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NIH funding notice PA-18-574

PHS 2018-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)

Closed on April 5, 2019.

Posted
January 16, 2018
Close date
April 5, 2019
Activity codes
R43, R44
Institutes taking part
NCI, NEI, NHLBI, NHGRI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDCD, NIDCR, NIDDK, NIDA, NIEHS, NIGMS, NIMH, NINDS, NINR, NIMHD, NLM, NCCIH, NCATS, ORIP, CGH, NCBDDD, NCCDPHP, NCEZID, NCHHSTP, NCIRD, NCIPC, NIOSH, OPHPR, NCEH, CBER, CDER, CFSAN, CDRH, CVM, CPI, OOPD

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

  1. Reissues: PA-17-302 PHS 2017-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  2. 2 steps back: PA-16-302 PHS 2016-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  3. 3 steps back: PA-15-269 PHS 2015-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  4. 4 steps back: PA-14-071 PHS 2014-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  5. 5 steps back: PA-13-234 Reissue PHS 2013-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  6. 6 steps back: PA-13-088 PHS 2013-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  7. 7 steps back: PA-12-088 PHS 2012-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  8. 8 steps back: PA-11-096 PHS 2011-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  9. 9 steps back: PA-10-050 PHS 2010-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  10. 10 steps back: PA-09-080 PHS 2009-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])

Replaced by PA-19-272.

Who won it before

4,393 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $1,603,523,693 in first-year total cost, median $225,009.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 SBIB-T (10)]232
  2. Special Emphasis Panel[ZRG1 ETTN-G (12)]210
  3. Special Emphasis Panel[ZRG1 IMST-H (15)]159
  4. Special Emphasis Panel[ZRG1 IDM-V (12)]143
  5. Special Emphasis Panel[ZRG1 IMST-K (14)]131

Most frequent institutions

  1. PHYSICAL SCIENCES, INC29
  2. AFFINERGY, LLC28
  3. EPICYPHER, INC.28
  4. PANORAMA RESEARCH, INC.22
  5. LYNNTECH, INC.20
Competing awards under PA-18-574 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2020Inhaled IRK inhibitors as a novel therapeutic for IPF1R44HL151067-01HAVA, DAVID LMETERA PHARMACEUTICALS, INC., MA$1,515,600ZRG1
2020Development of an Integrated Platform for the Use of Adult Human Primary Cardiomyocytes in Preclinical Safety Assessment1R44TR003162-01ABI GERGES, NAJAHANABIOS CORPORATION, CA$1,132,289ZRG1
2020Paradigm Surgical Phase II-Development and Validation of SafeClose Roller Mesh Augmentation System for Hernia Treatment and Prevention2R44GM123789-02FISCHER, JOHN PATRICKPETERS, REXPARADIGM SURGICAL, LLC, PA$1,026,094ZRG1
2020Therapeutic UV Disinfection System to Prevent Catheter Related Bloodstream Infections (CRBSIs) in Patients with Peripherally Inserted Central Catheters (PICCs)2R44AI134553-02A1FOURKAS, MICHAELRASOOLY, JULIAPURACATH MEDICAL, INC., CA$1,000,000ZRG1
2020MucoCept-CVN, a genetically enhanced vaginal Lactobacillus strain for the prevention of HIV acquisition in women: Finalization of formulation for the first-in-human clinical trial1R44AI149807-01LAGENAUR, LAUREL A.OSEL, INC., CA$1,000,000ZRG1
2020Therapy and Prophylaxis for Genital Tract Infection2R44AI104067-04A1AUCI, DOMINICKRUSSELL, MICHAEL WTHERAPYX, INC., NY$1,000,000ZRG1
2020A Once-Weekly Oral Tacrolimus-Prednisone Fixed-Dose Combination Therapy for Post-Transplant Maintenance Immunosuppressive Therapy1R44AI149979-01ZALE, STEPHENLYNDRA THERAPEUTICS, INC., MA$1,000,000ZRG1
2020Third line treatment of drug resistant FLT3-positive acute myeloid leukemia with a novel FLT3 kinase inhibitor1R44CA247134-01HOLTSBERG, FREDERICK WAYNESINTIM, HERMAN OKINARX, LLC, MD$1,000,000ZRG1
2020Bloodstream infection detection directly on whole blood2R44AI124871-02A1CELEDON, ALFREDO ANDRESSCANOGEN, INC., MD$1,000,000ZRG1
2020Pre-IND Development of an Arenavirus Antiviral2R44AI112097-05HENKEL, GREGORY WILLIAMARISAN THERAPEUTICS, INC., CA$1,000,000ZRG1
2020Assessing the polypharmacology of kinase inhibitors by transcription factor activity profiling1R44GM136083-01MAKAROV, SERGEI SATTAGENE, INC., NC$999,998ZRG1
2020Cryopreservation of Anopheles Embryos2R44AI088853-06BILLINGSLEY, PETER F.SANARIA, INC., MD$999,997ZRG1
