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NIH funding notice PA-19-272

PHS 2019-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed

Closed on July 6, 2020.

Posted
May 7, 2019
Close date
July 6, 2020
Activity codes
R43, R44
Institutes taking part
NCI, NEI, NHLBI, NHGRI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDCD, NIDCR, NIDDK, NIDA, NIEHS, NIGMS, NIMH, NINDS, NINR, NIMHD, NLM, NCCIH, NCATS, ORIP, CGH, NCBDDD, NCCDPHP, NCEZID, NCHHSTP, NCIRD, NCIPC, NIOSH, NCEH, CPR, CBER, CDER, CFSAN, CDRH, CVM, CPI, OOPD

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

  1. Reissues: PA-18-574 PHS 2018-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)
  2. 2 steps back: PA-17-302 PHS 2017-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  3. 3 steps back: PA-16-302 PHS 2016-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  4. 4 steps back: PA-15-269 PHS 2015-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  5. 5 steps back: PA-14-071 PHS 2014-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  6. 6 steps back: PA-13-234 Reissue PHS 2013-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  7. 7 steps back: PA-13-088 PHS 2013-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  8. 8 steps back: PA-12-088 PHS 2012-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  9. 9 steps back: PA-11-096 PHS 2011-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  10. 10 steps back: PA-10-050 PHS 2010-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  11. 11 steps back: PA-09-080 PHS 2009-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])

Replaced by PA-20-260.

Who won it before

5,056 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $1,918,953,764 in first-year total cost, median $244,450.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 SBIB-T (10)]267
  2. Special Emphasis Panel[ZRG1 ETTN-G (12)]236
  3. Special Emphasis Panel[ZRG1 IMST-H (15)]202
  4. Special Emphasis Panel[ZRG1 IDM-V (12)]173
  5. Special Emphasis Panel[ZRG1 IMST-B (12)]158

Most frequent institutions

  1. PHYSICAL SCIENCES, INC32
  2. AFFINERGY, LLC28
  3. EPICYPHER, INC.28
  4. LYNNTECH, INC.24
  5. PANORAMA RESEARCH, INC.22
Competing awards under PA-19-272 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2021Leadless Pacemaker Betavoltaic Power Source2R44HL145950-02A1CABAUY, PETERCITY LABS, INC., FL$2,242,432ZRG1
2021Non-opiate topical formulations for treating pain associated with molar extractions2R44DE028208-02A1PARR, ALANARCATO LABORATORIES, INC., NC$1,542,183ZRG1
2021Improved Treatment of Distal Radius Fractures Using an Image-Guided, Percutaneous Delivery of a Novel Bone Adhesive2R44AG060881-02HESS, BRIANREVBIO, INC., MA$1,368,425ZRG1
2021Development of a metabolomics and machine learning based high-throughput screening platform for data-driven drug discovery2R44GM130268-02BORDBAR, AARASHNEMKOV, TRAVISSINOPIA BIOSCIENCES, INC., CA$1,335,997ZRG1
2021A comprehensive quality control testing strategy for engineered cells1R44TR003554-01TOMPKINS, CHRISTOPHER JOHNKROMATID, INC., CO$1,284,984ZRG1
2021A New Device to measure Whole and Tissue Level Bone Strength.1R44AG071034-01BURKS, PETERTANG, SIMON YUE-CHEONGACTIVE LIFE SCIENTIFIC, INC., CA$1,213,580ZRG1
2021Automated Ultra-Long DNA and RNA Extraction for Long-read Sequencing Applications2R44GM131530-02A1BROWN, MARK TCLAREMONT BIOSOLUTIONS, LLC, CA$1,164,571ZRG1
2021Mechanism to Promote Safe and Efficient Oral Feeding in Preterm Infants2R44HD092210-02A1MATHUR, AMIT MOHANOLEKSY, THOMASPINEDA, ROBERTAPREEMIE-PACER, LLC, MO$1,062,573ZRG1
2021Ultrasound-based diagnostic and monitoring of bladder cancer treatment with drug released from nanoparticles2R44CA232778-02A1ASSOULINE, JOENANOMEDTRIX, LLC, IA$1,043,125ZRG1
2021Elution of a Small Molecule from a Bio Ceramic Collagen Bone Graft Device Heals Bone while InhibitingBreast Cancer Bone Metastases2R44CA221553-02A1MARGULIES, BRYAN SAMUELZETAGEN THERAPEUTICS, INC., NY$1,014,441ZRG1
2021Development of a Polymeric Percutaneous Pulmonary Valve for Use in Young Children2R44HL129577-02A1CLIFTON, WILLPOLYVASCULAR CORPORATION, TX$1,007,115ZRG1
2021A Novel Immunologically Enhanced Probiotic for Treating Rheumatoid Arthritis1R44AI157031-01FANGER, GARYRISE THERAPEUTICS, LLC, MD$1,000,000ZRG1
2021Massively Multiplexed dsDNA Invasion Arrays1R44AI157322-01SINGER, ALONHELIXBIND, INC., MA$1,000,000ZRG1
