Clasping Score
0–3 scale severity classification
ConductVision · Behavioral Analysis
Hindlimb Clasping
Automated hindlimb clasping severity scoring for Huntington's disease and neurodegeneration biomarker research.
Coming SoonRodentNeurodegenerationAuto Export
ConductVision / Hindlimb Clasping
Recording / Trial 3subject tracked
Clasping Scorelive
Clasping Latency7.2s
Clasping Duration27%
Key Parameters
Metrics automatically extracted by ConductVision.
Clasping Latency
Time from tail suspension to first clasp
Clasping Duration
Cumulative time in clasping posture
Symmetric vs Asymmetric
Bilateral vs unilateral clasping classification
Hindlimb Position Angle
Angle of hindlimb retraction from body axis
Progression Over Time
Clasping score change across longitudinal assessments
What is Hindlimb Clasping Detection?
Hindlimb clasping — retraction of the hindlimbs toward the body when suspended by the tail — is a widely used neurological sign in Huntington's disease (R6/2 model), spinocerebellar ataxia, and other neurodegenerative conditions. Clasping severity is scored 0–3 based on hindlimb position, with progression over weeks serving as a functional biomarker of disease stage.
ConductVision is developing automated hindlimb clasping detection using pose estimation and supervised classification. Contact our team to discuss early access or custom classifier training for your research.
Research Applications
Huntington's Disease
- R6/2 and R6/1 transgenic mouse clasping progression
- Q175 knock-in model — onset age determination
- Therapeutic intervention — clasping delay as efficacy measure
Spinocerebellar Ataxia
- SCA1, SCA3, SCA7 transgenic model staging
- Progressive clasping as cerebellar degeneration marker
- Gene therapy rescue — clasping reversal assessment
Longitudinal Phenotyping
- Weekly clasping score tracking for disease progression
- Multi-endpoint correlation — clasping vs rotarod vs survival
- Preclinical trial endpoint — clasping onset delay
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