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NIH funding notice PA-21-259

PHS 2021-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)

Closed on April 5, 2022.

Posted
July 8, 2021
Close date
April 5, 2022
Activity codes
R43, R44
Institutes taking part
OD, NEI, NHLBI, NHGRI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDCD, NIDCR, NIDDK, NIDA, NIEHS, NIGMS, NIMH, NINDS, NINR, NIMHD, NLM, NCCIH, NCATS, ORIP, NCI, CGH, NCBDDD, NCCDPHP, NCEZID, NCHHSTP, NCIRD, NCIPC, NIOSH, NCEH, CPR, CBER, CDER, CFSAN, CDRH, CVM, CPI, OOPD

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

  1. Reissues: PA-20-260 PHS 2020-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)
  2. 2 steps back: PA-19-272 PHS 2019-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed
  3. 3 steps back: PA-18-574 PHS 2018-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)
  4. 4 steps back: PA-17-302 PHS 2017-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  5. 5 steps back: PA-16-302 PHS 2016-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  6. 6 steps back: PA-15-269 PHS 2015-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  7. 7 steps back: PA-14-071 PHS 2014-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  8. 8 steps back: PA-13-234 Reissue PHS 2013-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  9. 9 steps back: PA-13-088 PHS 2013-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  10. 10 steps back: PA-12-088 PHS 2012-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  11. 11 steps back: PA-11-096 PHS 2011-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  12. 12 steps back: PA-10-050 PHS 2010-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  13. 13 steps back: PA-09-080 PHS 2009-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])

Replaced by PA-22-176.

Who won it before

6,331 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $2,571,152,904 in first-year total cost, median $276,415.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 SBIB-T (10)]284
  2. Special Emphasis Panel[ZRG1 ETTN-G (12)]236
  3. Special Emphasis Panel[ZRG1 IMST-H (15)]202
  4. Special Emphasis Panel[ZRG1 IDM-V (12)]185
  5. Special Emphasis Panel[ZRG1 IMST-B (12)]179

Most frequent institutions

  1. EPICYPHER, INC.42
  2. PHYSICAL SCIENCES, INC42
  3. AFFINERGY, LLC30
  4. LYNNTECH, INC.26
  5. MINNESOTA HEALTHSOLUTIONS CORPORATION24
Competing awards under PA-21-259 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2023A youth-specific helmet for preventing traumatic brain injury2R44NS119134-03A1AVERY, GORDONCECCHI, NICHOLAS JAMESSAVIOR BRAIN INC., VA$2,864,855ZRG1
2023Development of a SYF2 antisense oligonucleotide treatment for ALS and FTD1R44AG085411-01ALWORTH, SAMUEL VFENG, ZHIHUAACURASTEM, INC., CA$1,492,509ZRG1
2023A Disease-Modifying Protein Therapeutic for the Treatment of COPD2R44HL149580-02PRINCE, CHRISTOPHER LUCASVERRA THERAPEUTICS, INC., NY$1,364,498ZRG1
2023Development of a novel peptide therapeutic for traumatic brain injury1R44NS130776-01MANN, AMANAIVOCODE, LLP, CA$1,290,957ZRG1
2023Novel recombinant sensors to study histone ubiquitin signaling1R44GM149036-01SUN, ZU-WENEPICYPHER, INC., NC$1,276,822ZRG1
2023Development of a Novel Bone Adhesive Scaffold to Accelerate Bone Regeneration and Improve Ridge Height Maintenance for the Treatment of Patients with Residual Ridge Resorption1R44DE032564-01JADIA, RAHULKAY, GEORGEREVBIO, INC., MA$1,265,448ZRG1
2023Expansion and validation of novel mobile app for guiding home modifications for aging in place2R44AG067804-02TENENBAUM, LOUISHOMESRENEWED VENTURES LLC, DC$1,170,977ZRG1
2023ViTrack: Wearable, accurate, continuous blood pressure monitor to improve outcomes in hypertensive diseases of pregnancy1R44HL167356-01THANIKACHALAM, MOHANDYNOCARDIA, INC., MA$1,168,681ZRG1
2023Combined Biomarker and EMR Data for Heterogeneous Treatment Effects and Surrogate Endpoints in Sepsis1R44GM149065-01REDDY, BOBBYPRENOSIS, INC., IL$1,161,624ZRG1
2023Development of a high precision and high order DNA counting platform1R44GM149104-01SHUM, ELEEN YEE LAMENUMERIX, INC., CA$1,080,705ZRG1
2023Platform for the High Throughput Generation and Validation of Affinity Reagents1R44GM148998-01WEINER, MICHAEL PABBRATECH, INC., CT$1,080,240ZRG1
2023Diagnostic tool for assessment and tracking of microbial load in bloodstream infections1R44AI174578-01SINGER, ALONHELIXBIND, INC., MA$1,050,000ZRG1
2023Trypanocidal Agents that Kill Multiple Stages of the Trypanosoma cruzi Life Cycle2R44AI152788-03MCDONNELL, MARK EFOX CHASE CHEMICAL DIVERSITY CENTER, INC, PA$1,050,000ZRG1
