Disintegration Tester BJ Series
Single-basket pharmaceutical disintegration tester with microprocessor control, programmable timing (1-900 minutes), and precise temperature regulation (RT-50°C) for tablet and capsule evaluation.
Louise Corscadden, PhD
Director of Science · ConductScience
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The Disintegration Tester BJ Series is a single-basket pharmaceutical testing instrument designed for evaluating tablet and capsule disintegration characteristics according to pharmacopeial methods. The system employs a vertically oscillating stainless steel basket mechanism that cycles at 30-31 times per minute with a 55±1mm stroke height, providing consistent mechanical agitation for disintegration analysis in controlled temperature conditions.
Built around a microprocessor control system with LCD display, the instrument features individual beaker operation capability and maintains precise temperature control through water circulation with magnetic pump integration. The system accommodates 1000ml beaker capacity with 2mm standard mesh sizing and offers programmable timing from 1 to 900 minutes with ±0.5 minute precision. Temperature regulation spans ambient to 50°C with ±0.3°C accuracy, while auto-diagnostic and alarm functions provide operational monitoring for extended testing protocols.
How It Works
The disintegration tester operates on the principle of mechanical agitation combined with controlled aqueous immersion to simulate physiological conditions encountered by oral solid dosage forms. The system employs a vertically oscillating stainless steel basket containing the test specimen, which moves through the dissolution medium at a precise frequency of 30-31 cycles per minute with a consistent 55±1mm stroke height.
During testing, tablets or capsules are placed within the mesh basket (2mm aperture) and immersed in the appropriate dissolution medium maintained at physiological temperature through water circulation. The mechanical agitation promotes fluid penetration into the dosage form while preventing artificial breakage, allowing assessment of true disintegration behavior. The microprocessor control system monitors elapsed time until complete disintegration occurs, defined as the point when no residue remains on the mesh screen except fragments of insoluble coating material.
Temperature control is achieved through continuous water circulation maintained by an integrated magnetic pump, ensuring thermal uniformity throughout the test medium. The LCD display provides real-time monitoring of temperature, elapsed time, and system status, while programmable timing functions allow automated testing protocols ranging from 1 to 900 minutes with high precision.
Features & Benefits
auto_diagnose
- Yes
auto_alarm
- Yes
processor_type
- Micro processor
individual_beaker_operation
- Each beaker can work alone
temperature_control
- Water circulating in the bath to keep the temperature conformity with magnetic pump
basket_material
- Stainless steel
paddle_material
- Stainless steel
Automation Level
- semi-automated
Basket Quantity
- 1pc
Basket Lifting Frequency
- 30~31 times/min
Stroke Height
- 55±1mm
Temperature Precision
- ±0.3°C
Timing Range
- 1~900min
External Size (W×D×H)
- 260×300×440mm
Material
- Stainless Steel
Display Type
- LCD
Research Domain
- Analytical Chemistry
- Pharmaceutical QC
Temperature Range
- RT~50°C
Power/Voltage
- AC 220V/110V±10%, 50/60Hz
Weight
- 12kg
Weight
- 26.46 kg
Dimensions
- L: 17.32 mm
- W: 11.81 mm
- H: 10.24 mm
| Feature | This Product | Typical Alternative | Advantage |
|---|---|---|---|
| Basket Quantity | Single basket with individual beaker operation | Entry-level models often offer manual operation without individual control | Allows precise control over individual test conditions and efficient use of dissolution media for method development work. |
| Temperature Control | Water circulation with magnetic pump, ±0.3°C accuracy | Basic models may lack circulation pumps or have lower temperature precision | Ensures uniform temperature distribution throughout the test medium for reliable and reproducible results. |
| Timing Precision | Programmable 1-900 minutes with ±0.5 minute accuracy | Manual timing or limited programmable ranges in basic units | Enables automated testing protocols and precise documentation for regulatory compliance requirements. |
| Control System | Microprocessor control with LCD display and auto-diagnostics | Basic models often use analog controls with limited monitoring | Provides real-time parameter monitoring and system status alerts for quality assurance and unattended operation. |
| Mechanical Precision | 30-31 cycles/minute frequency with 55±1mm stroke height | Variable frequency control or less precise stroke measurement | Meets pharmacopeial specifications exactly for standardized testing conditions and regulatory acceptance. |
The BJ Series offers microprocessor control with precise temperature regulation and programmable timing in a single-basket configuration. The water circulation system and auto-diagnostic capabilities provide reliable operation for pharmaceutical disintegration testing according to pharmacopeial standards.
