Compact Nucleic acid extraction systems BK-HS
Automated magnetic bead-based nucleic acid extraction system processing 32 or 96 samples per run with >98% bead recovery and ≤3% inter-well variation for consistent DNA/RNA isolation.
Louise Corscadden, PhD
Neuroscience · ConductScience
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The Compact Nucleic Acid Extraction System BK-HS automates DNA and RNA isolation from biological samples using magnetic bead-based purification technology. The system processes serum, body fluids, plasma, and virus-infected cell cultures with sample capacities of 32 or 96 samples per run. Magnetic bead recovery exceeds 98% with inter-well coefficient of variation ≤3%, ensuring consistent nucleic acid yields across all sample positions.
The system features 6 plate positions with specialized functions: plates 1 and 6 provide vibration and heating capabilities, while plate 5 offers both heating and refrigeration for temperature-sensitive protocols. Eight independent heating modules allow customizable lysis and elution temperatures according to specific extraction requirements. Extracted nucleic acids are directly compatible with qPCR and qRT-PCR detection platforms without additional purification steps.
Safety features include door opening protection, UV protection, and a wide observation window for monitoring extraction progress. The system includes UV disinfection capability with selectable disinfection time for contamination control between runs.
How It Works
The system employs magnetic bead-based purification technology where nucleic acids bind to paramagnetic particles under specific buffer conditions. Samples are first lysed using temperature-controlled heating modules, releasing DNA and RNA into solution. Magnetic beads coated with nucleic acid-binding ligands are then introduced, forming nucleic acid-bead complexes through electrostatic and hydrophobic interactions.
Magnetic separation occurs through coordinated movement of magnetic rods within the system's 6-plate configuration. The magnetic field gradient captures bead-bound nucleic acids while allowing cellular debris and proteins to be washed away through multiple buffer exchange steps. Plates 1 and 6 provide vibration agitation to enhance mixing efficiency, while plate 5's heating and refrigeration capabilities enable temperature-dependent binding and release protocols.
Final elution utilizes low-salt buffers and controlled heating to disrupt nucleic acid-bead interactions, releasing purified DNA or RNA into collection plates. The anti-drip plate design and magnetic sleeve frame ensure precise liquid handling throughout the automated workflow, achieving >98% magnetic bead recovery and maintaining ≤3% coefficient of variation across sample positions.
Features & Benefits
Sample capacity quantity
- 32 samples
- 96 samples
External Size (W*D*H)
- 450*440*532mm (BB-BK-HS32)
Package Size(W*D*H)
- 538*538*750mm (BB-BK-HS32)
- 940*710*910mm (BB-BK-HS96)
frequency
- 50Hz/60Hz
package_size_32_sample
- 538*538*750mm (BB-BK-HS32)
package_size_96_sample
- 940*710*910mm (BB-BK-HS96)
extraction_method
- magnetic bead method
plate_positions
- 6 plate positions
plate_functions
- plate 1 and 6 has vibration and heat function, plate 5 has heat and refrigeration function
safety_features
- door opening protection, UV protection, wide window for observation
sample_types
- serum, body fluids, plasma, virus-infected cell cultures
downstream_applications
- qPCR and qRT-PCR detection
storage_temperature
- -20°C to -80°C
uv_disinfection
- available with selectable disinfection time
components
- magnetic sleeve frame, magnetic rod, anti-drip plate
Automation Level
- fully-automated
Brand
- Biobase
Weight
- 110kg (BB-BK-HS96)
- 37kg (BB-BK-HS32), 110kg (BB-BK-HS96)
- 37kg(BB-BK-HS32)
Power/Voltage
- AC100~240V
- AC100~240V, 50Hz/60Hz
Capacity
- 32 samples, 96 samples
Dimensions
- 440mm x 450mm x 532mm
Research Domain
- Analytical Chemistry
- Cell Biology
- Clinical Diagnostics
- Immunology
- Microbiology
- Pharmaceutical QC
Weight
- 81.57 kg
Dimensions
- L: 20.94 mm
- W: 17.72 mm
- H: 17.32 mm
| Feature | This Product | Typical Alternative | Advantage |
|---|---|---|---|
| Sample Throughput | 32 or 96 samples per run | Entry-level systems often process 8-24 samples per run | Higher throughput reduces processing time and increases laboratory productivity for diagnostic workflows. |
| Temperature Control | 8 independent heating modules with heating/cooling on specific plates | Basic systems typically offer single-temperature operation | Multiple temperature zones enable complex protocols and optimization for different sample types. |
| Precision Specification | ≤3% inter-well coefficient of variation | Standard systems often show 5-15% variation | Lower variability improves data quality and reduces the need for technical replicates in quantitative assays. |
| Magnetic Bead Recovery | >98% magnetic bead recovery efficiency | Basic magnetic systems may achieve 85-95% recovery | Higher recovery rates maximize nucleic acid yield and minimize sample waste. |
| Safety Features | UV protection, door opening protection, wide observation window | Entry-level models often lack comprehensive safety systems | Enhanced safety features protect operators while enabling process monitoring and contamination control. |
| Capacity Options | Available in both 32 and 96-sample configurations | Many systems offer fixed capacity only | Flexible capacity options allow laboratories to match throughput requirements with budget and space constraints. |
The BK-HS system combines high-precision magnetic bead extraction with flexible capacity options and comprehensive temperature control. The ≤3% inter-well variation and >98% bead recovery specifications support quantitative applications requiring consistent results across sample batches.