2021Preclinical development of an immunomodulatory agent capable of mitigating SARS-CoV-2 virus related hypercytokinemia1R44AI157719-01CRAIGO, JODI KCYTOAGENTS, INC., PA$1,000,000ZRG1
2021A Unique Automated Bioreactor for Rearing Aseptic Mosquitoes from Larvae to Adults to Support Manufacture of Sanaria PfSPZ Products2R44AI138943-03BILLINGSLEY, PETER F.SANARIA, INC., MD$1,000,000ZRG1
2021Screening for rAAV transduction enhancers2R44AI125043-03BOWLIN, TERRY L.MICROBIOTIX, INC, MA$999,976ZRG1
2021Point-of-Care Rapid RNA test for Zika1R44TR003549-01CHO, HYUNDAECROSSLIFE TECHNOLOGIES, INC., CA$999,916ZRG1
2021Product optimization to commercialize an oral bacteriophage cocktail that prevents cholera in real-world settings2R44AI142960-03CAMILLI, ANDREWYEN, MINMINPHAGEPRO, INC., MA$999,585ZRG1
2021Novel therapy for Fragile X syndrome2R44MH115529-03MUOTRI, ALYSSON R.TUCCI, FABIO COHENEPIGEN BIOSCIENCES, INC., CA$998,958ZRG1
2021A New Approach to Treat Prosthetic Joint Infections with a ClpP Activating Antibiotic1R44AI157081-01LAFLEUR, MICHAELARIETIS, MA$995,100ZRG1
2021Aptamer therapeutic for safe and low-cost treatment of snake bite envenomation1R44OD030205-01VARADHACHARY, ATULVEGA, STEPHANIE PRISCILLAFANNIN PARTNERS, LLC, TX$993,974ZRG1
2021Mechanical device for the prevention of VTE in high risk patient populations2R44HL145860-02WELSH, JOHN DOSCIFLEX LLC, PA$986,710ZRG1
2021MycoMEIA - Urine Diagnostic for Aspergillosis1R44AI157572-01HANNAN, MICHAELMARR, KIEREN A.PEARL DIAGNOSTICS, INC., MD$976,576ZRG1
2021An automated, scalable, and rapid AST system for Gonorrhea STIs1R44AI157675-01SWIGER, ROY RACENXION BIOSYSTEMS, INC., KS$967,087ZRG1
2021A Comprehensive 5K Plus Glycan Microarray2R44GM123820-03LI, LEIZHANG, JIANZ BIOTECH, LLC, CO$940,980ZRG1
2021Neuregulin-4: A Novel Therapy for Inflammatory Bowel Disease2R44DK112435-02A1GHOSH, SOUMITRAAVEXEGEN THERAPEUTICS, INC., CA$867,924ZRG1
2021An Ultrafast Electron Counting Camera for 100 kV Cryo-EM1R44GM140797-01BAMMES, BENJAMIN EUGENEDIRECT ELECTRON, LP, CA$866,770ZRG1
2021PANDAA for universal, pan-lineage molecular detection of Crimean-Congo Hemorrhagic Fever virus1R44AI157650-01MACLEOD, IAIN JAMESALDATU BIOSCIENCES, INC., MA$865,501ZRG1
2021Clinical Validation of Sinu-Test, A Multiplexed Device for Rapid Diagnosis of Acute Bacterial Sinusitis, to support CLIA Waiver2R44AI150203-02HAWKINS, ORIANA E.ENTVANTAGE DX, TX$860,876ZRG1
2021Platform for genotyping and phenotyping each cell in a high throughput assay2R44GM128472-02YELLEN, BENJAMIN BIRONCELLDOM, INC., CA$831,964ZRG1
2021New Algorithms and Software for Mass Spectrometric Analysis of Intact Proteins and Complexes2R44GM133239-02BERN, MARSHALL WAYNEPROTEIN METRICS, LLC, CA$799,604ZRG1
2021Targeting integrin outside-in signaling for treating sepsis2R44HL142396-02A1SKIDGEL, RANDAL ADUPAGE MEDICAL TECHNOLOGY, INC., IL$776,915ZRG1
2021Development of an automated healthcare system for effective management of patients with chronic diseases.2R44NR018631-02YANN, MARGOTADVINOW, INC., AZ$776,150ZRG1
2021Novel Small Molecule Anti-Inflammatory Eye Drops for Ocular Graft Versus Host Disease2R44EY029185-02A1LIU, AMYPULSAR LIFE SCIENCES, INC., NC$749,999ZRG1
2021A microED pipeline for the pharmaceutical and biotechnology industry1R44GM140666-01BRUHN, JESSICA FOXSCAPIN, GIOVANNANANOIMAGING SERVICES, INC., CA$719,038ZRG1
2021A Photo-based Menstrual Blood Loss Metric1R44HD102235-01A1BURNETT, DANIEL ROGERSJACOBY, VANESSATHERANOVA, LLC, CA$717,254ZRG1
2021Optimization of biliverdin IXβ reductase redox inhibitors as novel reagents for enhancing platelet production1R44HL150927-01A1NESBITT, NATASHA M.BLOOD CELL TECHNOLOGIES, LLC, NY$690,965ZRG1
2021Thermostabilized Subunit Glycoprotein Vaccine Platform: Immune Characterization of an Emulsified Adjuvant with SARS-CoV-2 Spike Protein and EBOV GP1R44AI157593-01DONINI, OREOLASOLIGENIX, INC., NJ$636,664ZRG1
2021An Agent-Based Modeling Platform for Environmental Biotechnology2R44ES026541-02SHIRAZI, FATEMEHSOHEILYPOUR, MOHAMMADMICROVI BIOTECH, INC., CA$630,992ZRG1
2021Bioinformatic Tools for Interpretation of Glycan Array Data2R44GM131430-02HAAB, BRIAN B.ZHANG, JIANZ BIOTECH, LLC, CO$557,113ZRG1
2021Explore Slow-Release Formulation of a Peptide Therapeutic for Migraine1R43NS120440-01SOARES, CHRISTOPHER JOSEPHACHERX, CA$500,000ZRG1
2021A New and Disruptive Gene Based Therapy for Atrial Fibrillation1R44HL154912-01A1MOEN, ROBERT CHARLESINOMAGEN THERAPEUTICS, INC, IL$462,689ZRG1
2021Improving the performance of an AI-enabled clinical decision support tool for detecting suicidal risk and other mental health concerns1R43MH125461-01COHEN, JOSHUASPREADING ACTIVATION TECHNOLOGIES, LLC, OH$459,188ZRG1
2021NanoSafe Tested Third Party Verification Process for Characterizing Exposures to Products Containing Engineered Nanomaterials2R44ES030650-02HILL, WILLIAM CARYNANOSAFE, INC., VA$458,457ZRG1
2021Novel Therapeutic Agent for Reversing Vascular Dysfunction in Alzheimer's Disease1R43AG071399-01HUSSAIN, SAZIDAIVOCODE, LLP, CA$433,894ZRG1
2021TempO-LINC high throughput, high sensitivity single cell gene expression profiling assay1R43GM140771-01SELIGMANN, BRUCE E.BIOSPYDER TECHNOLOGIES, INC., CA$402,266ZRG1
2021Magnetic Bronchoscope for Improved Pulmonary Access1R43HL156598-01BLUME, WALTERUNANDUP, LLC, MO$401,401ZRG1
2021High-throughput Label-free Biosensor Platform for Rapid Detection of Antigen-specific T Cells with Single Cell Resolution1R43CA254684-01A1GHASEMI, FARSHIDWEDDELL TECHNOLOGIES LLC, MA$400,000ZRG1
2021Engineering a potent locally-acting interleukin 12-expressing synthetic self-replicating mRNA to augment responses to anti-PD-1 therapy in neoadjuvant triple negative breast cancer1R43CA250745-01A1KITADA, TASUKUSTRAND THERAPEUTICS INC, MA$399,725ZRG1
2021Simultaneous Targeting of Tumor and Stroma Cells to Enhance Solid Tumor CAR-T Cell Therapy1R43CA254820-01A1SHIRKEY-SON, NICOLE J.LUMINARY THERAPEUTICS, INC., MN$399,658ZRG1
2021VDX-111: A novel targeted therapeutic for triple-negative breast cancer1R44CA250674-01A1GARI, HAMID HVONA ONCOLOGY, LLC, CO$398,493ZRG1
2021Hepatocyte production from ice-free cryopreserved and nanowarmed livers1R43DK126551-01A1LEE, CHARLES YVITRISTOR LLC, NC$374,262ZRG1
2021A Novel RNA Therapeutics Platform to Treat Facioscapulohumeral Muscular Dystrophy and other Neuromuscular Disorders1R44NS119147-01A1SALEH, ANTHONY DMIRECULE, INC., MD$370,531ZRG1
2021Tackling the MARCKS-PIP3 Circuit to Attenuate Chronic Pulmonary Fibrosis1R43HL156578-01WU, REENEFFECTORBIO, INC., CA$347,749ZRG1
2021iPSC-derived cardiac fibroblast extracellular matrix for cardiac cell therapy1R43HL156351-01KAMP, TIMOTHY J.SCHMUCK, ERIC GARYCELLULAR LOGISTICS INC., WI$320,678ZRG1
2021High-throughput chemical screens for GPCR functional selectivity1R43TR003567-01FISCHER, CURT R.KOSURI, SRIRAMOCTANT, INC., CA$316,638ZRG1
2021Acute Inhibition of TAK1 as a Means to Control COVID-19 Pulmonary Hyperinflammation1R43HL156706-01HAYSTEAD, TIMOTHY ASCARNEO, SCOTTEYDIS BIO, INC., NC$309,288ZRG1
2021SBIR: In vivo validation and IND-enabling development of MM004, a bispecific inhaled immunotherapy for RSV and MPV1R44AI157661-01CONE, RICHARDMUCOMMUNE, LLC, NC$306,500ZRG1
2021Vaginal ring for sustained release of lactic acid to prevent bacterial vaginosis and associated health risks1R43AI157652-01CONE, RICHARDMUCOMMUNE, LLC, NC$306,500ZRG1
2021High-order Cavities for Enabling High-field MAS-DNP-NMR with Low-cost THz Sources1R43GM140650-01DOTY, FRANCIS DAVIDDOTY SCIENTIFIC, INC., SC$300,001ZRG1
2021Next-day whole genome sequencing and analysis using nanopore sequencing for real-time outbreak and transmission determination in healthcare facilities1R43AI156979-01SATER, MOHAMADDAY ZERO DIAGNOSTICS, INC., MA$300,000ZRG1
2021Novel Immunoregulatory Therapeutics for Systemic Lupus Erythematosus1R43AI156952-01LEBER, ANDREWBIOTHERAPEUTICS, INC., VA$300,000ZRG1
2021Non-Activated Natural Killer Cell Engineering For Enhanced Cytotoxic Potential1R44AI157181-01GRANT, BETHANY FOCHKYTOPEN CORP, MA$300,000ZRG1
2021A New HBV Drug For Establishing Durable Antiviral Efficacy of HBV Treatment1R43AI155066-01A1ZHANG, YONG-YUANHBVTECH, MD$300,000ZRG1
2021Discovery of broad-spectrum, cross-neutralizing bispecific antibodies against SARS-CoV-2 using high throughput functional screening1R43AI157382-01WU, GEORGE GUIKAIAMBERSTONE BIOSCIENCES, INC, CA$300,000ZRG1
2021Attenuation of Liquid Formulation for PfSPZ Vaccine by X-Ray1R43AI157532-01HOFFMAN, STEPHEN LEVJAMES, ERIC ROBERTSANARIA, INC., MD$300,000ZRG1
2021Manganese-based Contrast Agent for Cardiovascular MRI1R43HL156713-01HOFFMAN, VERAREVEAL PHARMA, MA$300,000ZRG1
2021Development and validation of precision blood volume diagnostic and decision support device for acute decompensated heart failure1R43HL156731-01FELDSCHUH, JONATHANDAXOR CORPORATION, TN$299,999ZRG1