2023Rapid, Handheld, Point-of-Care Stool Sample-prep Device for the Extraction and Detection of Nucleic Acid from Diarrheal Pathogens2R44AI155367-02KIM, CHANG HEEGODX, INC., WI$1,050,000ZRG1
2023A Novel Synthetic Biology-Derived Microbiome Therapeutic to Treat Viral-Induced Acute Respiratory Distress Syndrome (ARDS)1R44AI174332-01FANGER, GARYFURLAN FREGUIA, CHRISTIANRISE THERAPEUTICS, LLC, MD$1,026,596ZRG1
2023Point-of-care diagnostic test for T. cruzi (Chagas) infection2R44AI136172-03A1LEVIN, ANDREW E.KEPHERA DIAGNOSTICS, LLC, MA$1,020,000ZRG1
2023A silicon nanopore membrane blood filter enabling anticoagulant free continuous renal replacement therapy for acute kidney injury2R44DK120242-02A1BLAHA, CHARLESSILICON KIDNEY, LLC, CA$1,019,979ZRG1
2023Scalable single-cell workflow for multiomic analyses of chromatin interactions, accessibility, gene expression and cell surface proteins to unravel mechanisms of cellular diversity1R44GM149103-01SCHMITT, ANTHONYARIMA GENOMICS, INC., CA$1,013,363ZRG1
2023Non-Clinical Pharmacology of CX-012R44AI106283-06A1VID, GALINACERAMEDIX HOLDING, LLC, NY$1,011,743ZRG1
2023Quantitative Analysis of Cancer-associated EVs1R44CA272098-01A1NOLAN, JOHN PCELLARCUS BIOSCIENCES INC, CA$1,008,320ZRG1
2023Development of ultra-efficient antibodies for single cell mapping applications1R44AI174357-01JOHNSTONE, ANDREA LYNNEPICYPHER, INC., NC$1,007,748ZRG1
2023Novel Sample Introduction Methodologies for Molecular Rotational Resonance (MRR) Spectroscopy1R44GM146526-01A1BLAGOJEVIC, VOISLAVBRIGHTSPEC, INC., VA$1,006,315ZRG1
2023A state-of-the-art web platform for collaborative, longitudinal genome diagnostics1R44HG012885-01WARD, ALISTAIRFRAMESHIFT LABS, INC., MA$1,000,930ZRG1
2023HaloFilm: a spray-on, re-chargeable, re-applicable antimicrobial coating2R44AI155114-02DEMIR, BUKETHALOMINE, INC., NY$1,000,000ZRG1
2023Enabling Toxoplasma gondii Kinome Directed Drug Discovery2R44AI145502-02ZUTSHI, REENALUCEOME BIOTECHNOLOGIES, LLC, AZ$1,000,000ZRG1
2023Rapid structure-based software to enhance antibody affinity and developability for high-throughput screening: Aiming toward total in silico design of antibodies2R44AI155254-04BLATTNER, FREDERICK RDARNELL, STEVEN JOSEPHLANDRY, CHARLES FDNASTAR, INC., WI$1,000,000ZRG1
2023Novel drug combinations for improving survival from acute radiation syndrome when administered 48 hours post- irradiation2R44AI142909-03COX, GEORGE NORBERTBOLDER BIOTECHNOLOGY, INC., CO$1,000,000ZRG1
2023A single antiviral to treat multiple opportunistic infections2R44AI114079-05REMISZEWSKI, STACYEVRYS BIO, LLC, PA$999,998ZRG1
2023ARRAY: A novel polymeric mesh for prophylactic antibiotic protection of cardiac implantable electronic devices1R44HL167315-01YU, JIAYI21MEDTECH LLC, NC$999,978ZRG1
2023A genetically modified Plasmodium falciparum sporozoite vaccine attenuated at the late-liver stage2R44AI149927-03SIM, B. KIM LEESANARIA, INC., MD$999,880ZRG1
2023Development of TP-317 in Ulcerative Colitis2R44DK116460-04PARKINSON, JOHNTHETIS PHARMACEUTICALS, LLC, CT$997,635ZRG1
2023Development of D6PV- a novel ApoC-II peptide mimetic therapeutic1R44DK135188-01DEVALARAJA, MATTPROTEAN BIO INC., MA$997,484ZRG1
2023SynthoPlate: Intravenous Hemostatic Nanotechnology to Mitigate Bleeding in Thrombocytopenia2R44HL145948-02BRUCKMAN, MICHAEL ARTHURHAIMA THERAPEUTICS, LLC, OH$994,448ZRG1
2023Novel hand hygiene product to remove Clostridioides difficile spores1R44AI170313-01A1LABIB, MOHAMED ENOVAFLUX, INC., NJ$993,963ZRG1
2023Humanized monoclonal antibodies to treat mucormycosis2R44AI138904-03A1IBRAHIM, ASHRAF S.LAZAR, GARYVITALEX BIOSCIENCES, LLC, CA$987,901ZRG1
2023Development of an RNA-based anticoagulant and antidote for precise on/off coagulation control during cardiovascular procedures1R44HL167436-01KRISSANAPRASIT, ABHICHARTHELIXOMER, INC., NC$983,573ZRG1
2023Functionally Closed Purification and Elution of Untouched Cells using Cleavable Magnetic Beads with Digital Magnetic Sorting1R44GM149063-01MURRAY, COLEMANFERROLOGIX, INC., CA$921,412ZRG1
2023Beacon-OUD: Behavioral Economic Screening Tool of Opioid Use Disorder for Use in Clinical Practice2R44DA048689-02SNIDER, SARAH EMILYBEAM DIAGNOSTICS, INC., VA$902,713ZRG1
2023Multiplexed Analysis of the Epitranscriptome2R44HG012170-02STENGEL, GUDRUNALIDA BIOSCIENCES, INC., CA$865,189ZRG1
2023Development of a shelf-stable universal mucosal HA-vaccine for the prevention of influenza1R44AI174337-01DAVENPORT, GREGORYTFF PHARMACEUTICALS, INC., TX$864,948ZRG1
