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NIH funding notice PA-24-194

NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed)

Open. Closes May 7, 2027.

Posted
April 24, 2024
Close date
May 7, 2027
Activity codes
K99, R00
Institutes taking part
NEI, NHLBI, NHGRI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDCD, NIDCR, NIDDK, NIDA, NIEHS, NIGMS, NIMH, NINDS, NINR, NIMHD, NLM, NCCIH, ORWH, ODSS

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

  1. Reissues: PA-20-188 NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed)
  2. 2 steps back: PA-19-130 NIH Pathway to Independence Award (Parent K99/R00 - Independent Clinical Trial Not Allowed)
  3. 3 steps back: PA-18-398 NIH Pathway to Independence Award (Parent K99/R00 - Independent Clinical Trial Not Allowed)
  4. 4 steps back: PA-16-193 NIH Pathway to Independence Award (Parent K99/R00)
  5. 5 steps back: PA-16-077 NIH Pathway to Independence Award (Parent K99/R00)
  6. 6 steps back: PA-15-083 NIH Pathway to Independence Award (Parent K99/R00)
  7. 7 steps back: PA-14-042 NIH Pathway to Independence Award (Parent K99/R00)
  8. 8 steps back: PA-11-197 NIH Pathway to Independence Award (Parent K99/R00)
  9. 9 steps back: PA-10-063 NIH Pathway to Independence Award (Parent K99/R00)
  10. 10 steps back: PA-09-036 NIH Pathway to Independence Award (K99/R00)
  11. 11 steps back: PA-07-297 NIH Pathway to Independence (PI) Award (K99/R00)
  12. 12 steps back: PA-06-133

Who won it before

3,006 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $351,213,141 in first-year total cost, median $116,144.

Most frequent study sections

  1. Transition to Independence Study Section (I)[NCI-I]383
  2. NST-2 Study Section [NST-2]169
  3. NHLBI Mentored Transition to Independence Study Section[MTI (MA)]117
  4. NHLBI Mentored Transition to Independence Study Section[MTI (JA)]111
  5. Career Development Facilitating The Transition to Independence Study Section[AGCD-1]103

Most frequent institutions

  1. STANFORD UNIVERSITY239
  2. UNIVERSITY OF CALIFORNIA, SAN FRANCISCO126
  3. MASSACHUSETTS GENERAL HOSPITAL102
  4. COLUMBIA UNIVERSITY HEALTH SCIENCES87
  5. JOHNS HOPKINS UNIVERSITY69
Competing awards under PA-24-194 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2025From Child Maltreatment to Violence Involvement: Life Course Pathways, Trajectories, and Patterns.1K99HD120616-01DIAZ-FAES, DIEGO A.COLUMBIA UNIVERSITY HEALTH SCIENCES, NY$264,600ZRG1
2025The role of prenatal nutrition in placental gene regulation and spontaneous preterm birth1K99HD120649-01PARENTI, MARIANA GENOVEVA LEALSEATTLE CHILDREN'S HOSPITAL, WA$259,076ZRG1
2025Affective States and Large-scale Network Activity1K99DA061974-01A1DOUTON, JOAQUIN EUNIV OF NORTH CAROLINA CHAPEL HILL, NC$206,955NIDA
2025Building evidence for effective extended-release buprenorphine treatment for opioid use disorder1K99DA061935-01A1ROSS, RACHAEL KENDRAUTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, UT$201,960NIDA
2025Exploring mechanisms of activation of an innate immune pathway by fungal extracellular vesicles1K99AI185158-01A1BROWN, HANNAH ELIZABETHMASSACHUSETTS GENERAL HOSPITAL, MA$197,240AITC
2025B cell dynamics and immune memory formation in human vaccination1K99AI185149-01A1GLASS, DAVID RICHARDFRED HUTCHINSON CANCER CENTER, WA$190,944AITC
2025Enhancing Prostate Cancer Treatment Outcomes with Combined Radioimmunotherapy and Antibody Drug Conjugates1K99CA304511-01BIDKAR, ANIL PARSRAMUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$185,760NCI
2025Contributions of itch-sensing neurons to skin anti-helminth immunity1K99AI187730-01A1INCLAN RICO, JUAN MANUELUNIVERSITY OF PENNSYLVANIA, PA$184,680AITC
2025Metabolite Transport Modulation to Mitigate Ischemic-Reperfusion Injury1K99HL175185-01A1VISKER, JOSEPH R.UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, UT$183,600MTI
2025Hemozoin and liver stage malaria vaccine efficacy1K99AI190129-01HASSERT, MARIAH AUNIVERSITY OF IOWA, IA$183,276MID
2025A mixed-methods assessment of decisional needs and development of health communication intervention for anal cancer screening among people with HIV1K99CA304505-01GARG, ASHVITAMEDICAL UNIVERSITY OF SOUTH CAROLINA, SC$181,007NCI
2025Neurobiological Threat Reactivity as a Biomarker of Chronic Pain and Alcohol Use Disorder1K99AA032329-01RADOMAN, MILENAYALE UNIVERSITY, CT$180,939AA
2025Exploring Transcriptional Adaptation: Therapeutic Potential and Impact on Human Genetics1K99HG014205-01EL-BROLOSY, MOHAMEDWHITEHEAD INSTITUTE FOR BIOMEDICAL RES, MA$178,416GNOM
2025The effect of aging on cDC1 function and CD8 T cell immunity in tumors1K99CA296769-01 · under PA-20-188CHEN, CHANG-YU ALEXMASSACHUSETTS GENERAL HOSPITAL, MA$176,040NCI