Practical Tips
Verify magnetic rod positioning accuracy monthly using provided calibration standards to maintain optimal bead capture efficiency.
Why: Proper magnetic field alignment is critical for achieving specified >98% bead recovery rates.
Clean anti-drip plates and magnetic sleeve components after every 10 runs to prevent sample carryover.
Why: Residual magnetic beads can cause cross-contamination and affect subsequent extraction efficiency.
Allow the system to equilibrate for 15 minutes before processing temperature-sensitive samples when using plate 5's refrigeration function.
Why: Temperature stability ensures consistent lysis and binding conditions across all sample positions.
If inter-well variation exceeds 3%, check for magnetic rod wear and verify plate-to-plate alignment.
Why: Mechanical precision directly affects the uniformity of magnetic separation across sample positions.
Run negative controls in positions 1, 32/96 to verify absence of cross-contamination across the plate.
Why: Edge positions are most susceptible to liquid handling variations and contamination events.
Always use UV disinfection cycles between different sample types, especially when processing clinical specimens.
Why: UV treatment eliminates potential nucleic acid contamination that could affect sensitive downstream PCR assays.
Pre-warm elution buffers to 65°C when processing RNA samples to improve recovery from magnetic beads.
Why: Elevated temperature reduces secondary structure formation and enhances RNA release efficiency.
Replace magnetic beads according to manufacturer specifications as binding capacity decreases with repeated freeze-thaw cycles.
Why: Fresh magnetic beads maintain optimal nucleic acid binding capacity and extraction efficiency.
Setup Guide
What’s in the Box
- Main extraction unit
- Magnetic sleeve frame
- Magnetic rod assembly
- Anti-drip plates
- Power cable
- User manual and protocol guides
- Calibration certificate (typical)
- USB communication cable (typical)
Warranty
ConductScience provides a standard 1-year manufacturer warranty covering parts and labor, with comprehensive technical support for setup, calibration, and protocol optimization.
Compliance
References
Background reading relevant to this product:
What types of biological samples can be processed and what are the input volume requirements?
The system processes serum, body fluids, plasma, and virus-infected cell cultures. Consult product datasheet for specific input volume requirements for each sample type.
How does the magnetic bead recovery specification translate to nucleic acid yield consistency?
The >98% magnetic bead recovery with ≤3% inter-well coefficient of variation ensures consistent nucleic acid yields across all sample positions, critical for quantitative downstream applications.
What maintenance procedures are required for the magnetic separation components?
Regular cleaning of magnetic rods and anti-drip plates is required, along with periodic calibration of magnetic field strength and positioning accuracy.
Can extraction protocols be customized for different nucleic acid types or sample matrices?
Yes, the 8 independent heating modules allow temperature customization for different lysis and elution requirements, while the multi-plate system supports varied protocol steps.
What data output formats are available for integration with laboratory information systems?
Consult product datasheet for specific data output formats and LIMS integration capabilities.
How does this system compare to traditional column-based extraction methods?
Magnetic bead technology offers higher throughput, reduced manual handling, and eliminates centrifugation steps while maintaining comparable or superior nucleic acid purity.
What quality control features ensure extraction consistency between runs?
UV disinfection with selectable timing, door protection systems, and precision magnetic field control maintain consistent conditions and prevent cross-contamination.
Are extracted nucleic acids immediately ready for PCR amplification?
Yes, extracted nucleic acids are directly compatible with qPCR and qRT-PCR platforms without requiring additional purification steps.
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