2020Bone targeted delivery of an antimicrobial drug for osteomyelitis therapy2R44AI125060-02EBETINO, FRANK H.BIOVINC, LLC, CA$999,300ZRG1
2020Commercialization of a highly-sensitive, scalable and low-input compatible kit-based solution for discovery of translocations from FFPE tumor biopsies1R44CA247185-01SELVARAJ, SIDDARTHARIMA GENOMICS, INC., CA$999,273ZRG1
2020Strain-Independent Therapeutic Antibodies for Influenza2R44AI106077-05KAUVAR, LAWRENCE MICHAELTRELLIS BIOSCIENCE, INC., CA$999,214ZRG1
2020Biofilm disrupting antibody to treat respiratory and musculoskeletal infections1R44AI150143-01KAUVAR, LAWRENCE MICHAELTRELLIS BIOSCIENCE, INC., CA$999,192ZRG1
2020In vivo dose finding for IN-002 in neonatal lambs for inhaled immunotherapy of RSV2R44AI138728-02CONE, RICHARDMUCOMMUNE, LLC, NC$999,032ZRG1
2020An H/F/X/Y Fast-MAS NMR Probe Particularly for Alzheimer's and Cancer Research2R44GM119937-02DOTY, FRANCIS DAVIDDOTY SCIENTIFIC, INC., SC$997,231ZRG1
2020Rapid quantification of nuclear citrullination in human neutrophils2R44AI134162-02JOHNSTONE, ANDREA LYNNEPICYPHER, INC., NC$993,542ZRG1
2020Kinase Targeted Antimalarial Agents1R44AI150237-01ZUTSHI, REENALUCEOME BIOTECHNOLOGIES, LLC, AZ$957,654ZRG1
2020Myocardial Delivery of MMP Inhibiting Hydrogels2R44HL140645-02PURCELL, BRENDANPROHIBIX, LLC, PA$954,900ZRG1
2020Oral PCSK9/LDLR antagonist direction to the clinic1R44HL150923-01ELSHOURBAGY, NABIL AMOUSA, SHAKER ASHIFA BIOMEDICAL CORPORATION, PA$943,895ZRG1
2020Towards a New Generation of Glycoengineered Pneumococcal Bioconjugate Vaccines2R44AI131742-02HARDING, CHRISTIANVAXNEWMO, LLC, MO$931,060ZRG1
2020Multiplex nucleosome-based profiling for the development of next-generation chromatin labeling reagents1R44GM136172-01SUN, ZU-WENEPICYPHER, INC., NC$920,218ZRG1
2020Quantitative and highly versatile chromatin accessibility platform1R44HG011006-01KEOGH, MICHAEL-CHRISTOPHEREPICYPHER, INC., NC$910,411ZRG1
2020Portable Ultrasound System for Automated Detection of Abdominal Free-Fluid2R44GM123821-02FELDMAN, JAMES ALANVAZIRI, ASHKANBIOSENSICS, LLC, MA$818,052ZRG1
2020New infusible ECM hydrogel for treating acute myocardial infarction1R43HL150917-01CHRISTMAN, KAREN LKINSEY, ADAM MVENTRIX, INC., CA$791,543ZRG1
2020Feasibility and validation of an integrated newborn screening algorithm with targeted Next Generation Sequencing (tNGS) technology as part of a 2nd-tier test for Pompe and MPS I2R44HD094543-02BHATTACHARJEE, ARINDAMBAEBIES, INC., NC$778,727ZRG1
2020Novel strategies for storage and recovery of cadaveric bone marrow stem cells2R44HL142418-02WOODS, ERIK J.OSSIUM HEALTH, INC., CA$778,661ZRG1
2020Sinu-Test, A Multiplexed Device for Rapid Diagnosis of Acute Bacterial Sinusitis1R44AI150203-01HAWKINS, ORIANA E.ENTVANTAGE DX, TX$762,667ZRG1
2020PROTECT: optima4BP 2.0: prediction of Optimal Treatment and Route to achieve and maintain BP Target2R44HL140624-02VOSKERICIAN, GABRIELAOPTIMA INTEGRATED HEALTH, INC., CA$750,249ZRG1
2020FVIII Point-of-Care Monitoring Device and App1R44HL151147-01CHAN, EUGENE YAN-HODNA MEDICINE INSTITUTE, MA$749,250ZRG1
2020Digital representation of chemical mixtures to aid drug discovery and formulation2R44TR002528-02BUNIN, BARRY ACOLLABORATIVE DRUG DISCOVERY, INC., CA$748,733ZRG1
2020An Integrated Software Platform for Accelerating Image-Driven Ophthalmic Research and Driving New Insights and Endpoints to the Clinic1R44EY031198-01BUCKLAND, ERIC L.TRANSLATIONAL IMAGING INNOVATIONS, INC., NC$743,347ZRG1
2020Directed evolution of N-terminal amino acid binding proteins for application to protein sequencing2R44GM123836-02A1KUHN, KENNETH MENCODIA, INC., CA$736,945ZRG1
2020Validating Automated Photoreceptor Analytics Software For Degenerative Eye Disease Research and Biopharma Clinical Trials.1R44EY031278-01BUCKLAND, ERIC L.CARROLL, JOSEPHTRANSLATIONAL IMAGING INNOVATIONS, INC., NC$726,590ZRG1
2020Advancing CAP4196 into in vivo Proof of Concept Translational Studies2R44EY027236-03PRASAD, SRIDHAR GPLEX PHARMACEUTICALS, INC., CA$662,896ZRG1
2020IOPSxV: Novel Visualization for Non-Fluoroscopic 3D Image Guidance for Peripheral Vascular Interventions.1R44HL151148-01GOEL, VIKASHCENTERLINE BIOMEDICAL, INC., OH$636,861ZRG1
2020A proximity ligation method to track mobile element hosts1R44AI150008-01LIACHKO, IVANPHASE GENOMICS, INC., WA$599,017ZRG1
