Tail Suspension
Standardized apparatus for tail suspension behavioral despair testing in mice and rats, commonly used for antidepressant screening and depression research.
| Set of | Set of four, Set of one |
| Automation Level | manual |
| Species | Mouse, Rat |
The Tail Suspension Test apparatus provides a standardized platform for evaluating behavioral despair and screening antidepressant compounds in rodents. This established behavioral assay measures immobility time when animals are suspended by their tail, serving as a reliable model for depression-like behavior and drug efficacy testing.
Available in mouse and rat configurations with detachable aluminum trays for easy cleaning and maintenance. The apparatus features aluminum suspension bars with species-specific station dimensions optimized for proper positioning during testing protocols.
How It Works
The tail suspension test operates on the principle of behavioral despair, where rodents suspended by their tail initially exhibit escape-oriented behaviors before transitioning to immobility. This behavioral pattern reflects a learned helplessness response analogous to depressive states in humans.
During testing, animals are suspended from the aluminum bar using tape or clips, with their head positioned at the appropriate distance from the apparatus base. Immobility is quantified as the absence of escape-oriented movements, typically measured over a 6-minute testing period. The aluminum construction ensures consistent suspension geometry while the detachable tray facilitates cleaning between subjects.
Antidepressant compounds typically reduce immobility time by restoring escape behaviors, making this assay a validated screening tool for therapeutic efficacy. The standardized station dimensions (19cm for mice, 24cm for rats) ensure consistent testing conditions across experimental sessions.
Features & Benefits
Set of
- Set of four
- Set of one
Set of
- Set of four
- Set of one
Behavioral Construct
- Depression-like behavior
- Behavioral despair
- Immobility
- Antidepressant response
- Stress-related behavior
Automation Level
- manual
Research Domain
- Anxiety and Depression Research
- Behavioral Pharmacology
- Drug Discovery
- Neuropsychiatric Research
- Neuroscience
- Psychopharmacology
Species
- Mouse
- Rat
Weight
- 6.06 kg
Dimensions
- L: 65.0 mm
- W: 36.0 mm
- H: 27.0 mm
Comparison Guide
| Feature | This Product | Typical Alternative | Advantage |
|---|---|---|---|
| Construction Material | Aluminum suspension bar and detachable tray | Many alternatives use plastic or steel components | Aluminum provides optimal durability while remaining lightweight and corrosion-resistant for long-term laboratory use |
| Species Configurations | Dedicated mouse (19cm) and rat (24cm) station dimensions | Some models use adjustable or universal sizing | Species-specific dimensions ensure consistent behavioral responses and reduce protocol variability |
| Tray Design | Detachable aluminum tray system | Fixed base designs are common in basic models | Removable components enable thorough cleaning and disinfection between subjects |
| Set Options | Available as single units or four-unit sets | Many suppliers offer fixed quantity configurations | Flexible purchasing options accommodate both low-throughput and high-throughput research needs |
This tail suspension apparatus combines aluminum construction with species-optimized dimensions and modular design. The detachable tray system and flexible set configurations provide practical advantages for laboratories conducting behavioral despair research with varying throughput requirements.
Practical Tips
Verify station height measurements before each experimental session to ensure consistent suspension geometry.
Why: Proper positioning is critical for reliable behavioral responses and data reproducibility
Inspect aluminum components monthly for signs of wear or damage that could affect animal safety or data quality.
Why: Regular maintenance prevents equipment-related artifacts and ensures animal welfare standards
Allow animals to acclimate to the testing room for at least 30 minutes before suspension testing.
Why: Environmental acclimation reduces stress-related confounds that can mask antidepressant effects
If animals consistently show excessive climbing behavior, check tail tape placement and suspension height alignment.
Why: Improper positioning can lead to atypical behaviors that compromise behavioral despair measurements
Score immobility behaviors in real-time or from video recordings using trained observers to ensure consistent criteria application.
Why: Standardized scoring methods are essential for detecting subtle antidepressant effects and reducing inter-observer variability
Limit suspension duration to established protocols and monitor animals continuously throughout testing.
Why: Proper timing and supervision prevent animal distress while maintaining experimental validity
Randomize testing order and blind scorers to experimental groups when possible to minimize bias.
Why: Blinded protocols improve data objectivity and strengthen statistical power for detecting treatment effects
Setup Guide
What’s in the Box
- Aluminum suspension bar
- Detachable aluminum tray
- Mounting hardware (typical)
- User manual with testing protocols (typical)
Warranty
ConductScience provides a one-year manufacturer warranty covering defects in materials and workmanship, with technical support for setup and protocol optimization.
Compliance
References
Background reading relevant to this product:
What is the Tail Suspension Test?
The Tail Suspension Test is a behavioral assay for depression-like behavior in mice. Animals are suspended by the tail and the duration of immobility versus escape-oriented behavior is measured.
How does the Tail Suspension Test work?
A mouse is suspended by its tail from an elevated bar. After initial struggling, mice become immobile. The immobility time correlates with depression-like phenotype and is reduced by antidepressant drug pretreatment.
What research applications use the Tail Suspension Test?
The Tail Suspension Test complements the Forced Swim Test for antidepressant screening. It is used in genetic studies of depression, serotonin transporter research, and rapid screening of novel antidepressant compounds.
Have a question about this product?
Frequently Bought Together