Practical Tips
Verify temperature accuracy using a calibrated thermometer at multiple set points across the operating range before beginning test protocols.
Why: Temperature variations can significantly affect disintegration kinetics and lead to invalid test results.
Clean the stainless steel basket thoroughly between different formulations and inspect mesh integrity regularly for damage or clogging.
Why: Residual material or mesh damage can interfere with disintegration assessment and compromise test validity.
Allow the system to reach thermal equilibrium for at least 15 minutes before placing test specimens to ensure stable temperature conditions.
Why: Temperature fluctuations during testing can cause variability in disintegration times and affect reproducibility.
If oscillation frequency drifts from 30-31 cycles/minute, check for mechanical binding or excessive wear in the drive mechanism.
Why: Incorrect agitation frequency violates pharmacopeial requirements and can lead to non-compliant test results.
Record ambient laboratory conditions alongside test parameters as environmental factors can influence disintegration behavior.
Why: Complete documentation supports method validation and helps identify sources of variability in test results.
Ensure proper ventilation when testing formulations containing volatile components and use appropriate personal protective equipment.
Why: Some dissolution media and tablet excipients may release vapors during disintegration testing that require safety precautions.
Use deaerated dissolution medium when specified in the test method to prevent air bubbles from interfering with disintegration.
Why: Dissolved gases can create bubbles that adhere to tablets and artificially extend apparent disintegration times.
Verify stroke height measurement using a calibrated ruler or measurement tool to confirm the 55±1mm specification is maintained.
Why: Incorrect stroke height affects the intensity of mechanical agitation and can lead to non-pharmacopeial test conditions.
Setup Guide
What’s in the Box
- Disintegration tester main unit
- Stainless steel oscillating basket
- 1000ml glass beaker (typical)
- Temperature probe and circulation tubing (typical)
- Power cord
- User manual and operation guide (typical)
- Calibration certificate (typical)
Warranty
ConductScience provides a standard one-year manufacturer warranty covering defects in materials and workmanship, with technical support available for operational guidance and troubleshooting assistance.
Compliance
References
Background reading relevant to this product:
What dissolution media can be used with this disintegration tester?
The stainless steel construction is compatible with standard pharmacopeial media including water, simulated gastric fluid, simulated intestinal fluid, and buffer solutions. Consult product datasheet for specific chemical compatibility information.
How is temperature uniformity maintained during testing?
Temperature control is achieved through continuous water circulation driven by an integrated magnetic pump, maintaining ±0.3°C accuracy across the 1000ml beaker volume.
Can this instrument handle enteric-coated tablets?
Yes, the temperature range (RT-50°C) and programmable timing (1-900 minutes) accommodate extended testing protocols required for enteric-coated formulations under physiological conditions.
What maintenance is required for the oscillating mechanism?
Regular inspection of the basket oscillation frequency (30-31 cycles/minute) and stroke height (55±1mm) is recommended, along with periodic lubrication of mechanical components according to the maintenance schedule.
How does the auto-diagnostic function work?
The microprocessor system continuously monitors temperature, timing, and mechanical parameters, providing alarm alerts for deviations that could affect test validity.
Can multiple samples be tested simultaneously?
This is a single-basket system designed for individual sample testing, though the rapid cycle time and individual beaker operation allows efficient sequential testing.
What data output capabilities are available?
The LCD display provides real-time monitoring of test parameters. Consult product datasheet for specific data logging or connectivity options.
How does this compare to multi-basket dissolution testers?
Single-basket design offers precise control for individual samples and method development work, while multi-basket systems provide higher throughput for routine quality control testing.
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