2025Subcellular one-carbon metabolism, S-Adenosylmethionine availability and cancer1K99CA296774-01A1BERNASOCCHI, TIZIANOMASSACHUSETTS GENERAL HOSPITAL, MA$176,040NCI
2025Leveraging the sensitivity of antigen-specific T cells to interrogate disease mechanisms and identify therapeutic targets for Long COVID1K99AI187316-01A1PAINTER, MARK MUNIVERSITY OF PENNSYLVANIA, PA$175,428AITC
2025Midbrain opioid circuit dynamics in pain and endogenous analgesia1K99DA060979-01 · under PA-20-188KIMMEY, BLAKEUNIVERSITY OF PENNSYLVANIA, PA$173,799NIDA
2025Systematic Identification and Mechanistic Characterization of Novel Oxidative Protective Genes to Prevent RPE Degeneration1K99EY037340-01LU, YUANCHENGWHITEHEAD INSTITUTE FOR BIOMEDICAL RES, MA$173,016ZEY1
2025Retinal circuit integration and degeneration in Neurofibromatosis type-11K99EY036954-01 · under PA-20-188YOUNG, BRENT KEVINSTANFORD UNIVERSITY, CA$172,818ZEY1
2025The Role of Histone Cleavage in Breast Cancer1K99CA297044-01 · under PA-20-188LI, ZHEQIDANA-FARBER CANCER INST, MA$170,640NCI
2025Targeting the USP2-POU2F3 signaling pathway for small cell lung cancer (SCLC-P) treatment1K99CA302523-01HUANG, DAOYUANBETH ISRAEL DEACONESS MEDICAL CENTER, MA$169,884NCI
2025Unraveling myeloid-mediated mechanisms of immunotherapy resistance in prostate cancer bone metastases at single-cell resolution1K99CA304360-01LYU, ARAMFRED HUTCHINSON CANCER CENTER, WA$169,776NCI
2025Impact of obesity and diabetes on coronary microvascular defects in HFpEF1K99HL181303-01EATON, DEBORAHUNIVERSITY OF PENNSYLVANIA, PA$169,020MTI
2025Deciphering One Carbon Metabolism Defect in Heart Failure1K99HL181289-01JUNG, JAE WOOUNIVERSITY OF PENNSYLVANIA, PA$169,020MTI
2025Decoding Nuclear Mechanosignaling and Epigenetic Mediators of Mechanical Memory in Cardiomyocytes1K99HL181288-01BOUHRIRA, NESRINEUNIVERSITY OF PENNSYLVANIA, PA$169,020MTI
2025The Impact of Pulmonary Influenza Infection on the Pathogenesis of Myocardial Infarction and Heart Failure1K99HL177314-01A1DOWNEY, JEFFREYICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$167,940MTI
2025An Athero-Protective Pathway Mediated by Macrophage Tryptophan Metabolism and AhR Activation1K99HL181285-01SUKKA, SANTOSH RCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$167,400MTI
2025Dynamics and function of peritoneal myeloid cells during colorectal cancer peritoneal dissemination and implications for immunotherapy1K99CA300889-01HAN, JICHANGWASHINGTON UNIVERSITY, MO$166,752NCI
2025Synthetic morphogenesis to recapitulate multicellular patterns for regenerative medicine1K99HL177312-01A1KINSTLINGER, IAN SBOSTON UNIVERSITY (CHARLES RIVER CAMPUS), MA$166,752MTI
2025Integration of novel contextual and genomic blood pressure measures to enhance cardiovascular disease prediction and management in young adults1K99HL177340-01 · under PA-20-188CHO, SO MIBROAD INSTITUTE, INC., MA$165,364MTI
2025IL-27 functions as a novel signal 3 cytokine and promotes cytotoxic T cell responses to tumors1K99CA290077-01A1 · under PA-20-188LAFLEUR, MARTINHARVARD MEDICAL SCHOOL, MA$163,296NCI
2025Investigating the Regulatory Logic Underlying Meningeal Development and Tumorigenesis1K99DE034827-01DESINGU RAJAN, AYYAPPA RAJACALIFORNIA INSTITUTE OF TECHNOLOGY, CA$162,281DSR
2025From Crest to Bone: Understanding neural crest skeletogenic capacity along the neural axis1K99DE034068-01A1STUNDL, JANCALIFORNIA INSTITUTE OF TECHNOLOGY, CA$162,281DSR
2025Effects and equity impacts of cannabis policy on tobacco and cannabis co-use in young adults1K99DA060268-01A1GLASSER, ALLISON MARIERUTGERS BIOMEDICAL AND HEALTH SCIENCES, NJ$162,259NIDA
2025Discovery of novel antivirulence drug targets in C. difficile by systematically demystifying its genetic network controlling toxin biosynthesis1K99AI193247-01DUREJA, CHETNATEXAS A&M UNIVERSITY HEALTH SCIENCE CTR, TX$161,859MID
2025Dissecting Lung Spatial-Biological Niches in Early Fibrogenesis1K99HL181187-01GUO, JASON LIWEISTANFORD UNIVERSITY, CA$161,568MTI
2025Identifying Druggable Genetic Factors Underlying Radiation-induced Heart Disease1K99HL177331-01A1CAO, XUSTANFORD UNIVERSITY, CA$160,818MTI
2025Predicting craving and relapse using neurobehavioral markers of goals and habits in opioid use disorder1K99DA060948-01A1CECELI, AHMET OGUZICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$159,615NIDA
2025Signaling pathways in tumoricidal macrophages in pancreatic cancer1K99CA293136-01A1QIANG, LIDANA-FARBER CANCER INST, MA$159,304NCI
2025Genomic Conflict Resolution: Establishment of a new model for unconstrained germline selection1K99HG014014-01 · under PA-20-188BIEGLER, MATTHEW THEODORROCKEFELLER UNIVERSITY, NY$158,509GNOM
