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NIH funding notice PA-22-176

PHS 2022-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)

Closed on April 5, 2023.

Posted
June 2, 2022
Close date
April 5, 2023
Activity codes
R43, R44
Institutes taking part
OD, NEI, NHLBI, NHGRI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDCD, NIDCR, NIDDK, NIDA, NIEHS, NIGMS, NIMH, NINDS, NINR, NIMHD, NLM, NCCIH, NCATS, NCI, ORIP, CGH, NCBDDD, NCCDPHP, NCEZID, NCHHSTP, NCIRD, NCIPC, NIOSH, NCEH, CPR, CBER, CDER, CFSAN, CDRH, CVM, CPI, OOPD

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

  1. Reissues: PA-21-259 PHS 2021-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)
  2. 2 steps back: PA-20-260 PHS 2020-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)
  3. 3 steps back: PA-19-272 PHS 2019-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed
  4. 4 steps back: PA-18-574 PHS 2018-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)
  5. 5 steps back: PA-17-302 PHS 2017-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  6. 6 steps back: PA-16-302 PHS 2016-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  7. 7 steps back: PA-15-269 PHS 2015-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  8. 8 steps back: PA-14-071 PHS 2014-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  9. 9 steps back: PA-13-234 Reissue PHS 2013-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  10. 10 steps back: PA-13-088 PHS 2013-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  11. 11 steps back: PA-12-088 PHS 2012-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  12. 12 steps back: PA-11-096 PHS 2011-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  13. 13 steps back: PA-10-050 PHS 2010-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
  14. 14 steps back: PA-09-080 PHS 2009-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])

Replaced by PA-23-230.

Who won it before

7,012 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $2,943,074,724 in first-year total cost, median $293,438.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 SBIB-T (10)]284
  2. Special Emphasis Panel[ZRG1 ETTN-G (12)]236
  3. Special Emphasis Panel[ZRG1 IMST-H (15)]202
  4. Special Emphasis Panel[ZRG1 IDM-V (12)]185
  5. Special Emphasis Panel[ZRG1 IMST-B (12)]179

Most frequent institutions

  1. EPICYPHER, INC.46
  2. PHYSICAL SCIENCES, INC45
  3. AFFINERGY, LLC31
  4. MINNESOTA HEALTHSOLUTIONS CORPORATION28
  5. LYNNTECH, INC.27
Competing awards under PA-22-176 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2024Optimization of Cannabinoids for Development as FDA-Approved Migraine Therapeutics2R44DA051309-02A1PAPPAS, GEORGESCHEDULE 1 THERAPEUTICS, INC., IL$2,019,222ZRG1
2024Development of a Novel Hyaluronan Inhibitor for the Treatment of Group 3 Pulmonary Hypertension (PH)1R44HL169052-01A1PALADINI, RUDYHALO BIOSCIENCES, INC., CA$1,957,305ZRG1
2024Measuring Whole and Tissue Level Bone Strength in men2R44AG071034-03A1BURKS, PETERTANG, SIMON YUE-CHEONGACTIVE LIFE SCIENTIFIC, INC., CA$1,716,342ZRG1
2024Preclinical assessment of a novel compound for treating radiation-induced oral mucositis2R44DE031464-02LLOYD, COLTON JOSEPHSINOPIA BIOSCIENCES, INC., CA$1,493,635ZRG1
2024Preclinical Toxicology Study of Intrathecal VersaMab-101 for spinal cord injury treatment2R44NS127712-02SUN, MIAOVERSAPEUTICS INC, CA$1,430,030ZRG1
2024Biochemical and genomic tools to study histone ADP ribosylation signaling1R44GM153000-01HUNT, SABRINA ROBINSUN, ZU-WENEPICYPHER, INC., NC$1,274,494ZRG1
2024A high-efficiency, low-cost, single-use purification technology for therapeutic antibody manufacturing2R44GM134776-04HOWELL, DAVID W.BONDWELL TECHNOLOGIES LP, TX$1,253,658ZRG1
2024A mobile application to offer upfront healthcare prices and automated medical billing for socioeconomically disadvantaged Americans2R44NR021119-03A1MARMOUSH, AHMEDHANDL HEALTH LLC, CA$1,185,981ZRG1
2024Developing small molecule inhibitors of Pleckstrin-2 to treat thrombosis2R44HL165997-02YANG, JINGAPLEXIS, INC., IL$1,101,337ZRG1
2024Open Source Hearing Assessment System for Open Science1R44DC021123-01A1CLAVIER, ODILE HCREARE, LLC, NH$1,100,864ZRG1
2024A novel, pleiotropic oral drug class that inhibits gut migration of activated T cells1R44DK136458-01A1THACHER, SCOTT MCNEARORPHAGEN PHARMACEUTICALS, CA$1,078,081ZRG1
2024SBIR: IND-enabling development of IN-007, an inhaled muco-trapping immunotherapy for COVID19 and other ACE2-targeted infections1R44AI177199-01A1HUTCHINS, JEFF TINHALON BIOPHARMA, INC., NC$1,024,986ZRG1
2024A novel flexible approach for high-throughput single-cell phenotyping and genotyping1R44HG013448-01SOUMILLON, MAGALIFLEXOMICS LLC, MA$1,009,871ZRG1
2024A Novel Anti-inflammatoryand Anti-oxidant Therapy for Treating Non-healing Diabetic Foot Ulcers1R44DK136463-01A1JACKSON, DAVIDCERIA THERAPEUTICS, INC., AZ$1,006,408ZRG1
2024Direct-from-specimen identification of pathogens common in endocarditis2R44AI136064-05A1SINGER, ALONHELIXBIND, INC., MA$1,001,029ZRG1
2024A novel long-acting conjugate of the vasodilative hormone, human brain natriuretic peptide (hBNP), to treat resistant hypertension1R44HL169016-01A1JOHNSON, BRIAN LAURENCEANTLIA BIOSCIENCE INC, CA$999,998ZRG1
2024High-content behavioral phenotyping of model organisms in three dimensions with a gigapixel microscope1R44OD036187-01HARFOUCHE, MARKRAMONA OPTICS, INC., NC$999,997ZRG1
2024Recombinant Outer Membrane Vesicles as a Novel Adjuvant for a Malaria Vaccine1R44AI181242-01LOCHER, CHRISTOPHERVERSATOPE THERAPEUTICS, INC., MA$999,762ZRG1
2024Multiplexed Assay for Point-of-Care UTI Diagnosis (ID/AMR)1R44AI181154-01BURKLUND, ALISONTADIMETY, AMOGHANANOPATHDX, INC., MA$996,726ZRG1
2024A Vaccine for Lymphatic Filariasis, LFGuard™2R44AI140708-05CARTER, DARRICK ALBERTKALYANASUNDARAM, RAMASWAMYPAI LIFE SCIENCES, INC., WA$995,460ZRG1
2024Chikungunya Recombinant Subunit Vaccine2R44AI120388-05CLEMENTS, DAVID EHAWAII BIOTECH, INC., HI$967,053ZRG1
