Research data

Animal models in behavioral research

From 2021 to 2025, 12,400 animal research papers mentioned a behavioral test and one of these 53 animal models, from drugs and surgery to stress and diet.

12,400 animal research papers from 2021 to 2025 mentioned a test and one of these animal models
38% of the 32,277 animal research papers from 2021 to 2025 that mention a test also mention one of these animal models
53 animal models counted, 43 with a page of their own

Every animal model we count

Each bar counts the animal research papers from 2021 to 2025 that mention the animal model and at least one of the 90 behavioral tests. Under each name are the three tests mentioned most in its papers, with the share of its papers that mention each. Each animal model with 100 or more such papers has a page of its own, except haloperidol, which most of the papers we read give as a comparison drug rather than to produce a condition.

Drugs and toxins

Lipopolysaccharide (LPS)Forced swim test 23% · Morris water maze 22% · Open field 21%
876 papers
Streptozotocin diabetesMorris water maze 35% · Treadmill running 13% · Elevated plus maze 11%
510 papers
ScopolamineMorris water maze 46% · Y-maze 32% · Novel object recognition 28%
483 papers
Chemotherapy drugsVon Frey test 35% · Hot plate 14% · Novel object recognition 10%
323 papers
CarrageenanWrithing test 49% · Hot plate 38% · Formalin test 32%
317 papers
6-OHDARotarod 24% · Open field 20% · Rotational behavior (rotometer) 16%
255 papers
MPTPRotarod 51% · Open field 33% · Pole test 28%
249 papers
D-galactoseMorris water maze 64% · Novel object recognition 18% · Y-maze 15%
244 papers
Complete Freund's adjuvant (CFA)Von Frey test 42% · Hot plate 14% · Open field 13%
216 papers
Pentylenetetrazole (PTZ)Elevated plus maze 25% · Open field 20% · Rotarod 19%
212 papers
MK-801Prepulse inhibition and acoustic startle 28% · Novel object recognition 23% · Open field 16%
190 papers
Streptozotocin in the brain (ICV-STZ)Morris water maze 65% · Novel object recognition 30% · Passive avoidance 25%
174 papers
Kainic acid or pilocarpine seizuresMorris water maze 37% · Novel object recognition 19% · Open field 12%
161 papers
RotenoneRotarod 45% · Open field 25% · Catalepsy bar test 19%
160 papers
Aluminum chlorideMorris water maze 61% · Y-maze 20% · Novel object recognition 20%
157 papers
Prenatal valproic acidThree-chamber sociability test 28% · Social interaction test 19% · Elevated plus maze 19%
149 papers
HaloperidolCatalepsy bar test 44% · Rotarod 15% · Open field 14%
135 papers
Radiation exposureMorris water maze 25% · Novel object recognition 23% · Open field 18%
125 papers
Chronic corticosteroneForced swim test 50% · Sucrose preference test 32% · Tail suspension test 28%
109 papers
ReserpineForced swim test 48% · Open field 28% · Catalepsy bar test 18%
109 papers
Maternal immune activationPrepulse inhibition and acoustic startle 40% · Open field 19% · Novel object recognition 16%
103 papers
CuprizoneRotarod 36% · Y-maze 26% · Open field 15%
85 papers
Monosodium iodoacetateVon Frey test 39% · Treadmill running 14% · Gait analysis 13%
69 papers
3-Nitropropionic acid (3-NP)Rotarod 61% · Beam walking 34% · Open field 26%
38 papers