2020Development of Kv1.3 Monoclonal Antibodies Targeting TEM Cells for Treating Autoimmune Disorders2R44GM112181-03RUCKER, JOSEPH BENJAMININTEGRAL MOLECULAR, PA$585,859ZRG1
2020Rapid Test Kit for Measurement of Urinary Iodine2R44HD095689-02VAIDYA, BIKASLYNNTECH, INC., TX$538,447ZRG1
2020Novel Low Temperature Sterilization Method for Flexible Endoscopes2R44AI122405-02A1WILLIAMS, JOEL LBRIGHTON DEVELOPMENT, LLC, NC$521,870ZRG1
2020CHABMAP (Cyanobacterial Harmful Algal Bloom Mapping and Analyses Platform) technology automates the quantification of toxic CyanoHABs exposure epochs for any waterbody.2R44ES025513-02A1TORBICK, NATHANAPPLIED GEOSOLUTIONS, LLC, NH$504,200ZRG1
2020FoxWare™, An Advanced Data Analysis Package for Hydroxyl Radical Foot-Printing Higher Order Structural Analysis2R44GM126617-02WEINBERGER, SCOT RANDYGENNEXT TECHNOLOGIES, INC., CA$477,220ZRG1
2020Enhancing Pediatric Diagnosis of Tuberculosis with FLOW Technology1R44HD101201-01BERRY, SCOTT MMULLINS, BRIANNAWARRICK, JAY WYATTSALUS DISCOVERY, LLC, WI$436,366ZRG1
2020Circulating Organ-enriched microRNAs as biomarkers of Rett Syndrome1R43NS115212-01UMANSKY, SAMUIL RDIAMIR, LLC, NJ$387,616ZRG1
2020Phosphosulindac for dry eye1R44EY031193-01RIGAS, BASILAPIS THERAPEUTICS, LLC, NY$377,136ZRG1
2020Multi-gram enzymatic production of complex glycans by flow processes1R44GM136085-01HOEPKER, ALEXANDER CHRISZYMTRONIX CATALYTIC SYSTEMS, INC., NY$354,457ZRG1
2020Platelet Production in a Pulmonary-based Microfluidic Reactor1R43HL150946-01YEHIA, ALIFLUXION BIOSCIENCES, INC., CA$308,559ZRG1
2020Heterocyclic Inhibitors of QcrB as Novel Drugs for Tuberculosis1R43AI149833-01HANNAN, THOMAS JOSEPHFIMBRION THERAPEUTICS, INC., MO$300,000ZRG1
2020Discovery of Treponema pallidum antigens for development of a sensitive and specific diagnostic test for syphilis1R43AI149804-01CAMPO, JOSEPH J.IMMPORT THERAPEUTICS, INC., CA$300,000ZRG1
2020Discovery of Enterovirus D68 2A protease inhibitors for antiviral therapy1R43AI149822-01LIU, GAIMICROBIOTIX, INC, MA$300,000ZRG1
2020Discovery and Development of Broad-spectrum Protease Inhibitors of Flaviviruses of Significant Public Health Threats1R43AI145617-01A1PRASAD, SRIDHAR GPLEX PHARMACEUTICALS, INC., CA$300,000ZRG1
2020Development of Intact Proviral DNA Assays for SIV and SHIV1R43AI149816-01LAIRD, GREGORY MICHAELACCELEVIR DIAGNOSTICS, LLC, MD$300,000ZRG1
2020A Novel Probiotic-Based Nanobody Delivery Platform1R43AI149906-01FANGER, NEIL AVIRTICI, LLC, WA$300,000ZRG1
2020Production and Testing of VLP-based RSV Vaccine1R43AI145499-01A1GALARZA, JOSE M.TECHNOVAX, INC., NY$300,000ZRG1
2020Ice-free cryopreservation of whole pediatric testes for autologous banking and replantation.1R43HD101325-01BROCKBANK, KELVIN G.M.TISSUE TESTING TECHNOLOGIES, LLC, SC$300,000ZRG1
2020Rapid Point-of-Care Assay for Diagnosis of Neurocysticercosis in Seizure Patients1R43AI149903-01LEVIN, ANDREW E.KEPHERA DIAGNOSTICS, LLC, MA$299,998ZRG1
2020Prodrugs and Derivatives of Hydroxymethylfurfural (5-HMF) to Develop a Novel, Bioavailable Treatment for Sickle Cell Disease1R43HL150961-01BURNETT, JAMESILLEXCOR THERAPEUTICS, LLC, VA$299,962ZRG1
2020An Improved Intra-Arterial Delivery Platform for Glioblastoma Multiforme1R43CA239945-01A1CREIGHTON, FRANCIS MILTONGREENSPAN, DAVID CUNANDUP, LLC, MO$299,946ZRG1
2020Engineering a Potent Immune-evading Uricase1R43AI149839-01BAILEY-KELLOGG, CHRISSTEALTH BIOLOGICS, LLC, NH$299,870ZRG1
2020Algorithms to Detect In-Home Falls of Elderly Using Structured Light Sensing1R43AG066263-01GIBSON, PAULAPPLIED UNIVERSAL DYNAMICS CORPORATION, MN$299,824ZRG1
2020Immunoprofiling to develop a novel diagnostic array for cardiac sarcoidosis1R43HL150911-01DARBY, MARTYNAFFINERGY, LLC, NC$299,802ZRG1
2020Development of a peptide-based diagnostic for amyotrophic lateral sclerosis1R43NS115201-01NAIR, SHRIKUMAR AMBUJAKSHANAFFINERGY, LLC, NC$299,778ZRG1
2020Development of a Mucosal Nanoemulsion-Adjuvanted RSV Vaccine using Recombinant Pre-Fusion F Protein1R44AI145431-01A1BITKO, VIRABLUEWILLOW BIOLOGICS, INC., MI$299,650ZRG1
2020A High Sensitivity Multiplexed Immunoassay for Aging-Related Inflammation Biomarker Quantification1R43AG066380-01CRICK, SCOTT LAURAGENT BIOSCIENCE, LLC, MO$299,578ZRG1
2020Mitral Valve Repair System to Percutaneously Treat Moderate to Severe Regurgitation Using Alfieri Edge-to-Edge Technique1R43HL147825-01A1BASUDE, RAGHUVEERMEDFREE, INC., CA$299,413ZRG1