2023Development of a first-in-class combination of DNA damage response inhibitors for the treatment of high-grade serous ovarian cancer1R44CA278078-01BROWN, ERIC JGILAD, ORENSIMPKINS, FIONAAPREA THERAPEUTICS, INC., MA$862,205ZRG1
2023A Novel Waveguide to Enable MAS-DNP-NMR in Standard-bore High-field Magnets2R44GM139468-02DOTY, FRANCIS DAVIDDOTY SCIENTIFIC, INC., SC$860,734ZRG1
2023Advancing Fetal Assessment during Labor with Transabdominal Fetal Oximetry2R44HD094486-02A1RAY, NEIL PADHARIARAYDIANT OXIMETRY, INC., CA$855,675ZRG1
2023Field Instrument for Assessment of Arsenic Exposure1R44ES034314-01ARGUN, AVNI AGINER, INC., MA$845,085ZRG1
2023Development of a Colorimetric Sensor for Detection of Cerebrospinal Fluid Leaks1R44NS130769-01HU, MINDRINKSAVVY, INC., MA$840,440ZRG1
2023MomNet: Development of a Coach-Training Program for an Empirically Supported, Guided ehealth Intervention for Depressed Mothers2R44MH123278-02DAVIS, BETSYFEIL, EDWARD GUSTAVSMITH, DAVID RANDOLPHOREGON RES BEHAVIORAL INTERVENTION STRAT, OR$825,964ZRG1
2023Scaling Volumetric Imaging, Analysis and Science Communication Using Immersive Virtual Reality2R44MH125238-03DORETTO, GIANFRANCOMOREHEAD, MICHAEL DAVIDSPIROU, GEORGE AISTOVISR, WV$798,921ZRG1
2023Minimally Invasive High Intensity Therapeutic Ultrasound for the Treatment of Obstructive Hypertrophic Cardiomyopathy1R44HL167428-01LEVIN, HOWARDCORIDEA, LLC, NY$784,548ZRG1
2023Development of a Molecular Diagnostic to Identify Dangerous Intracranial Aneurysms2R44NS115314-02POPPENBERG, KERRYTUTINO, VINCENT MATTHEWNEUROVASCULAR DIAGNOSTICS, INC., NY$766,944ZRG1
2023Preclinical development of ONCT-505, an Androgen Receptor Antagonist and Degrader, as new potential therapeutic for Kennedy's Disease1R44NS130806-01KRISHNAN, RAJESHONCTERNAL THERAPEUTICS, INC., CA$753,745ZRG1
2023Mitochondrial-Targeted Therapy for Macular Degeneration1R44EY034732-01COUSINS, SCOTT WILLIAMECLIPSE LIFE SCIENCES, INC., NC$749,999ZRG1
2023Noregen, a regenerative medicine ocular therapeutic2R44EY030807-02DRENSER, KIMBERLYRETINAL SOLUTIONS LLC, MI$717,783ZRG1
2023In vivo high-definition 3D corneal imaging2R44EY029906-02CANAVESI, CRISTINALIGHTOPTECH CORPORATION, NY$717,714ZRG1
2023Interstitial pressure sensor to detect fluid status1R43HL164166-01A1SCHWARTZ, ROBERTNXT BIOMEDICAL, LLC, CA$634,926ZRG1
2023Novel therapeutic for HPA hyperactivity2R44AA027971-02LLOYD, LINDA SSTRESS THERAPEUTICS, INC., CA$605,405ZRG1
2023Toward urinary catheterization with long-term resistance to bacterial colonization2R44DK103398-05ZOLOTARSKAYA, OLGAWYNNVISION, LLC, VA$514,604ZRG1
2023Optimizing virtual hits of human CGAS inhibitors to treat neurodegeneration1R43AG080954-01GAN, LISINHA, ANJANAAETON THERAPEUTICS, INC., CA$499,540ZRG1
2023Development of Novel sgp130-Fc Bioconjugates for TBI1R44NS130780-01HASKINS, WILLIAM EGRYPHON BIO, INC., CA$484,997ZRG1
2023In vivo Evaluation of USP30 Inhibitors in Models Relevant to Parkinson's Disease1R43NS127693-01A1BEHROUZ, BAHAREHHENDERSON, MICHAELVINCERE BIOSCIENCES, INC., MA$470,514ZRG1
2023An innovative telomerase-targeted, circulating tumor cell assay for monitoring NSCLC treated with radiation and immunotherapy1R43CA275541-01SAXENA, DEEKSHALIQUID BIODX LLC, PA$399,499ZRG1
2023High-throughput functional analysis and clinical relevance of all possible variants of a gene1R43HG012537-01A1SCHILLER, MARTIN R.HELIGENICS INC, NV$398,526ZRG1
2023Deep learning methods to accelerate discoveryof drugs targeting gene regulatory proteins1R43GM146472-01A1FONDRIE, WILLIAM ELLISTALUS BIOSCIENCE, INC., WA$398,441ZRG1
2023Chimeric antigen receptor-modified iNKT cell therapy for CD7+ malignancies1R43CA277958-01ZHOU, XIANZHENGTINKESO THERAPEUTICS INC, NY$398,040ZRG1
2023Development of first-in-class antagonists of the retinoid pathway as novel oral immunotherapies for solid cancers1R43CA278127-01ESPOSITO, MARKKAYOTHERA INC., NJ$398,040ZRG1
2023Two-Color Near-Infrared Fluorescence Guided Surgery Tools Enabling Simultaneous Cancer Margin and Nerve Visualization during Head and Neck Squamous Cell Carcinoma Resection1R43CA272030-01A1BARTH, CONNOR WILLIAMTRACE BIOSCIENCES INC, OR$386,211ZRG1
2023PRECARE is an innovative and integrated platform designed to improve the developmental surveillance of the baby.1R43HD107740-01A1MA, TONY XUYENBENTEN TECHNOLOGIES, INC., VA$385,000ZRG1
2023Quantitative Normalization of Spatial Metabolomics for Molecular Signatures of Tissue Heterogeneity1R43GM149044-01HEJAZI, LEILAZHANG, GUANSHISYGNAMAP, INC., TX$356,499ZRG1
2023Development of a Novel Calcium Channel Therapeutic for the Treatment of Asthma1R43HL167426-01GREENBERG, MILTON LVIVREON BIOSCIENCES, LLC, CA$352,030ZRG1