2025From Childhood to Adulthood: the Co-occurrence of Trauma, Substance Use, and Additional Stressors1K99DA060978-01A1PATEL, HERRYUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$158,246NIDA
2025The Role of Tunneling Nanotubes and Mitochondrial programming in HIV-Associated Placental Dysfunction1K99AI194972-01TOMOYA MICHITA, RAFAELBAYLOR COLLEGE OF MEDICINE, TX$156,744AIDS
2025Hematopoietic cells and chemokine regulation in abdominal aortic aneurysm associated thrombosis1K99HL181189-01BENSON, TYLER WENDORFUNIVERSITY OF CINCINNATI, OH$156,276MTI
2025Decoding therapeutic, cross-presented tumor antigens in pancreatic cancer1K99CA304503-01HUNG, JESSICAUNIVERSITY OF CALIFORNIA BERKELEY, CA$156,276NCI
2025The role of BNST PKCdelta neurons in compulsive ethanol intake1K99AA031509-01A1DOYLE, MARIE ALTHEAUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$156,204AA
2025Exploring the role of Hedgehog pathway-Primary cilia axis in human lung alveologenesis and disease1K99HL177341-01A1BELGACEMI, RANDA SONIALUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER, CA$156,168MTI
2025Elucidating pathways underlying the association of contraception use with ovarian cancers through metabolic profiling1K99CA293266-01A1MONGIOVI, JENNIFERBRIGHAM AND WOMEN'S HOSPITAL, MA$155,605NCI
2025Parental influences on early alcohol initiation: Leveraging family-based genetic designs and genomic data to unravel genetic and environmental pathways1K99AA032540-01CHEN, TONGUNIVERSITY OF COLORADO, CO$154,967AA
2025Role of arginine as a metabolic cue during enteric infection1K99AI192938-01JASWAL, KANCHANUNIVERSITY OF ILLINOIS AT CHICAGO, IL$154,052MID
2025Novel GluN2BR Radioligand for PET Neuroimaging in Alcohol Use Disorder1K99AA032043-01A1RAVAL, NAKUL RAVIYALE UNIVERSITY, CT$152,643AA
2025Elucidating the processes mediating mosquito basement membrane repair and the implications on within-mosquito virus dynamics1K99AI190134-01JOHNSON, REBECCA MARGARET MAYCONNECTICUT AGRICULTURAL EXPERIMENT STA, CT$152,527MID
2025Understanding paracrine interactions induced by morphogens in PDAC1K99CA293134-01A1HASSELLUHN, MARIE CHRISTINCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$151,263NCI
2025Role of BMP signaling in cardiac neural crest development1K99HL175104-01A1GANDHI, SHASHANKUNIVERSITY OF CALIFORNIA BERKELEY, CA$150,876MTI
2025Harnessing Heterogeneity to Isolate and Eradicate the Clonal CD4 HIV Reservoir1K99AI191911-01FERREIRA, ISABELLAWEILL MEDICAL COLL OF CORNELL UNIV, NY$149,389AIDS
2025Investigating Close-in-time Mediators and Moderators of SocialMedia Use, Alcohol-related Content Exposure and Young Adult Drinking Behavior1K99AA032331-01STROWGER, MEGANSTATE UNIVERSITY OF NEW YORK AT BUFFALO, NY$148,842AA
2025Deconstructing pathogenic myelopoiesis in cancer immunosuppression and treatment resistance1K99CA293148-01A1HEGDE, SAMARTHICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$147,083NCI
2025Investigating CNR1+ Corticostriatal Activity in Co-Exposure Models of FASD1K99AA032336-01ROUZER, SIARATEXAS A&M UNIVERSITY HEALTH SCIENCE CTR, TX$146,100AA
2025Metabolically Reprogramming Hepatic Macrophages to Conquer Immune Desert Tumors1K99CA297030-01 · under PA-20-188JI, LIANGLIANGSLOAN-KETTERING INST CAN RESEARCH, NY$145,336NCI
2025Genetic dependencies in KIAA1549-BRAF rearranged pediatric low-grade gliomas1K99CA290163-01A1 · under PA-20-188MISEK, SEAN ALEXANDERBROAD INSTITUTE, INC., MA$143,788NCI
2025Investigating the mechanism of corneal lens development1K99EY037847-01GHOSH, NEHANEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$142,749ZEY1
2025Functions of Lipid Homeostasis During Neural Tube Closure1K99HD116973-01A1KAKEBEEN, ANNEKE DUNIVERSITY OF COLORADO, CO$140,400CHHD
2025Elucidating Thiol Reductive Stress in Lung Cancer Growth and Metastasis1K99CA296772-01 · under PA-20-188GE, MAOLINMASSACHUSETTS GENERAL HOSPITAL, MA$140,130NCI
2025Data-driven mechanistic models of morphology-controlled Ras oncogenic signaling1K99CA283246-01A1 · under PA-20-188MAZLOOM FARSIBAF, HANIEHUT SOUTHWESTERN MEDICAL CENTER, TX$140,097NCI
2025The RNA components of the translation apparatus in prostate cancer plasticity and therapy response1K99CA300907-01KIM, YEON SOOFRED HUTCHINSON CANCER CENTER, WA$139,184NCI
2025Phosphate dysregulation as a driver of age-related vascular disease1K99HL177272-01A1TURNER, MANDY ELIZABETH MARYBRIGHAM AND WOMEN'S HOSPITAL, MA$138,523MTI
2025Integrating Genetics and Socio-Environmental Factors to Predict Disease Progression1K99HG013969-01 · under PA-20-188WANG, YINGMASSACHUSETTS GENERAL HOSPITAL, MA$138,499GNOM
2025Mechanism of TFEB-mediated proviral and antiviral autophagy during EV-D68 infection1K99AI184679-01A1JASSEY, ALAGIEUNIVERSITY OF MARYLAND BALTIMORE, MD$136,988MID
2025Circuit mechanisms underlying inflexible habitual behaviors following chronic cocaine use1K99DA060930-01A1CHEVEE, MAXIME F.VANDERBILT UNIVERSITY, TN$136,929NIDA