2020Deimmunized Griffithsin Microbicide1R44AI150235-01BAILEY-KELLOGG, CHRISSTEALTH BIOLOGICS, LLC, NH$299,275ZRG1
2020Development of NH101: A Simple and Efficient Outpatient Dry Powder Amphotericin B-DryNeb(dry powder nebulizer) for Treatment of Susceptible and Multidrug Resistant Aspergillus/ Fungal Infections1R43HL147749-01A1REED, MATTHEWNOB HILL THERAPEUTICS, INC., NM$299,058ZRG1
2020Improving gene expression via Massively Parallel Synonymous Codon Variant Screening1R43GM135955-01WYCOFF, KEITHPLANET BIOTECHNOLOGY, INC., CA$298,634ZRG1
2020Dynamic Breath Gas Sensor (DBGS™) for Detection of Pulmonary Edema1R43HL150884-01SHEKARRIZ, REZAEXHALIX, LLC, NM$298,273ZRG1
2020Evaluation of the Effect of Commercial Processing on Artificial Lung Zwitterionic Coatings1R43HL150977-01SKOOG, DAVIDADVANCED RESPIRATORY TECHNOLOGIES, LLC, PA$298,100ZRG1
2020Degradable hydrogel for retinal tamponade (phase 2)2R44EY027635-02A1BRAITHWAITE, GAVIN JAMESCAMBRIDGE POLYMER GROUP, INC., MA$296,103ZRG1
2020Safety and efficacy of an allergy therapeutic targeting FcERI bound IgE in human immune reconstituted mice.1R43AI149739-01SAXON, ANDREWSIXAL CORPORATION, CA$286,656ZRG1
2020Novel Dual Acting Antibiotics for Pulmonary Disease1R43AI145766-01A1DONN, KARL HPARION SCIENCES, INC., NC$274,173ZRG1
2020Detection of fetal platelets in maternal blood using platelet RNA biomarkers.1R43HL147793-01A1GNATENKO, DMITRI VBLOOD CELL TECHNOLOGIES, LLC, NY$272,302ZRG1
2020MosaicVillage: A Youth-Informed Platform to Reduce Youth Homelessness Through Collective Impact1R43HD099003-01A1CEARLEY, JENNIFER JOYWENDT, ADAM JOHNIRIS MEDIA, INC., OR$262,499ZRG1
2020Targeted Exosome-Associated AAV-Mediated Gene Therapy to Eliminate Metastatic Neuroendocrine Cancers1R43CA246883-01GARNER, JOSEPH NLIU, XIAOGUANG MARGARETWHITT, JASON DEREKTECHNOLOGY COMMERCIALIZATION PARTNERS, LLC, AL$243,144ZRG1
2020Super-sensitive detection of universal markers of allograft rejection1R43AI150530-01MURRAY, JAMES LGENETAG TECHNOLOGY, INC., GA$242,610ZRG1
2020Targeting ALS-linked FUS with allele-specific antisense oligonucleotides1R43NS115350-01GERBER, DAVID JULIANWILLIAMS, LUIS ALBERTOQ-STATE BIOSCIENCES, INC., MA$236,911ZRG1
2020A Web Service for Fragment-based Selectivity Analysis of Drug Leads1R43GM133284-01A1KULP III, JOHN LAURENCECONIFER POINT PHARMACEUTICALS, LLC, PA$234,737ZRG1
2020Ultra-Sensitive Vapor Phase Hydrogen Peroxide Sensor for Decontaminating Pharmaceutical Manufacturing Facilities and Equipment1R43GM135957-01BRUMFIELD, BRIAN EPHYSICAL SCIENCES, INC, MA$231,250ZRG1
2020Biological Equivalence of In Vitro Plasmodium falciparum Culture for Practical Malaria Vaccine Development1R43AI149889-01AVRIL, MARIONWILDER, BRANDON KEITHMALARVX, INC., WA$230,288ZRG1
2020Optical probe for in situ assessment of pulmonary fibrosis1R43HL150948-01IFTIMIA, NICUSORPHYSICAL SCIENCES, INC, MA$229,963ZRG1
2020A Rapid Multiplexed Test for the Screening of Sepsis and Organ Dysfunction at the Point of Care1R43GM135985-01DESA, JOHANNINSTADIAGNOSTICS, INC., PA$225,000ZRG1
2020Predictive assessment of acute and chronic cardiotoxicity using combinatorially matured hPSC-CMs1R44HL151094-01GEISSE, NICHOLAS ANDREWCURI BIO INC, WA$225,000ZRG1
2020Anti-angiogenic gene therapy of ocular vascular diseases1R43EY031238-01LI, WEITIAN, HONGWEBSTER, KEITH AEVERGLADES BIOPHARMA, LLC, TX$225,000ZRG1
2020Fully modified bispecific aptamer for effective combination therapy of neovascular ocular diseases1R44EY030822-01A1GONG, QIANGAPTITUDE MEDICAL SYSTEMS, INC., CA$224,973ZRG1
2020Safety-Enhancing Motor Vehicle Child Safety Seat1R43HD101139-01RYDBERG, NICKMINNESOTA HEALTHSOLUTIONS CORPORATION, MN$224,953ZRG1
2020Novel anti-fibrotic therapy for IPF1R43HL150897-01LARRICK, JAMES WYU, BOLARIX BIOSCIENCE, LLC, CA$224,924ZRG1
2020Targeted Gene Insertion by Directed Evolution of ΦC31 Integrase for Therapeutic Gene Editing1R44GM136045-01CHEN-TSAI, RUBY YANRUAPPLIED STEMCELL, INC., CA$224,854ZRG1
2020Multiplexed wireless battery-free sensors for pediatric intensive care units (PICU).1R43HD101189-01MODEL, JEFFREYWEARIFI, INC., IL$224,821ZRG1
2020Continuous Non-Invasive Blood Pressure Monitor for Neonates1R43HD101175-01QUAN, XINAPYRAMES, INC., CA$224,556ZRG1
2020Cell-based assay directly monitoring viral polymerase activity for drug discovery.1R43AI150006-01O'HANLON, RYANLUCERNA, INC., NY$224,323ZRG1
