Research data ยท Fear and avoidance

Fear conditioning

From 2021 to 2025, 2,010 animal research papers mentioned fear conditioning in their title or abstract, ranking it seventh of the 90 tests we track.

That is about the same as the 2,034 papers of 2011 to 2015. Papers that mention any of the 90 tests rose 22% over the same span. The 2021 to 2025 count may run low because of a dip in PubMed's indexing, explained under the year chart.

2,010 animal research papers from 2021 to 2025 mentioned the test
About the same number of papers as in 2011 to 2015
7th of the 90 tests by papers from 2021 to 2025
58% of these papers used mice and 35% used rats

Papers by year

Animal research papers that mention fear conditioning, by year, 2001 to 2026

The 2026 bar counts papers added to PubMed by November 8, 2026.

  • Papers in a full year
  • 2026 so far
Show the counts for each year
Papers by year
YearPapers
2001127
2002155
2003187
2004186
2005198
2006249
2007240
2008301
2009313
2010318
2011330
2012386
2013424
2014489
2015405
2016467
2017427
2018466
2019454
2020428
2021478
2022405
2023370
2024378
2025379
2026 (part year)353

Papers that mention fear conditioning fell from 478 in 2021 to 370 in 2023, then rose to 379 in 2025. Papers that PubMed indexed under the MeSH heading Animals also fell and rose, from 200,221 in 2021 to 156,447 in 2023 and 235,479 in 2025. We take each paper's species from PubMed's indexing whenever it names one, so part of this dip may come from the indexing rather than from fewer studies.

Papers that mention fear conditioning in mice and in rats, by year, 2001 to 2025

  • Mouse
  • Rat
Show the counts for each year and species
Papers by year, mice and rats
YearMouseRat
20013283
20024394
20036599
200453119
200570110
200669162
2007101120
2008106177
2009126165
2010139167
2011150163
2012181170
2013186219
2014252219
2015189185
2016238206
2017219181
2018235205
2019245185
2020233179
2021272178
2022228153
2023218127
2024230121
2025226129

Which species the papers used

Each bar is a share of the 2,010 papers from 2021 to 2025. A paper can use more than one species, so the shares can add to more than 100%.

Species

Mouse
1,174 papers 58%
Rat
708 papers 35%
Other animals
155 papers 8%
Zebrafish
10 papers under 1%
Fruit fly
2 papers under 1%
Nonhuman primate
2 papers under 1%

โ€œOther animalsโ€ counts papers that use none of the other species in this chart.

Strains and genetic lines

Strain names come from the MeSH terms PubMed adds when it indexes a paper. PubMed has indexed 1,698 of the 2,010 papers, so each bar is a share of those 1,698.

C57BL mice
482 papers 28%
Sprague-Dawley rats
182 papers 11%
Knockout mice
125 papers 7%
Wistar rats
119 papers 7%
Transgenic mice
118 papers 7%
Long-Evans rats
51 papers 3%
Transgenic rats
8 papers under 1%
129 mice
8 papers under 1%

A paper indexed under two of these headings, such as knockout mice and a strain, counts under both.

Disease models these papers study

Each bar counts the papers from 2021 to 2025 that mention fear conditioning and study that disease model, with its share of the 2,010 papers. The model comes from a paper's MeSH terms. For a paper PubMed has not indexed, it comes from PubTator 3, NCBI's text-mining service, when that service finds the disease in the title or abstract. A paper can count under more than one model.

Papers from 2021 to 2025 by disease model

268 papers 13%
222 papers 11%
125 papers 6%
48 papers 2%
45 papers 2%
39 papers 2%
28 papers 1%

Tests mentioned alongside fear conditioning

Each bar counts the papers from 2021 to 2025 that mention both tests, with its share of the 2,010 papers that mention fear conditioning.

Papers from 2021 to 2025 that mention both tests

161 papers 8%
135 papers 7%
127 papers 6%
96 papers 5%
55 papers 3%
43 papers 2%

The most cited papers from 2021 to 2025

These papers from 2021 to 2025 mention fear conditioning and have the most citations, as counted by NIH's iCite on November 5, 2026. We show four of the five most cited papers and leave out one because of words in its title.

  1. Dexmedetomidine attenuates sepsis-associated inflammation and encephalopathy via central ฮฑ2A adrenoceptor.

    Brain Behav Immun, 2021. 216 citations.

  2. Representational drift in primary olfactory cortex.

    Nature, 2021. 214 citations.

  3. Brain-wide mapping reveals that engrams for a single memory are distributed across multiple brain regions.

    Nat Commun, 2022. 192 citations.

  4. NLRP3 Deficiency Protects Against Intermittent Hypoxia-Induced Neuroinflammation and Mitochondrial ROS by Promoting the PINK1-Parkin Pathway of Mitophagy in a Murine Model of Sleep Apnea.

    Front Immunol, 2021. 150 citations.

How we counted

A count is the number of animal research papers whose title or abstract mentions one of the test's search terms. It is not a count of experiments, labs or animals.

A paper that mentions fear conditioning only in its methods is missed, so the count runs low. The count includes 101 reviews. For 313 of the 2,010 papers, PubMed's indexing gave no species, so the species came from PubTator 3 finding one in the title or abstract.

The test's search terms are in the test list download. The full method, with each source and its terms of use, is on our main page, Behavioral tests in published research.

More fear and avoidance tests

These fear and avoidance tests also have a page, with their papers from 2021 to 2025. Each test with 30 or more papers gets one.

How to cite

APA

ConductScience. (2026, November 10). Fear conditioning in published research [Data set]. https://conductscience.com/data/behavioral-tests/fear-conditioning

BibTeX

@misc{conductscience_fear_conditioning_2026,
  author = {{ConductScience}},
  title = {Fear conditioning in published research},
  year = {2026},
  month = nov,
  url = {https://conductscience.com/data/behavioral-tests/fear-conditioning},
  note = {Data set, released November 10, 2026},
}

Apparatus for fear conditioning

Our store sells one product for fear conditioning.

Shop the apparatus

Papers that name our apparatus

We keep our own list of published papers whose text names our equipment. Those that mention fear conditioning in the title or abstract are already in the counts above.

  • 13 papers from 2020 to 2026 name our Fear Conditioning System. See the papers