2025The Role of GCN2 in Ponatinib-Induced Cardiotoxicity1K99HL177315-01A1YAN, GEGEUNIVERSITY OF ILLINOIS AT CHICAGO, IL$136,804MTI
2025Transformations of photic information in melanopsin pathways1K99EY037374-01CAVAL-HOLME, FRANKLINBOSTON CHILDREN'S HOSPITAL, MA$136,512ZEY1
2025Defining and interrupting metabolic crosstalk in the glioblastoma microenvironment1K99CA300923-01SCOTT, ANDREW JOSEPHUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$136,412NCI
2025Therapeutic Strategies to Prevent Small Cell Lung Cancer Histological Transformation1K99CA304214-01LI, YIXIANGDANA-FARBER CANCER INST, MA$136,266NCI
2025Ultra-long-acting delivery for the prevention and treatment of HIV/AIDS1K99AI191990-01LEE, SOHYUNGBRIGHAM AND WOMEN'S HOSPITAL, MA$135,540AIDS
2025Deciphering the Transcriptomic Basis of Chemo Fog1K99CA293268-01A1LEE, JONATHAN DBETH ISRAEL DEACONESS MEDICAL CENTER, MA$135,513NCI
2025Developing Single-Cell Functional Genomic Technologies to Investigate DNA Methylation Changes in Human Diseases1K99HG014204-01DENG, CHENGYUUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$135,206GNOM
2025Uncovering the Mechanisms that Enable Cardiac Progenitors to Build the Linear Heart Tube1K99HL177318-01A1MUNCIE-VASIC, JONATHON MICHAELJ. DAVID GLADSTONE INSTITUTES, CA$134,998MTI
2025Interrogation of Genetic and Nutritional Control of Sleep across Seasons1K99HL177253-01A1LEVINE, DANIEL CUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$134,982MTI
2025Subtyping tinnitus based on fMRI dynamic functional connectivity1K99DC022305-01 · under PA-20-188HAKONEN, MARIAMASSACHUSETTS GENERAL HOSPITAL, MA$134,730CDRC
2025Structural and Functional Alteration of host RBCs by Babesia1K99AI182422-01A1 · under PA-20-188BERI, DIVYANEW YORK BLOOD CENTER, NY$134,730MID
2025Fingerprinting Spatiotemporal Patterns of Brain Maturation with Combined Diffusion-Relaxometry Microstructure Imaging1K99EB037396-01A1GONG, TINGMASSACHUSETTS GENERAL HOSPITAL, MA$134,730ZEB1
2025Pulse-oximetry method for un-biased assessment of arterial saturation1K99HL181290-01BLANEY, GILESTUFTS UNIVERSITY MEDFORD, MA$134,537MTI
2025A calvarial stem cell mediating a new bone-brain axis in Alzheimer's disease1K99AG090732-01 · under PA-20-188BOK, SEOYEONWEILL MEDICAL COLL OF CORNELL UNIV, NY$134,325AGCD
2025The contribution of the mammalian visual cortex to stabilizing locomotion1K99EY037782-01ATLAN, GALUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$134,106ZEY1
2025Utilizing patient-derived premalignant colon organoid biobank to interrogate existing and novel chemoprevention strategies1K99CA304361-01WHITE, SHANNON MARIESTANFORD UNIVERSITY, CA$133,598NCI
2025Discerning L-type trafficking modulation by targeted excision of ubiquitin and SUMO1K99HL177343-01 · under PA-20-188SHANMUGAM, SRI KARTHIKACOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$133,436MTI
2025T cell surveillance of senescent cells under homeostasis and aging1K99AG090620-01 · under PA-20-188STURMLECHNER, INESMAYO CLINIC ROCHESTER, MN$133,353AGCD
2025Functional Mapping of Translation Initiation Kinetics to Quantify the Protein-Coding Capacity of the Human Genome1K99HG014240-01CHEMLA, YONATANMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$133,332GNOM
2025Role of TLR7/8-activating microRNAs in fetal inflammatory response syndrome1K99HD116981-01 · under PA-20-188GEORGES, HANAH MYALE UNIVERSITY, CT$132,779CHHD
2025Targeting Metabolic Vulnerabilities to Restore Balanced Hematopoiesis during Aging1K99AG086600-01A1 · under PA-20-188GHELLER, BRANDONBOSTON CHILDREN'S HOSPITAL, MA$132,705AGCD
2025Mapping inflammatory bowel disease variants to genes and functional phenotypes in human macrophages1K99AI193231-01HAN, HUAJUNICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$132,677MID
2025Prenatal and Early Life Air Pollution Exposure and Pubertal Development1K99ES037404-01PETERSON, ALICIA KRISTINKAISER FOUNDATION RESEARCH INSTITUTE, CA$132,651ZES1
2025Regulating host neural activity to improve retinal ganglion cell replacement therapies1K99EY036122-01A1 · under PA-20-188SOUCY, JONATHAN RSCHEPENS EYE RESEARCH INSTITUTE, MA$132,597ZEY1
2025Apoptotic Dysregulation Across Cell Types in Aging and Neurodegeneration1K99AG086405-01A1 · under PA-20-188INDE, ZINTISUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$132,472AGCD
2025The multifaceted roles of PI(4,5)P2 on HIV-1 assembly1K99AI194970-01DE SOUZA CARDOSO, RICARDOUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$132,300AIDS
2025Continuous Glucose and Fetal State Monitoring: A Novel Approach to Understanding Neurodevelopmental Trajectories in Gestational Diabetes1K99HD119289-01MUELLER, ISABELLECOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$132,257ZHD1