2020Feasibility Testing of a Microphone System to Facilitate Patient Communication During Noninvasive Ventilation1R43HL147788-01A1BREWER, LARA MAXON MEDICAL, INC., UT$224,225ZRG1
2020Temperature-Responsive Clips for Removable Dental Prostheses1R43DE028777-01A1SEO, YOUNGRODO MEDICAL, INC., CA$223,891ZRG1
2020Computer-Aided Decision Support System for Catheter-Based Pulmonary Valve Replacement1R43HL147747-01A1ARIKATLA, VENKATA SREEKANTHKITWARE, INC., NY$223,020ZRG1
2020A New Superconducting Detector Technology for Mass Spectrometry of Large Biomolecules1R43GM135959-01KELLY, THOMAS FREDSTEAM INSTRUMENTS, INC., WI$221,263ZRG1
2020CDK2 inhibitors for protecting hearing loss1R43DC018463-01ZALLOCCHI, MARISA L.TING THERAPEUTICS, INC., CA$220,653ZRG1
2020Light engineering module for fast high-resolution whole-cell imaging1R43EB028726-01A1COLOMB, WARRENDOUBLE HELIX OPTICS INC., CO$218,223ZRG1
2020Targeting Neutrophil Extracellular Traps for Acute Lung Injury1R43HL150944-01FUCHS, TOBIASNEUTROLIS, INC., MA$209,500ZRG1
2020A PULSED CONDENSATION PARTICLE COUNTER FOR LOW-COST MONITORING OF ULTRAFINE AIRBORNE PARTICLES1R43ES031458-01HERING, SUSANNE VERAAEROSOL DYNAMICS, INC., CA$180,958ZRG1
2020AI platform for microscopy image restoration and virtual staining1U44GM136091-01LEE, SHIH-JONG JDRVISION TECHNOLOGIES, LLC, WA$172,359ZRG1
2020Encapsulated Silver Diamine Fluoride (E-SDF)1R43DE028762-01A1MILGROM, PETER MADP SILVER DENTAL ARREST, LLC, OR$162,464ZRG1
2020Fiber adsorbent for remediation of multisolute contamination in drinking water.1R43ES031443-01TSUKAMOTO, TAKUJICHEMICA TECHNOLOGIES, INC., OR$159,012ZRG1
2020High-stability solid-state cooled Cryo-TEM transfer holder1R43GM135954-01ALSEM, DAAN HEINHUMMINGBIRD PRECISION MACHINE COMPANY, WA$150,000ZRG1
2020Reducing the prohibitive costs of protein production for therapeutic development1R43GM136097-01SHEPHERD, RYAN W.PHYLLOTECH, LLC, WI$150,000ZRG1
2020Ultra-low Fouling and Nitric Oxide Releasing Intravascular Catheters for Prevention of Thrombosis and Infection1R43HL149595-01A1HOPKINS, SEANINNOVETA BIOMEDICAL LLC, GA$149,848ZRG1
2019Human Neural Cell Exosomes as a therapeutic treatment for stroke2R44NS103596-02BAKER, EMILY WARUNA BIOMEDICAL, INC., GA$2,880,097ZRG1
2019A Single Dose Long-Acting Non-Addictive Polymer Conjugate Formulation of Buprenorphine that Provides Immediate and Prolonged Analgesia for Post-Operative Pain1R44NS115196-01MOREADITH, RANDALL WVIEGAS, TACEY XAVIERSERINA THERAPEUTICS, INC., AL$1,658,634ZRG1
2019Peripherally-Restricted Long-Acting Somatostatin Receptor 4 (LA-SSTR4) Agonists for Pain2R44DA045410-02RIVIERE, PIERREPEPTIDE LOGIC, LLC, CA$1,585,395ZRG1
2019Catheter for Large Volume Intraparenchymal Brain Therapies2R44NS084701-03A1ABRAMOV, VASILIYCREOSALUS, INC., KY$1,493,724ZRG1
2019CTRA Software Solution for Fracture Risk Assessment of Axial Skeleton1R44AG065014-01NAZARIAN, ARAVAZIRI, ASHKANYASZEMSKI, MICHAEL JBIOSENSICS, LLC, MA$1,490,863ZRG1
2019A gel patch for replacing surgical eardrum repair with an office-based procedure1R44DC018255-01HORN-RANNEY, ELAINE LARKIETYMPANOGEN, LLC, VA$1,479,163ZRG1
2019Completion of IND-package for a novel, non-narcotic painkiller2R44DA041912-03 · under PA-17-302YEKKIRALA, AJAY SBLUE THERAPEUTICS, INC., MA$1,474,091ZRG1
2019Software for OCT Analysis of Vascular Stents2R44HL137500-02SHALEV, RONNYDYAD MEDICAL, INC., MA$1,265,906ZRG1
2019System and comprehensive approach for blood compatibility of medical devices and biomaterial2R44HL131338-02CAHALAN, PATRICK THOMASENSION, INC., PA$1,261,442ZRG1
2019Development of a New Carbohydrate-based Anticoagulant Drug2R44HL139187-02PAGADALA, VIJAYAKANTHGLYCAN THERAPEUTICS CORPORATION, NC$1,244,412ZRG1
2019Preclinical Oxygen Imager to Model Efficient Cancer Treatment2R44CA224840-02KOTECHA, MRIGNAYANIO2M TECHNOLOGIES, LLC, IL$1,168,365ZRG1
2019Tailoring the Hydroxyl Radical Foot-Printing Approach to Provide a Solution for the Higher Order Structural Analysis Needs of the Biopharmaceutical Industry2R44GM125420-02WEINBERGER, SCOT RANDYGENNEXT TECHNOLOGIES, INC., CA$1,134,434ZRG1
2019Perfusion decellularization and recellularization for the creation of a bioengineered transplantable liver1R44DK122894-01A1ROSS, JEFFREY JAMESMIROMATRIX MEDICAL, INC., MN$1,129,548ZRG1
2019A Platform for Safe, Noninvasive Prenatal Genetic Testing at Five Weeks of Pregnancy2R44HD092205-02ARMANT, DAVID RANDALLGLIGORICH, KEITH MICHAELCRADLE GENOMICS, INC., CA$1,098,375ZRG1
2019Translational feasibility of an oral, non-hormonal, male contraceptive pill1R44HD100256-01CROWE, PAUL DORPHAGEN PHARMACEUTICALS, CA$1,093,784ZRG1
2019Performance Evaluation of a non-Degradable Synthetic Device for Chondral and Osteochondral Defects of the Knee2R44AR067533-02A1CHEN, TONYHYDRO-GEN, LLC, NJ$1,090,977ZRG1
2019Phase II: Development of a Neurovascular Magnetic Particle Imaging system with sub-millimeter resolution and real time speed for non-radiative 3D perfusion angiography2R44DA041814-02GOODWILL, PATRICKWINTERMARK, MAXMAGNETIC INSIGHT, INC., CA$1,066,136ZRG1
2019Intratumoral immunotherapy with formulated resiquimod for metastatic melanoma2R44CA217489-03WANG, YEN TUNCUREBIOTECH, INC., PA$1,024,973ZRG1
2019Humanization, Production, and PK/PD Characterization of anti-TIP1 antibody against Non-Small Cell Lung Cancer2R44CA210687-02A1DEORE, SAPNAMEDICAL GUIDANCE SYSTEMS, LLC, MO$1,011,611ZRG1
2019Predevelopment of VV2003, a Novel CRAC Channel Inhibitor, to Improve Outcomes Associated with Checkpoint Inhibitor Immunotherapy2R44CA224454-02GREENBERG, MILTON LVIVREON BIOSCIENCES, LLC, CA$1,004,278ZRG1
2019Measureable Residual Disease testing for acute myeloid leukemia with single-cell genotyping1R44CA247135-01RUFF, DAVID WMISSION BIO, INC., CA$1,000,002ZRG1
2019Therapeutic Antibody for RSV IIB2R44AI122360-03KAUVAR, LAWRENCE MICHAELTRELLIS BIOSCIENCE, INC., CA$1,000,000ZRG1
2019An automated platform for direct-from-specimen identification of pathogens common in endocarditis2R44AI136064-02SINGER, ALONHELIXBIND, INC., MA$1,000,000ZRG1
2019Development of VLP vaccine for RSV2R44AI109926-04A1BLANCO, JORGE CSIGMOVIR BIOSYSTEMS, INC., MD$1,000,000ZRG1
2019Development of GPER Agonists as Cancer Therapeutics2R44CA228695-02GARYANTES, TINALINNAEUS THERAPEUTICS, LLC, PA$1,000,000ZRG1
2019Advancement of antiviral inhibitors of chikungunya virus2R44AI118115-03PEVEAR, DANIEL CVENATORX PHARMACEUTICALS, INC., PA$1,000,000ZRG1
2019Toxoid adjuvant CRM197 production in a stable reduced genome E. coli strain2R44AI094823-04A1BLATTNER, FREDERICK RLANDRY, CHARLES FSCARAB GENOMICS, LLC, WI$1,000,000ZRG1
2019New Class of Bright, Sharp, Tunable Near-Infrared Fluorophores for Flow Cytometry2R44AI112302-04A1MACNEVIN, CHRISTOPHER JNIRVANA SCIENCES, INC., NC$1,000,000ZRG1
2019Development of a Highly Sensitive Quantitative Rapid Digital LSPR Diagnostic for Acute Dengue and Zika Virus Infection2R44AI127055-02A1GERION, DANIELEHENKEL, GREGORY WILLIAMARISAN THERAPEUTICS, INC., CA$1,000,000ZRG1
2019Optically Sensorized, Actuated Needles for Oncological Applications1R44CA243925-01MOSLEHI, BEHZADINTELLIGENT FIBER OPTIC SYSTEMS CORP, CA$1,000,000ZRG1
2019IND-enabling preclinical development of a system for the multipurpose prevention of HIV and unintended pregnancy2R44AI124815-02A1SMITH, THOMAS J.AURITEC PHARMACEUTICALS, INC., CA$999,998ZRG1
2019Development and Validation of a Collaborative Web/Cloud-Based Dosimetry System for Radiopharmaceutical Therapy.2R44CA213782-02FREY, ERIC C.GHALY, MICHAELRADIOPHARMACEUTICAL IMAGING AND DOSIMETRY, LLC, MD$999,998ZRG1
2019A single antiviral to treat multiple opportunistic infections2R44AI114079-02REMISZEWSKI, STACYEVRYS BIO, LLC, PA$999,997ZRG1
2019Multiplex Platform for Point-of-Care Newborn Screening of Hyperbilirubinemia2R44HD072853-06PAMULA, VAMSEE K.BAEBIES, INC., NC$999,995ZRG1
2019Preclinical development of Novo29, a new antibiotic2R44AI136137-02A1LING, LOSEE LUCYNOVOBIOTIC PHARMACEUTICALS, LLC, MA$999,992ZRG1
2019Novel Plasmodial Surface Anion Channel Inhibitors as Antimalarial Drugs2R44AI100339-05BUTLER, MICHELLE M.MICROBIOTIX, INC, MA$999,986ZRG1
2019A Multiscale Simulation Toolkit for Computational Pharmacology of Trans/Intradermally Administered Compounds in Healthy and Diseased Population2R44FD005345-02GARIMELLA, HARSHA TEJACFD RESEARCH CORPORATION, AL$999,921ZRG1
2019Rapid, Point-of-Care Nucleic Acid Test for HCV1R44DK123849-01CHO, HYUNDAECROSSLIFE TECHNOLOGIES, INC., CA$999,841ZRG1
2019System for faster microarray assays and end-to-end workflow automation2R44GM122159-02A1FISHER, JAY KENNETHREDBUD LABS, INC., NC$999,735ZRG1
2019Novel Spectinamide Antibiotics for the Treatment of MDR/XDR Tuberculosis2R44AI098271-06BUTLER, MICHELLE M.MICROBIOTIX, INC, MA$999,559ZRG1
