Research data ยท Depression-like behavior

Learned helplessness

From 2021 to 2025, 85 animal research papers mentioned learned helplessness in their title or abstract, ranking it 60th of the 90 tests we track.

That is 33% fewer than the 126 papers of 2011 to 2015. Papers that mention any of the 90 tests rose 22% over the same span.

85 animal research papers from 2021 to 2025 mentioned the test
33% fewer papers than in 2011 to 2015
60th of the 90 tests by papers from 2021 to 2025
53% of these papers used rats and 47% used mice

Papers by year

Animal research papers that mention learned helplessness, by year, 2001 to 2026

The 2026 bar counts papers added to PubMed by November 8, 2026.

  • Papers in a full year
  • 2026 so far
Show the counts for each year
Papers by year
YearPapers
200123
200217
200321
200423
200530
200613
200727
200833
200918
201034
201127
201225
201324
201425
201525
201646
201730
201826
201928
202020
202121
202221
202316
202417
202510
2026 (part year)10

Papers that mention learned helplessness in mice and in rats, by year, 2001 to 2025

  • Mouse
  • Rat
Show the counts for each year and species
Papers by year, mice and rats
YearMouseRat
2001419
2002411
2003219
2004915
2005717
2006310
2007919
20081418
2009215
20101123
2011719
20121115
2013617
2014719
20151213
20162717
20171316
20181116
20191216
2020127
2021813
20221011
2023105
2024612
202564

Which species the papers used

Each bar is a share of the 85 papers from 2021 to 2025. A paper can use more than one species, so the shares can add to more than 100%.

Species

Rat
45 papers 53%
Mouse
40 papers 47%
Other animals
6 papers 7%

โ€œOther animalsโ€ counts papers that use none of the other species in this chart.

Strains and genetic lines

Strain names come from the MeSH terms PubMed adds when it indexes a paper. PubMed has indexed 71 of the 85 papers, so each bar is a share of those 71.

Sprague-Dawley rats
16 papers 23%
C57BL mice
15 papers 21%
Wistar rats
4 papers 6%
Knockout mice
3 papers 4%
ICR mice
2 papers 3%
Transgenic mice
2 papers 3%

A paper indexed under two of these headings, such as knockout mice and a strain, counts under both.

Disease models these papers study

Each bar counts the papers from 2021 to 2025 that mention learned helplessness and study that disease model, with its share of the 85 papers. The model comes from a paper's MeSH terms. For a paper PubMed has not indexed, it comes from PubTator 3, NCBI's text-mining service, when that service finds the disease in the title or abstract. A paper can count under more than one model.

Papers from 2021 to 2025 by disease model

Tests mentioned alongside learned helplessness

Each bar counts the papers from 2021 to 2025 that mention both tests, with its share of the 85 papers that mention learned helplessness.

Papers from 2021 to 2025 that mention both tests

The most cited papers from 2021 to 2025

These papers from 2021 to 2025 mention learned helplessness and have the most citations, as counted by NIH's iCite on November 5, 2026. We show four of the five most cited papers and leave out one because of words in its title.

  1. Sex differences in anxiety and depression: circuits and mechanisms.

    Nat Rev Neurosci, 2021. 383 citations.

  2. Animal Models of Depression: What Can They Teach Us about the Human Disease?

    Diagnostics (Basel), 2021. 136 citations.

  3. Dopamine pathways mediating affective state transitions after sleep loss.

    Neuron, 2024. 72 citations.

  4. AKT and MAPK signaling pathways in hippocampus reveals the pathogenesis of depression in four stress-induced models.

    Transl Psychiatry, 2023. 64 citations.

How we counted

A count is the number of animal research papers whose title or abstract mentions one of the test's search terms. It is not a count of experiments, labs or animals.

A paper that mentions learned helplessness only in its methods is missed, so the count runs low. The count includes 4 reviews. For 14 of the 85 papers, PubMed's indexing gave no species, so the species came from PubTator 3 finding one in the title or abstract.

The test's search terms are in the test list download. The full method, with each source and its terms of use, is on our main page, Behavioral tests in published research.

More depression-like behavior tests

These depression-like behavior tests also have a page, with their papers from 2021 to 2025. Each test with 30 or more papers gets one.

How to cite

APA

ConductScience. (2026, November 10). Learned helplessness in published research [Data set]. https://conductscience.com/data/behavioral-tests/learned-helplessness

BibTeX

@misc{conductscience_learned_helplessness_2026,
  author = {{ConductScience}},
  title = {Learned helplessness in published research},
  year = {2026},
  month = nov,
  url = {https://conductscience.com/data/behavioral-tests/learned-helplessness},
  note = {Data set, released November 10, 2026},
}

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