2021Preclinical Development of GV-MVA-VLP Vaccines Against COVID-191R43AI157578-01NEWMAN, MARKGEOVAX, INC., GA$299,927ZRG1
2021Selection of a lead candidate for the development of a novel anti-inflammatory therapeutic1R43AI155239-01A1CAULIN, ALEAH FOXPEEL THERAPEUTICS, INC., UT$299,675ZRG1
2021A Novel LIGHT/TL1A Bispecific Antibody for the Treatment of Fibrotic Diseases1R43AI157119-01FANGER, NEIL AVIRTICI, LLC, WA$299,015ZRG1
2021Development of Coccidioides Cytokine Release Assay1R43AI152654-01A1WHEAT, LAWRENCE JOSEPHMIRAVISTA DIAGNOSTICS, LLC, IN$298,530ZRG1
2021A Novel Device Alternative to Temporary Diverting Ostomies after Rectal Cancer Surgery1R43CA246987-01A1FONG, KENTON DODYANSAVAGE MEDICAL, CA$298,509ZRG1
2021Novel therapeutic approach for severe ARDS with a potent pharmacologic allosteric hemoglobin modifier1R43HL156334-01LIGHT, DAVID RICHARDILLEXCOR THERAPEUTICS, LLC, VA$298,412ZRG1
2021Targeted therapeutic delivery to diseased lungs using enucleated mesenchymal stem cells1R43HL156665-01WANG, HUAWEICYTONUS THERAPEUTICS, INC., OH$297,553ZRG1
2021Humanization of ACE2 and Associated Priming Proteases in New Mouse Models for Downstream Disease and Therapy Investigations of COVID-191R43AI157534-01WENG, WEIINGENIOUS TARGETING LABORATORY, INC., NY$297,204ZRG1
2021A Liposomal Enzyme System for Removal of Ethanol from the Blood1R43AA028974-01KOKSHAROV, MIKHAILSYNLIFE INC, MA$295,962ZRG1
2021Rapid identification and selection of functional antigen-specific monoclonal antibodies by FcGR-enabled screening on CytoSort Arrays in the CellRaft AIR System1R43AI157022-01HARTMAN, JESSICACELL MICROSYSTEMS, INC., NC$292,047ZRG1
2021Oral autoantigen therapy for the treatment of Multiple Sclerosis1R43AI155401-01A1PILLER, KENNETH JSOYMEDS, INC., NC$288,580ZRG1
2021Low-cost Production of a Vaccine for Lyme Disease in Maize1R43AI152650-01A1EGELKROUT, ERINGOMES-SOLECKI, MARIAAPPLIED BIOTECHNOLOGY INSTITUTE, CA$282,857ZRG1
2021Rapid Differential Diagnosis of COVID-19 and Common Respiratory Infections1R44AI157716-01PAMULA, VAMSEE K.BAEBIES, INC., NC$278,148ZRG1
2021Inhalation Repurposing of An Approved Drug to Treat Severe Asthma1R44HL156372-01SULLIVAN, JOHNAEON RESPIRE, INC., CA$276,752ZRG1
2021Real-time, High Resolution Ultrasound-based Image Guidance System for Pericardial Access1R43HL156374-01LEE, RANDALL J.MA, IVANPERCEPTIVE NAVIGATION, LLC, MD$261,094ZRG1
2021A High-Speed, User-Friendly, Handheld OCT System for Patients who are Unable to Cooperate1R43EY032394-01DHALLA, AL-HAFEEZ ZAHIRVIEHLAND, CHRISTIANTHEIA IMAGING LLC, NC$259,612ZRG1
2021Low Cost OCT Angiography with Spectroscopic Contrast1R43HL156668-01BROWN, WILLIAMLUMEDICA, INC., NC$259,079ZRG1
2021Versatile Eye Tracking for Improved High-resolution Retinal Imaging1R43EY032417-01MUJAT, MIRCEAPHYSICAL SCIENCES, INC, MA$258,433ZRG1
2021Personalized tVNS device for research and treatment of PTSD1R43MH125660-01EULIANO, NEIL R.EVREN TECHNOLOGIES, INC., FL$256,581ZRG1
2021DEPOFILMTM - A NOVEL AND EFFICIENT METHOD FOR PRODUCING ORAL SOLUBLE FILM FOR DRUG DELIVERY1R43GM140539-01HARIHARAN, MADHU SNOVA THIN FILM PHARMACEUTICALS LLC, NC$256,560ZRG1
2021Preclinical Development of VERSAMAB-101 for Spinal Cord Injury1R43NS120397-01SUN, MIAOVERSAPEUTICS INC, CA$256,122ZRG1
2021New BioCascade System for Investigating the Airborne Transmission Modes of Respiratory Viruses1R43AI157123-01EIGUREN FERNANDEZ, ARANTZAZUAEROSOL DYNAMICS, INC., CA$256,005ZRG1
2021Micro Breath Biomarker Analyzer1R43ES032752-01NGUYEN, CHIENZEBRA ANALYTIX, INC., AR$256,000ZRG1
2021Polymer-Strengthened AcellularBiologically-Derived Grafts for Pelvic Organ Prolapse1R43HD102296-01A1PASHOS, NICHOLASBIOAESTHETICS CORPORATION, NC$255,971ZRG1
2021Urgent and unmet need for a long-term solution for increasing pediatric heart-failure population: BiVACOR Rotary Total Artificial Heart1R44HL156370-01ADACHI, IKITIMMS, DANIELBIVACOR, INC., TX$255,247ZRG1
2021Detecting drug-resistant HBV and HCV variants using a DDS probe array1R43AI156961-01SHAFER, DAVID AGENETAG TECHNOLOGY, INC., GA$253,385ZRG1
2021Sample Barcoding for Ultra High-Throughput Flow Cytometry1R43GM140527-01KWOK, SHELDON J.J.LASE INNOVATION INC., MA$253,256ZRG1
2021Silicon Photonic Detection of anti-ABO Antibodies1R43HL156294-01DRURY-STEWART, DANIELLESIDX, INC., WA$253,054ZRG1
