animal models and brain techniques
- Chronic unpredictable stress 382 papers
- Lipopolysaccharide (LPS) 188 papers
- Exercise 106 papers
- High-fat diet 97 papers
- Intracerebroventricular (ICV) injection 84 papers
- MPTP 81 papers
- Maternal separation and early-life stress 72 papers
- AAV vectors 70 papers
- Sleep deprivation 70 papers
- Middle cerebral artery occlusion (MCAO) 61 papers
- Social isolation 57 papers
- Chemogenetics (DREADDs) 56 papers
- EEG and ECoG 51 papers
- 6-OHDA 50 papers
- Social defeat stress 49 papers
- Streptozotocin diabetes 47 papers
- Pentylenetetrazole (PTZ) 43 papers
- Traumatic brain injury (CCI, fluid percussion, weight drop) 43 papers
- Spinal cord injury 42 papers
- Nerve injury 41 papers
- Rotenone 40 papers
- Sepsis 40 papers
- Intranasal delivery 37 papers
- Environmental enrichment 36 papers
- Ovariectomy 36 papers
- In vivo electrophysiology 33 papers
- MK-801 31 papers
- Optogenetics 31 papers
- Scopolamine 31 papers
- Reserpine 30 papers
The page on the open field counts all the papers that mention it, whatever they study. The page on restraint stress ranks the tests mentioned with it.
How to cite
APA
ConductScience. (2026, November 13). Open field with restraint stress [Data set]. https://conductscience.com/resources/data/animal-models/restraint-stress/open-field
BibTeX
@misc{conductscience_restraint_stress_open_field_2026,
author = {{ConductScience}},
title = {Open field with restraint stress},
year = {2026},
month = nov,
url = {https://conductscience.com/resources/data/animal-models/restraint-stress/open-field},
note = {Data set, released November 13, 2026},
}Open field apparatus in our store
In the test battery tool, pick every test your study will run and add the apparatus we sell for them to one quote.
For studies with restraint stress, our store sells:
