Electrochemical Small Molecule Detection Chip
Microfluidic chip with 3-electrode array for amperometric and voltammetric detection of small molecules in clinical and environmental samples. Reusable chip — designed for multiple experimental runs. Compatible with standard microfluidic tubing: steel pins (0.7 mm ID / 1.0 mm OD) and silicone tubing (0.8 mm ID / 1.9 mm OD). Available in bulk packs (5‑, 10‑, and 25‑unit) for lab-scale and consumable workflows.
Louise Corscadden, PhD
Neuroscience · ConductScience
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The Electrochemical Small Molecule Detection Chip is a microfluidic device featuring a 3-electrode array configuration for on-chip electrochemical analysis. This lab-on-chip platform enables both amperometric and voltammetric detection methods, providing researchers with a miniaturized analytical system for small molecule characterization in clinical and environmental applications.
The chip integrates working, reference, and counter electrodes within a microfluidic channel network, allowing for precise electrochemical measurements in small sample volumes. The device supports standard electroanalytical techniques including cyclic voltammetry, differential pulse voltammetry, and chronoamperometry, making it suitable for quantitative detection of electroactive compounds in biological and environmental samples.
How It Works
The chip operates on fundamental electrochemical principles using a three-electrode system miniaturized within microfluidic channels. The working electrode serves as the detection surface where target analytes undergo oxidation or reduction reactions. The reference electrode maintains a stable potential against which measurements are made, while the counter electrode completes the electrical circuit and carries the current.
In amperometric mode, a constant potential is applied to the working electrode, and the resulting current is measured as a function of analyte concentration. For voltammetric measurements, the potential is swept across a range while monitoring current response, generating characteristic peaks that identify and quantify specific compounds. The microfluidic design ensures precise sample delivery, reduces reagent consumption, and minimizes diffusion effects that can compromise measurement accuracy.
Sample introduction occurs through integrated microchannels that direct fluid flow across the electrode array. The small volume requirements (typically microliters) enable analysis of precious samples while the controlled flow conditions enhance reproducibility and reduce analysis time compared to conventional electrochemical cells.
Features & Benefits
Pack Size
- 5-Pack
- 10-Pack
- 25-Pack
Weight
- 3.3 kg
Dimensions
- L: 181.8 mm
- W: 136.3 mm
- H: 90.9 mm
| Feature | This Product | Typical Alternative | Advantage |
|---|---|---|---|
| Electrode Configuration | 3-electrode array (working, reference, counter) | Many entry-level systems use 2-electrode configurations | Enables precise potential control and eliminates potential drop effects for more accurate quantitative measurements. |
| Detection Methods | Dual capability: amperometric and voltammetric detection | Single-mode detection systems are common | Provides analytical flexibility to optimize detection method based on specific analyte properties and concentration ranges. |
| Sample Format | Integrated microfluidic channels | Conventional electrochemical cells require larger sample volumes | Reduces sample volume requirements to microliters while improving mass transport control and measurement reproducibility. |
| Application Range | Clinical and environmental detection applications | Many devices target single application areas | Versatile platform suitable for both biological fluid analysis and environmental monitoring workflows. |
| Integration Level | On-chip electrode fabrication with microfluidic integration | Separate electrode and flow cell components | Ensures consistent electrode geometry and eliminates assembly variables that can affect measurement reproducibility. |
This electrochemical detection chip combines 3-electrode array precision with microfluidic sample efficiency, offering dual amperometric and voltammetric detection modes. The integrated design provides consistent electrode geometry and reduced sample volume requirements while supporting both clinical and environmental applications.
Practical Tips
Perform electrode conditioning with multiple cyclic voltammetry scans in supporting electrolyte before each measurement session.
Why: Conditioning ensures stable and reproducible electrode response by removing surface contaminants and establishing consistent surface chemistry.
Rinse channels thoroughly with deionized water immediately after use and store dry to prevent electrode corrosion.
Why: Proper cleaning prevents analyte carryover and electrode degradation that can compromise future measurement accuracy.
Maintain consistent flow rates and sample introduction timing across measurements to ensure reproducible mass transport conditions.
Why: Electrochemical signals are sensitive to convective effects, so controlled flow conditions improve measurement precision and comparability.
Check for air bubbles in microchannels if erratic signals occur, and re-prime the system if necessary.
Why: Air bubbles disrupt electrical contact and create irregular flow patterns that interfere with stable electrochemical measurements.
Record multiple replicate measurements and monitor baseline stability to assess measurement reliability.
Why: Replicate analysis helps identify measurement precision and detect systematic errors in electrode performance or sample preparation.
Use appropriate personal protective equipment when handling biological or chemical samples, especially when working with unknown contaminants.
Why: Clinical and environmental samples may contain pathogens or toxic compounds that require proper safety protocols to prevent exposure.
Prepare fresh calibration standards daily and verify standard concentrations when working with unstable analytes.
Why: Many electroactive compounds degrade over time, so fresh standards ensure accurate calibration and reliable quantitative results.
Document electrode history and performance to track device lifetime and identify when replacement is needed.
Why: Electrode surfaces gradually change with use, and systematic tracking helps maintain consistent analytical performance over time.
Setup Guide
What’s in the Box
- Electrochemical detection chip
- Electrode connection leads (typical)
- Sample introduction tubing (typical)
- User manual and protocol guide (typical)
- Quality control certificate (typical)
Warranty
ConductScience provides a standard 1-year manufacturer warranty covering defects in materials and workmanship, along with technical support for setup and operational questions.
Compliance
What sample volumes are required for analysis?
Microfluidic design typically requires microliter sample volumes. Consult product datasheet for specific channel capacity and minimum volume requirements for your application.
Which potentiostat systems are compatible with this chip?
Standard 3-electrode potentiostats with appropriate current sensitivity for microelectrode measurements. Verify current range and connection specifications with your instrument.
How many measurements can be performed per chip?
Depends on analyte type and concentration. Electrode surfaces may require regeneration between measurements. Consult protocol for specific analyte stability and reusability guidelines.
What detection limits can be achieved?
Detection limits depend on analyte electrochemical activity, sample matrix, and measurement conditions. Consult product specifications for performance data with specific target compounds.
Can the chip be used with organic solvents?
Compatibility depends on chip material construction. Verify solvent compatibility specifications before use with non-aqueous samples to prevent device damage.
How should the chip be stored between uses?
Store in dry conditions at room temperature. If electrodes have been used, rinse with deionized water and dry completely before storage to prevent contamination.
What electrode materials are used in the array?
Consult product datasheet for specific electrode material composition, as this affects the range of detectable analytes and operating potential windows.
Is temperature control required during measurements?
Temperature affects electrochemical reaction kinetics and mass transport. Consider temperature control for quantitative work, especially when comparing results across measurement sessions.
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