2021Discovery of inhibitors that target HBx for the treatment of chronic HBV infection1R43AI157533-01COBURN, GLEN ANDREWVENATORX PHARMACEUTICALS, INC., PA$252,813ZRG1
2021Reading workstation for clinical contrast echocardiography1R43HL152939-01A1DAVIDSON, BRIAN PEREZSKLENAR, JIRINARNAR, LLC, OR$252,399ZRG1
2021Advancing native top-down protein analysis with hybrid SID/ECD technology1R43GM140749-01SHAW, JARED BRYANE-MSION, INC., OR$252,070ZRG1
2021Novel therapy for myocardial ischemia-reperfusion injury1R43HL149492-01A1LARRICK, JAMES WYU, BOLARIX BIOSCIENCE, LLC, CA$252,000ZRG1
2021Better bioassays via designs for robots analyses with improved model selection and similarity bounds that limit potency bias1R43GM140743-01LANSKY, DAVID MATTHEWPRECISION BIOASSAY, INC, VT$251,991ZRG1
2021Development of an application ("app") for training and assessment of home modification installations for aging in place1R43AG067804-01A1TENENBAUM, LOUISHOMESRENEWED VENTURES LLC, DC$251,841ZRG1
2021Anatomy-augmented visual training on mobile devices for rapid dissemination of best practices during pandemics1R43GM140751-01LEVINE, ROBERT JARCHIEMD, INC., FL$251,643ZRG1
2021DEVELOPMENT OF BASELINE GENE EXPRESSION-BASED RESPONSE PREDICTOR FOR ANTI-TNFA THERAPY IN PATIENTS WITH INFLAMMATORY BOWEL DISEASES1R43DK127578-01SWEENEY, TIMOTHY EINFLAMMATIX, INC., CA$251,371ZRG1
2021Rationally designed lipid- and food-based drug formulations to enhance oral bioavailability1R43GM140759-01CARRIER, REBECCA LREZHDO, OLJORAMECHASIM INC., MA$251,316ZRG1
2021Facile Method for Enhanced Pathogen Detection1R43AI157563-01TIAN, HARVEY CHENINSO BIOSCIENCES INC, NY$250,894ZRG1
2021Development of Self-Detoxifying Filter Media for Active Decontamination1R43AI157785-01BATTAGLIA, DAVID MARKLYNNTECH, INC., TX$250,768ZRG1
2021Validation of the online Toddler Autism and Development Adaptive Screener (TADAS) at 18 months1R44HD104973-01A1HOWARD, BARBARA JOSTURNER, RAYMONDTOTAL CHILD HEALTH, INC., MD$250,263ZRG1
2021Fast-Track: Improving therapeutic protein purification with new, high-productivity multimodal membranes1R44GM140542-01ZHOU, JINXIANGPURILOGICS, LLC, SC$250,115ZRG1
2021Treatment of Onychomycosis Utilizing Targeted, Controlled High-Frequency Energy1R43AI157174-01KING, LAURAVAN DER WEIDE, DANIELACCURE MEDICAL, LLC, WI$250,114ZRG1
2021Mutational profiling in human cells as an in vitro alternative to in vivo mutagenicity assessments1R43ES032751-01AUMAN, JAMES TODDINTEGRATED LABORATORY SYSTEMS, LLC, NC$249,903ZRG1
2021Microglia models for Alzheimer's disease drug screening1R43AG071341-01ESSEX, ANTHONY WEBEREVANS, JAMESPHENOVISTA BIOSCIENCES, LLC, CA$249,900ZRG1
2021Crosslinkable Tissue Particles for Regenerating Craniofacial Bone in an Ovine Model1R43DE029738-01A1TOWNSEND, JAKOBLEEFA BIOTECH, LLC, OK$249,315ZRG1
2021Development of a selective PI3K-Akt-activating neurotrophic small molecule drug, MT-002, for the healing of corneal wounds in Neurotrophic Keratitis.1R43EY032018-01A1MALLON, ANDREW PETERMOHAN, RAJIV RAVINDRACALISTA THERAPEUTICS, INC., RI$247,998ZRG1
2021Demonstration of repeated Positionally Assisted Negative particle Rejection for High-Speed Sorting1R43GM139436-01GRAVES, STEVEN WBENNUBIO INC, NM$247,435ZRG1
2021Continuous liquid-liquid extractors for doubling of productivity and henhancement of batch based drug manufacturing1R43GM140701-01ADAMO, ANDREAZAIPUT FLOW TECHNOLOGIES LLC, MA$247,065ZRG1
2021Autoantibody depletion for the therapy of autoimmune disease1R43AI157024-01KANNANGANAT SIDHARTHAN, SUNILASTERO ERADO INC, TX$246,229ZRG1
2021Pharmacokinetic Assessment of Peptide-Based Therapy HV-3 for the Treatment of Huntington's Disease1R43NS119006-01SCHILB, ANDREW LORINGJANUSQ, LLC, OH$240,938ZRG1
2021A COVID-19 Point of Care Serological Assay for Rapid Quantification of Antibody Titer.1R44AI157776-01GANDINI, ALBERTOACCEL DIAGNOSTICS, LLC, TX$240,405ZRG1
2021Development of an Usher Gene Therapy1R43EY031603-01A1STAERZ, UWE DYANG, JUNGREFFEX, INC., CO$227,497ZRG1
2021Development of SupraGuard ETT, A Next Generation Composite Endotracheal Tube for the Prevention of Ventilator-Associated Pneumonia1R43HL156363-01VACHON, DAVID JOHNIASIS MOLECULAR SCIENCES, INC, WA$225,135ZRG1
2021High Resolution Mapping of Air Pollutants Using Rideshare and Other Vehicles1R43ES031884-01A1BIRKS, JOHN WLUDLUM MEASUREMENTS, INC., CO$225,000ZRG1
2021Filtration Media for In-Home PFAS Removal from Drinking Water1R43ES032735-01DIETZ, STEVEN DTDA RESEARCH, INC., CO$225,000ZRG1
