Research data ยท Animal model

D-galactose

From 2021 to 2025, 244 animal research papers mentioned D-galactose and at least one behavioral test.

That is 3.4 times the 71 papers of 2011 to 2015. Between the same two periods, all the animal research papers that mention any of the 90 tests we count grew more slowly, to 1.2 times as many.

244 animal research papers from 2021 to 2025 mentioned D-galactose and a test
3.4 times as many papers as in 2011 to 2015
64% of these papers mention the Morris water maze
24% of the 1,036 animal research papers from 2021 to 2025 that mention D-galactose also mention a test

The tests mentioned with D-galactose

The Morris water maze appears in 64% of these papers and in 17% of all 32,277 papers that mention a test. That makes it 3.9 times as common in this research. Each bar is one test, with how many of the 244 papers from 2021 to 2025 mention it, and what share that is. A paper that mentions two tests counts under both.

The 15 tests these papers mention most

157 papers 64%
37 papers 15%
21 papers 9%
21 papers 9%
16 papers 7%
10 papers 4%
7 papers 3%
4 papers 2%
All 27 tests these papers mention
Papers from 2021 to 2025 that mention D-galactose and each test
TestPapersShare of the 244 papers
Morris water maze15764%
Novel object recognition4418%
Y-maze3715%
Open field219%
Grip strength219%
Passive avoidance167%
Elevated plus maze104%
Treadmill running94%
Step-down avoidance73%
Fear conditioning73%
Radial arm maze73%
Forced swim test42%
Tail suspension test42%
Sucrose preference test31%
Active avoidance (shuttle box)31%
Object location test21%
Rotarod21%
Barnes maze21%
Nest building21%
Light-dark box21%
Wire hang and inverted grid21%
Novelty-suppressed feeding1under 1%
T-maze1under 1%
Social interaction test1under 1%
Writhing test1under 1%
Gait analysis1under 1%
Splash test1under 1%

Tests named in 30 or more of these papers link to a page on that test with D-galactose. To count the papers that mention two or more tests together, use the test battery tool.

Papers by year

Animal research papers that mention D-galactose and a behavioral test, by year, 2001 to 2026

The 2026 bar counts papers added to PubMed by November 8, 2026.

  • Papers in a full year
  • 2026 so far
Show the counts for each year
Papers by year
YearPapers
20011
20023
20032
20041
20052
20067
20075
20087
20099
201011
201114
201211
20139
201418
201519
201626
201726
201832
201923
202036
202147
202247
202344
202445
202561
2026 (part year)69

Disease models in papers that mention D-galactose

Each bar is one disease model, with how many of the 244 papers from 2021 to 2025 are tagged with it, and what share that is. The model comes from the paper's MeSH terms, the subject headings the National Library of Medicine adds when it indexes a paper. A paper without MeSH terms gets its model from PubTator 3, NCBI's text-mining service, if PubTator 3 finds the disease in the title or abstract. A paper can count under more than one model.

Papers from 2021 to 2025 by disease model

88 papers 36%
74 papers 30%
10 papers 4%
7 papers 3%
2 papers 1%
1 paper under 1%

Which species the papers used

Each bar is a share of the 244 papers from 2021 to 2025. A paper can use more than one species, so the shares can add to more than 100%.

Species

Mouse
146 papers 60%
Rat
105 papers 43%
Zebrafish
1 paper under 1%

The most cited papers from 2021 to 2025

These papers from 2021 to 2025 mention D-galactose and a behavioral test and have the most citations, as counted by NIH's iCite on November 5, 2026.

  1. Vitamin D exerts neuroprotection via SIRT1/nrf-2/ NF-kB signaling pathways against D-galactose-induced memory impairment in adult mice.

    Neurochem Int, 2021. 83 citations.

  2. Effects of melatonin and resveratrol on recognition memory and passive avoidance performance in a mouse model of Alzheimer's disease.

    Behav Brain Res, 2021. 69 citations.

  3. Anti-aging effect of phlorizin on D-galactose-induced aging in mice through antioxidant and anti-inflammatory activity, prevention of apoptosis, and regulation of the gut microbiota.

    Exp Gerontol, 2022. 59 citations.

  4. Metrnl regulates cognitive dysfunction and hippocampal BDNF levels in D-galactose-induced aging mice.

    Acta Pharmacol Sin, 2023. 56 citations.

  5. Taxifolin retards the D-galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in mice.

    Food Funct, 2021. 55 citations.

How we counted

A paper counts here when it is animal research and its title or abstract mentions D-galactose and at least one of the 90 behavioral tests. A count is a number of papers, not of experiments, labs or animals. A paper that mentions D-galactose only in its methods is missed, so the count runs low.

A paper is animal research when its MeSH terms name an animal species. If they name none, NCBI's text-mining service PubTator 3 has to find one in the title or abstract. Papers on animals other than mice, rats, zebrafish, flies and primates count only when they also mention a test. Many of them study people or use the same words for something else.

The search terms for D-galactose are in the download Animal models and brain techniques. The counts in the chart of tests are in Tests mentioned with each model or technique. The full method, with each source and its terms of use, is on our main page, Behavioral tests in published research.

More animal models

Each animal model with 100 or more papers from 2021 to 2025 that mention a test has a page. These are the others, each with that count.

How to cite

APA

ConductScience. (2026, November 13). Behavioral tests with D-galactose [Data set]. https://conductscience.com/resources/data/animal-models/d-galactose

BibTeX

@misc{conductscience_d_galactose_2026,
  author = {{ConductScience}},
  title = {Behavioral tests with D-galactose},
  year = {2026},
  month = nov,
  url = {https://conductscience.com/resources/data/animal-models/d-galactose},
  note = {Data set, released November 13, 2026},
}

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