2025Bridging Social Epidemiology and Policy for ADRD Prevention: Effects of Poverty Alleviation Policies on Alzheimer's Disease and Related Dementias Risk and Disparities1K99AG088369-01A1CHEN, RUIJIABOSTON UNIVERSITY MEDICAL CAMPUS, MA$131,813AGCD
2025Central auditory processing of natural sound category following sensorineural hearing loss1K99DC022330-01A1PARIDA, SATYABRATAOREGON HEALTH & SCIENCE UNIVERSITY, OR$131,555CDRC
2025Maladaptive cortico-amygdalar plasticity after noise-induced hearing loss1K99DC022957-01AWWAD, BISHARAMASSACHUSETTS EYE AND EAR INFIRMARY, MA$131,408CDRC
2025High-resolution tracking of T cell differentiation to predict and control alloreactive disease1K99HL179392-01BADER, CAMERON SCOTTSTANFORD UNIVERSITY, CA$131,211MTI
2025Novel Role of SEL1L-HRD1 ERAD in Neurodevelopment1K99HD118580-01A1WANG, HUILUNUNIVERSITY OF VIRGINIA, VA$131,166CHHD
2025A Novel Strategy to Identify Protective T cell Epitopes for HPV Therapeutic Vaccine1K99AI185150-01A1GAO, FEISTANFORD UNIVERSITY, CA$131,166MID
2025Investigation of obesity paradox for renal cell cancer: a multilevel approach from molecular to neighborhood impacts1K99CA290086-01A1DENG, ZHENGYISTANFORD UNIVERSITY, CA$131,099NCI
2025Elucidating Drug Interactomes for Cardiac Protection by SGLT2 Inhibitors1K99HL179400-01CAUDAL, ARIANNESTANFORD UNIVERSITY, CA$131,085MTI
2025Ultrasound-Interrogated Implantable Sensor for Intracranial Pressure Monitoring1K99EB037171-01SHASHIDHARA SURAPPA, SUSHRUTASTANFORD UNIVERSITY, CA$131,085ZEB1
2025Unraveling neuronal and molecular mechanisms of flexible social behavior in mice1K99HD118168-01YANG, RENZHISTANFORD UNIVERSITY, CA$131,085CHHD
2025Towards a functional understanding of genotypic and phenotypic diversity across the Salmonella species1K99AI190131-01WANG, BENJAMINSTANFORD UNIVERSITY, CA$131,076MID
2025Computational Technology for Single-Cell Functional Genomics1K99HG013662-01A1ZHENG, RONGBINBOSTON CHILDREN'S HOSPITAL, MA$130,680GNOM
2025Investigating Histone Acetylation Modulator Function in Alveolar Regeneration and Disease Pathogenesis1K99HL181185-01SUN, DAWEIBROAD INSTITUTE, INC., MA$130,593MTI
2025Transcriptional Regulation and Therapeutic Modulation of Muscle CDKN1A in Cancer Cachexia1K99CA304466-01WANG, HUISALK INSTITUTE FOR BIOLOGICAL STUDIES, CA$130,501NCI
2025Understanding the Nature and Regulation of Extramedullary Hematopoiesis in the Liver1K99HL173841-01A1 · under PA-20-188GAO, LONGFEICOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$130,337MTI
2025Parental Responses to Children’s Negative Emotions: Impact on Neural and Physiological Self-Regulation1K99HD119293-01HONG, YELIMUNIVERSITY OF TEXAS AT AUSTIN, TX$130,210CHHD
2025Life-course stressors, Mitochondrial Dysfunction, and the Risk of Preterm Birth among Black Women1K99MD020773-01ZHAO, TINGTINGCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$129,748ZMD1
2025Computational Strategies for Deciphering Cellular Differentiation and Cancer Progression1K99GM159044-01OTTO, DOMINIK JENZFRED HUTCHINSON CANCER CENTER, WA$129,708ZGM1
2025Adipose tissue as a novel facilitator of tumor growth and cachexia1K99CA304501-01SNOKE, DEENA BUNIVERSITY OF VERMONT & ST AGRIC COLLEGE, VT$129,624NCI
2025Novel mechanisms of macrophage foam cell formation.1K99HL177310-01A1MA, CHENG-I JONATHANWEILL MEDICAL COLL OF CORNELL UNIV, NY$129,600MTI
2025Regulating Skeletal Stem Cell and Neutrophil Dynamics for Improved Cleft Palate Bone Regeneration by Newly Designed Surrogate Bone Morphogenetic Protein-21K99DE032773-01A1 · under PA-20-188TAKEMATSU, ERISTANFORD UNIVERSITY, CA$129,420DSR
2025Mapping Genotype to Developmental Course Across an Autism-Schizophrenia Gradient1K99MH137253-01A1KUO, SZU-YU SUSANMASSACHUSETTS GENERAL HOSPITAL, MA$129,290ZMH1
2025Lysosome-targeting chimeras degrading immune checkpoint proteins to enhance immunoradiotherapy of head and neck cancer1K99DE034475-01A1JIANG, YUYANSTANFORD UNIVERSITY, CA$129,289ZDE1
2025Understanding the Genetic and Epigenetic Mechanisms in X-linked Dystonia Parkinsonism and Repeat Expansion Diseases1K99NS144514-01MEJIA MAZA, ALANMASSACHUSETTS GENERAL HOSPITAL, MA$129,170NST
2025Functional Contributions of the Noncoding Genome in Atherosclerosis Risk Factors1K99HL175030-01A1WANG, DANUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$129,137MTI
20253D genome-based transcriptional program for male germline differentiation1K99HD119268-01KITAMURA, YUKAUNIVERSITY OF CALIFORNIA AT DAVIS, CA$128,898CHHD
2025Comprehensive monitoring of diverse cancer outcomes using genomic and epigenomic sequencing of cfDNA1K99CA290092-01A1 · under PA-20-188LI, SHUOUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$128,509NCI
