Research data ยท Spatial learning and memory

Morris water maze

From 2021 to 2025, 5,392 animal research papers mentioned the Morris water maze in their title or abstract, more than any other of the 90 tests we track.

That is 1.6 times the 3,430 papers of 2011 to 2015. Papers that mention any of the 90 tests grew to 1.2 times as many over the same span.

5,392 animal research papers from 2021 to 2025 mentioned the test
1.6 times as many papers as in 2011 to 2015
1st of the 90 tests by papers from 2021 to 2025
51% of these papers used mice and 51% used rats

Papers by year

Animal research papers that mention the Morris water maze, by year, 2001 to 2026

The 2026 bar counts papers added to PubMed by November 8, 2026.

  • Papers in a full year
  • 2026 so far
Show the counts for each year
Papers by year
YearPapers
2001241
2002278
2003278
2004322
2005306
2006364
2007389
2008438
2009492
2010471
2011536
2012630
2013759
2014693
2015812
2016815
2017894
2018914
2019948
20201,024
20211,099
20221,069
2023970
20241,044
20251,210
2026 (part year)1,008

Papers that mention the Morris water maze fell from 1,099 in 2021 to 970 in 2023, then rose to 1,210 in 2025. Papers that PubMed indexed under the MeSH heading Animals also fell and rose, from 200,221 in 2021 to 156,447 in 2023 and 235,479 in 2025. We take each paper's species from PubMed's indexing whenever it names one, so part of this dip may come from the indexing rather than from fewer studies.

Rats led every year from 2001 to 2023, and mice led in 2024 and 2025.

Papers that mention the Morris water maze in mice and in rats, by year, 2001 to 2025

  • Mouse
  • Rat
Show the counts for each year and species
Papers by year, mice and rats
YearMouseRat
200178168
200281194
200386201
2004100226
2005107200
2006147226
2007144248
2008172275
2009183313
2010194283
2011230318
2012253394
2013311468
2014299407
2015320504
2016347484
2017389509
2018411512
2019434526
2020459591
2021538581
2022519570
2023487507
2024563491
2025644586

Which species the papers used

Each bar is a share of the 5,392 papers from 2021 to 2025. A paper can use more than one species, so the shares can add to more than 100%.

Species

Mouse
2,751 papers 51%
Rat
2,735 papers 51%
Other animals
64 papers 1%
Zebrafish
5 papers under 1%
Fruit fly
2 papers under 1%
Nonhuman primate
1 paper under 1%

โ€œOther animalsโ€ counts papers that use none of the other species in this chart.

Strains and genetic lines

Strain names come from the MeSH terms PubMed adds when it indexes a paper. PubMed has indexed 4,269 of the 5,392 papers, so each bar is a share of those 4,269.

Sprague-Dawley rats
869 papers 20%
C57BL mice
858 papers 20%
Wistar rats
638 papers 15%
Transgenic mice
483 papers 11%
Knockout mice
117 papers 3%
ICR mice
38 papers 1%
BALB/c mice
33 papers 1%
Long-Evans rats
25 papers 1%

A paper indexed under two of these headings, such as knockout mice and a strain, counts under both.

Disease models these papers study

Each bar counts the papers from 2021 to 2025 that mention the Morris water maze and study that disease model, with its share of the 5,392 papers. The model comes from a paper's MeSH terms. For a paper PubMed has not indexed, it comes from PubTator 3, NCBI's text-mining service, when that service finds the disease in the title or abstract. A paper can count under more than one model.

Papers from 2021 to 2025 by disease model

1,456 papers 27%
319 papers 6%
269 papers 5%
229 papers 4%
182 papers 3%
181 papers 3%

Tests mentioned alongside the Morris water maze

Each bar counts the papers from 2021 to 2025 that mention both tests, with its share of the 5,392 papers that mention the Morris water maze.

Papers from 2021 to 2025 that mention both tests

607 papers 11%
562 papers 10%
376 papers 7%
368 papers 7%
192 papers 4%
187 papers 3%
161 papers 3%

The most cited papers from 2021 to 2025

These papers from 2021 to 2025 mention the Morris water maze and have the most citations, as counted by NIH's iCite on November 5, 2026.

  1. Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K/AKT/Nrf2 and SLC7A11/GPX4 signaling pathway after ischemia.

    J Ethnopharmacol, 2022. 313 citations.

  2. Morris water maze: a versatile and pertinent tool for assessing spatial learning and memory.

    Exp Anim, 2022. 295 citations.

  3. Bone marrow mesenchymal stem cell-derived exosomes attenuate cerebral ischemia-reperfusion injury-induced neuroinflammation and pyroptosis by modulating microglia M1/M2 phenotypes.

    Exp Neurol, 2021. 281 citations.

  4. Rifaximin-mediated gut microbiota regulation modulates the function of microglia and protects against CUMS-induced depression-like behaviors in adolescent rat.

    J Neuroinflammation, 2021. 227 citations.

  5. Quercetin: A promising therapy for diabetic encephalopathy through inhibition of hippocampal ferroptosis.

    Phytomedicine, 2024. 220 citations.

How we counted

A count is the number of animal research papers whose title or abstract mentions one of the test's search terms. It is not a count of experiments, labs or animals.

A paper that mentions the Morris water maze only in its methods is missed, so the count runs low. The count includes 46 reviews. For 1,125 of the 5,392 papers, PubMed's indexing gave no species, so the species came from PubTator 3 finding one in the title or abstract.

The test's search terms are in the test list download. The full method, with each source and its terms of use, is on our main page, Behavioral tests in published research.

More spatial learning and memory tests

These spatial learning and memory tests also have a page, with their papers from 2021 to 2025. Each test with 30 or more papers gets one.

How to cite

APA

ConductScience. (2026, November 10). Morris water maze in published research [Data set]. https://conductscience.com/data/behavioral-tests/morris-water-maze

BibTeX

@misc{conductscience_morris_water_maze_2026,
  author = {{ConductScience}},
  title = {Morris water maze in published research},
  year = {2026},
  month = nov,
  url = {https://conductscience.com/data/behavioral-tests/morris-water-maze},
  note = {Data set, released November 10, 2026},
}

Apparatus for the Morris water maze

Our store sells one product for the Morris water maze.

Shop the apparatus

Papers that name our apparatus

We keep our own list of published papers whose text names our equipment. Those that mention the Morris water maze in the title or abstract are already in the counts above.

  • 13 papers from 2018 to 2026 name our Morris Water Maze. See the papers