2024Advanced testing of a hexavalent adjuvanted influenza vaccine platform for dose sparing, multiplexing, and rapid deployment1R44AI181479-01KUTSCHER, HILLIARDPOP BIOTECHNOLOGIES, INC, NY$950,225ZRG1
2024Establishment of a First-in-Class Biocompatible and Efficient Cryopreservation Technology Platform for the Next Generation of Cell-Based Therapeutics in Regenerative Medicine and Drug Discovery1R44OD035392-01A1HAN, XUCRYOCRATE, LLC, MO$940,821ZRG1
2024High throughput CAR-T potency assay based on functional and transcriptional measurements on single cell co-cultures1R44CA281575-01A1YELLEN, BENJAMIN BIRONCELLDOM, INC., CA$938,647ZRG1
2024A Novel Peptide for the Oral Treatment and Prevention of P. Gingivalis Infection1R44DE033568-01FANGER, NEIL AVIRTICI, LLC, WA$923,623ZRG1
2024Autonomous Monitor for Toxic Gas Exposure2R44ES032369-02A1MICHALEK, JOHN ANTHONYZEBRA ANALYTIX, INC., AR$919,218ZRG1
2024Multi-Media Professional Development for Parenting Educators to Deliver Oral Hygiene Education for Parents of Young Children2R44DE030019-02FEIL, EDWARD GUSTAVSMITH, DAVID RANDOLPHOREGON RES BEHAVIORAL INTERVENTION STRAT, OR$908,824ZRG1
2024Hybridization Chain Reaction: Automated Ultrasensitive Multiplex RNA and Protein Imaging1R44GM153075-01CHOI, HARRY MING TAKMOLECULAR INSTRUMENTS, INC., CA$905,853ZRG1
2024Development of a web-based platform implementing novel Predictor of Toxicity for Medical Devices (PredTox/MD)2R44ES032371-02A1GOLBRAIKH, ALEXANDERPREDICTIVE, LLC, NC$898,248ZRG1
2024Development of a Route of Exposure Model Using Silicone Wristbands as Personal Samplers2R44ES033586-02A1O'CONNELL, STEVEN GEHRIGMYEXPOSOME, INC., PA$896,020ZRG1
2024Pharmacokinetic and Efficacy Studies of the Aerosolized PAR2 Antagonist, C781, for the Treatment of Asthma2R44HL160424-02A1BOITANO, SCOTTDEFEA, KATHRYN ANNEPARMEDICS, INC., CA$878,390ZRG1
2024REPTOR: accelerating antibody discovery and improving hits with machine learning2R44GM137688-02CASTELLANA, NATALIEABTERRA BIOSCIENCES, INC., CA$856,396ZRG1
2024Development of a Rapid Phenotypic Pyrazinamide Susceptibility Testing for Mycobacterium tuberculosis Using Well-Standardized Protocol1R44AI181252-01SHI, WANLIANGPZA INNOVATION LLC, MD$840,857ZRG1
2024Interactive Hand Hygiene Trainer for School-Age Children2R44GM144007-02A1CRILEY, JASMINKAINDELIBLE LEARNING, INC., CA$835,202ZRG1
2024Multi-specific long-acting antibodies for the treatment of retinal neovascular diseases2R44EY030821-02TRAN, HIEP TABZYME THERAPEUTICS, LLC, PA$831,927ZRG1
2024Synthetic PreImplantation Factor (sPIF) plus hypothermia to treat neonatal brain injury2R44HD100269-02BARNEA, EYTAN RBIOINCEPT, LLC, OH$831,440ZRG1
2024Advancing emergency medicine training with remote stereoscopic livestream technology2R44TR003956-02A1BAILEY, SHANNON KYLE TEDDERBURNS, MICHEALIMMERSIVE TECH, INC., FL$758,394ZRG1
2024Development of streamlined one-pot chemoenzymatic glycan remodeling systems for antibody conjugation1R44GM153003-01ZONG, GUANGHUIGLYCOT THERAPEUTICS, LLC, MD$758,302ZRG1
2024Fluorescence-based sequence-specific imaging of RNA modifications2R44GM137636-02A1TIAN, LINGMEDIOMICS, LLC, MO$745,796ZRG1