2019Radiation Sterilizable, RFID Tagged Vials for Biomedical Samples2R44OD020162-04 · under PA-17-302DAVIDOWITZ, HANANELBIO TILLION, LLC, NJ$999,504ZRG1
2019Continuing Preclinical Development of PPCM Vaginal Contraceptive MPT to IND2R44HD092206-03JERSE, ANN E.NORTH, BARBARA BESTWALLER, DONALD PWEITZEL, MARY BYASO THERAPEUTICS INC, TX$999,102ZRG1
2019Stream Dx: Point of Care Cellular Enabled IoT Communication Hub for Improved Diagnosis, Monitoring, and Post-Treatment Evaluation of LUTS2R44DK113878-03HOTALING, JAMESMCCLELLAN, SCOTT BRADFORDSTREAM DX, INC., UT$998,995ZRG1
2019Microneedle Delivery of Zanamivir for Treatment of Influenza2R44AI129122-03A1LIPKA, ELKETSRL, INC., MI$998,654ZRG1
2019Uterine Wall-Membrane Anchor Device for the Prevention of Preterm Premature Rupture of the Membranes Following Fetoscopic Surgery2R44HD094456-02VARADHACHARY, ATULFANNIN PARTNERS, LLC, TX$998,650ZRG1
2019Development of a Balloon Occlusion Sheath for Stroke (BOSS)2R44NS103670-02HATCHER, BRADYKALLMES, DAVID FMARBLEHEAD MEDICAL, LLC, MN$998,169ZRG1
2019A computational platform to improve the prioritization of drugs and target genes for therapeutic intervention2R44TR002035-02MCGARY, KRISTON LYLEGENETIC NETWORKS, LLC, FL$991,290ZRG1
2019Medical Device Cyber-Security2R44GM126614-02UPLINGER, JAMESNOKOMIS, INC., PA$990,726ZRG1
2019Advancing Protein Engineering Using Artificial Intelligence and the ProtaBank Mutation Database2R44GM117961-04A1OLAFSON, BARRY DPROTABIT, LLC, CA$990,318ZRG1
2019Optimization of novel pyranopyridine efflux pump inhibitors2R44AI100332-06OPPERMAN, TIMOTHY J.MICROBIOTIX, INC, MA$987,681ZRG1
2019Sensitive and Portable Physician Office-Based Urine Analyzer to Tackle Prescription Drug Abuse2R44DA043325-02HEFFERNAN, MICHAEL JOHNBREVITEST TECHNOLOGIES, INC., TX$986,127ZRG1
2019Treating Peritoneal Malignancies with Paclitaxel-Loaded Expansile Nanoparticles2R44CA189215-02A1COLBY, AARON HENRYIONIC PHARMACEUTICALS, MA$982,798ZRG1
2019IND-enabling assay validation and toxicology studies on AKS-107: a novel antigen-specific B cell therapeutic to prevent Type 1 Diabetes2R44DK107099-04ZION, TODD CAKSTON BIOSCIENCES CORPORATION, MA$978,643ZRG1
2019Novel enzyme inhibitor screening platform using modified designer nucleosomes2R44GM119893-02A1SUN, ZU-WENEPICYPHER, INC., NC$968,299ZRG1
2019Rapid and Effective Localized Neurovascular Cooling Using the Khione Insulative Catheter2R44NS095573-03A1MERRILL, THOMAS LFOCALCOOL, LLC, NJ$967,506ZRG1
2019Safe and Effective Whole Blood ID/AST Device for Use in Neonatal ICU Settings2R44HD084033-04GAU, VINCENT JEN-JRGENEFLUIDICS, INC., CA$966,760ZRG1
2019A Novel Probiotic for the Treatment of Sjogren's Syndrome2R44DE026379-02FANGER, GARYRISE THERAPEUTICS, LLC, MD$956,644ZRG1
2019Product Development of Intensity Modulation for Bolus Electron Conformal Therapy2R44CA199838-02ERHART, KEVIN JAMESDECIMAL, INC., FL$940,905ZRG1
2019An Improved Method of Delivering a Sclerosing Agent for the Treatment of a Malignant Pleural Effusion.2R44CA210696-02HUNEKE, RICHARD BRIANLAUB, GLENN WTDL INNOVATIONS, LLC, NJ$930,483ZRG1
2019PIC1 pre-clinical formulation and optimization as a novel anti-inflammatory pharmacological agent2R44AI131764-02A1KRISHNA, NEEL KUMARREALTA LIFE SCIENCES, INC., VA$919,171ZRG1
2019Targeting Irritable Bowel Syndrome (IBS) with astressins2R44DK116362-02BEHAN, DOMINICLARAUCHE, MURIELRIVIER, JEAN ESENTIA MEDICAL SCIENCES, INC., CA$906,525ZRG1
2019Protein therapeutic to facilitate healing of chronic wounds.2R44GM123887-02TAN, TAOTRIM-EDICINE, INC., OH$898,170ZRG1
2019Development of MTX-211 for the Treatment of KRAS Mutant Colorectal Cancer2R44CA213715-02LEOPOLD, JUDITH SWHITEHEAD, CHRISTOPHER EMILMEKANISTIC THERAPEUTICS, LLC, MI$888,572ZRG1
2019A therapeutic vaccine for chronic hepatitis B2R44AI088919-06A1MILICH, DAVID R.VLP BIOTECH, INC., CA$878,409ZRG1
2019A user-friendly point-of-care device for G6PDH determination2R44AI129057-02A1HARPER, ROBERTANALYTICAL DIAGNOSTIC SOLUTIONS, INC., NJ$873,090ZRG1
2019IND-enabling preclinical development of a sustained-release Pritelivir intravaginal ring for the treatment and prophylaxis of Genital Herpes in women2R44AI136201-02A1SMITH, THOMAS J.AURITEC PHARMACEUTICALS, INC., CA$860,561ZRG1