2021A Photochemically 3D Printed High-Resolution Biodegradable Suture Retention Clip1R43GM140802-01RUPPERT, DAVIDDEEP BLUE MEDICAL ADVANCES, INC., NC$225,000ZRG1
2021ViraTag: A Scalable Purification Technology for Adeno-Associated Virus Gene Therapy Vectors1R44GM139503-01A1LUGINBUHL, KELLI MICHELLEISOLERE BIO, INC., NC$224,890ZRG1
2021Clinical Translation of Near Infrared Nerve-Specific Fluorophores for Nerve-sparing Prostatectomy1R44CA247639-01A1BARTH, CONNOR WILLIAMINHERENT TARGETING, LLC, OR$224,658ZRG1
2021Building a Toolbox to Study the SARS-CoV-2 Proteome1R43AI157021-01KAY, BRIAN KENNETHTANGO BIOSCIENCES, INC., IL$222,329ZRG1
2021Portable, Patient-Administered, Sensor-Enhanced Scalp Cooling Cap and Smartphone App to Reduce Provider Burden, Improve Patient Access, and Improve Patient Outcomes for Chemotherapy-induced Alopecia1R43CA254560-01A1DILLIGAN, KATECOOLER HEADS CARE INC, CA$210,997ZRG1
2021SCIENTIFIC FEASIBILITY OF HIGH FLUORIDE-POVIDONE IODINE TOOTHPASTE1R43DE030303-01MILGROM, PETER MADP SILVER DENTAL ARREST, LLC, OR$178,410ZRG1
2021Fizz Reader: Interactive Accessible Data Visualizations Through an NLG Interface1R43GM140807-01SCHEPERS, DOUGLAS ALANFIZZ STUDIO LLC, NC$175,784ZRG1
2021Green and Sustainable in situ Remediation of Heavy Metals Contaminated Soils and Aqueous Systems1R43ES031892-01A1ADAM, NADIABIOMINERAL SYSTEMS, LLC, IN$168,087ZRG1
2021Development of a commercial assay for the rapid and general detection of PFAS in environmental matrices (Phase I)1R43ES030677-01A1MAY, ALEXAWEAVER LABS, LLC, OK$167,999ZRG1
2021Dual-Tracer PET Tumor Imaging1R43CA257522-01KADRMAS, DAN JMULTIFUNCTIONAL IMAGING, INC., UT$150,000ZRG1
2021Hybridization Chain Reaction: Highly Multiplexed Quantitative RNA and Protein Imaging1R44GM140796-01CHOI, HARRY MING TAKMOLECULAR INSTRUMENTS, INC., CA$150,000ZRG1
2021An Affordable and Improved PM Monitor with Enhanced PM2.5 and Simultaneous PM0.30 Measurement Capabilities1R43ES032640-01ANDERSEN, JILLAIRVIZ INC., PA$149,825ZRG1
2021Scoring ligand/protein interactions using a novel high performance implementation of DFT quantum mechanics1R43GM140578-01PEARLMAN, DAVID AQUANTUM SIMULATION TECHNOLOGIES, INC., MA$147,454ZRG1
2021Same day embryo viability sensor for high throughput embryo transfer selection1R43OD030028-01A1BEY, YUSHARAVATA SOLUTIONS, INC., CA$144,560ZRG1
2021Intelligent in silico antibody library design and optimization for therapeutic use1R43GM140499-01CASTELLANA, NATALIEDIGITAL PROTEOMICS LLC, CA$24,590ZRG1
2021Software for sequencing human antibody proteins from polyclonal immune responses1R44GM140607-01PATEL, ANANDDIGITAL PROTEOMICS LLC, CA$23,935ZRG1
2020Motion-robust brain MRI for infants1R44MH124567-01DECKARD, TODD WILLIAMDOSENBACH, NICOFAIR, DAMIEN ATURING MEDICAL TECHNOLOGIES INC, MO$1,790,169ZRG1
2020Analgesic Drug for Local Delivery by Fluoroscopy1R44NS120840-01BEUTLER, ANDREAS S.INTERVENTIONAL ANALGESIX, INC., NC$1,586,882ZRG1
2020Inhaled IRK inhibitors as a novel therapeutic for IPF1R44HL151067-01 · under PA-18-574HAVA, DAVID LMETERA PHARMACEUTICALS, INC., MA$1,515,600ZRG1
2020Development of Novel Intra-aneurysmal Rapid Occlusion Device2R44NS107048-02HEBERT, STEPHEN JKALLMES, DAVID FNEUROGAMI MEDICAL, INC., CA$1,499,299ZRG1
2020Targeting tau for the development of novel Alzheimer's disease therapeutics2R44AG060843-02LARSEN, GLENNWOLOZIN, BENJAMIN LAQUINNAH PHARMACEUTICALS, INC., MA$1,475,961ZRG1
2020Developing Heparan Sulfate Glycan Array2R44GM123792-03SU, GUOWEIGLYCAN THERAPEUTICS CORPORATION, NC$1,443,680ZRG1
2020Disrupting Insulin Delivery with a Novel, Stabilized Insulin that is Ultra-rapid at U100 or U5001R44DK126613-01A1MICHAEL, MERVYN DODSONTHERMALIN, INC., OH$1,423,451ZRG1
2020Microparticle Therapy for Cerebral Amyloid Angiopathy2R44AG059478-03KIRSCH, WOLFF M.KARAMEDICA, INC., NC$1,380,461ZRG1
2020A Novel Bioresorbable Bone Adhesive Used to Fixate Cranial Flaps and Reduce Infection Rates1R44NS115386-01A1HESS, BRIANREVBIO, INC., MA$1,325,488ZRG1
2020Treating severe asthma in the small airways with a highly efficient and penetrating inhaled dry powder1R44HL152780-01A1BEVERLIN II, BRYCEQUENCH MEDICAL, INC., MN$1,247,479ZRG1
2020PHS 2019-02 Omnibus Solicitation of the NIH, CDC, and FDA for SmallBusiness Innovation Research Grant Applications (Parent SBIR [R43/R44] ClinicalTrial Not Allowed1R44NS117214-01A1LEVINE, TODDCND LIFE SCIENCES, INC., AZ$1,214,227ZRG1
