Research data · Animal model
Lipopolysaccharide (LPS)
From 2021 to 2025, 876 animal research papers mentioned LPS and at least one behavioral test.
That is 2.8 times the 313 papers of 2011 to 2015. Between the same two periods, all the animal research papers that mention any of the 90 tests we count grew more slowly, to 1.2 times as many.
The tests mentioned with LPS
The tail suspension test appears in 15% of these papers and in 4.4% of all 32,277 papers that mention a test. That makes it 3.5 times as common in this research. Each bar is one test, with how many of the 876 papers from 2021 to 2025 mention it, and what share that is. A paper that mentions two tests counts under both.
The 15 tests these papers mention most
All 63 tests these papers mention
| Test | Papers | Share of the 876 papers |
|---|---|---|
| Forced swim test | 200 | 23% |
| Morris water maze | 193 | 22% |
| Open field | 188 | 21% |
| Tail suspension test | 134 | 15% |
| Y-maze | 117 | 13% |
| Sucrose preference test | 110 | 13% |
| Novel object recognition | 106 | 12% |
| Elevated plus maze | 85 | 10% |
| Rotarod | 45 | 5% |
| Passive avoidance | 42 | 5% |
| Fear conditioning | 35 | 4% |
| Von Frey test | 29 | 3% |
| Grip strength | 26 | 3% |
| Hot plate | 19 | 2% |
| Light-dark box | 19 | 2% |
| Barnes maze | 17 | 2% |
| Treadmill running | 16 | 2% |
| Novelty-suppressed feeding | 15 | 2% |
| Writhing test | 14 | 2% |
| Three-chamber sociability test | 14 | 2% |
| Formalin test | 12 | 1% |
| Social interaction test | 12 | 1% |
| Pole test | 11 | 1% |
| Beam walking | 9 | 1% |
| T-maze | 8 | 1% |
| Marble burying | 8 | 1% |
| Prepulse inhibition and acoustic startle | 7 | 1% |
| Operant conditioning | 7 | 1% |
| Wheel running | 7 | 1% |
| Hole-board | 7 | 1% |
| Olfactory tests | 7 | 1% |
| Self-grooming | 7 | 1% |
| Tail flick | 5 | 1% |
| Splash test | 5 | 1% |
| Active avoidance (shuttle box) | 5 | 1% |
| Wire hang and inverted grid | 5 | 1% |
| Negative geotaxis and climbing assays | 5 | 1% |
| Self-administration | 5 | 1% |
| Gait analysis | 5 | 1% |
| Elevated zero maze | 4 | under 1% |
| Conditioned place preference | 4 | under 1% |
| Object location test | 4 | under 1% |
| Radial arm maze | 3 | under 1% |
| Five-choice serial reaction time task | 3 | under 1% |
| Step-down avoidance | 3 | under 1% |
| Catalepsy bar test | 3 | under 1% |
| Predator odor exposure | 3 | under 1% |
| Nest building | 3 | under 1% |
| Learned helplessness | 2 | under 1% |
| Cylinder test | 2 | under 1% |
| Ladder rung walking | 2 | under 1% |
| Rotational behavior (rotometer) | 2 | under 1% |
| Novel tank test | 2 | under 1% |
| Resident-intruder test | 2 | under 1% |
| Cold plate | 2 | under 1% |
| Grid walking (foot fault) | 2 | under 1% |
| Attentional set shifting | 1 | under 1% |
| Puzzle box | 1 | under 1% |
| Burrowing | 1 | under 1% |
| Adhesive removal test | 1 | under 1% |
| Corner test | 1 | under 1% |
| Social approach and avoidance | 1 | under 1% |
| Paw pressure test | 1 | under 1% |
Tests named in 30 or more of these papers link to a page on that test with LPS. To count the papers that mention two or more tests together, use the test battery tool.
Papers by year
Animal research papers that mention LPS and a behavioral test, by year, 2001 to 2026
The 2026 bar counts papers added to PubMed by November 8, 2026.
- Papers in a full year
- 2026 so far
Show the counts for each year
| Year | Papers |
|---|---|
| 2001 | 14 |
| 2002 | 11 |
| 2003 | 6 |
| 2004 | 20 |
| 2005 | 24 |
| 2006 | 29 |
| 2007 | 26 |
| 2008 | 30 |
| 2009 | 31 |
| 2010 | 38 |
| 2011 | 52 |
| 2012 | 40 |
| 2013 | 64 |
| 2014 | 70 |
| 2015 | 87 |
| 2016 | 92 |
| 2017 | 104 |
| 2018 | 132 |
| 2019 | 150 |
| 2020 | 145 |
| 2021 | 157 |
| 2022 | 169 |
| 2023 | 171 |
| 2024 | 183 |
| 2025 | 196 |
| 2026 (part year) | 192 |
Disease models in papers that mention LPS
Each bar is one disease model, with how many of the 876 papers from 2021 to 2025 are tagged with it, and what share that is. The model comes from the paper's MeSH terms, the subject headings the National Library of Medicine adds when it indexes a paper. A paper without MeSH terms gets its model from PubTator 3, NCBI's text-mining service, if PubTator 3 finds the disease in the title or abstract. A paper can count under more than one model.