2023Development of a sensitive method to measure heparan sulfate 6-O-endosulfatase1R43GM149008-01SU, GUOWEIGLYCAN THERAPEUTICS CORPORATION, NC$350,000ZRG1
2023An early-intervention gene-editing therapeutic for Pulmonary Arterial Hypertension1R43HL167478-01JASKULA-RANGA, VINODSUSSAN, THOMAS EHUNTERIAN MEDICINE LLC, MA$350,000ZRG1
2023Remmie.ai: a deep learning diagnostic assistance engine for ear-nose-throat diseases1R43DC020868-01ZHANG, JANEREMMIE, INC., WA$349,902ZRG1
2023Topical Eyedrops Increasing Lysyl Oxidase Activity to Control Myopia1R43EY034770-01MOLOKHIA, SARAH ABDULLAIVEENA DELIVERY SYSTEMS, INC., UT$345,000ZRG1
2023DEVELOPMENT OF A SALIVARY ASSAY FOR MEASURING PERIODONTAL DISEASE ACTIVITY1R43DE032549-01GELLIBOLIAN, ROBERTCELLECTGEN, INC., CA$320,606ZRG1
2023MagPAD: Magnetic Puncture, Access, and Delivery of Large Bore Devices to the Heart Via the Venous System1R43HL167347-01DOHERTY, MARKMAGPAD, LLC, CA$308,401ZRG1
2023Activity-based regulome profiling for the discovery of covalent transcription factor inhibitors1R44TR004349-01FEDERATION, ALEXANDERTALUS BIOSCIENCE, INC., WA$307,465ZTR1
2023Development of a PCR assay for quantitative detection of HBV cccDNA1R43AI174349-01LIN, SELENAJBS SCIENCE, INC., PA$306,500ZRG1
2023PA21259, SBIR, Phase I, Development of a rapid, direct from blood, phenotypic antimicrobial susceptibility assay1R43IP001234-01DAMICO, LORENZOAINCOBIO LLC, NY$306,500ZRG1
2023Precision Guidance of Resuscitation and Deresuscitation in Sepsis1R43GM149094-01FELDSCHUH, JONATHANDAXOR CORPORATION, TN$305,000ZRG1
2023Development of a novel disease-modifying glycan therapeutic for early at-home intervention of acute vaso-occlusive crisis in sickle cell disease1R44HL167473-01JOHN PADERI, JOHN PADERI JOHN PADERIIHP THERAPEUTICS, INC., CA$301,480ZRG1
2023Multi-Omics And Synbio Enabled Discovery Of Antifungal Fernene Triterpenes1R43AI174407-01KELLEHER, NEIL LKELLER, NANCY PMEAD, DAVID ALANVARIGEN BIOSCIENCES CORPORATION, WI$300,000ZRG1
2023Novel antimicrobials in fighting carbapenem-resistant Klebsiella pneumoniae1R43AI174400-01WU, REENEFFECTORBIO, INC., CA$300,000ZRG1
2023Conditional male lethal Anopheles stephensi line for the efficient manufacture of malaria vaccines1R43AI174393-01BILLINGSLEY, PETER F.EAPPEN, ABRAHAM GEEVARGHESESANARIA, INC., MD$300,000ZRG1
2023A Novel Multi-Epitope-Based Universal Vaccine Against Multiple Coronavirus Variants of Concern1R43AI174383-01VAHED, HAWATECHIMMUNE, LLC, CA$300,000ZRG1
2023Acoustic-anatomic modeling and development of a patient-specific wearable therapeutic ultrasound device for peripheral arterial disease1R43HL167492-01ELSTAD, JULIANAVIBRATO MEDICAL, INC., CA$300,000ZRG1
2023FimH-Targeting Antibody-Recruiting Molecules as Novel Drugs for Preventing Complicated Urinary Tract Infections1R43AI174482-01HIBBING, MICHAEL EINERMCGRANE, LAURELFIMBRION THERAPEUTICS, INC., MO$300,000ZRG1
2023Advanced Pediatric Airway Trainer for Enhanced Clinical Education in Pediatric Critical Care1R43HD111155-01SRINIVAS, GIRISHTDA RESEARCH, INC., CO$300,000ZRG1
2023Double-Encapsulated mRNA Vaccine for COVID-191R43AI165352-01A1CASTOR, TREVOR P.APHIOS CORPORATION, MA$300,000ZRG1
2023Parametric design software for nanostructured CRISPR payloads1R43GM149023-01ARMENTROUT, STEVEN LPARABON NANOLABS, INC., VA$299,999ZRG1
2023Process development for manufacturing eCD4-Ig1R44AI170285-01A1ALPERT, MICHAEL DAVIDEMMUNE, INC, FL$299,998ZRG1
2023Validation and Improvement of ISPRI-HCP: An Innovative Platform for Immunogenicity Risk Assessment of Process-related Protein Impurities1R43AI174486-01HALTAUFDERHYDE, KIRK DONALDEPIVAX, INC., RI$299,917ZRG1
2023Stop pulmonary airleaks with a novel inhaled dry powder aerosol1R43HL165960-01A1BEVERLIN II, BRYCEQUENCH MEDICAL, INC., MN$299,838ZRG1
2023Development of a multi-RNA signature in blood towards a rapid diagnostic test to robustly distinguish patients with acute myocardial infarction1R43HL167483-01SWEENEY, TIMOTHY EINFLAMMATIX, INC., CA$299,762ZRG1
2023Ultra-low-temperature (6 K) static NMR-DNP for metalloproteins, proteins in cells, and materials1R43GM148111-01DOTY, FRANCIS DAVIDDOTY SCIENTIFIC, INC., SC$299,649ZRG1
2023Bacteria and pathogen characterizations using outer membrane vesicles1R43AI174576-01FARIS, GREGORY WNUMENTUS TECHNOLOGIES INC., CA$298,794ZRG1
2023A Redesigning Existing Drugs against Indispensable Targets (ReEDIT) platform technology for discovery of novel drugs to treat fungal infections1R43AI170288-01A1PARENT, STEPHENKATHERA BIOSCIENCE INC., NJ$298,530ZRG1
