Research data · Animal model

Scopolamine

From 2021 to 2025, 483 animal research papers mentioned scopolamine and at least one behavioral test.

That is 1.2 times the 388 papers of 2011 to 2015. Between the same two periods, all the animal research papers that mention any of the 90 tests we count grew about as fast, to 1.2 times as many.

483 animal research papers from 2021 to 2025 mentioned scopolamine and a test
1.2 times as many papers as in 2011 to 2015
46% of these papers mention the Morris water maze
54% of the 895 animal research papers from 2021 to 2025 that mention scopolamine also mention a test

The tests mentioned with scopolamine

Passive avoidance appears in 28% of these papers and in 3.5% of all 32,277 papers that mention a test. That makes it 8.0 times as common in this research. Each bar is one test, with how many of the 483 papers from 2021 to 2025 mention it, and what share that is. A paper that mentions two tests counts under both.

The 15 tests these papers mention most

223 papers 46%
153 papers 32%
136 papers 28%
43 papers 9%
31 papers 6%
23 papers 5%
21 papers 4%
21 papers 4%
12 papers 2%
8 papers 2%
8 papers 2%
7 papers 1%
All 40 tests these papers mention
Papers from 2021 to 2025 that mention scopolamine and each test
TestPapersShare of the 483 papers
Morris water maze22346%
Y-maze15332%
Novel object recognition13728%
Passive avoidance13628%
Elevated plus maze439%
Open field316%
Novel tank test235%
Forced swim test214%
T-maze214%
Fear conditioning122%
Step-down avoidance112%
Tail suspension test102%
Light-dark box82%
Radial arm maze82%
Rotarod71%
Barnes maze71%
Object location test61%
Novelty-suppressed feeding61%
Hole-board61%
Operant conditioning51%
Catalepsy bar test51%
Prepulse inhibition and acoustic startle41%
Attentional set shifting31%
Sucrose preference test31%
Grip strength31%
Self-grooming2under 1%
Active avoidance (shuttle box)2under 1%
Treadmill running2under 1%
Beam walking2under 1%
Marble burying2under 1%
Touchscreen operant tasks1under 1%
Elevated T-maze1under 1%
Olfactory tests1under 1%
Ladder rung walking1under 1%
Skilled reaching1under 1%
Von Frey test1under 1%
Gait analysis1under 1%
Splash test1under 1%
Conditioned place preference1under 1%
Rotational behavior (rotometer)1under 1%

Tests named in 30 or more of these papers link to a page on that test with scopolamine. To count the papers that mention two or more tests together, use the test battery tool.

Papers by year

Animal research papers that mention scopolamine and a behavioral test, by year, 2001 to 2026

The 2026 bar counts papers added to PubMed by November 8, 2026.

  • Papers in a full year
  • 2026 so far
Show the counts for each year
Papers by year
YearPapers
200167
200257
200351
200455
200549
200663
200773
200853
200968
201066
201174
201284
201371
201473
201586
201685
2017103
201888
201993
202085
202197
202297
202379
2024100
2025110
2026 (part year)88

Papers that mention scopolamine and a test fell from 97 in 2021 to 79 in 2023, then rose to 110 in 2025. Part of this dip may come from PubMed's indexing rather than from fewer studies. We take a paper's species from PubMed's indexing when the indexing names one. Otherwise PubTator 3, NCBI's text-mining service, has to find a species in the title or abstract, or the paper is not counted. Papers that PubMed indexed under the subject heading Animals also fell and rose, from 200,221 in 2021 to 156,447 in 2023 and 235,479 in 2025.

Disease models in papers that mention scopolamine

Each bar is one disease model, with how many of the 483 papers from 2021 to 2025 are tagged with it, and what share that is. The model comes from the paper's MeSH terms, the subject headings the National Library of Medicine adds when it indexes a paper. A paper without MeSH terms gets its model from PubTator 3, NCBI's text-mining service, if PubTator 3 finds the disease in the title or abstract. A paper can count under more than one model.