2025Determining the role of antibody epitope specificity in regulating Fc effector functions1K99AI185267-01A1COHEN, ALEXANDER ACALIFORNIA INSTITUTE OF TECHNOLOGY, CA$128,461AITC
2025Endothelial de novo nucleotide synthesis in atherosclerosis1K99HL175106-01A1MA, QIANBAYLOR COLLEGE OF MEDICINE, TX$128,341MTI
2025Inhalable Extracellular Vesicles Engineering for Lung Cancer Treatment1K99CA304506-01LIU, MENGRUICOLUMBIA UNIV NEW YORK MORNINGSIDE, NY$128,228NCI
2025Subdermal, implantable monitoring platform for heart attack and heart failure1K99EB036582-01A1KWAK, JEAN WONSTANFORD UNIVERSITY, CA$127,926ZEB1
2025Role and Regulation of a Distinct Optic Nerve Microglia Population in Glaucomatous Neuropathy1K99EY036932-01A1MAURYA, SHUBHAMUNIVERSITY OF CALIFORNIA BERKELEY, CA$127,861ZEY1
2025Dynamics of oxidative DNA demethylation from duplex DNA to chromatin1K99ES036599-01A1SCHAICH, MATTHEW ALLENUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$127,384ZES1
2025Investigating the role of frontal parvalbumin interneuron maturation in attentional development1K99MH137314-01A1NISHIOKA, TADAAKIICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$127,305ZMH1
2025Long-Range Regulatory Interactions in the Drosophila Brain.1K99NS138574-01A1LI, XIAOPRINCETON UNIVERSITY, NJ$127,145NST
2025Targeting T follicular helper cells for rejuvenating the aging germinal center1K99AG090739-01A1SURESHCHANDRA, SUHASUNIVERSITY OF CALIFORNIA-IRVINE, CA$127,019AGCD
2025Environmental mixtures, immune function, and vaccine antibody response in children1K99ES036168-01A1 · under PA-20-188HE, MIKE ZHONGYUICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$126,985ZES1
2025Endocrine-Disrupting Chemical (EDC) Mixtures in Relation to Metabolic Syndrome (MetS) and Metabolomic Mechanisms in a Prospective Cohort of Hispanic Women1K99ES037024-01A1INDIA ALDANA, SANDRAICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$126,970ZES1
2025Generation of new neurons in the aging adult brain: identifying mechanisms of adult neurogenesis by exploiting single cell spatial transcriptomics.1K99AG090813-01 · under PA-20-188MAIMON, ROYUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$126,956AGCD
2025Computational Approaches for Understanding Multi-Area Circuit Mechanisms Underlying Memory-Guided Movements1K99NS144599-01XIA, JICOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$126,900NST
2025Deciphering Determinants of Somatic Evolution with Single-Cell Genealogy1K99HG013991-01 · under PA-20-188WENG, CHENBOSTON CHILDREN'S HOSPITAL, MA$126,830GNOM
2025Identifying Ecological Drivers of Dysbiosis in the Female Reproductive Tract1K99AI187628-01 · under PA-20-188RADLINSKI, LAUREN CHRISTINEUNIVERSITY OF CALIFORNIA AT DAVIS, CA$126,460MID
2025Reduced hypusination of EIF5A impairs free ubiquitin generation resulting in the development of HFpEF1K99HL179380-01KOLEINI, NAVIDJOHNS HOPKINS UNIVERSITY, MD$126,387MTI
2025Neural population geometry and dynamics underlying multi-step cognitive-motor sequencing1K99NS140554-01 · under PA-20-188VYAS, SAURABHCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$126,333NST
2025High-Throughput Studies of MYH7 Variant Cardiomyocytes to Identify Pathogenic Variants and Factors Governing Variable Expressivity of Hypertrophic Cardiomyopathy1K99HL177347-01 · under PA-20-188FRIEDMAN, CLAYTON EUNIVERSITY OF WASHINGTON, WA$126,306MTI
2025A novel role for cell cycle regulators in oligodendrogenesis and myelination1K99NS144382-01CALL, CODY LEEOREGON HEALTH & SCIENCE UNIVERSITY, OR$126,122NST
2025Leveraging Drosophila to identify novel and conserved regulators of cardiomyocyte polyploidy1K99HL177179-01A1CHAKRABORTY, ARCHANDUKE UNIVERSITY, NC$125,983MTI
2025Cell-type-specific dysregulation and genetic control of alternative polyadenylation in neurodegeneration1K99AG095208-01BOIX, CARLESHARVARD MEDICAL SCHOOL, MA$125,901AGCD
2025Functional role of Wnt/Ca2+ signaling in triple-negative breast cancer metastasis and chemoresistance1K99CA290088-01A1 · under PA-20-188SI, HONGJIANGBAYLOR COLLEGE OF MEDICINE, TX$125,834NCI
2025Impacts of non-antibiotic medications on microbiome-mediated protection against intestinal pathogens1K99AI187630-01 · under PA-20-188KUMAR, AMANYALE UNIVERSITY, CT$125,809MID
2025Mechanisms of CDH1-inactivated advanced gastric adenocarcinoma tumorigenesis1K99CA286745-01A1 · under PA-20-188ZOU, GENGYIUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$125,783NCI
2025Epigenetic modulations by sleep to mitigate neurodegeneration1K99AG090693-01 · under PA-20-188PARHIZKAR, SAMIRAWASHINGTON UNIVERSITY, MO$125,000AGCD
2025Role of Protein N-Myristoylation in Driving DNA Damage Response1K99GM157498-01 · under PA-20-188LUONG, NHO CONGEMORY UNIVERSITY, GA$125,000ZGM1
