Operant Conditioning

Automated reinforcement schedules, lever/nose-poke tracking, pellet dispensing, and self-administration paradigms. ConductMaze controls every aspect of the operant chamber — from stimulus delivery to data collection.

Progressive Ratio

The progressive ratio (PR) schedule is the gold standard for measuring the reinforcing efficacy of drugs, food, and other rewards.

8 parameters

Fixed Ratio

The fixed ratio (FR) schedule is one of the four foundational reinforcement schedules described by B.

7 parameters

Variable Ratio

The variable ratio (VR) schedule delivers reinforcement after an unpredictable number of responses that varies around a specified mean.

7 parameters

Fixed Interval

The fixed interval (FI) schedule reinforces the first response emitted after a fixed period of time has elapsed since the last reinforcer.

7 parameters

Variable Interval

The variable interval (VI) schedule reinforces the first response after a variable time period that averages around a specified mean.

8 parameters

Discrimination Training

Discrimination training teaches an animal to respond in the presence of a specific discriminative stimulus (SD) and withhold responding in the presence of a different stimulus (S-delta).

8 parameters

Reversal Learning

Reversal learning assesses cognitive flexibility by training an animal on a stimulus-response contingency and then reversing the reward contingencies.

7 parameters

Delayed Matching-to-Sample

Delayed matching-to-sample (DMTS) is a working memory paradigm in which the subject is presented with a sample stimulus, followed by a delay period, and then must select the matching stimulus from a set of comparisons.

7 parameters

Delayed Non-Matching-to-Sample

Delayed non-matching-to-sample (DNMTS) is a recognition memory paradigm in which the subject must choose the novel (non-matching) stimulus after a delay period.

7 parameters

Extinction

Extinction is the process by which a previously reinforced operant response decreases in frequency when the reinforcement contingency is removed.

7 parameters

Go/No-Go

The go/no-go task measures inhibitory control — the ability to execute a response on "go" trials and withhold responding on "no-go" trials.

8 parameters

Differential Reinforcement

Differential reinforcement of low rates (DRL) is a schedule that reinforces a response only if a minimum inter-response time (IRT) has elapsed since the previous response.

7 parameters

Self-Administration

Intravenous self-administration (IVSA) is the gold standard for assessing the reinforcing properties of drugs of abuse.

9 parameters

Reinstatement

The reinstatement model is the most widely used preclinical paradigm for studying relapse to drug seeking.

8 parameters

Incubation of Craving

The incubation of craving phenomenon describes the time-dependent increase in drug-seeking behavior during protracted withdrawal.

8 parameters

Pavlovian Autoshaping

Pavlovian autoshaping (sign-tracking versus goal-tracking) measures individual differences in Pavlovian conditioned approach behavior by presenting a retractable lever-CS that predicts food delivery to an adjacent magazine.

8 parameters

Conditioned Taste Aversion

Conditioned taste aversion (CTA) is a robust associative learning paradigm in which a novel taste (typically saccharin solution) is paired with gastrointestinal malaise induced by lithium chloride injection, producing rapid and durable avoidance of the conditioned taste.

9 parameters

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