Research data ยท Fear and avoidance

Step-down avoidance

From 2021 to 2025, 97 animal research papers mentioned step-down avoidance in their title or abstract, ranking it 57th of the 90 tests we track.

That is 51% fewer than the 199 papers of 2011 to 2015. Papers that mention any of the 90 tests rose 22% over the same span.

97 animal research papers from 2021 to 2025 mentioned the test
51% fewer papers than in 2011 to 2015
57th of the 90 tests by papers from 2021 to 2025
68% of these papers used mice and 30% used rats

Papers by year

Animal research papers that mention step-down avoidance, by year, 2001 to 2026

The 2026 bar counts papers added to PubMed by November 8, 2026.

  • Papers in a full year
  • 2026 so far
Show the counts for each year
Papers by year
YearPapers
200119
200226
200321
200422
200525
200631
200730
200829
200925
201040
201139
201238
201347
201435
201540
201649
201740
201834
201939
202029
202126
202222
202319
202416
202514
2026 (part year)11

Papers that mention step-down avoidance in mice and in rats, by year, 2001 to 2025

  • Mouse
  • Rat
Show the counts for each year and species
Papers by year, mice and rats
YearMouseRat
2001811
20021114
2003815
20041011
2005518
20061813
20071218
20081117
20091710
20102218
20112218
20121721
20131534
20142119
20151822
20163316
20172716
20182214
20192615
20201811
2021169
2022129
2023136
2024142
2025113

Which species the papers used

Each bar is a share of the 97 papers from 2021 to 2025. A paper can use more than one species, so the shares can add to more than 100%.

Species

Mouse
66 papers 68%
Rat
29 papers 30%
Other animals
2 papers 2%

โ€œOther animalsโ€ counts papers that use none of the other species in this chart.

Strains and genetic lines

Strain names come from the MeSH terms PubMed adds when it indexes a paper. PubMed has indexed 76 of the 97 papers, so each bar is a share of those 76.

Wistar rats
10 papers 13%
C57BL mice
10 papers 13%
Sprague-Dawley rats
7 papers 9%
Transgenic mice
5 papers 7%
ICR mice
3 papers 4%
Other inbred mice
2 papers 3%
Knockout mice
2 papers 3%
BALB/c mice
1 paper 1%

A paper indexed under two of these headings, such as knockout mice and a strain, counts under both.

Disease models these papers study

Each bar counts the papers from 2021 to 2025 that mention step-down avoidance and study that disease model, with its share of the 97 papers. The model comes from a paper's MeSH terms. For a paper PubMed has not indexed, it comes from PubTator 3, NCBI's text-mining service, when that service finds the disease in the title or abstract. A paper can count under more than one model.

Papers from 2021 to 2025 by disease model

20 papers 21%
7 papers 7%
5 papers 5%
4 papers 4%
3 papers 3%

Tests mentioned alongside step-down avoidance

Each bar counts the papers from 2021 to 2025 that mention both tests, with its share of the 97 papers that mention step-down avoidance.

Papers from 2021 to 2025 that mention both tests

45 papers 46%
43 papers 44%
15 papers 15%
9 papers 9%
6 papers 6%
5 papers 5%

The most cited papers from 2021 to 2025

These papers from 2021 to 2025 mention step-down avoidance and have the most citations, as counted by NIH's iCite on November 5, 2026.

  1. A review of behavioral methods for the evaluation of cognitive performance in animal models: Current techniques and links to human cognition.

    Physiol Behav, 2022. 110 citations.

  2. GJ-4 ameliorates memory impairment in focal cerebral ischemia/reperfusion of rats via inhibiting JAK2/STAT1-mediated neuroinflammation.

    J Ethnopharmacol, 2021. 47 citations.

  3. Cornuside ameliorates cognitive impairments in scopolamine induced AD mice: Involvement of neurotransmitter and oxidative stress.

    J Ethnopharmacol, 2022. 41 citations.

  4. DL0410 Alleviates Memory Impairment in D-Galactose-Induced Aging Rats by Suppressing Neuroinflammation via the TLR4/MyD88/NF-ฮบB Pathway.

    Oxid Med Cell Longev, 2021. 41 citations.

  5. Naringin ameliorates memory deficits and exerts neuroprotective effects in a mouse model of Alzheimer's disease by regulating multiple metabolic pathways.

    Mol Med Rep, 2021. 40 citations.

How we counted

A count is the number of animal research papers whose title or abstract mentions one of the test's search terms. It is not a count of experiments, labs or animals.

A paper that mentions step-down avoidance only in its methods is missed, so the count runs low. The count includes 1 review. For 21 of the 97 papers, PubMed's indexing gave no species, so the species came from PubTator 3 finding one in the title or abstract.

The test's search terms are in the test list download. The full method, with each source and its terms of use, is on our main page, Behavioral tests in published research.

More fear and avoidance tests

These fear and avoidance tests also have a page, with their papers from 2021 to 2025. Each test with 30 or more papers gets one.

How to cite

APA

ConductScience. (2026, November 10). Step-down avoidance in published research [Data set]. https://conductscience.com/data/behavioral-tests/step-down-avoidance

BibTeX

@misc{conductscience_step_down_avoidance_2026,
  author = {{ConductScience}},
  title = {Step-down avoidance in published research},
  year = {2026},
  month = nov,
  url = {https://conductscience.com/data/behavioral-tests/step-down-avoidance},
  note = {Data set, released November 10, 2026},
}

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