Research data ยท Anxiety-like behavior

Marble burying

From 2021 to 2025, 328 animal research papers mentioned marble burying in their title or abstract, ranking it 34th of the 90 tests we track.

That is 1.9 times the 176 papers of 2011 to 2015. Papers that mention any of the 90 tests grew to 1.2 times as many over the same span.

328 animal research papers from 2021 to 2025 mentioned the test
1.9 times as many papers as in 2011 to 2015
34th of the 90 tests by papers from 2021 to 2025
77% of these papers used mice and 26% used rats

Papers by year

Animal research papers that mention marble burying, by year, 2001 to 2026

The 2026 bar counts papers added to PubMed by November 8, 2026.

  • Papers in a full year
  • 2026 so far
Show the counts for each year
Papers by year
YearPapers
20011
20028
20031
20045
20059
200612
200712
200816
200920
201015
201130
201232
201332
201442
201540
201639
201739
201858
201957
202065
202160
202256
202364
202467
202581
2026 (part year)74

Papers that mention marble burying in mice and in rats, by year, 2001 to 2025

  • Mouse
  • Rat
Show the counts for each year and species
Papers by year, mice and rats
YearMouseRat
200111
200261
200311
200451
200582
2006121
2007113
2008144
2009159
2010133
2011293
2012313
2013315
2014396
2015348
2016338
20173013
20184510
20194315
20205115
20214913
20224810
20234720
20244523
20256219

Which species the papers used

Each bar is a share of the 328 papers from 2021 to 2025. A paper can use more than one species, so the shares can add to more than 100%.

Species

Mouse
251 papers 77%
Rat
85 papers 26%
Other animals
2 papers 1%
Zebrafish
1 paper under 1%

โ€œOther animalsโ€ counts papers that use none of the other species in this chart.

Strains and genetic lines

Strain names come from the MeSH terms PubMed adds when it indexes a paper. PubMed has indexed 254 of the 328 papers, so each bar is a share of those 254.

C57BL mice
90 papers 35%
Wistar rats
26 papers 10%
Knockout mice
18 papers 7%
Sprague-Dawley rats
13 papers 5%
Transgenic mice
9 papers 4%
Other inbred mice
7 papers 3%
BALB/c mice
6 papers 2%
Long-Evans rats
4 papers 2%

A paper indexed under two of these headings, such as knockout mice and a strain, counts under both.

Disease models these papers study

Each bar counts the papers from 2021 to 2025 that mention marble burying and study that disease model, with its share of the 328 papers. The model comes from a paper's MeSH terms. For a paper PubMed has not indexed, it comes from PubTator 3, NCBI's text-mining service, when that service finds the disease in the title or abstract. A paper can count under more than one model.

Papers from 2021 to 2025 by disease model

120 papers 37%
53 papers 16%
9 papers 3%
Fragile X syndrome
7 papers 2%

Tests mentioned alongside marble burying

Each bar counts the papers from 2021 to 2025 that mention both tests, with its share of the 328 papers that mention marble burying.

Papers from 2021 to 2025 that mention both tests

108 papers 33%
83 papers 25%
63 papers 19%
41 papers 13%

The most cited papers from 2021 to 2025

These papers from 2021 to 2025 mention marble burying and have the most citations, as counted by NIH's iCite on November 5, 2026.

  1. Human-Derived Bifidobacterium dentium Modulates the Mammalian Serotonergic System and Gut-Brain Axis.

    Cell Mol Gastroenterol Hepatol, 2021. 139 citations.

  2. TNF signaling pathway-mediated microglial activation in the PFC underlies acute paradoxical sleep deprivation-induced anxiety-like behaviors in mice.

    Brain Behav Immun, 2022. 75 citations.

  3. Lipidomics reveals that acupuncture modulates the lipid metabolism and inflammatory interaction in a mouse model of depression.

    Brain Behav Immun, 2021. 73 citations.

  4. Antisense oligonucleotide treatment rescues UBE3A expression and multiple phenotypes of an Angelman syndrome mouse model.

    JCI Insight, 2021. 72 citations.

  5. Infiltrated regulatory T cells and Th2 cells in the brain contribute to attenuation of sepsis-associated encephalopathy and alleviation of mental impairments in mice with polymicrobial sepsis.

    Brain Behav Immun, 2021. 59 citations.

How we counted

A count is the number of animal research papers whose title or abstract mentions one of the test's search terms. It is not a count of experiments, labs or animals.

A paper that mentions marble burying only in its methods is missed, so the count runs low. The count includes 3 reviews. For 74 of the 328 papers, PubMed's indexing gave no species, so the species came from PubTator 3 finding one in the title or abstract.

The test's search terms are in the test list download. The full method, with each source and its terms of use, is on our main page, Behavioral tests in published research.

More anxiety-like behavior tests

These anxiety-like behavior tests also have a page, with their papers from 2021 to 2025. Each test with 30 or more papers gets one.

How to cite

APA

ConductScience. (2026, November 10). Marble burying in published research [Data set]. https://conductscience.com/data/behavioral-tests/marble-burying

BibTeX

@misc{conductscience_marble_burying_2026,
  author = {{ConductScience}},
  title = {Marble burying in published research},
  year = {2026},
  month = nov,
  url = {https://conductscience.com/data/behavioral-tests/marble-burying},
  note = {Data set, released November 10, 2026},
}