2023Development of BIO 300 as a novel treatment for idiopathic pulmonary fibrosis1R43HL167432-01KAYTOR, MICHAEL DHUMANETICS CORPORATION, MN$298,474ZRG1
2023A Vitamin K analog countermeasure for organophosphate poisoning1R43AI176434-01CHAN, SHERINE SNEUROENE THERAPEUTICS INC, DC$298,297ZRG1
2023A Novel Bone Targeted Antibiotic Therapy for the Treatment of Infected Fractures1R44AI175069-01EBETINO, FRANK H.BIOVINC, LLC, CA$296,779ZRG1
2023Stabilization of therapeutic microbes for inclusion in a liquid matrix for delivery to the intestines1R43GM146506-01A1ANSELMO, AARON CVITAKEY, INC., DC$295,924ZRG1
2023T-cell receptor mimic affinity reagent generation using an in vivo novel immunogen strategy1R43GM149009-01WEINER, MICHAEL PABBRATECH, INC., CT$295,460ZRG1
2023Development of B8C1ad as an Orphan Drug for Iatrogenic Botulism1R43NS130849-01BAND, PHILIP ARTHURCYTODEL, INC., NY$295,365ZRG1
2023An Inhaled Microbiome-Targeted Biotherapeutic for Treatment of COPD1R44HL164156-01A1NICOLA, TEODORARESBIOTIC, INC., AL$295,274ZRG1
2023Development of a tele-mentoring system integrated into an ultra-portable surgical microscope to treat cataract in underserved populations1R43EY034066-01A1MALTESE, MATTHEW RUDOLPHX-BIOMEDICAL, INC., PA$293,470ZRG1
2023Improved Patient Reported Outcomes (iPRO) -Sleep Diary: A Tool to Improve Sleep Assessment in Clinical Trials1R43HL167541-01BROOKS, JUSTIND-PRIME LLC, VA$291,872ZRG1
2023Preclinical Evaluation of a Novel Immunomodulatory Vaccine for Preventing and Treating HSV Infections1R44AI170133-01A1GERSHBURG, EDWARDRATIONAL VACCINES, INC., MA$288,088ZRG1
2023STI NG Plus, a Swab to Answer Molecular Panel Test for Point of Care Diagnosis and Treatment Recommendation1R43AI174562-01DONG, SHOULIANAMPLIFIDX INC, MA$286,775ZRG1
2023A recombinant elastin skin substitute for the treatment of burns1R43GM149096-01A1ROBERTS, STEFANINSOMA BIO, INC., NC$282,373ZRG1
2023Developing a High-Flow Acoustofluidic Loading Platform for Research Cell Stabilization in the Anhydrous State1R43TR004327-01JANIS, BRETT RDESICORP, INC., KY$281,873ZRG1
2023First-in-class TREM-1 inhibitors for neovascular retinal diseases1R44EY034015-01A1SIGALOV, ALEXANDER BSIGNABLOK, INC., MA$278,127ZRG1
2023Microfluidic Cartridge for Point-of-Care Hematology Analysis1R43HL167435-01MABRY, KELLYROBLES, FRANCISCO ECELLIA SCIENCE, INC., AR$275,985ZRG1
2023The SE-Learn Online Professional Development Platform for Enhanced Social Emotional Learning with Students1R43MH135947-01DEROSIER, MELISSA E.3-C INSTITUTE FOR SOCIAL DEVELOPMENT, NC$275,722ZRG1
2023Rapid and low-cost PFAS detection with advanced solid-state nanopore chips1R43ES034321-01A1XIA, ZEHUIGOEPPERT, LLC, PA$275,700ZRG1
2023Novel approaches for the treatment of autoimmune disease1R43AI174502-01KANNANGANAT SIDHARTHAN, SUNILASTERO ERADO INC, TX$275,213ZRG1
2023Simultaneous analysis of cell-borne and soluble biomarkers by high throughput acoustic flow cytometry1R43GM149072-01O'ROURKE, JOHN PETERBENNUBIO INC, NM$275,175ZRG1
2023Consumer-Therapist-Connector: Increasing Access to Quality Behavioral Healthcare1R43MH132156-01KRAUS, DAVID R.OUTCOME REFERRALS INC, MA$274,787ZRG1
2023PA TH2Caregiving: Data-Driven Digital Engagement to Assess and Address the Needs of Family Caregivers1R43NR020679-01VAUGHN, STEPHANIE ANNPATH2CAREGIVING LLC, NC$274,522ZRG1
2023Class II Human Leukocyte Antigen biologics for antibody-mediated graft rejection.1R43AI174328-01GUO, HONGJIELIU, CHANGANTIGER THERAPEUTICS INC., MO$272,503ZRG1
2023Preclinical validation of small molecule immunomodulators for the treatment of Crohn's disease1R43DK135153-01CHATZI, AIKATERININEGGERS, JASPER EPROMAKHOS THERAPEUTICS INC., MA$271,865ZRG1
2023Recombinant human CC10 protein for treatment and prevention of chronic lung allograft dysfunction1R43HL167372-01PILON, APRILE LAPCBIO INNOVATIONS, INC., MD$260,664ZRG1
2023VisitBoost: A Home Visiting Enhancement to Reduce Harm for Families Affected by Substance Misuse1R43DA057785-01CIOFFI, CAMILLE CSMITH, DAVID RANDOLPHOREGON RES BEHAVIORAL INTERVENTION STRAT, OR$259,611ZRG1
2023Developing a Digital Training and Assessment Platform to Disseminate a Successful NIH-Supported College Preparation Model for Diversifying the U.S. Biomedical Workforce1R43GM149014-01HORNBECK, BETHANYMOTHER COMMUNICATIONS CO., WV$259,610ZRG1
2023Tele-Sox: A Tele-Medicine solution based on wearables and gamification to prevent Venous thromboembolism in Oncology Geriatric Patients1R43AG074888-01A1JOSHI, ROSHANAJAFI, BIJANSTEXOLE LLC, TX$259,600ZRG1