2024Long term radiation treatment planning in brain tumors in the pediatric population1R44CA281709-01A1LEPORE, NATASHALOW, JUSTINOLCH, ARTHUR JACOBVOXEL HEALTHCARE, LLC, CA$718,740ZRG1
2024Multimodal intraoral camera1R44DE033307-01WILDER-SMITH, PETRA ELIGHT RESEARCH, INC., AZ$619,347ZRG1
2024Development of Smart Flocculants for the Treatment of PFAS Contaminated Water2R44ES032380-02A1HAUSER, ANASTASIAHILT, JAMES ZACHBLUEGRASS ADVANCED MATERIALS, LLC, KY$578,546ZRG1
2024In vitro myelination assay modeling the environment of MS lesions for predictive discovery of remyelinating therapies.1R43NS135867-01JAGIELSKA, ANNAARTIFICIAL AXON LABS INC., MA$506,083ZRG1
2024Novel device for the repair and sealing of dural perforations in minimally invasive surgery1R43NS135645-01MAYBERG, MARC ROBERTPATCHCLAMP MEDTECH, INC., WA$499,956ZRG1
2024Wraparound digital health support system to improve engagement and health outcomes of minority populations who are disadvantaged by social determinants of health in evidence-based protocols2R44MD015981-02DUTTA, DEBOLEENAVIORA HEALTH INC, PA$499,721ZRG1
2024Targeted Cerebral Spinal Fluid (CSF) Drug Delivery - Enclear Precision System1R44NS135792-01GLICKSMAN, MARCIE AENCLEAR THERAPIES, INC., MA$494,693ZRG1
2024Extending the Ischemic Penumbra in Large Vessel Occlusion Stroke1R41NS129388-01A1NEMOTO, EDWIN MSHEARIT, LLC, NM$490,049ZRG1
2024Software-guided Operative Planning of MitraClip Placement1R44HL169034-01A1GUCCIONE, JULIUS MATTEOKASSAB, GHASSAN S3DT HOLDINGS, LLC, CA$480,989ZRG1
2024Developing an "Out of the Box" Quality Improvement Library for Lung Diseases1R44HL172570-01TOBIAS, MARCPHRASE HEALTH, INC., PA$477,191ZRG1
2024A parallelized imaging platform for accurate and efficient long-term assessment of brain organoid development1R43MH133521-01A1HARFOUCHE, MARKRAMONA OPTICS, INC., NC$475,002ZRG1
2024A novel MICA/B based tumor-centric bispecific antibody that enhances NK cell activity in a hostile tumor microenvironment1R43CA287713-01BARUAH, HEMANTAAAKHA BIOLOGICS INC., TX$400,000ZRG1
2024Accurate prognosis and prediction of clinical benefits of adjuvant therapy for early-stage non-small cell lung cancer1R43CA281430-01A1GUO, NANCY LANYE, QINGSOSTOS LLC, WV$400,000ZRG1
2024A novel targeted antibody therapeutic to treat ovarian cancer1R43CA287501-01LAUS, REINERTRIO PHARMACEUTICALS INC., CA$399,478ZRG1
2024A Uniquely Scalable Approach to Single Cell Sequencing for the Development of Next Generation Cell Therapies1R43HG013446-01SPUHLER, PHILIPP STEFANSANSIMEON, INC, CA$399,369ZRG1
2024Targeting proton-sensing GPR68 as a ferroptosis-based therapy for glioblastoma1R43CA287513-01WILLIAMS, CHARLES HOUSTONPROTON BIO, INC., MD$399,214ZRG1
2024Engager T cell: A Simple Solution for Off-the-shelf T Cell Therapy for Cancer1R43CA281523-01A1LI, GONGBOIMMUNEBRO THERAPEUTICS INC., IL$361,635ZRG1
2024A rapid method for global and targeted miRNA next generation sequencing1R43HG013444-01RAO, VARSHACLARET BIOSCIENCE, LLC, MI$358,579ZRG1
