Research data ยท Depression-like behavior

Tail suspension test

From 2021 to 2025, 1,405 animal research papers mentioned the tail suspension test in their title or abstract, ranking it 11th of the 90 tests we track.

That is 1.9 times the 737 papers of 2011 to 2015. Papers that mention any of the 90 tests grew to 1.2 times as many over the same span.

1,405 animal research papers from 2021 to 2025 mentioned the test
1.9 times as many papers as in 2011 to 2015
11th of the 90 tests by papers from 2021 to 2025
89% of these papers used mice and 14% used rats

Papers by year

Animal research papers that mention the tail suspension test, by year, 2001 to 2026

The 2026 bar counts papers added to PubMed by November 8, 2026.

  • Papers in a full year
  • 2026 so far
Show the counts for each year
Papers by year
YearPapers
200118
200214
200327
200422
200527
200630
200762
200888
200968
2010103
2011104
2012129
2013164
2014185
2015155
2016194
2017209
2018212
2019246
2020244
2021260
2022294
2023252
2024262
2025337
2026 (part year)288

Mice led rats every year from 2001 to 2025.

Papers that mention the tail suspension test in mice and in rats, by year, 2001 to 2025

  • Mouse
  • Rat
Show the counts for each year and species
Papers by year, mice and rats
YearMouseRat
20011510
2002132
2003238
2004207
2005265
2006279
20075911
20088125
2009649
20109821
20119323
201211922
201315130
201417524
201514123
201617631
201719029
201818330
201921540
202022823
202123041
202225644
202322733
202423832
202530449

Which species the papers used

Each bar is a share of the 1,405 papers from 2021 to 2025. A paper can use more than one species, so the shares can add to more than 100%.

Species

Mouse
1,255 papers 89%
Rat
199 papers 14%
Other animals
12 papers 1%
Zebrafish
5 papers under 1%
Nonhuman primate
2 papers under 1%

โ€œOther animalsโ€ counts papers that use none of the other species in this chart.

Strains and genetic lines

Strain names come from the MeSH terms PubMed adds when it indexes a paper. PubMed has indexed 1,089 of the 1,405 papers, so each bar is a share of those 1,089.

C57BL mice
326 papers 30%
Sprague-Dawley rats
51 papers 5%
Knockout mice
44 papers 4%
ICR mice
42 papers 4%
Wistar rats
27 papers 2%
BALB/c mice
26 papers 2%
Transgenic mice
25 papers 2%
Other inbred mice
5 papers under 1%

A paper indexed under two of these headings, such as knockout mice and a strain, counts under both.

Disease models these papers study

Each bar counts the papers from 2021 to 2025 that mention the tail suspension test and study that disease model, with its share of the 1,405 papers. The model comes from a paper's MeSH terms. For a paper PubMed has not indexed, it comes from PubTator 3, NCBI's text-mining service, when that service finds the disease in the title or abstract. A paper can count under more than one model.

Papers from 2021 to 2025 by disease model

Tests mentioned alongside the tail suspension test

Each bar counts the papers from 2021 to 2025 that mention both tests, with its share of the 1,405 papers that mention the tail suspension test.

Papers from 2021 to 2025 that mention both tests

893 papers 64%
511 papers 36%
324 papers 23%
89 papers 6%
83 papers 6%
77 papers 5%

The most cited papers from 2021 to 2025

These papers from 2021 to 2025 mention the tail suspension test and have the most citations, as counted by NIH's iCite on November 5, 2026.

  1. Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway.

    J Neuroinflammation, 2022. 467 citations.

  2. Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive decline in AD-like mice by improving BDNF-related neuropathology.

    J Neuroinflammation, 2022. 271 citations.

  3. Hippocampal Function Is Impaired by a Short-Term High-Fat Diet in Mice: Increased Blood-Brain Barrier Permeability and Neuroinflammation as Triggering Events.

    Front Neurosci, 2021. 138 citations.

  4. Melatonin alleviates depression-like behaviors and cognitive dysfunction in mice by regulating the circadian rhythm of AQP4 polarization.

    Transl Psychiatry, 2023. 125 citations.

  5. 5-HT attenuates chronic stress-induced cognitive impairment in mice through intestinal flora disruption.

    J Neuroinflammation, 2023. 122 citations.

How we counted

A count is the number of animal research papers whose title or abstract mentions one of the test's search terms. It is not a count of experiments, labs or animals.

A paper that mentions the tail suspension test only in its methods is missed, so the count runs low. The count includes 17 reviews. For 316 of the 1,405 papers, PubMed's indexing gave no species, so the species came from PubTator 3 finding one in the title or abstract.

The test's search terms are in the test list download. The full method, with each source and its terms of use, is on our main page, Behavioral tests in published research.

More depression-like behavior tests

These depression-like behavior tests also have a page, with their papers from 2021 to 2025. Each test with 30 or more papers gets one.

How to cite

APA

ConductScience. (2026, November 10). Tail suspension test in published research [Data set]. https://conductscience.com/data/behavioral-tests/tail-suspension-test

BibTeX

@misc{conductscience_tail_suspension_test_2026,
  author = {{ConductScience}},
  title = {Tail suspension test in published research},
  year = {2026},
  month = nov,
  url = {https://conductscience.com/data/behavioral-tests/tail-suspension-test},
  note = {Data set, released November 10, 2026},
}

Apparatus for the tail suspension test

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