2023Portable Scaled Sample Preparation Device for Concentration and Recovery of Bacterial Contaminants1R43AI174492-01SU, XIAOLIVIC FOUNDRY, INC., AR$259,553ZRG1
2023Development, feasibility, and acceptability of Aim to Play, a user-friendly digital application for teacher skills training and physical education activities for K-2 elementary students1R43MD018245-01JOHNSON-SHELTON, DEBORAHRICCI, JEANETTEWESTLING, ERIKASAAVSUS, INC., OR$259,552ZRG1
2023Virtual Reality Train the Trainer (VRT3)1R43GM149022-01CROSS, ERNEST VINCENTDUGGAN, DANIEL JLYNN, SPENCERCHARLES RIVER ANALYTICS, INC., MA$259,381ZRG1
2023The Development of CSD peptides for the therapeutic treatment of post-acute sequelae of COVID-19 (PACS)1R43HL167437-01MACKENZIE, BREANNELUNG THERAPEUTICS, INC., TX$259,332ZRG1
2023Novel Peptide Immunomodulators for Treating Sepsis1R43AI174395-01AHMAD, SAIRAELDEC PHARMACEUTICALS, INC., NC$259,121ZRG1
2023Development of a rapid screening test for the detection of dihydroanatoxin-a1R43ES034301-01A1FORD, LANCE PATTOGENE, TX$259,002ZRG1
2023Multiplexed biosensor for personal wildfire exposure assessment1R43ES034322-01A1DU, DANDL ADV-TECH, LLC, WA$258,999ZRG1
2023Development of a Nematode-Derived Drug to Treat Asthma1R43HL167369-01NGUYEN, HUNGHOLOCLARA, INC., CA$258,996ZRG1
2023Ceragenin-coated pedicle screws to tackle surgical-site infections.1R43AI174666-01BRUNNER, GLENNN8 MEDICAL, INC., OH$258,455ZRG1
2023High-throughput profiling of proteases with phage and arrays1R43AI174404-01KAY, BRIAN KENNETHTANGO BIOSCIENCES, INC., IL$256,776ZRG1
2023A Digital Health Technology to Prevent Family Violence and Improve Child Mental Health1R43MH132191-01HAZEN, CHRISTOPHERSTORMSHAK, ELIZABETH ANORTHWEST PREVENTION SCIENCE INC, OR$251,907ZRG1
2023Wearable Device and Digital Health Platform to Optimize Sleep During Pregnancy1R43HD111096-01DUGAN, STEVE RSMART HUMAN DYNAMICS, INC., CA$251,622ZRG1
2023Designing safe, potent, and cost-effective small peptide erythropoietin analogs1R43HL167440-01GINESTE, CYRILLECOVENANT THERAPEUTICS, LLC, VA$249,965ZRG1
2023Novel therapies for obesity- or diabetes-related lymphatic dysfunction1R43HL154880-01A1HU, MICKEYLARIX BIOSCIENCE, LLC, CA$245,728ZRG1
2023Kv2.1-Targeted First in Class Neuroprotective Therapeutic for Acute Ischemic Stroke1R43NS127620-01A1COLEMAN, JULIE HCELDARA MEDICAL, LLC, NH$231,974ZRG1
2023Development of a rapid, scalable, and deployable point-of-care blood volume diagnostic for monitoring postpartum and trauma-related hemorrhage1R43HL167475-01BUSSE, LAWRENCE JQUANTIPORT, INC., OR$231,308ZRG1
2023Development of A Novel Nanoparticle Biosensor for Rapid, Point-of-Care Sepsis Diagnosis and Risk Assessment1R43AI174456-01LIU, KENAMI DIAGNOSTICS LLC, IL$224,079ZRG1
2023Developing an integrated pipeline for routine generation of orthogonal GPCR-targeting nanobodies1R43GM149069-01ZHOU, XICHUNVITAN-BIOTECH, LLC, CO$218,622ZRG1
2023Improved optimization of covalent ligands using a novel implementation of quantum mechanics suitable for large ligand/protein systems.1R43GM149031-01PEARLMAN, DAVID AQUANTUM SIMULATION TECHNOLOGIES, INC., MA$148,629ZRG1
2022A novel highly stable pancreatic enzyme replacement therapy to improve outcomes for patients with pancreatic insufficiency.1R44DK134212-01BAKER, SHENDAGALLOTTO, ROBERTSYNSPIRA THERAPEUTICS, INC., MA$1,796,643ZRG1
2022Advanced Nucleation Technologies for Membrane Protein Crystallization to Accelerate Structure-Based Drug Design for Substance Use Disorders2R44DA047146-02BOND, ANDREW H.DENOVX, LLC, IL$1,775,613ZRG1
2022Human Disease-Specific Induced Pluripotent Stem Cells For Preclinical Drug Testing and Drug Discovery1R44HL158281-01A1 · under PA-20-260BUI, LYNNE AKHLORIS BIOSCIENCES, INC., CA$1,728,439ZRG1
2022A Safe, Fast, and Cost-Effective System for Tissue Removal in Laparoscopic Hysterectomy and Other Minimally Invasive Surgery1R44HD105575-01A1 · under PA-20-260FRANCIS, DANIELCLARIA MEDICAL, INC., CA$1,569,462ZRG1
2022Manufacture of an intracerebroventricular Enzyme Replacement Therapy for CLN1 Batten Disease2R44NS107079-02A1EKINS, SEANCOLLABORATIONS PHARMACEUTICALS, INC., NC$1,499,923ZRG1
2022Development of gene replacement therapy for Sanfilippo Syndrome Type C1R44NS129393-01SINGAMSETTY, SRIKANTHPHOENIX NEST, INC., NY$1,495,610ZRG1
2022Retinal eye-tracking as a prognostic tool for traumatic brain injury and concussion2R44NS095090-02A1SHEEHY, CHRISTY KATHLEENC. LIGHT TECHNOLOGIES, INC., CA$1,454,697ZRG1
2022Eliminating Interference from Autofluorescence in Flow Cytometry2R44GM131619-02A1VACCA, GIACOMOKINETIC RIVER CORPORATION, CA$1,441,830ZRG1