2025Towards a structural understanding of transcriptional regulation by ZMYM2-KDM1A-CoREST1K99GM154065-01A1 · under PA-20-188WACHTER, FRANZISKADANA-FARBER CANCER INST, MA$125,000ZGM1
2025Combinatorial signal integration in the maintenance and renewal of adult germline stem cell fate1K99GM154143-01A1 · under PA-20-188RAZ, AMELIEWHITEHEAD INSTITUTE FOR BIOMEDICAL RES, MA$125,000ZGM1
2025Spatially-resolved, integrated cell state and lineage tracing to define progenitor cell dynamics in early mouse development1K99HD118574-01KOBLAN, LUKE WILLIAMWHITEHEAD INSTITUTE FOR BIOMEDICAL RES, MA$125,000CHHD
2025Intermolecular RNA-RNA interactions in stress granule regulation and disease1K99GM159062-01PARKER, DYLANUNIVERSITY OF COLORADO, CO$125,000ZGM1
2025Evolution and mechanisms of pathogen avoidance1K99GM159248-01AMOROSO, CAROLINEUNIVERSITY OF VIRGINIA, VA$125,000ZGM1
2025Elucidating the role of selective Golgi remodeling in cellular homeostasis1K99GM154111-01A1HICKEY, KELSEYHARVARD MEDICAL SCHOOL, MA$125,000ZGM1
2025Novel mechanisms of purine regulation and their roles in human pathophysiology1K99GM154116-01A1WU, ZHENGUT SOUTHWESTERN MEDICAL CENTER, TX$125,000ZGM1
2025Elucidating the role of cyclin D1-CDK4/6 in protein homeostasis.1K99GM155613-01A1KAISARI, SHARONNEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$125,000ZGM1
2025Uncovering the mechanisms of carrier-mediated WNT release and activity1K99GM160702-01MAGALHAES, TACIANI DE ALMEIDAHARVARD MEDICAL SCHOOL, MA$125,000ZGM1
2025Impacts of copy number variation on gene regulatory networks and fitness in Candida1K99GM160701-01VANDE ZANDE, PETRAUNIVERSITY OF MINNESOTA, MN$125,000ZGM1
2025Interaction between c-di-GMP and cAMP signaling in Pseudomonas aeruginosa biofilms1K99GM160696-01ZHENG, XUHUIUNIVERSITY OF WASHINGTON, WA$125,000ZGM1
2025Elucidating the Mechanisms of Microtubule Regulation at the Cellular Cortex1K99GM160792-01SANDHU, ANJALIUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$125,000ZGM1
2025Investigating the role of the mismatch repair proteins MSH2 and MSH6 in genome stability1K99GM155658-01A1REITZ, DIEDREUNIVERSITY OF CALIFORNIA AT DAVIS, CA$125,000ZGM1
2025Accurate High-Resolution Tissue Characterization for Breast Cancer Screening Using Transmission and Reflection Ultrasound Tomography1K99EB037080-01ALI, REHMANUNIVERSITY OF ROCHESTER, NY$124,999ZEB1
2025Behavioral Obesogenics: Environmental EDC effects on behavioral processes promoting obesity.1K99ES037720-01HILZ, EMILY NICOLEUNIVERSITY OF TEXAS AT AUSTIN, TX$124,808ZES1
2025Probing the Rules of Protein Structure-Function Relationships through the De Novo Design of Functional Proteins1K99GM157551-01 · under PA-20-188SCHNAIDER, LEEUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$124,767ZGM1
2025Dynamically reconfigurable materials for 4D bioprinting of a human gut-brain axis1K99EB037059-01GRAHAM, AUSTIN JOSEPHUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$124,738ZEB1
2025Gestational and Childhood Exposure to Endocrine Disruptors: Epigenetic and Proteomic Pathways to Adolescent Neurobehavior1K99ES037741-01PUVVULA, JAGADEESHUNIVERSITY OF PENNSYLVANIA, PA$124,728ZES1
2025Development of Highly Multiplexed Raman Imaging Platform for Alzheimer’s Disease1K99EB035706-01A1 · under PA-20-188EREMINA, OLGA E.UNIVERSITY OF SOUTHERN CALIFORNIA, CA$124,562ZEB1
2025Fused Imaging and Large Language Foundational Model for 90-day Stroke Outcome Prediction1K99NS140547-01 · under PA-20-188LIU, YONGKAISTANFORD UNIVERSITY, CA$124,485NST
2025Consequence of human satellite repeat expression and immunostimulatory potential in FSHD1K99AR081926-01A1ARENDS, TESSA AMANDAFRED HUTCHINSON CANCER CENTER, WA$124,308AMS
2025Advanced Base and Prime Editing Strategies to Correct Common ALS-causing SOD1 Mutations1K99NS136849-01A1 · under PA-20-188MEIJBOOM, KATHARINA EUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$124,246NST
2025Coordinated mental simulation in the hippocampus and primary visual cortex during active behavior1K99EY036953-01 · under PA-20-188LEE, KYU HYUNUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$124,205ZEY1
2025Novel role of ROCK2 in Immune Mechanisms of Takotsubo Cardiomyopathy1K99HL177309-01 · under PA-20-188FEHRENBACH, DANIEL JINDIANA UNIVERSITY INDIANAPOLIS, IN$123,930MTI
2025Reversing the Irreversible: Reshaping Plant Growth upon Recovery from Severe Stress1K99GM154136-01A1 · under PA-20-188ELIAZ, NATANELLASALK INSTITUTE FOR BIOLOGICAL STUDIES, CA$123,795ZGM1
2025Neuronal mechanisms of selective visual attention1K99EY036889-01 · under PA-20-188FRIGHETTO, GIOVANNIUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$123,794ZEY1
