Research data ยท Depression-like behavior

Novelty-suppressed feeding

From 2021 to 2025, 260 animal research papers mentioned novelty-suppressed feeding in their title or abstract, ranking it 36th of the 90 tests we track.

That is 1.6 times the 159 papers of 2011 to 2015. Papers that mention any of the 90 tests grew to 1.2 times as many over the same span.

260 animal research papers from 2021 to 2025 mentioned the test
1.6 times as many papers as in 2011 to 2015
36th of the 90 tests by papers from 2021 to 2025
63% of these papers used mice and 40% used rats

Papers by year

Animal research papers that mention novelty-suppressed feeding, by year, 2001 to 2026

The 2026 bar counts papers added to PubMed by November 8, 2026.

  • Papers in a full year
  • 2026 so far
Show the counts for each year
Papers by year
YearPapers
20010
20022
20032
20043
20054
20061
20078
200816
200922
201027
201131
201225
201336
201428
201539
201646
201746
201844
201940
202059
202155
202251
202345
202458
202551
2026 (part year)35

Papers that mention novelty-suppressed feeding fell from 55 in 2021 to 45 in 2023, then rose to 51 in 2025. Papers that PubMed indexed under the MeSH heading Animals also fell and rose, from 200,221 in 2021 to 156,447 in 2023 and 235,479 in 2025. We take each paper's species from PubMed's indexing whenever it names one, so part of this dip may come from the indexing rather than from fewer studies.

Papers that mention novelty-suppressed feeding in mice and in rats, by year, 2001 to 2025

  • Mouse
  • Rat
Show the counts for each year and species
Papers by year, mice and rats
YearMouseRat
200100
200202
200311
200412
200531
200610
200753
200889
2009167
20101711
20112112
20121513
20132611
2014199
20152615
20162919
20173216
20182321
20192615
20204317
20213622
20223518
20232917
20243524
20253022

Which species the papers used

Each bar is a share of the 260 papers from 2021 to 2025. A paper can use more than one species, so the shares can add to more than 100%.

Species

Mouse
165 papers 63%
Rat
103 papers 40%
Zebrafish
1 paper under 1%
Other animals
1 paper under 1%

โ€œOther animalsโ€ counts papers that use none of the other species in this chart.

Strains and genetic lines

Strain names come from the MeSH terms PubMed adds when it indexes a paper. PubMed has indexed 204 of the 260 papers, so each bar is a share of those 204.

C57BL mice
54 papers 26%
Sprague-Dawley rats
42 papers 21%
Wistar rats
19 papers 9%
Transgenic mice
8 papers 4%
Knockout mice
6 papers 3%
ICR mice
5 papers 2%
BALB/c mice
2 papers 1%
Transgenic rats
2 papers 1%

A paper indexed under two of these headings, such as knockout mice and a strain, counts under both.

Disease models these papers study

Each bar counts the papers from 2021 to 2025 that mention novelty-suppressed feeding and study that disease model, with its share of the 260 papers. The model comes from a paper's MeSH terms. For a paper PubMed has not indexed, it comes from PubTator 3, NCBI's text-mining service, when that service finds the disease in the title or abstract. A paper can count under more than one model.

Papers from 2021 to 2025 by disease model

Tests mentioned alongside novelty-suppressed feeding

Each bar counts the papers from 2021 to 2025 that mention both tests, with its share of the 260 papers that mention novelty-suppressed feeding.

Papers from 2021 to 2025 that mention both tests

143 papers 55%
80 papers 31%
80 papers 31%
26 papers 10%
18 papers 7%
15 papers 6%

The most cited papers from 2021 to 2025

These papers from 2021 to 2025 mention novelty-suppressed feeding and have the most citations, as counted by NIH's iCite on November 5, 2026. We show four of the five most cited papers and leave out one because of words in its title.

  1. Stellate ganglion block ameliorated central post-stroke pain with comorbid anxiety and depression through inhibiting HIF-1ฮฑ/NLRP3 signaling following thalamic hemorrhagic stroke.

    J Neuroinflammation, 2023. 115 citations.

  2. Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapid antidepressant responses.

    Mol Psychiatry, 2021. 108 citations.

  3. Radix Polygalae extract exerts antidepressant effects in behavioral despair mice and chronic restraint stress-induced rats probably by promoting autophagy and inhibiting neuroinflammation.

    J Ethnopharmacol, 2021. 67 citations.

  4. Music prevents stress-induced depression and anxiety-like behavior in mice.

    Transl Psychiatry, 2023. 65 citations.

How we counted

A count is the number of animal research papers whose title or abstract mentions one of the test's search terms. It is not a count of experiments, labs or animals.

A paper that mentions novelty-suppressed feeding only in its methods is missed, so the count runs low. The count includes 0 reviews. For 56 of the 260 papers, PubMed's indexing gave no species, so the species came from PubTator 3 finding one in the title or abstract.

The test's search terms are in the test list download. The full method, with each source and its terms of use, is on our main page, Behavioral tests in published research.

More depression-like behavior tests

These depression-like behavior tests also have a page, with their papers from 2021 to 2025. Each test with 30 or more papers gets one.

How to cite

APA

ConductScience. (2026, November 10). Novelty-suppressed feeding in published research [Data set]. https://conductscience.com/data/behavioral-tests/novelty-suppressed-feeding

BibTeX

@misc{conductscience_novelty_suppressed_feeding_2026,
  author = {{ConductScience}},
  title = {Novelty-suppressed feeding in published research},
  year = {2026},
  month = nov,
  url = {https://conductscience.com/data/behavioral-tests/novelty-suppressed-feeding},
  note = {Data set, released November 10, 2026},
}