2024Development of Novel Immunoregulatory Therapeutics for Asthma1R43HL172516-01BASSAGANYA-RIERA, JOSEPBIOTHERAPEUTICS, INC., VA$355,935ZRG1
2024Testing Novel Advancements to Recombinant Heparin Production1R43HL172567-01GLASS, CHARLES ALEXANDERTEGA THERAPEUTICS, INC., CA$355,222ZRG1
2024Topical treatment for burn pain by blocking cutaneous pain receptors.1R43GM150295-01A1BHARGAVA, KUMARILSERENTRIX, LLC, PA$340,685ZRG1
2024LentiSAFE Ligands: Mild-Elution Immunoaffinity Ligands for Enrichment and Purification of Lentiviral Vectors1R43TR004551-01A1ONAKUNLE, YEMIMABSWITCH, INC., CA$338,997ZRG1
2024Using an Inclined Plane System to Triage TBI Patients1R43NS135862-01GALEN, PETERHEMEX HEALTH, INC., OR$332,122ZRG1
2024Enhanced Gene Therapy Delivery Through Electric Pulsing Double-Balloon Catheter1R43TR004536-01A1HAGNESS, SUSAN CPHILLIPS, JANETVECTOR SURGICAL, LLC, WI$331,034ZRG1
2024Clinically-useful vehicles for in vivo delivery of mRNA to stem and progenitor cells1R43GM153144-01RAMUNAS, JOHNREJUVENATION TECHNOLOGIES, INC., CA$324,998ZRG1
2024Programmable Microfluidic Perfusion Bioreactor for 3D Organoid Culture and Screening Applications1R43HL172397-01MYERS, FRANKMOSAIC ENGINEERING LLC, CA$321,963ZRG1
2024Development of IFNA2-LNP01 for tumor lung metastases immunotherapy1R43CA287611-01REDD, PRISCILLA SIMONCHEMEDIMMUNE, INC., GA$320,597ZRG1
2024Novel Gene Therapy, Techniques, and Devices to Prevent Ventricular Tachycardia1R44HL172541-01ANDERSON, RONALD LEERITHIM BIOLOGICS, INC., MD$317,285ZRG1
2024Development of Quantitative In Vivo Imaging of Oral Biofilm pH to Allow Prevention of Enamel Demineralization1R43DE032985-01A1MCMORROW, GERALDVERAVANTI, INC., WA$309,428ZRG1
2024A new class of antiviral directed at HBV capsid protein1R43AI181057-01NAIR, SMITADOOR PHARMACEUTICALS, LLC, IN$306,500ZRG1
2024Device Automation of an FDA-cleared CD-Microfluidic Platform for Rapid Tissue Microsizing1R43TR004975-01ZOBI, AHMED NABILSYNTR HEALTH TECHNOLOGIES, LLC, CA$306,161ZRG1
2024Novel therapy to prevent alveolar bone loss in severe periodontitis1R43DE033577-01BOR, BATBILEGLARRICK, JAMES WMENDELSOHN, ANDREW RPANORAMA RESEARCH, INC., CA$304,019ZRG1
2024Head-mounted, high-speed confocal imager for voltage-sensitive neuronal recording1R43MH126790-01A1YOO, HYEJINPHYSICAL SCIENCES, INC, MA$300,837ZRG1
2024Pharmacological rejuvenation of human hematopoietic stem cells1R43HL172285-01MULLOY, JAMES CZHENG, YIMOGLING BIO INC, OH$299,781ZRG1
2024Development of a Marburgvirus subunit vaccineadjuvanted with a novel TLR7/TLR8 agonist1R43AI181292-01KAILASAN, SHWETAABVACC, INC., MD$299,528ZRG1
2024Novel Broad Spectrum Inhibitors of Dihydrofolate Reductase (DHFR) for Treatment of Infections from High Threat Fungal Pathogens1R44AI181163-01PARENT, STEPHENKATHERA BIOSCIENCE INC., NJ$298,530ZRG1
2024Rapid, versatile PCR1R43AI181390-01FARIS, GREGORY WNUMENTUS TECHNOLOGIES INC., CA$297,872ZRG1
2024E. coli platform for expression of low-cost malaria fusion proteins1R43AI181078-01LEES, ANDREWFINA BIOSOLUTIONS, LLC, MD$297,809ZRG1