Surgery

Middle cerebral artery occlusion (MCAO)Morris water maze 30% · Rotarod 23% · Open field 12%
494 papers
Nerve injuryVon Frey test 49% · Hot plate 12% · Open field 8%
485 papers
Spinal cord injuryGait analysis 33% · Treadmill running 19% · Von Frey test 13%
395 papers
Traumatic brain injury (CCI, fluid percussion, weight drop)Morris water maze 36% · Rotarod 18% · Beam walking 16%
334 papers
OvariectomyForced swim test 18% · Morris water maze 16% · Treadmill running 13%
309 papers
Carotid artery occlusion (BCCAO, 2VO)Morris water maze 70% · Novel object recognition 22% · Y-maze 14%
264 papers
SepsisMorris water maze 47% · Open field 25% · Novel object recognition 25%
161 papers
Neonatal hypoxia-ischemiaMorris water maze 43% · Rotarod 17% · Novel object recognition 16%
125 papers
Intracerebral hemorrhageRotarod 26% · Corner test 20% · Morris water maze 16%
114 papers
Photothrombotic strokeGrid walking (foot fault) 29% · Cylinder test 21% · Skilled reaching 18%
87 papers
Subarachnoid hemorrhageMorris water maze 39% · Rotarod 38% · Beam walking 27%
64 papers
Olfactory bulbectomySucrose preference test 17% · Open field 14% · Tail suspension test 14%
35 papers

Stress

Chronic unpredictable stressForced swim test 59% · Sucrose preference test 59% · Open field 39%
973 papers
Restraint stressForced swim test 34% · Elevated plus maze 28% · Open field 25%
553 papers
Maternal separation and early-life stressForced swim test 27% · Elevated plus maze 24% · Open field 21%
343 papers
Social defeat stressForced swim test 30% · Social interaction test 23% · Sucrose preference test 22%
304 papers
Social isolationOpen field 21% · Forced swim test 19% · Elevated plus maze 18%
276 papers
Predator stressPredator odor exposure 83% · Elevated plus maze 19% · Fear conditioning 9%
206 papers
Single prolonged stressFear conditioning 49% · Elevated plus maze 44% · Forced swim test 20%
142 papers

Diet, sleep, exercise and housing

ExerciseGrip strength 20% · Morris water maze 17% · Forced swim test 13%
916 papers
High-fat dietMorris water maze 22% · Treadmill running 21% · Novel object recognition 12%
868 papers
Sleep deprivationMorris water maze 32% · Open field 23% · Novel object recognition 15%
306 papers
Environmental enrichmentMorris water maze 24% · Elevated plus maze 18% · Novel object recognition 16%
295 papers
Gut microbiota depletion or transplantMorris water maze 19% · Novel object recognition 13% · Elevated plus maze 13%
166 papers
Calorie restriction and fastingElevated plus maze 16% · Open field 14% · Novel object recognition 13%
120 papers
Intermittent or chronic hypoxiaMorris water maze 48% · Open field 18% · Novel object recognition 13%
113 papers
Circadian disruptionWheel running 32% · Open field 18% · Novel object recognition 17%
66 papers
Chronic intermittent ethanol (CIE)Self-administration 28% · Forced swim test 19% · Elevated plus maze 12%
58 papers
Ketogenic dietMorris water maze 25% · Novel object recognition 15% · Treadmill running 12%
52 papers

The 9 other animal models without a link have fewer than 100 such papers.

How we counted

A paper counts when it is animal research and its title or abstract mentions one of an animal model's search terms and one of the 90 behavioral tests. A count is a number of papers, not of experiments, labs or animals. A paper that mentions the animal model only in its methods is missed, so the counts run low.

Each model has its own search terms, matched as whole words, with rules that skip other meanings. Streptozotocin given into the brain counts apart from streptozotocin that causes diabetes, and CFA counts as a pain model only in papers that name neither EAE nor immunization. A paper is animal research when its MeSH terms name an animal species. If they name none, NCBI's text-mining service PubTator 3 has to find one in the title or abstract. Papers on animals other than mice, rats, zebrafish, flies and primates count only when they also mention a test. Many of them study people or use the same words for something else. A paper can count under more than one animal model.

The search terms for each animal model are in the downloads below. The full method, with each source and its terms of use, is on our main page, Behavioral tests in published research.

Download the data

Each file covers both the animal models and the brain techniques.

How to cite

APA

ConductScience. (2026, November 13). Animal models in behavioral research [Data set]. https://conductscience.com/resources/data/animal-models

BibTeX

@misc{conductscience_animal_models_2026,
  author = {{ConductScience}},
  title = {Animal models in behavioral research},
  year = {2026},
  month = nov,
  url = {https://conductscience.com/resources/data/animal-models},
  note = {Data set, released November 13, 2026},
}

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