Conditioned Place Preference Kelsey 1994
SKU CS-958284
$1,830.00
Unit: Each
IncludesStandard Care
Behavioral testing apparatus for assessing drug reward and place conditioning in rodents using established Kelsey 1994 methodology.
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Louise Corscadden, PhD
Director of Science · ConductScience
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Papers that mention conditioned place preference
From 2021 to 2025, 1,078 animal research papers mentioned conditioned place preference. The count covers the test on any apparatus, not only this one.
Key Specifications
Full details →- Automation Level
- Semi-automated
- Species
- Mouse, Rat
- Compatible Tracking Software
- ConductVision
- SKU family
- CS-958284
- Shipping box
- 65.0 × 36.0 × 27.0 cm
- Ordering
- Online checkout and quote request available
The Conditioned Place Preference (CPP) apparatus based on Kelsey 1994 methodology is a behavioral testing system designed to assess place conditioning and drug reward mechanisms in rodents. This apparatus allows researchers to evaluate the reinforcing properties of pharmacological agents by measuring an animal's preference for environments previously paired with drug administration.
The system enables systematic investigation of addiction potential, reward pathways, and conditioned learning behaviors through controlled environmental conditioning protocols. Researchers can quantify place preference changes to assess both rewarding and aversive properties of test compounds in preclinical studies.
How It Works
The conditioned place preference paradigm operates on classical conditioning principles, where animals learn to associate specific environmental cues with drug effects. During conditioning sessions, subjects receive drug injections in one chamber and vehicle injections in the alternate chamber, creating distinct contextual associations.
The apparatus typically consists of two or three distinct chambers with different visual, tactile, or olfactory cues to facilitate discrimination learning. Animals initially show no preference between chambers during baseline testing. Following repeated drug-environment pairings, subjects develop measurable preferences for drug-associated contexts when tested in a drug-free state.
Preference is quantified by measuring time spent in each chamber during test sessions, with increased time in the drug-paired environment indicating positive reinforcing effects. Conversely, avoidance of the drug-paired chamber suggests aversive properties of the test compound.
Features & Benefits
Multi-chamber design with distinct environmental cues
Facilitates clear discrimination learning and robust place conditioning responses
Removable chamber inserts
Enables easy cleaning between subjects and prevents cross-contamination of scent cues
Standardized chamber dimensions
Ensures consistent testing conditions and reproducible results across experimental sessions
Compatible with automated tracking systems
Allows precise quantification of time spent in each chamber and detailed movement analysis
Durable construction materials
Withstands repeated cleaning protocols and maintains structural integrity through extended use
Kelsey 1994 methodology compliance
Follows established protocols for reliable assessment of conditioned place preference behaviors
Research identifiers
These IDs come from the Measurement Method Ontology (MMO) and NCBI Taxonomy. Use them in data records and methods sections.
- Behavioral test
- Conditioned place preference
MMO:0000592 - Species
- Mouse
NCBITaxon:10090 - Rat
NCBITaxon:10116
- Mouse
Behavioral Construct
- Place Preference
- Conditioned Learning
- Drug Reward
- Environmental Association
- Spatial Memory
Automation Level
- semi-automated
Research Domain
- Addiction Research
- Anxiety and Depression
- Behavioral Pharmacology
- Learning and Memory
- Neuroscience
Species
- Mouse
- Rat
Compatible Tracking Software
- ConductVision
Shipping weight
- 6.06 lb
Shipping box
- L: 65.0 cm
- W: 36.0 cm
- H: 27.0 cm
| Feature | This Product | Typical Alternative | Advantage |
|---|---|---|---|
| Protocol Standardization | Based on established Kelsey 1994 methodology | Many systems use non-standardized or modified protocols | Ensures reproducible results and facilitates comparison with published literature |
| Chamber Design | Multi-chamber configuration with distinct environmental cues | Basic two-chamber designs may lack sufficient environmental differentiation | Enhanced discrimination learning leads to more robust conditioning responses |
| Construction Quality | Durable materials suitable for repeated cleaning | Entry-level models may use materials that degrade with sanitization | Maintains experimental integrity through extended use in research facilities |
| Tracking Compatibility | Compatible with automated tracking systems | Some models require manual observation and timing | Reduces observer bias and provides precise behavioral quantification |
This apparatus provides standardized methodology implementation with robust construction for reliable conditioned place preference studies. The system supports both manual and automated data collection approaches for flexible experimental design.
Addiction Research
Evaluating the rewarding properties of novel psychoactive substances by measuring conditioned place preference development in rodent models.