Papers from 2021 to 2025 by disease model

166 papers 34%
24 papers 5%
20 papers 4%
9 papers 2%
4 papers 1%

Which species the papers used

Each bar is a share of the 483 papers from 2021 to 2025. A paper can use more than one species, so the shares can add to more than 100%.

Species

Mouse
259 papers 54%
Rat
207 papers 43%
Zebrafish
31 papers 6%
Other animals
7 papers 1%
Nonhuman primate
1 paper under 1%

“Other animals” counts papers that use none of the species this chart names.

NIH funding

7 of the 483 papers (1%) had NIH funding. NIMH, the National Institute of Mental Health, funded the most, 5 of them. A paper counts as NIH-funded when its PubMed record lists an NIH grant, or when NIH RePORTER links it to an NIH project.

NIH-funded papers by institute

NIMHNational Institute of Mental Health
5 papers 71%
NIDA
2 papers 29%
NCINational Cancer Institute
1 paper 14%
NIANational Institute on Aging
1 paper 14%
NINDSNational Institute of Neurological Disorders and Stroke
1 paper 14%
NIAAANational Institute on Alcohol Abuse and Alcoholism
1 paper 14%

Each share is of the NIH-funded papers. A paper with grants from two institutes counts under both.

The most cited papers from 2021 to 2025

These papers from 2021 to 2025 mention scopolamine and a behavioral test and have the most citations, as counted by NIH's iCite on November 5, 2026.

  1. Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapid antidepressant responses.

    Mol Psychiatry, 2021. 108 citations.

  2. Walnut-Derived Peptide Activates PINK1 via the NRF2/KEAP1/HO-1 Pathway, Promotes Mitophagy, and Alleviates Learning and Memory Impairments in a Mice Model.

    J Agric Food Chem, 2021. 59 citations.

  3. Protective effect of ginsenoside Rh2 on scopolamine-induced memory deficits through regulation of cholinergic transmission, oxidative stress and the ERK-CREB-BDNF signaling pathway.

    Phytother Res, 2021. 59 citations.

  4. Pharmacokinetic and pharmacodynamic evaluation of nasal liposome and nanoparticle based rivastigmine formulations in acute and chronic models of Alzheimer's disease.

    Naunyn Schmiedebergs Arch Pharmacol, 2021. 56 citations.

  5. Histological and imunohistochemical alterations of hippocampus and prefrontal cortex in a rat model of Alzheimer like-disease with a preferential role of the flavonoid "hesperidin".

    J Mol Histol, 2021. 43 citations.

How we counted

A paper counts here when it is animal research and its title or abstract mentions scopolamine and at least one of the 90 behavioral tests. A count is a number of papers, not of experiments, labs or animals. A paper that mentions scopolamine only in its methods is missed, so the count runs low.

A paper is animal research when its MeSH terms name an animal species. If they name none, NCBI's text-mining service PubTator 3 has to find one in the title or abstract. Papers on animals other than mice, rats, zebrafish, flies and primates count only when they also mention a test. Many of them study people or use the same words for something else.

The search terms for scopolamine are in the download Animal models and brain techniques. The counts in the chart of tests are in Tests mentioned with each model or technique. The full method, with each source and its terms of use, is on our main page, Behavioral tests in published research.

More animal models

Each animal model with 100 or more papers from 2021 to 2025 that mention a test has a page. These are the others, each with that count.

How to cite

APA

ConductScience. (2026, November 13). Behavioral tests with scopolamine [Data set]. https://conductscience.com/resources/data/animal-models/scopolamine

BibTeX

@misc{conductscience_scopolamine_2026,
  author = {{ConductScience}},
  title = {Behavioral tests with scopolamine},
  year = {2026},
  month = nov,
  url = {https://conductscience.com/resources/data/animal-models/scopolamine},
  note = {Data set, released November 13, 2026},
}

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