2022Development of a novel dual HIF-α inhibitor and inducer of ferroptosis for kidney cancer2R44CA217385-03A1LIPPERT, ROBERTKUDA THERAPEUTICS, INC., UT$1,425,000ZRG1
2022IND-Enabling Toxicology for a Novel Ca2+ Channel Therapeutic to Improve Outcomes Associated with Checkpoint Inhibitor Immunotherapy1R44CA268541-01A1GREENBERG, MILTON LVIVREON BIOSCIENCES, LLC, CA$1,371,030ZRG1
2022In-cell Automated Flash Oxidation (IC-AutoFox™) Protein Footprinting System2R44GM137728-02WEINBERGER, SCOT RANDYGENNEXT TECHNOLOGIES, INC., CA$1,334,584ZRG1
2022A reagent kit for spatial transcriptomic analysis1R44HG012532-01FAN, CHRISTINACURIO BIOSCIENCE INC., CA$1,299,179ZRG1
2022Functional drug fingerprinting with all-optical electrophysiology2R44MH122052-03DELANEY-BUSCH, NATHANIEL MCREEHARWOOD, BENJAMIN NATHANIELQ-STATE BIOSCIENCES, INC., MA$1,296,058ZRG1
2022Long-acting Stable Glucagons for Treatment of Hyperinsulinism2R44DK111304-05FLUDZINSKI, PAWELAMIDEBIO, LLC, CO$1,287,693ZRG1
2022Continuation Application for the development of Integrated continuous and single-use (ICS) bioproduction platform (Phase IIB)2R44GM117682-04 · under PA-20-260SHINKAZH, OLEGCHROMATAN CORPORATION, MA$1,284,233ZRG1
2022DUCTUS ARTERIOSUS STENT TO IMPROVE CONGENITAL HEART DEFECT MORTALITY2R44HL158304-02TANG, BEVERLYSTARLIGHT CARDIOVASCULAR, INC., CA$1,256,635ZRG1
2022A rapid microfluidic diagnostic assay for the measurement of Direct Oral Anticoagulants from patient whole blood2R44HL149480-02A1CUKER, ADAMKUNKEL, MARKROSSI, JASON MFLOBIO, LLC, PA$1,222,556ZRG1
2022Development of a Multi-species Vaccine for Prevention of Bacterial Otitis Media1R44DC019874-01 · under PA-20-260MCOSKER, CHARLES C.CLARAMETYX BIOSCIENCE, INC., OH$1,207,921ZRG1
2022Novel Sensor Integrated Proteome on Chip (SPOC) platform for evaluating kinetic parameters of protein interactions in high throughput1R44TR004297-01TAKULAPALLI, BHARATHSPOC PROTEOMICS INC., AZ$1,178,727ZRG1
2022Novel patient-derived 3D platform for detecting TDP-43 proteinopathy and associated biomarkers for ALS/FTD1R44NS124457-01A1 · under PA-20-260DE MAJO, MARTINAULLIAN, ERIK MSYNAPTICURE, INC., IL$1,171,621ZRG1
2022Preventing Neurovascular Matrix Degradation and Hemorrhage in Acute Ischemic Stroke2R44HL147676-02A1JEONG, SUN YONGREED, GUY LTRANSLATIONAL SCIENCES, INC., AZ$1,161,162ZRG1
2022Development of a potent and selective oral ENPP1 inhibitor for oncology1R44CA278144-01KAADIGE, MOHAN RAOSHARMA, SUNILSTINGRAY THERAPEUTICS, INC., TX$1,160,011ZRG1
2022Development of NH101: A Simple and Efficient Outpatient Dry Powder Amphotericin B-DryNeb(dry powder nebulizer) for Treatment of Susceptible and Multidrug Resistant Aspergillus/ Fungal Infections2R44HL147749-02REED, MATTHEWNOB HILL THERAPEUTICS, INC., NM$1,158,273ZRG1
2022A novel approach for prevention of Bronchopulmonary dysplasia in at-risk pre-term infants1R44HD107857-01A1ACHARYA, SUCHISMITAAYUVIS RESEARCH, INC., TX$1,109,134ZRG1
2022A Portable PET Insert System for Simultaneous TOF-PET and MR Brain Imaging2R44MH123253-03CHANG, CHENMINGPETCOIL, INC., CA$1,106,983ZRG1
2022An Improved Robotic Electrophysiology Platform for Arrhythmia Ablation2R44HL147745-02A1CREIGHTON, FRANCIS MILTONFADDIS, MITCHUNANDUP, LLC, MO$1,103,426ZRG1
2022Cutaneous Phosphorylated Alpha-Synuclein for Detection of Prodromal Synucleinopathies1R44NS127696-01LEVINE, TODDCND LIFE SCIENCES, INC., AZ$1,092,613ZRG1
2022Phase 2 Enabling Studies of a Candidate Drug Therapy (T3D-959) Regulating Neurometabolism for the Treatment of Huntington's Disease1R44NS127671-01DIDSBURY, JOHNT3D THERAPEUTICS, INC., NC$1,088,768ZRG1
2022DataJoint SciOps: A Managed Service for Neuroscience Data Workflows1R44NS129492-01YATSENKO, DIMITRIVATHES INC., TX$1,084,634ZRG1
2022A Highly Multiplexed, Multiomic 3D Mouse Brain Map Using MALDI-IHC1R44MH132196-01LIM, MARKAMBERGEN, INC, MA$1,084,108ZRG1
2022Continuous liquid-liquid extractors for doubling of productivity and henhancement of batch based drug manufacturing2R44GM140701-02ADAMO, ANDREAZAIPUT FLOW TECHNOLOGIES LLC, MA$1,080,331ZRG1
2022Novel small molecules for protection against doxorubicin cardiotoxicity in TNBC1R44HL164314-01DAS, ANINDITASALLOUM, FADI NSWINDLEHURST, CATHY ANOVOMEDIX, INC., CA$1,062,913ZRG1
2022DNA 3.0: Development of a novel, efficient and cost-effective enzymatic process for synthesis of DNA oligonucleotides2R44HG010995-02ZIELER, HELGEPRIMROSE BIO, INC., CA$1,059,968ZRG1
2022STARLIGHT, The Next Generation X-ray Imaging Technology1R44CA268468-01 · under PA-20-260SILVER, ERICIMAGINE SCIENTIFIC, INC., MA$1,057,480ZRG1