Papers from 2021 to 2025 by disease model
Which species the papers used
Each bar is a share of the 876 papers from 2021 to 2025. A paper can use more than one species, so the shares can add to more than 100%.
Species
“Other animals” counts papers that use none of the species this chart names.
NIH funding
56 of the 876 papers (6%) had NIH funding. NIMH, the National Institute of Mental Health, funded the most, 15 of them. A paper counts as NIH-funded when its PubMed record lists an NIH grant, or when NIH RePORTER links it to an NIH project.
NIH-funded papers by institute
Each share is of the NIH-funded papers. A paper with grants from two institutes counts under both.
The most cited papers from 2021 to 2025
These papers from 2021 to 2025 mention LPS and a behavioral test and have the most citations, as counted by NIH's iCite on November 5, 2026.
Autophagy, 2023. 187 citations.
Br J Pharmacol, 2021. 158 citations.
Lipopolysaccharide-induced depression-like model in mice: meta-analysis and systematic evaluation.
Front Immunol, 2023. 139 citations.
J Neuroinflammation, 2022. 125 citations.
Redox Biol, 2024. 121 citations.
How we counted
A paper counts here when it is animal research and its title or abstract mentions LPS and at least one of the 90 behavioral tests. A count is a number of papers, not of experiments, labs or animals. A paper that mentions LPS only in its methods is missed, so the count runs low.
Many animal research papers that mention LPS use it on cells, measure it in blood or study it in bacteria. We count LPS only in papers that also mention a behavioral test, since a test is a sign that the animals received it.
A paper is animal research when its MeSH terms name an animal species. If they name none, NCBI's text-mining service PubTator 3 has to find one in the title or abstract.
The search terms for LPS are in the download Animal models and brain techniques. The counts in the chart of tests are in Tests mentioned with each model or technique. The full method, with each source and its terms of use, is on our main page, Behavioral tests in published research.
More animal models
Each animal model with 100 or more papers from 2021 to 2025 that mention a test has a page. These are the others, each with that count.
- Chronic unpredictable stress 973 papers
- Exercise 916 papers
- High-fat diet 868 papers
- Restraint stress 553 papers
- Streptozotocin diabetes 510 papers
- Middle cerebral artery occlusion (MCAO) 494 papers
- Nerve injury 485 papers
- Scopolamine 483 papers
- Spinal cord injury 395 papers
- Maternal separation and early-life stress 343 papers
- Traumatic brain injury (CCI, fluid percussion, weight drop) 334 papers
- Chemotherapy drugs 323 papers
- Carrageenan 317 papers
- Ovariectomy 309 papers
- Sleep deprivation 306 papers
- Social defeat stress 304 papers
- Environmental enrichment 295 papers
- Social isolation 276 papers
- Carotid artery occlusion (BCCAO, 2VO) 264 papers
- 6-OHDA 255 papers
- MPTP 249 papers
- D-galactose 244 papers
- Complete Freund's adjuvant (CFA) 216 papers
- Pentylenetetrazole (PTZ) 212 papers
- Predator stress 206 papers
- MK-801 190 papers
- Streptozotocin in the brain (ICV-STZ) 174 papers
- Gut microbiota depletion or transplant 166 papers
- Kainic acid or pilocarpine seizures 161 papers
- Sepsis 161 papers
- Rotenone 160 papers
- Aluminum chloride 157 papers
- Prenatal valproic acid 149 papers
- Single prolonged stress 142 papers
- Neonatal hypoxia-ischemia 125 papers
- Radiation exposure 125 papers
- Calorie restriction and fasting 120 papers
- Intracerebral hemorrhage 114 papers
- Intermittent or chronic hypoxia 113 papers
- Chronic corticosterone 109 papers
- Reserpine 109 papers
- Maternal immune activation 103 papers
How to cite
APA
ConductScience. (2026, November 13). Behavioral tests with LPS [Data set]. https://conductscience.com/resources/data/animal-models/lps
BibTeX
@misc{conductscience_lps_2026,
author = {{ConductScience}},
title = {Behavioral tests with LPS},
year = {2026},
month = nov,
url = {https://conductscience.com/resources/data/animal-models/lps},
note = {Data set, released November 13, 2026},
}Shop apparatus by test
Our store sells apparatus for all the 10 tests these papers mention most.
