Research data ยท Anxiety-like behavior

Elevated zero maze

From 2021 to 2025, 136 animal research papers mentioned the elevated zero maze in their title or abstract, ranking it 49th of the 90 tests we track.

That is 1.3 times the 108 papers of 2011 to 2015. Papers that mention any of the 90 tests grew to 1.2 times as many over the same span.

136 animal research papers from 2021 to 2025 mentioned the test
1.3 times as many papers as in 2011 to 2015
49th of the 90 tests by papers from 2021 to 2025
63% of these papers used mice and 39% used rats

Papers by year

Animal research papers that mention the elevated zero maze, by year, 2001 to 2026

The 2026 bar counts papers added to PubMed by November 8, 2026.

  • Papers in a full year
  • 2026 so far
Show the counts for each year
Papers by year
YearPapers
20013
20027
20033
20049
200510
20069
200718
200821
200920
201014
201118
201217
201325
201424
201524
201617
201724
201825
201930
202023
202130
202226
202326
202425
202529
2026 (part year)26

Papers that mention the elevated zero maze fell from 30 in 2021 to 25 in 2024, then rose to 29 in 2025. Papers that PubMed indexed under the MeSH heading Animals also fell and rose, from 200,221 in 2021 to 156,447 in 2023 and 235,479 in 2025. We take each paper's species from PubMed's indexing whenever it names one, so part of this dip may come from the indexing rather than from fewer studies.

Papers that mention the elevated zero maze in mice and in rats, by year, 2001 to 2025

  • Mouse
  • Rat
Show the counts for each year and species
Papers by year, mice and rats
YearMouseRat
200121
200243
200312
200473
200564
200673
2007145
2008185
2009176
201087
2011135
2012125
2013207
2014159
20151411
2016126
2017205
20181510
2019228
2020166
20211613
2022197
20231411
2024189
20251813

Which species the papers used

Each bar is a share of the 136 papers from 2021 to 2025. A paper can use more than one species, so the shares can add to more than 100%.

Species

Mouse
85 papers 63%
Rat
53 papers 39%
Other animals
4 papers 3%

โ€œOther animalsโ€ counts papers that use none of the other species in this chart.

Strains and genetic lines

Strain names come from the MeSH terms PubMed adds when it indexes a paper. PubMed has indexed 109 of the 136 papers, so each bar is a share of those 109.

C57BL mice
33 papers 30%
Sprague-Dawley rats
15 papers 14%
Wistar rats
13 papers 12%
Knockout mice
7 papers 6%
Transgenic mice
6 papers 6%
Long-Evans rats
3 papers 3%
BALB/c mice
1 paper 1%
ICR mice
1 paper 1%

A paper indexed under two of these headings, such as knockout mice and a strain, counts under both.

Disease models these papers study

Each bar counts the papers from 2021 to 2025 that mention the elevated zero maze and study that disease model, with its share of the 136 papers. The model comes from a paper's MeSH terms. For a paper PubMed has not indexed, it comes from PubTator 3, NCBI's text-mining service, when that service finds the disease in the title or abstract. A paper can count under more than one model.

Papers from 2021 to 2025 by disease model

Tests mentioned alongside the elevated zero maze

Each bar counts the papers from 2021 to 2025 that mention both tests, with its share of the 136 papers that mention the elevated zero maze.

Papers from 2021 to 2025 that mention both tests

40 papers 29%
32 papers 24%
17 papers 13%
16 papers 12%
14 papers 10%

The most cited papers from 2021 to 2025

These papers from 2021 to 2025 mention the elevated zero maze and have the most citations, as counted by NIH's iCite on November 5, 2026.

  1. Transgenerational transmission of aspartame-induced anxiety and changes in glutamate-GABA signaling and gene expression in the amygdala.

    Proc Natl Acad Sci U S A, 2022. 59 citations.

  2. The Impact of Chronic Unpredictable Mild Stress-Induced Depression on Spatial, Recognition and Reference Memory Tasks in Mice: Behavioral and Histological Study.

    Behav Sci (Basel), 2022. 56 citations.

  3. Co-released norepinephrine and galanin act on different timescales to promote stress-induced anxiety-like behavior.

    Neuropsychopharmacology, 2021. 43 citations.

  4. Behavioral outcomes of complete Freund adjuvant-induced inflammatory pain in the rodent hind paw: a systematic review and meta-analysis.

    Pain, 2022. 38 citations.

  5. A two-hit adversity model in developing rats reveals sex-specific impacts on prefrontal cortex structure and behavior.

    Dev Cogn Neurosci, 2021. 38 citations.

How we counted

A count is the number of animal research papers whose title or abstract mentions one of the test's search terms. It is not a count of experiments, labs or animals.

A paper that mentions the elevated zero maze only in its methods is missed, so the count runs low. The count includes 2 reviews. For 27 of the 136 papers, PubMed's indexing gave no species, so the species came from PubTator 3 finding one in the title or abstract.

The test's search terms are in the test list download. The full method, with each source and its terms of use, is on our main page, Behavioral tests in published research.

More anxiety-like behavior tests

These anxiety-like behavior tests also have a page, with their papers from 2021 to 2025. Each test with 30 or more papers gets one.

How to cite

APA

ConductScience. (2026, November 10). Elevated zero maze in published research [Data set]. https://conductscience.com/data/behavioral-tests/elevated-zero-maze

BibTeX

@misc{conductscience_elevated_zero_maze_2026,
  author = {{ConductScience}},
  title = {Elevated zero maze in published research},
  year = {2026},
  month = nov,
  url = {https://conductscience.com/data/behavioral-tests/elevated-zero-maze},
  note = {Data set, released November 10, 2026},
}

Apparatus for the elevated zero maze

Our store sells one product for the elevated zero maze.

Shop the apparatus

Papers that name our apparatus

We keep our own list of published papers whose text names our equipment. Those that mention the elevated zero maze in the title or abstract are already in the counts above.