Research data ยท Pain and nociception

Hargreaves plantar test

From 2021 to 2025, 174 animal research papers mentioned the Hargreaves plantar test in their title or abstract, ranking it 44th of the 90 tests we track.

That is about the same as the 183 papers of 2011 to 2015. Papers that mention any of the 90 tests rose 22% over the same span. The 2021 to 2025 count may run low because of a dip in PubMed's indexing, explained under the year chart.

174 animal research papers from 2021 to 2025 mentioned the test
About the same number of papers as in 2011 to 2015
44th of the 90 tests by papers from 2021 to 2025
53% of these papers used mice and 49% used rats

Papers by year

Animal research papers that mention the Hargreaves plantar test, by year, 2001 to 2026

The 2026 bar counts papers added to PubMed by November 8, 2026.

  • Papers in a full year
  • 2026 so far
Show the counts for each year
Papers by year
YearPapers
200113
200210
200311
200419
200514
200629
200721
200815
200921
201029
201129
201234
201338
201447
201535
201642
201734
201830
201935
202042
202137
202224
202333
202437
202543
2026 (part year)51

Papers that mention the Hargreaves plantar test fell from 37 in 2021 to 24 in 2022, then rose to 43 in 2025. Papers that PubMed indexed under the MeSH heading Animals also fell and rose, from 200,221 in 2021 to 156,447 in 2023 and 235,479 in 2025. We take each paper's species from PubMed's indexing whenever it names one, so part of this dip may come from the indexing rather than from fewer studies.

Papers that mention the Hargreaves plantar test in mice and in rats, by year, 2001 to 2025

  • Mouse
  • Rat
Show the counts for each year and species
Papers by year, mice and rats
YearMouseRat
2001212
200228
200338
2004516
2005411
20061023
2007517
2008511
2009813
20101022
2011921
2012927
20131329
20141433
20151819
20161032
20171224
2018918
20191024
20201626
20212314
20221511
20231518
20241723
20252320

Which species the papers used

Each bar is a share of the 174 papers from 2021 to 2025. A paper can use more than one species, so the shares can add to more than 100%.

Species

Mouse
93 papers 53%
Rat
86 papers 49%
Other animals
5 papers 3%

โ€œOther animalsโ€ counts papers that use none of the other species in this chart.

Strains and genetic lines

Strain names come from the MeSH terms PubMed adds when it indexes a paper. PubMed has indexed 121 of the 174 papers, so each bar is a share of those 121.

Sprague-Dawley rats
37 papers 31%
C57BL mice
29 papers 24%
Wistar rats
15 papers 12%
Knockout mice
9 papers 7%
ICR mice
3 papers 2%
Fischer 344 rats
2 papers 2%
Other inbred mice
1 paper 1%
Mutant mice
1 paper 1%

A paper indexed under two of these headings, such as knockout mice and a strain, counts under both.

Disease models these papers study

Each bar counts the papers from 2021 to 2025 that mention the Hargreaves plantar test and study that disease model, with its share of the 174 papers. The model comes from a paper's MeSH terms. For a paper PubMed has not indexed, it comes from PubTator 3, NCBI's text-mining service, when that service finds the disease in the title or abstract. A paper can count under more than one model.

Papers from 2021 to 2025 by disease model

Tests mentioned alongside the Hargreaves plantar test

Each bar counts the papers from 2021 to 2025 that mention both tests, with its share of the 174 papers that mention the Hargreaves plantar test.

Papers from 2021 to 2025 that mention both tests

112 papers 64%
16 papers 9%
11 papers 6%
11 papers 6%
9 papers 5%
8 papers 5%
8 papers 5%

The most cited papers from 2021 to 2025

These papers from 2021 to 2025 mention the Hargreaves plantar test and have the most citations, as counted by NIH's iCite on November 5, 2026.

  1. Diterbutyl phthalate attenuates osteoarthritis in ACLT mice via suppressing ERK/c-fos/NFATc1 pathway, and subsequently inhibiting subchondral osteoclast fusion.

    Acta Pharmacol Sin, 2022. 62 citations.

  2. Nrf2 Activation Attenuates Chronic Constriction Injury-Induced Neuropathic Pain via Induction of PGC-1ฮฑ-Mediated Mitochondrial Biogenesis in the Spinal Cord.

    Oxid Med Cell Longev, 2021. 55 citations.

  3. SIRT3 alleviates neuropathic pain by deacetylating FoxO3a in the spinal dorsal horn of diabetic model rats.

    Reg Anesth Pain Med, 2021. 54 citations.

  4. Targeting insulin-like growth factor-1 receptor (IGF1R) for brain delivery of biologics.

    FASEB J, 2022. 48 citations.

  5. Sex Differences in Pain: Spinal Cord Injury in Female and Male Mice Elicits Behaviors Related to Neuropathic Pain.

    J Neurotrauma, 2023. 45 citations.

How we counted

A count is the number of animal research papers whose title or abstract mentions one of the test's search terms. It is not a count of experiments, labs or animals.

A paper that mentions the Hargreaves plantar test only in its methods is missed, so the count runs low. The count includes 2 reviews. For 53 of the 174 papers, PubMed's indexing gave no species, so the species came from PubTator 3 finding one in the title or abstract.

The test's search terms are in the test list download. The full method, with each source and its terms of use, is on our main page, Behavioral tests in published research.

More pain and nociception tests

These pain and nociception tests also have a page, with their papers from 2021 to 2025. Each test with 30 or more papers gets one.

How to cite

APA

ConductScience. (2026, November 10). Hargreaves plantar test in published research [Data set]. https://conductscience.com/data/behavioral-tests/hargreaves-test

BibTeX

@misc{conductscience_hargreaves_test_2026,
  author = {{ConductScience}},
  title = {Hargreaves plantar test in published research},
  year = {2026},
  month = nov,
  url = {https://conductscience.com/data/behavioral-tests/hargreaves-test},
  note = {Data set, released November 10, 2026},
}

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