Research data ยท Social behavior

Social interaction test

From 2021 to 2025, 482 animal research papers mentioned the social interaction test in their title or abstract, ranking it 28th of the 90 tests we track.

That is 1.5 times the 320 papers of 2011 to 2015. Papers that mention any of the 90 tests grew to 1.2 times as many over the same span.

482 animal research papers from 2021 to 2025 mentioned the test
1.5 times as many papers as in 2011 to 2015
28th of the 90 tests by papers from 2021 to 2025
44% of these papers used mice and 41% used rats

Papers by year

Animal research papers that mention the social interaction test, by year, 2001 to 2026

The 2026 bar counts papers added to PubMed by November 8, 2026.

  • Papers in a full year
  • 2026 so far
Show the counts for each year
Papers by year
YearPapers
200130
200220
200325
200443
200526
200628
200732
200837
200940
201039
201169
201251
201345
201479
201576
201672
201777
201897
201994
2020103
202198
202298
202383
202493
2025110
2026 (part year)98

Papers that mention the social interaction test fell from 98 in 2021 to 83 in 2023, then rose to 110 in 2025. Papers that PubMed indexed under the MeSH heading Animals also fell and rose, from 200,221 in 2021 to 156,447 in 2023 and 235,479 in 2025. We take each paper's species from PubMed's indexing whenever it names one, so part of this dip may come from the indexing rather than from fewer studies.

Papers that mention the social interaction test in mice and in rats, by year, 2001 to 2025

  • Mouse
  • Rat
Show the counts for each year and species
Papers by year, mice and rats
YearMouseRat
2001522
2002214
2003419
20041429
2005422
2006417
20071216
20081423
20091721
20101917
20112534
20122318
20131920
20142440
20153135
20163037
20173031
20183346
20194537
20204837
20214340
20225235
20232739
20244339
20254944

Which species the papers used

Each bar is a share of the 482 papers from 2021 to 2025. A paper can use more than one species, so the shares can add to more than 100%.

Species

Mouse
214 papers 44%
Rat
197 papers 41%
Other animals
51 papers 11%
Zebrafish
15 papers 3%
Nonhuman primate
15 papers 3%
Fruit fly
2 papers under 1%

โ€œOther animalsโ€ counts papers that use none of the other species in this chart.

Strains and genetic lines

Strain names come from the MeSH terms PubMed adds when it indexes a paper. PubMed has indexed 384 of the 482 papers, so each bar is a share of those 384.

C57BL mice
73 papers 19%
Wistar rats
52 papers 14%
Sprague-Dawley rats
40 papers 10%
Knockout mice
13 papers 3%
BALB/c mice
10 papers 3%
Long-Evans rats
8 papers 2%
Transgenic mice
5 papers 1%
Fischer 344 rats
4 papers 1%

A paper indexed under two of these headings, such as knockout mice and a strain, counts under both.

Disease models these papers study

Each bar counts the papers from 2021 to 2025 that mention the social interaction test and study that disease model, with its share of the 482 papers. The model comes from a paper's MeSH terms. For a paper PubMed has not indexed, it comes from PubTator 3, NCBI's text-mining service, when that service finds the disease in the title or abstract. A paper can count under more than one model.

Papers from 2021 to 2025 by disease model

Tests mentioned alongside the social interaction test

Each bar counts the papers from 2021 to 2025 that mention both tests, with its share of the 482 papers that mention the social interaction test.

Papers from 2021 to 2025 that mention both tests

The most cited papers from 2021 to 2025

These papers from 2021 to 2025 mention the social interaction test and have the most citations, as counted by NIH's iCite on November 5, 2026. We show three of the five most cited papers and leave out two because of words in their titles.

  1. Tris (1-chloro-2-propyl) phosphate exposure to zebrafish causes neurodevelopmental toxicity and abnormal locomotor behavior.

    Sci Total Environ, 2021. 74 citations.

  2. Increased efficacy of combining prebiotic and postbiotic in mouse models relevant to autism and depression.

    Neuropharmacology, 2021. 58 citations.

  3. A comparative study of the neuroprotective effects of dl-3-n-butylphthalide and edaravone dexborneol on cerebral ischemic stroke rats.

    Eur J Pharmacol, 2023. 53 citations.

How we counted

A count is the number of animal research papers whose title or abstract mentions one of the test's search terms. It is not a count of experiments, labs or animals.

A paper that mentions the social interaction test only in its methods is missed, so the count runs low. The count includes 20 reviews. For 98 of the 482 papers, PubMed's indexing gave no species, so the species came from PubTator 3 finding one in the title or abstract.

The test's search terms are in the test list download. The full method, with each source and its terms of use, is on our main page, Behavioral tests in published research.

More social behavior tests

These social behavior tests also have a page, with their papers from 2021 to 2025. Each test with 30 or more papers gets one.

How to cite

APA

ConductScience. (2026, November 10). Social interaction test in published research [Data set]. https://conductscience.com/data/behavioral-tests/social-interaction-test

BibTeX

@misc{conductscience_social_interaction_test_2026,
  author = {{ConductScience}},
  title = {Social interaction test in published research},
  year = {2026},
  month = nov,
  url = {https://conductscience.com/data/behavioral-tests/social-interaction-test},
  note = {Data set, released November 10, 2026},
}

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