Research data ยท Pain and nociception

Paw pressure test

From 2021 to 2025, 70 animal research papers mentioned the paw pressure test in their title or abstract, ranking it 64th of the 90 tests we track.

That is 45% fewer than the 128 papers of 2011 to 2015. Papers that mention any of the 90 tests rose 22% over the same span. The 2021 to 2025 count may run low because of a dip in PubMed's indexing, explained under the year chart.

70 animal research papers from 2021 to 2025 mentioned the test
45% fewer papers than in 2011 to 2015
64th of the 90 tests by papers from 2021 to 2025
77% of these papers used rats and 29% used mice

Papers by year

Animal research papers that mention the paw pressure test, by year, 2001 to 2026

The 2026 bar counts papers added to PubMed by November 8, 2026.

  • Papers in a full year
  • 2026 so far
Show the counts for each year
Papers by year
YearPapers
200119
200212
200324
200427
200521
200619
200729
200823
200927
201016
201134
201223
201328
201419
201524
201614
201726
201820
201917
202015
202119
202212
202311
202413
202515
2026 (part year)15

Papers that mention the paw pressure test fell from 19 in 2021 to 11 in 2023, then rose to 15 in 2025. Papers that PubMed indexed under the MeSH heading Animals also fell and rose, from 200,221 in 2021 to 156,447 in 2023 and 235,479 in 2025. We take each paper's species from PubMed's indexing whenever it names one, so part of this dip may come from the indexing rather than from fewer studies.

Rats led mice every year from 2001 to 2025.

Papers that mention the paw pressure test in mice and in rats, by year, 2001 to 2025

  • Mouse
  • Rat
Show the counts for each year and species
Papers by year, mice and rats
YearMouseRat
2001219
200249
2003323
2004326
2005121
2006416
2007627
2008421
2009325
2010414
2011533
2012621
2013626
2014416
2015720
2016213
2017822
2018616
2019415
2020410
2021415
202267
2023211
202459
2025312

Which species the papers used

Each bar is a share of the 70 papers from 2021 to 2025. A paper can use more than one species, so the shares can add to more than 100%.

Species

Rat
54 papers 77%
Mouse
20 papers 29%

Strains and genetic lines

Strain names come from the MeSH terms PubMed adds when it indexes a paper. PubMed has indexed 56 of the 70 papers, so each bar is a share of those 56.

Sprague-Dawley rats
17 papers 30%
Wistar rats
13 papers 23%
C57BL mice
3 papers 5%
Dahl rats
2 papers 4%
ICR mice
1 paper 2%
Brown Norway rats
1 paper 2%
Fischer 344 rats
1 paper 2%

Disease models these papers study

Each bar counts the papers from 2021 to 2025 that mention the paw pressure test and study that disease model, with its share of the 70 papers. The model comes from a paper's MeSH terms. For a paper PubMed has not indexed, it comes from PubTator 3, NCBI's text-mining service, when that service finds the disease in the title or abstract. A paper can count under more than one model.

Papers from 2021 to 2025 by disease model

Tests mentioned alongside the paw pressure test

Each bar counts the papers from 2021 to 2025 that mention both tests, with its share of the 70 papers that mention the paw pressure test.

Papers from 2021 to 2025 that mention both tests

19 papers 27%
14 papers 20%
13 papers 19%
6 papers 9%
5 papers 7%
5 papers 7%
4 papers 6%

The most cited papers from 2021 to 2025

These papers from 2021 to 2025 mention the paw pressure test and have the most citations, as counted by NIH's iCite on November 5, 2026. We show four of the five most cited papers and leave out one because of words in its title.

  1. The mechanism of Annexin A1 to modulate TRPV1 and nociception in dorsal root ganglion neurons.

    Cell Biosci, 2021. 25 citations.

  2. The preferential effect of Clemastine on F3/Contactin-1/Notch-1 compared to Jagged-1/Notch-1 justifies its remyelinating effect in an experimental model of multiple sclerosis in rats.

    Int Immunopharmacol, 2024. 21 citations.

  3. Impaired amygdala astrocytic signaling worsens neuropathic pain-associated neuronal functions and behaviors.

    Front Pharmacol, 2024. 20 citations.

  4. Efficacy of Posidonia oceanica Extract against Inflammatory Pain: In Vivo Studies in Mice.

    Mar Drugs, 2021. 16 citations.

How we counted

A count is the number of animal research papers whose title or abstract mentions one of the test's search terms. It is not a count of experiments, labs or animals.

A paper that mentions the paw pressure test only in its methods is missed, so the count runs low. The count includes 0 reviews. For 14 of the 70 papers, PubMed's indexing gave no species, so the species came from PubTator 3 finding one in the title or abstract.

The test's search terms are in the test list download. The full method, with each source and its terms of use, is on our main page, Behavioral tests in published research.

More pain and nociception tests

These pain and nociception tests also have a page, with their papers from 2021 to 2025. Each test with 30 or more papers gets one.

How to cite

APA

ConductScience. (2026, November 10). Paw pressure test in published research [Data set]. https://conductscience.com/data/behavioral-tests/paw-pressure

BibTeX

@misc{conductscience_paw_pressure_2026,
  author = {{ConductScience}},
  title = {Paw pressure test in published research},
  year = {2026},
  month = nov,
  url = {https://conductscience.com/data/behavioral-tests/paw-pressure},
  note = {Data set, released November 10, 2026},
}