2020Novel microfluidic platform for versatile, fast, low-cost DNA synthesis and assembly1R44HG011433-01HILL, MATTHEWELEGEN CORPORATION, CA$1,210,045ZRG1
2020Solving the MRI motion problem with Framewise Integrated Real-Time MRI Monitoring (FIRMM) software1R44MH121276-01A1DECKARD, TODD WILLIAMDOSENBACH, NICOFAIR, DAMIEN ATURING MEDICAL TECHNOLOGIES INC, MO$1,190,011ZRG1
2020Reducing the incidence of febrile neutropenia in cancer patients treated with chemotherapy with PointCheck: a portable non-invasive neutropenia analyzer2R44CA228920-02A1CASTRO-GONZALEZ, CARLOSLEUKO LABS, INC., MA$1,182,313ZRG1
2020Proprietary drug to treat radiodermatitis1R44AR078669-01WANG, XIAO-JINGYOUNG, CHRISTIANALLANDER BIOTECHNOLOGIES, INC., CO$1,157,986ZRG1
2020A novel glutaminase-free mammalian asparaginase with minimized immunogenicity to enable expanded use in cancer therapy2R44CA228622-02SCHALK, AMANDA MENZYME BY DESIGN, INC., IL$1,156,734ZRG1
2020Development of superior polymerases for next-generation mRNA therapeutic & vaccine manufacturing2R44GM131548-02ZIELER, HELGEPRIMROSE BIO, INC., CA$1,152,047ZRG1
2020Rapid highly multi-plexed immuno-profiling of solid tumors by SpectralEdge imaging2R44CA224503-02KALDJIAN, ERICREESE, STEVENRARECYTE, INC., WA$1,145,798ZRG1
2020Development of Tumor and Immuno-Metabolism Based Small Molecule Therapeutics for Refractory Breast Cancer1R44CA257588-01SANDANAYAKA, VINCENTNIROGYONE THERAPEUTICS, LLC, MA$1,145,470ZRG1
2020Enzyme Replacement Therapeutics for Rare Childhood Genetic Diseases: An ERT Delivery System that Mitigates Immune-sensitization2R44HD087099-02A1ACOSTA, WALTERCRAMER, CAROLE L.RADIN, DAVIDBIOSTRATEGIES, LC, AR$1,144,737ZRG1
2020Clinical Development and Evaluation of a Deep Learning Approach to Improve Diagnostic Accuracy2R44DC017422-02SHELTON, RYAN LPHOTONICARE, INC., IL$1,136,886ZRG1
2020Development of an Integrated Platform for the Use of Adult Human Primary Cardiomyocytes in Preclinical Safety Assessment1R44TR003162-01 · under PA-18-574ABI GERGES, NAJAHANABIOS CORPORATION, CA$1,132,289ZRG1
2020CDK8/19 inhibitors for therapy of advanced prostate cancer2R44CA203184-02A1CHEN, MENGQIANLILLY, MICHAEL BRONINSON, IGOR BSHIOZAWA, YUSUKESENEX BIOTECHNOLOGY, INC., SC$1,130,935ZRG1
2020IMPROVEMENT TO OZONATING WATER FOR POST-HARVEST WASHING THROUGH NANOBUBBLES2R44FD006465-02HAY, TODDEN SOLUCION, INC., DE$1,120,586ZRG1
2020Natural Glycans for Functional Glycomics2R44GM133252-02SMITH, DAVID FLETCHERNATGLYCAN, LLC, GA$1,090,714ZRG1
2020Probe for Quantitative Fluorescence. Phase 22R44NS108845-02ROBERTS, DAVID WINSIGHT SURGICAL TECHNOLOGIES INC., NH$1,088,424ZRG1
2020Automated, high-throughput identification of genetic structural variants for gene editing and undiagnosed genetic diseases screening1R44HG011442-01TOMPKINS, CHRISTOPHER JOHNKROMATID, INC., CO$1,088,162ZRG1
2020Generation of Tissue Engineered Nerve Grafts from GalSafe Porcine Neurons2R44NS108869-02KATIYAR, KRITIKAAXONOVA MEDICAL, LLC, PA$1,083,394ZRG1
2020Multiplexed Nucleation Approaches for Enhanced High Throughput Screening of Co-Crystals2R44GM116285-02BOND, ANDREW H.DENOVX, LLC, IL$1,078,661ZRG1
2020A Proton Tomography System for Optimization of Proton Therapy1R44CA243939-01A1DEJONGH, DON FPROTONVDA LLC, IL$1,076,547ZRG1
2020Aerosolized Vitamin A: Impact on Neonatal Lung Maturation, Hyperoxic Lung Injury and Bronchopulmonary Dysplasia2R44HL142353-02A1GELFAND, CRAIGREHAN, VIRENDER KADVENT THERAPEUTICS, INC., PA$1,071,824ZRG1
2020Dihydroceramide Desaturase-1 Inhibitors for Treatment of Diabetes and Other Metabolic Diseases2R44DK116450-04BLITZER, JEREMYSUMMERS, SCOTT APOTRERO HILL THERAPEUTICS, INC., CA$1,069,999ZRG1
2020Ergonomic fluorescence-guided surgery imaging platform for intraoperative assessment of blood and lymphatic vasculature2R44CA206754-02A1USELMANN, ADAM JOHNONLUME, LLC, WI$1,057,099ZRG1
2020Paradigm Surgical Phase II-Development and Validation of SafeClose Roller Mesh Augmentation System for Hernia Treatment and Prevention2R44GM123789-02 · under PA-18-574FISCHER, JOHN PATRICKPETERS, REXPARADIGM SURGICAL, LLC, PA$1,026,094ZRG1
2020Gas Chromatography-Molecular Rotational Resonance Spectrometer1R44GM139446-01NEILL, JUSTIN LINDSAYBRIGHTSPEC, INC., VA$1,011,550ZRG1
2020Development of synthetic sphingolipids for prostate cancer therapy1R44CA257568-01GIL, DANIELSIEGE PHARMACEUTICALS, INC., CA$1,008,833ZRG1
