Research data ยท Fear and avoidance

Active avoidance (shuttle box)

From 2021 to 2025, 210 animal research papers mentioned active avoidance (shuttle box) in their title or abstract, ranking it 40th of the 90 tests we track.

That is 17% fewer than the 252 papers of 2011 to 2015. Papers that mention any of the 90 tests rose 22% over the same span. The 2021 to 2025 count may run low because of a dip in PubMed's indexing, explained under the year chart.

210 animal research papers from 2021 to 2025 mentioned the test
17% fewer papers than in 2011 to 2015
40th of the 90 tests by papers from 2021 to 2025
53% of these papers used rats and 33% used mice

Papers by year

Animal research papers that mention active avoidance (shuttle box), by year, 2001 to 2026

The 2026 bar counts papers added to PubMed by November 8, 2026.

  • Papers in a full year
  • 2026 so far
Show the counts for each year
Papers by year
YearPapers
200165
200259
200358
200448
200545
200649
200744
200851
200947
201048
201144
201240
201351
201460
201557
201643
201741
201839
201948
202046
202153
202236
202337
202443
202541
2026 (part year)64

Papers that mention active avoidance (shuttle box) fell from 53 in 2021 to 36 in 2022, then rose to 41 in 2025. Papers that PubMed indexed under the MeSH heading Animals also fell and rose, from 200,221 in 2021 to 156,447 in 2023 and 235,479 in 2025. We take each paper's species from PubMed's indexing whenever it names one, so part of this dip may come from the indexing rather than from fewer studies.

Rats led mice every year from 2001 to 2025.

Papers that mention active avoidance (shuttle box) in mice and in rats, by year, 2001 to 2025

  • Mouse
  • Rat
Show the counts for each year and species
Papers by year, mice and rats
YearMouseRat
2001951
20021246
2003849
2004835
2005836
2006939
2007732
20081134
2009634
2010935
20111033
20121128
20131037
20141240
20151937
20161326
20171422
2018726
20191128
2020829
20211628
20221219
20231520
20241720
20251025

Which species the papers used

Each bar is a share of the 210 papers from 2021 to 2025. A paper can use more than one species, so the shares can add to more than 100%.

Species

Rat
112 papers 53%
Mouse
70 papers 33%
Other animals
21 papers 10%
Zebrafish
6 papers 3%
Fruit fly
2 papers 1%
Nonhuman primate
1 paper under 1%

โ€œOther animalsโ€ counts papers that use none of the other species in this chart.

Strains and genetic lines

Strain names come from the MeSH terms PubMed adds when it indexes a paper. PubMed has indexed 167 of the 210 papers, so each bar is a share of those 167.

Wistar rats
26 papers 16%
C57BL mice
25 papers 15%
Sprague-Dawley rats
21 papers 13%
Knockout mice
5 papers 3%
Long-Evans rats
4 papers 2%
Transgenic mice
3 papers 2%
Neurological mutant mice
1 paper 1%
Other inbred mice
1 paper 1%

A paper indexed under two of these headings, such as knockout mice and a strain, counts under both.

Disease models these papers study

Each bar counts the papers from 2021 to 2025 that mention active avoidance (shuttle box) and study that disease model, with its share of the 210 papers. The model comes from a paper's MeSH terms. For a paper PubMed has not indexed, it comes from PubTator 3, NCBI's text-mining service, when that service finds the disease in the title or abstract. A paper can count under more than one model.

Papers from 2021 to 2025 by disease model

Tests mentioned alongside active avoidance (shuttle box)

Each bar counts the papers from 2021 to 2025 that mention both tests, with its share of the 210 papers that mention active avoidance (shuttle box).

Papers from 2021 to 2025 that mention both tests

45 papers 21%
17 papers 8%
14 papers 7%
14 papers 7%
14 papers 7%
12 papers 6%

The most cited papers from 2021 to 2025

These papers from 2021 to 2025 mention active avoidance (shuttle box) and have the most citations, as counted by NIH's iCite on November 5, 2026.

  1. A review of behavioral methods for the evaluation of cognitive performance in animal models: Current techniques and links to human cognition.

    Physiol Behav, 2022. 110 citations.

  2. Vision rescue via unconstrained in vivo prime editing in degenerating neural retinas.

    J Exp Med, 2023. 81 citations.

  3. Bone marrow mesenchymal stem cell-derived exosomal lncRNA KLF3-AS1 stabilizes Sirt1 protein to improve cerebral ischemia/reperfusion injury via miR-206/USP22 axis.

    Mol Med, 2023. 67 citations.

  4. Divergent projections of the paraventricular nucleus of the thalamus mediate the selection of passive and active defensive behaviors.

    Nat Neurosci, 2021. 63 citations.

  5. Zebrafish capable of generating future state prediction error show improved active avoidance behavior in virtual reality.

    Nat Commun, 2021. 44 citations.

How we counted

A count is the number of animal research papers whose title or abstract mentions one of the test's search terms. It is not a count of experiments, labs or animals.

A paper that mentions active avoidance (shuttle box) only in its methods is missed, so the count runs low. The count includes 12 reviews. For 43 of the 210 papers, PubMed's indexing gave no species, so the species came from PubTator 3 finding one in the title or abstract.

The test's search terms are in the test list download. The full method, with each source and its terms of use, is on our main page, Behavioral tests in published research.

More fear and avoidance tests

These fear and avoidance tests also have a page, with their papers from 2021 to 2025. Each test with 30 or more papers gets one.

How to cite

APA

ConductScience. (2026, November 10). Active avoidance (shuttle box) in published research [Data set]. https://conductscience.com/data/behavioral-tests/active-avoidance

BibTeX

@misc{conductscience_active_avoidance_2026,
  author = {{ConductScience}},
  title = {Active avoidance (shuttle box) in published research},
  year = {2026},
  month = nov,
  url = {https://conductscience.com/data/behavioral-tests/active-avoidance},
  note = {Data set, released November 10, 2026},
}

Apparatus for active avoidance (shuttle box)

Our store sells one product for active avoidance (shuttle box).

Shop the apparatus

Papers that name our apparatus

We keep our own list of published papers whose text names our equipment. Those that mention active avoidance (shuttle box) in the title or abstract are already in the counts above.

  • 11 papers from 2021 to 2025 name our Active/Passive Avoidance Shuttle Box. See the papers