2022Nanoparticle-based Intraperitoneal Delivery of Combined Chemo-radiotherapy for Treatment of Ovarian Cancer Metastases2R44CA239989-02A1JAY, MICHAELNAMI THERAPEUTICS CORP., CT$1,054,145ZRG1
2022Thermoacoustic Range Verification During Delivery of a Clinical Plan by a Synchrocyclotron: transition from research prototype to turnkey clinical device2R44CA243764-02A1PATCH, SARAH KATHRYNACOUSTIC RANGE ESTIMATES, LLC, IL$1,050,635ZRG1
2022Direct detection and identification of antimicrobial resistance genes in bloodstream infections1R44AI172441-01SINGER, ALONHELIXBIND, INC., MA$1,050,000ZRG1
2022Novel, Non-hormonal Therapeutic for Endometriosis2R44HD100289-04BURNS, KATHERINE ANNEPETROSSIAN, TANYA CHRISTINEHENDOMET BIOSCIENCES, INC, CA$1,049,997ZRG1
2022Plasma-Generated Hydroxyl Radicals for Analysis of Three-Dimensional Structures in Protein Therapeutics2R44GM134849-02CHOUDHURY, FARAZIMMUTO SCIENTIFIC, INC., WI$1,037,792ZRG1
2022PERSEVERE-PEF: optimizing medical therapy saves lives in heart failure with preserved ejection fraction1R44HL162139-01 · under PA-20-260VOSKERICIAN, GABRIELAOPTIMA INTEGRATED HEALTH, INC., CA$1,034,876ZRG1
2022A molecular toolbox to accelerate drug development for histone lysine methylation regulators1R44TR004227-01BURG, JONATHAN MICHAELKEOGH, MICHAEL-CHRISTOPHEREPICYPHER, INC., NC$1,025,085ZRG1
2022Quantification of combinatorial epigenetic modifications using defined nucleosome standards2R44GM131560-02JOHNSTONE, ANDREA LYNNKEOGH, MICHAEL-CHRISTOPHEREPICYPHER, INC., NC$1,024,490ZRG1
2022Engineered super-affinity reagents for detection of histone post-translational modifications1R44GM145007-01 · under PA-20-260SUN, ZU-WENEPICYPHER, INC., NC$1,024,329ZRG1
2022Long-acting injectable tacrolimus for chronic immunosuppression1R44AI170362-01A1SHAH, SARJANSMITH, THOMAS J.AURITEC PHARMACEUTICALS, INC., CA$1,024,014ZRG1
2022Reading workstation for clinical contrast echocardiography2R44HL152939-02SKLENAR, JIRINARNAR, LLC, OR$1,023,511ZRG1
2022MammoCAT Advanced Full Field Digital Mammography System1R44CA268305-01A1BAMBOT, SHABBIR BAKIRFISCHER IMAGING, INC., CO$1,023,397ZRG1
2022IND-enabling development for IN-002, an inhaled muco-trapping mAb against respiratory syncytial virus1R44AI167461-01 · under PA-20-260HUTCHINS, JEFF TINHALON BIOPHARMA, INC., NC$1,023,232ZRG1
2022Quantitative mapping of dynamic epigenetic states in rare and stimulated immune cells1R44AI167215-01A1KEOGH, MICHAEL-CHRISTOPHEREPICYPHER, INC., NC$1,022,665ZRG1
2022A Novel Immunologically Directed Probiotic for the Treatment of Type 1 Diabetes1R44DK134274-01FANGER, GARYFURLAN FREGUIA, CHRISTIANRISE THERAPEUTICS, LLC, MD$1,021,316ZRG1
2022Development of SUMO1 small molecule degraders as the first-in-class anticancerdrugs for metastatic colorectal cancer1R44CA265547-01A1BELLAIL, ANITAHAO, CHUNHAI CHARLIELO, HO YINHB THERAPEUTICS, INC., IN$1,019,583ZRG1
2022Clinical Decision Support for Assessing Pulmonary Embolism using Machine Learning2R44HL152825-02 · under PA-20-260KRAMER, KEVIN M.MINNESOTA HEALTHSOLUTIONS CORPORATION, MN$1,018,633ZRG1
2022Development of a Precision Medicine-based Diagnostic Tool for Membranous Nephropathy2R44DK130702-02LARSEN, CHRISTOPHER PSTOREY, AARON JOSEPHNEPHROPATHOLOGY ASSOCIATES, AR$1,018,450ZRG1
2022Comprehensive validation and commercial readiness of SpliceIO, a software platform for neoantigen discovery using RNA-seq data1R44CA265446-01A1AKERMAN, MARTINARUN, GAYATRIENVISAGENICS, INC., NY$1,018,170ZRG1
2022A Web Service for Fragment-based Selectivity Analysis of Drug Leads2R44GM133284-02A1KULP III, JOHN LAURENCECONIFER POINT PHARMACEUTICALS, LLC, PA$1,016,453ZRG1
2022Benchtop Q-Band Pulsed EPR Spectrometer for Intermolecular Distance Measurements2R44GM137640-02MALY, THORSTENBRIDGE 12 TECHNOLOGIES, INC., MA$1,014,127ZRG1
2022Comprehensive Assessment of Cancer Immunotherapy Response2R44CA257253-02PERK, TIMOTHYAIQ SOLUTIONS, INC., WI$1,012,057ZRG1
2022Development of an oral analgesic with reduced liabilities1R44DA056336-01GEHLERT, DONALD RSCHMIDT, WILLIAM KEPIODYNE, INC., CA$1,011,134ZRG1
2022Phase IIB: Development of TruT Algorithm for Commercialization in Androgen Disorders2R44AG045011-04JASUJA, RAVIFUNCTION PROMOTING THERAPIES, LLC, MA$1,008,781ZRG1
2022Development of the Inspired Therapeutics NeoMate Mechanical Circulatory Support System for Neonates and Infants2R44HL144214-02DASSE, KURT AINSPIRED THERAPEUTICS, LLC, VA$1,002,565ZRG1

Showing the 200 most recent of 6,331 awards.

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