2020Urine Diagnostic Tool for the Detection of High-grade Prostate Cancer1R44CA254692-01NIKNAFS, YASHAR SHARIFILYNX DX, INC., MI$1,004,315ZRG1
2020Instrument for Holographic Characterization of Protein Aggregates2R44TR001590-04A1PHILIPS, LAURA ASPHERYX, INC., NY$1,003,165ZRG1
2020Therapeutic UV Disinfection System to Prevent Catheter Related Bloodstream Infections (CRBSIs) in Patients with Peripherally Inserted Central Catheters (PICCs)2R44AI134553-02A1 · under PA-18-574FOURKAS, MICHAELRASOOLY, JULIAPURACATH MEDICAL, INC., CA$1,000,000ZRG1
2020MucoCept-CVN, a genetically enhanced vaginal Lactobacillus strain for the prevention of HIV acquisition in women: Finalization of formulation for the first-in-human clinical trial1R44AI149807-01 · under PA-18-574LAGENAUR, LAUREL A.OSEL, INC., CA$1,000,000ZRG1
2020Therapy and Prophylaxis for Genital Tract Infection2R44AI104067-04A1 · under PA-18-574AUCI, DOMINICKRUSSELL, MICHAEL WTHERAPYX, INC., NY$1,000,000ZRG1
2020A Once-Weekly Oral Tacrolimus-Prednisone Fixed-Dose Combination Therapy for Post-Transplant Maintenance Immunosuppressive Therapy1R44AI149979-01 · under PA-18-574ZALE, STEPHENLYNDRA THERAPEUTICS, INC., MA$1,000,000ZRG1
2020Third line treatment of drug resistant FLT3-positive acute myeloid leukemia with a novel FLT3 kinase inhibitor1R44CA247134-01 · under PA-18-574HOLTSBERG, FREDERICK WAYNESINTIM, HERMAN OKINARX, LLC, MD$1,000,000ZRG1
2020Bloodstream infection detection directly on whole blood2R44AI124871-02A1 · under PA-18-574CELEDON, ALFREDO ANDRESSCANOGEN, INC., MD$1,000,000ZRG1
2020Pre-IND Development of an Arenavirus Antiviral2R44AI112097-05 · under PA-18-574HENKEL, GREGORY WILLIAMARISAN THERAPEUTICS, INC., CA$1,000,000ZRG1
2020A next-generation meningococcal serogroup B vaccine with improved effectiveness for all age groups2R44AI124759-02MOE, GREGORY ROBERTOMVAX, INC., CA$1,000,000ZRG1
2020A Culture-Free Platform for Rapid Fungal Pathogen Identification2R44AI109913-04SINGER, ALONHELIXBIND, INC., MA$1,000,000ZRG1
2020Chikungunya Recombinant Subunit Vaccine2R44AI120388-03A1CLEMENTS, DAVID EHAWAII BIOTECH, INC., HI$1,000,000ZRG1
2020A new class of broad-spectrum antibacterials for treating MDR infections1R44AI152665-01TESTA, CHARLESCURZA INC, UT$1,000,000ZRG1
2020In-Vitro Culture of Plasmodium falciparum Sporozoites for Malaria Vaccine2R44AI085740-06A1HOFFMAN, STEPHEN LEVSANARIA, INC., MD$1,000,000ZRG1
2020Novel Targeted Nanomedicine Delivering MicroRNA-30-5p ReplacementTherapy for Multi-drug Resistant Cancer Treatment2U44CA221567-02A1PLACE, ROBERT FSALEH, ANTHONY DMIRECULE, INC., MD$1,000,000ZRG1
2020Development of an automated IVD for the ultra-sensitive, direct, molecular detection of Borrelia for early Lyme Disease1R44AI152628-01A1SINGER, ALONHELIXBIND, INC., MA$1,000,000ZRG1
2020The Development of Inorganic Ultraviolet Filters Exhibiting Improved Topical Retention on Human Skin for The Prevention of Skin Cancer2R44CA236265-02A1ISAACMAN, STEVENNANOMETICS, LLC, CA$1,000,000ZRG1
2020Serologic assays for detection of Zika virus antibodies for clinical diagnosis and blood donor counseling2R44AI134502-03LEVIN, ANDREW E.KEPHERA DIAGNOSTICS, LLC, MA$1,000,000ZRG1
2020Production of antibody therapeutic fragments by reduced genome E. coli in continuous culture1R44AI155307-01BLATTNER, FREDERICK RLANDRY, CHARLES FSCARAB GENOMICS, LLC, WI$1,000,000ZRG1
2020A Vaccine for Lymphatic Filariasis, LFGuard™2R44AI140708-02CARTER, DARRICK ALBERTKALYANASUNDARAM, RAMASWAMYPAI LIFE SCIENCES, INC., WA$1,000,000ZRG1
2020Fully-Automated Lesion Characterization in Ultrawide-Field Retinal Images2R44EY028081-02BHAT, SANDEEPEYENUK, INC., CA$1,000,000ZRG1
2020Urine glycated CD59 as novel diabetes biomarker amenable to measure with a point-of-care device1R44DK127725-01SAUL, RICHARDMELLITUS, LLC, MA$1,000,000ZRG1
2020Novel outside-in dialyzer with long filter life and reduced anticoagulation therapies1R44DK125230-01A1LABIB, MOHAMED ENOVAFLUX, INC., NJ$999,999ZRG1
2020Assessing the polypharmacology of kinase inhibitors by transcription factor activity profiling1R44GM136083-01 · under PA-18-574MAKAROV, SERGEI SATTAGENE, INC., NC$999,998ZRG1
2020Cryopreservation of Anopheles Embryos2R44AI088853-06 · under PA-18-574BILLINGSLEY, PETER F.SANARIA, INC., MD$999,997ZRG1

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Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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