Behavioral Pharmacology
Assessing the reinforcing potential of pharmaceutical compounds during preclinical drug development to predict abuse liability.
Neuroscience
Investigating neural mechanisms of reward and motivation by examining place conditioning behaviors following targeted brain interventions.
Learning and Memory
Studying associative learning processes and memory formation through environmental-drug pairing paradigms.
Anxiety and Depression
Evaluating the rewarding or aversive properties of antidepressant medications using place preference conditioning protocols.
Practical Tips
Best Practices
Conduct all conditioning and test sessions at the same time of day to control for circadian rhythm effects.
Why: Temporal consistency reduces behavioral variability and improves experimental reliability.
Calibration
Verify that naive animals show no initial chamber preference during baseline sessions before beginning conditioning.
Why: Pre-existing preferences can confound conditioning effects and lead to misinterpretation of results.
Maintenance
Replace chamber inserts or apply new environmental cues periodically to maintain stimulus salience.
Why: Worn or faded cues may reduce discrimination ability and weaken conditioning responses.
Data Quality
Record both time spent and number of entries into each chamber to assess exploration patterns.
Why: Entry frequency provides additional information about behavioral patterns beyond simple time measurements.
Troubleshooting
If animals show no conditioning response, increase the drug dose or extend the conditioning period.
Why: Insufficient conditioning parameters may prevent the development of measurable place preferences.
Safety
Ensure proper ventilation in the testing room when using volatile test compounds.
Why: Adequate air circulation prevents researcher exposure and maintains consistent drug delivery to subjects.
Setup Guide
Unpack and Inspect
Remove apparatus components from packaging and inspect for damage. Verify all chambers, doors, and connecting hardware are present.
Chamber Assembly
Assemble the multi-chamber system according to manufacturer specifications. Ensure chambers are properly aligned and doors operate smoothly.
Environmental Setup
Position apparatus in a quiet testing room with consistent lighting and temperature. Minimize external distractions and maintain standard laboratory conditions.
Tracking System Calibration
If equipped with automated tracking, calibrate the detection system to accurately monitor animal position and movement between chambers.
Baseline Testing
Conduct initial preference assessments with naive animals to establish baseline chamber preferences before beginning conditioning protocols.
Protocol Implementation
Begin conditioning phases following established Kelsey 1994 methodology with appropriate drug-vehicle pairing schedules.
What’s in the Box
- Multi-chamber testing apparatus (typical)
- Removable chamber inserts (typical)
- Connecting hardware and doors (typical)
- Assembly instructions (typical)
- User manual with Kelsey 1994 protocols (typical)
Warranty
ConductScience provides a standard one-year manufacturer warranty covering defects in materials and workmanship, with technical support for setup and operation questions.
Compliance
IACUC GuidelinesCommonly used in animal research facilities subject to institutional animal care and use committee oversight for behavioral studies.
Guide for Care and Use of Laboratory AnimalsSupports behavioral testing protocols conducted under NIH guidelines for laboratory animal research.
Q
What conditioning schedule should be used for reliable CPP development?
A
The Kelsey 1994 protocol typically employs an 8-day conditioning paradigm with alternating drug and vehicle sessions. Consult the methodology paper for specific timing and dosing parameters.
Q
How long should test sessions be conducted to measure place preference?
A
Standard test sessions are typically 15-20 minutes in duration, allowing sufficient time for animals to explore both chambers and demonstrate preference behaviors.
Q
Can the apparatus accommodate different rodent species?
A
The system is designed for standard laboratory rodents including mice and rats. Chamber dimensions should be verified for compatibility with your specific animal model.
Q
What data parameters are typically measured in CPP studies?
A
Primary measures include time spent in each chamber, number of chamber entries, and preference scores calculated as time in drug-paired minus vehicle-paired chambers.
Q
How should chambers be cleaned between subjects?
A
Thorough cleaning with appropriate disinfectants is essential to eliminate scent cues. Allow complete drying before introducing new subjects to prevent olfactory confounds.
Q
What environmental factors can influence CPP results?
A
Lighting conditions, ambient noise, temperature, and time of day can affect results. Maintain consistent environmental conditions throughout all phases of testing.
Have a question about this product?
Track rodents with ConductVision
ConductVision is our video-tracking software. Record your sessions on video, and it scores standard rodent tests, such as those listed below.
Examples of tests it scores
To check whether ConductVision scores your protocol in this apparatus, ask in your quote request.
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Conditioned Place Preference Kelsey 1994
$1,830.00
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