2024Slippery, Omniphobic Coating to Prevent Thrombosis and Biofilm Formation on Peripheral Vascular Grafts1R44HL172473-01MCFARLAND, TODDMYERS, DANIEL DURANTOBI, ANDREA TARACERULEAN SCIENTIFIC INC., PA$297,732ZRG1
2024Development of circRNA manufacturing platform in yeast1R43TR004890-01PICKERING, BRIAN FREDERICKCHIMERNA THERAPEUTICS INC., NY$297,608ZRG1
2024Advanced 3D model of the Human Cornea for Keratoconus1R43EY035893-01ROEHM, KEVINCFD RESEARCH CORPORATION, AL$297,153ZRG1
2024Development of Heterobivalent Small-Molecule Therapeutics for the Treatment of Triple-Negative Breast Cancer1R43CA287494-01COGNETTA, ARMANDWEATHERWAX BIOTECHNOLOGIES CORPORATION, CA$296,286ZRG1
2024Improving survival from Burkholderia pseudomallei and other pathogenic intracellular bacteria1R43AI181293-01COX, GEORGE NORBERTBOLDER BIOTECHNOLOGY, INC., CO$295,924ZRG1
2024Multiplexed Nuclear Receptor BioAssay platform to inexpensively and broadly survey the nation's water supply for contamination by endocrine disrupting chemicals1R43ES036049-01SCHAUFELE, FRED JXCELLASSAY, INC., CA$295,923ZRG1
2024HealthyU-Native: A Technology-Based Tool for Addressing Health Literacy in Native American/Alaska Native Secondary Students1R43MD019203-01HAMILTON, ALEXANDRAHUSCROFT-D'ANGELO, JACQUELINEMARQUEZ, JESSIEOREGON RES BEHAVIORAL INTERVENTION STRAT, OR$295,922ZRG1
2024Quantitative measurement of PlGF using a rapid, low-cost, point-of-care (POC) diagnostic platform for prediction and detection of pre-eclampsia1R43HL172410-01SEIMETZ, JOSEPHRICOVR HEALTHCARE INC., NJ$295,895ZRG1
2024Smart CSF Delivery System for CNS Drug Therapy for Leptomeningeal Disease1R43CA281429-01A1GLICKSMAN, MARCIE AENCLEAR THERAPIES, INC., MA$295,851ZRG1
2024Development of a high throughput in vivo screening platform for identifying novel pro-and postbiotic bacterial strains1R43AT012449-01A1QURESHI, MOHAMMED ADNAN MOHAMMED HANIFNEMALIFE INC., TX$295,780ZRG1
2024Device for assessment of 8th nerve function and cochlear implant candidacy1R43DC021116-01A1DELGADO, RAFAEL EINTELLIGENT HEARING SYSTEMS, FL$295,770ZRG1
2024BioBricks-Env: AI driven, open-source, modular, composable platform to organize, store, retrieve, extract, and integrate environmental health & risk related data1R43ES036069-01LUECHTEFELD, THOMASINSILICA, LLC, MD$295,662ZRG1
2024Advancement of a Point-of-Need (PoN) platform device for accurate and destigmatized detection of recent cannabis use1R43DA059318-01SEIMETZ, JOSEPHRICOVR HEALTHCARE INC., NJ$295,606ZRG1
2024Development of a safe and effective topically administered pharmacotherapy to treat acute corneal pain1R43EY035872-01FONG, TUNGSOPPIMATH, KUMARESHVYLUMA INC., NJ$295,086ZRG1
2024Delivering genetic medicines to photoreceptors with lipid nanoparticles1R43EY035865-01TUTTLE, ADAMENTERX BIOSCIENCES, INC., OR$294,052ZRG1
2024Hybrid surgical stapler with tissue sensing technology1R43EB035458-01WENCHELL, THOMAS GEORGEREVMEDICA, INC., CT$293,989ZRG1
2024Development of H.E.R.O. (Health/care environment for research or organizations): A platform to develop, host, and maintain digital health interventions and programs1R43LM014476-01MITCHELL, JASON WUDUPI, SANTHOSH KNESTOTUS LLC, MI$293,978ZRG1