2019An Interactive, Patient-Specific Virtual Surgical Planning System for Upper Airway Obstruction Treatments2R44EB023121-02ENQUOBAHRIE, ANDINET ASMAMAWKITWARE, INC., NY$849,999ZRG1
2019Renalase: Development as an Innovative New Drug for Acute Pancreatitis2R44DK111251-02A1BERKOWITZ, BARRY ADESIR, GARY V.BESSOR PHARMA, LLC, MA$849,303ZRG1
2019Cross-Protective Multivalent Vaccine for Tick-Borne Flaviviruses2R44AI118017-03CLEMENTS, DAVID EHAWAII BIOTECH, INC., HI$839,920ZRG1
2019Ice-free vitrification and nanowarming of large osteochondral grafts for transplantation2R44AR073136-02BROCKBANK, KELVIN G.M.TISSUE TESTING TECHNOLOGIES, LLC, SC$838,363ZRG1
2019Patient/Resident Mobility Tracker (PREEMPT)2R44NR015934-02CLARK, BRIAN RBARRON ASSOCIATES, INC., VA$825,939ZRG1
2019Development of A Topical siRNA Therapy to Promote Burn Wound Healing via Depletion of the Novel Microtubule Regulatory, Fidgetin-Like-22R44AR070696-02A1DEY, ABHINAVSHARP, DAVID JAMESMICROCURES, INC., CA$823,988ZRG1
2019Development of a novel class of immunotherapeutic antibody for metastatic prostate cancer1R44CA247503-01RISDON, GRANT HWU, JENNIFER DCANCURE, LLC, WA$818,940ZRG1
2019Stabilization of the RNA Complement of Enveloped Viruses: Beta Testing and Manufacturing Scale-up of a Novel Filter Paper Product for the Field Collection of Dried Blood Spots2R44AI132032-03NASARABADI, SHANAVAZGENTEGRA, LLC, CA$817,026ZRG1
2019An Ultra-fast Cooling Device for Vitrification and Cryopreservation of Cells and Tissues2R44OD020163-02A1HAN, XUCRYOCRATE, LLC, MO$815,083ZRG1
2019Developing a systems biology platform for predicting, preventing, and treating drug side effects2R44GM121117-02BORDBAR, AARASHSINOPIA BIOSCIENCES, INC., CA$802,538ZRG1
2019Nucleation Enhanced Crystallization of Pharmaceuticals in Continuous Flow Manufacturing to Mitigate Therapeutic Drug Shortages2R44TR001380-02A1BOND, ANDREW H.DENOVX, LLC, IL$800,139ZRG1
2019First-in-class TREM-1 inhibitors in combination therapy for pancreatic cancer2R44CA217400-02SIGALOV, ALEXANDER BSIGNABLOK, INC., MA$799,560ZRG1
2019Targeting the Unfolded Protein Response to Treat Retinitis Pigmentosa2R44EY026370-02KEENAN, RICHARD MCCULLOCHOPTIKIRA, LLC, OH$795,163ZRG1
2019SBIR Phase II: Protein A Membrane Columns for Rapid Protein Purification2R44GM125429-02ZHOU, JINXIANGPURILOGICS, LLC, SC$792,607ZRG1
2019Development of a Next Generation Visual Performance Assessment System for Rodents2R44EY025913-02CHEN, DONG FENGLUO, GANGXIE, XINMIN SIMONAFASCI, INC., CA$788,405ZRG1
2019Wireless System for Ambulatory Rodents to Measure Pressure and Volume in the Left Ventricle2R44HL132705-02A1RIEHLE, TIMOTHY H.KORONIS BIOMEDICAL TECHNOLOGIES CORPORAT, MN$781,601ZRG1
2019A CLOSED SYSTEM FOR PATHOGEN REDUCTION OF RED BLOOD CELLS FOR TRANSFUSION1R44HL145783-01TABATADZE, DAVID RZATA PHARMACEUTICALS, INC., MA$780,492ZRG1
2019Augmented Reality System for the Education of Clinical Caregivers of Older Adults2R44AG057257-02BECKER, ADAMINNOVATIVE DESIGN LABS, INC., MN$779,815ZRG1
2019Chromatography-Free Antibody Purification by Affinity-Phase Separation2R44GM128557-02LUGINBUHL, KELLI MICHELLEISOLERE BIO, INC., NC$778,207ZRG1
2019Compensation-Free, Highly Multiplexed Flow Cytometer2R44GM123906-02A1VACCA, GIACOMOKINETIC RIVER CORPORATION, CA$774,933ZRG1
2019Bioresorbable Nanoparticles for Visual Detection of Early-Stage Dental Caries2R44DE027903-02BLOEMBERGEN, STEVENGREENMARK BIOMEDICAL, INC., MI$770,105ZRG1
2019Selection & Optimization of a Therapeutic Protein for Acute Ischemic Stroke Functional Recovery1R44NS107152-01A1ADKISSON, HUSTON DAVISSTREAM BIOMEDICAL, INC., TX$767,588ZRG1
2019Fast, flexible, and economical system for affinity-tag protein purification and tag removal2R44GM126676-02BRYAN, PHILIP NPOTOMAC AFFINITY PROTEINS, LLC, MD$760,681ZRG1
2019Next-generation phenotypic antimicrobial susceptibility test platform: rapid results and comprehensive menus2R44AI136125-02STERN, ERICSELUX DIAGNOSTICS, INC., MA$760,449ZRG1
2019High Throughput Screening of Pharmaceuticals Targeting Heart Cell Contractile Function2R44HL137603-02A1PALMER, BRADLEY MIONOPTIX, LLC, MA$754,124ZRG1
2019An automated test for gestational diabetes based on glycated CD591R44DK124056-01PACHECO, CHRISMELLITUS, LLC, MA$750,632ZRG1

Showing the 200 most recent of 4,393 awards.

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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