2025Neurobehavioral Analysis After Spinal Cord Injury: Exploring the Relationship Between Altered Motor Behavior and Dopamine Transients in the Dorsolateral Striatum1K99NS144632-01EISDORFER, JACLYN T.RUTGERS, THE STATE UNIV OF N.J., NJ$123,588NST
2025The role of Gasdermin D in the bone marrow microenvironment during clonal hematopoiesis progression1K99CA289959-01A1 · under PA-20-188REN, KEHANNORTHWESTERN UNIVERSITY, IL$123,409NCI
2025Convergent mechanisms of respiratory dysregulation after seizures and alcohol poisoning1K99NS140499-01A1PURNELL, BENTON SCOTTRUTGERS BIOMEDICAL AND HEALTH SCIENCES, NJ$123,349NST
2025Mechanisms of dormant breast cancer cell communication with their environment1K99CA304508-01DRAPELA, STANISLAVH. LEE MOFFITT CANCER CTR & RES INST, FL$123,182NCI
2025An idiographic approach to the neurobiological underpinnings of adolescent chronic pelvic pain1K99HD116935-01A1HIDALGO LOPEZ, ESMERALDAUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$123,156CHHD
2025Molecular profiles for mortality risk and longevity: a multiomics approach1K99AG086538-01A1 · under PA-20-188WANG, FENGLEIHARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH, MA$122,858AGCD
2025The role of error-prone polymerases in mutagenesis and evolution1K99ES037493-01CARVAJAL GARCIA, JUANVANDERBILT UNIVERSITY, TN$122,850ZES1
2025Macrophage identity as a function of cell of origin1K99AI187733-01 · under PA-20-188FRENIS, KATIEBOSTON CHILDREN'S HOSPITAL, MA$122,839AITC
2025The phase separation of neuronal pentraxins: from synapse formation to plasticity.1K99NS140628-01A1CHEN, XUDONGSTANFORD UNIVERSITY, CA$122,526NST
2025Dissecting the Molecular Mechanisms of NLRP3 Inflammasome Activation and Regulation.1K99AI190055-01XIAO, LEBOSTON CHILDREN'S HOSPITAL, MA$122,472AITC
2025Development of Radiofluorination Methods and Prosthetic Groups Suitable for Quick Iterative Constructions of PET Tracer Analogs in Rapid Radiopharmaceutical Development and SAR Study1K99EB037078-01LI, MANSHUUNIV OF NORTH CAROLINA CHAPEL HILL, NC$122,260ZEB1
2025Compartment-Specific Synaptic Organization and Plasticity During Learning1K99MH140060-01WRIGHT, WILLIAM JAMESUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$121,933ZMH1
2025Dissecting the neural basis of visual continuity using blinks1K99EY037819-01WILLETT, SHAWNUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$121,771ZEY1
2025Using Novel Machine Learning Approaches to Understand Subgingival Microbiome Heterogeneity in Relation to Health and Disease1K99DE034829-01LI, LUSTATE UNIVERSITY OF NEW YORK AT BUFFALO, NY$121,630DSR
2025Investigating nuclear plasticity in the human placental syncytium1K99HD119226-01KEENEN, MADELINEDUKE UNIVERSITY, NC$121,515CHHD
2025Environmental Mixtures, Dietary Patterns, and Risk of Type 2 Diabetes: From Prospective Associations to Metabolomic Pathways1K99ES037025-01A1CHEN, JIEHARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH, MA$121,473ZES1
2025A Prospective Study of Per-and Polyfluoroalkyl Substance (PFAS) Mixtures and Pregnancy Outcomes among Black Women1K99ES036288-01A1 · under PA-20-188SCHILDROTH, SAMANTHABOSTON UNIVERSITY MEDICAL CAMPUS, MA$121,057ZES1
2025Atomic-level Structural-omics of Platelet Membrane Proteins via Multi-scale Structural Biology Approaches1K99HL179260-01HAN, XUCASE WESTERN RESERVE UNIVERSITY, OH$121,003MTI
2025Molecular mechanisms underlying interstitial axon branching in the mammalian brain1K99NS138586-01A1ZIAK, JAKUBJOHNS HOPKINS UNIVERSITY, MD$120,987NST
2025Uncovering the Impact of Air Pollution Sources on Autism Spectrum Disorder: A Metabolomic Approach to Identifying Critical Biological Pathways1K99ES037743-01O'SHARKEY, KARLUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$120,663ZES1
2025Identifying transcriptomic axes governing neural dynamics, behavior, and states1K99MH138830-01 · under PA-20-188SEO, CHANGWOOHARVARD UNIVERSITY, MA$120,015ZMH1
2025The dynamics, functions and evolution of a miniature RNA-guided enzyme1K99GM160778-01SHI, HONGLUEUNIVERSITY OF CALIFORNIA BERKELEY, CA$119,907ZGM1
2025RNA-Related Function and Dysfunction of Tau in FTD1K99NS142567-01DIXON, GARYUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$119,367NST
2025Role of novel activity-associated postsynaptic proteins in synaptic function1K99NS140624-01A1YONG, ADELINE JING HUIUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$119,367NST
2025Harnessing multi-modal and multi-omics data integration to decipher therapeutic response in non-small cell lung cancer1K99CA293249-01A1ZHENG, YUANNINGSTANFORD UNIVERSITY, CA$119,172NCI
2025In Utero Exposure to Medications for Cardiometabolic Conditions and Risk of Congenital Malformations1K99HD116975-01A1BROWN, JEREMY PHILIPHARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH, MA$119,084CHHD

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