2024srvc-EHSR: Sysrev Version Control - Environmental and Health Related Systematic Reviews1R43ES035359-01A1LUECHTEFELD, THOMASINSILICA, LLC, MD$293,741ZRG1
2024A Spatially Uniform Illumination Source for Widefield Multi-Spectral Optical Imaging1R43NS135877-01SEYMOUR, ELIFIRIS KINETICS INC, MA$293,588ZRG1
2024A novel mobile phone technology to improve access for preeclampsia and hypertension detection1R43HL172484-01HEIRONIMUS, JOHN CONRADHUECKER , MARTIN RICHARDWOLFSON, DAVIDTELE-STETHOSCOPE INC., KY$292,897ZRG1
2024IND-enabling development of MM010, a PEG-specific intervention that blocks allergic response and restores repeated dosing for select PEGylated medicines impacted by anti-PEG antibody1R43AI181354-01KUSHIRO, KEIICHIROMUCOMMUNE, LLC, NC$291,458ZRG1
2024Novel Biosensor for Detection of Endotoxin1R43TR004888-01QUIJANO RUBIO, ALFREDOMONOD BIO, INC., WA$290,066ZRG1
2024Artificial Intelligence Tool to Optimize Organ Transplantation Outcomes (Transplant-AI)1R44HL172564-01HAVELKA, JIMINFORMAI, INC., TX$289,762ZRG1
2024A Palette of Near-Infrared Voltage Sensors for Cardiac Research and Safety Pharmacology1R43HL172546-01ACKER, COREYPOTENTIOMETRIC PROBES, LLC, CT$282,266ZRG1
2024A Numerical Platform for Microbubble Enhanced Sonothrombolysis1R43HL172528-01MA, JINGSENDYNAFLOW, INC., MD$281,956ZRG1
2024Cholesterol Removal as a Treatment for Dry Age-Related Macular Degeneration1R43EY035876-01MEHTA, NEHAL NMOBIUS SCIENTIFIC INC., DC$276,758ZRG1
2024A new platform for inexpensive and scalable recombinant protein and growth factor production to support cell culture applications in therapeutics.1R43GM146560-01A1LIANG, JULIE MINGOPERA BIOSCIENCE, INC., IL$275,765ZRG1
2024Non-metallic earbuds for auditory stimuli in MRI scanners1R43DC021136-01A1VON WIEGAND, THOMAS EDWARDSENSIMETRICS CORPORATION, MA$275,765ZRG1
2024Accurate and cost-effective detection of mutagenicity and mutagenic exposure1R43ES036101-01MASLOV, ALEXANDER Y.SHARIFI, MOHAMED SAMINMUTAGENTECH, INC., NY$275,763ZRG1
20243STEP: A swab-seal-read, point-of-care nucleic acid test to address disparity in STI screening and prevention1R43AI181122-01MULLINS, BRIANNAWARRICK, JAY WYATTSALUS DISCOVERY, LLC, WI$275,736ZRG1
2024Development of an Extracochlear Device to Restore Hearing1R43DC021615-01WONG, FRANCISAURICLE HEALTH INC, CA$275,371ZRG1
2024Developing a novel epigenetic regulator as a treatment for opioid use disorder1R43DA058603-01A1KIM, THOMASEPIVARIO, LLC, PA$275,253ZRG1
2024High Efficiency Sorption System for Removing Harmful Contaminants from Indoor Air1R43ES036089-01JAYARAMAN, AMBALAVANANTDA RESEARCH, INC., CO$274,853ZRG1
2024Development of next-generation biologics programmed with multifunctional synthetic chemistries1R43GM150368-01A1CHATTOPADHYAY, SOUVIKPEARL BIO, INC., MA$274,692ZRG1
2024EcoWell- A planet in a plate.1R44ES036060-01ELL, BRIANSNOWFLACK, DANIELLESYKORA, PETERAMELIA TECHNOLOGIES, LLC, DC$274,458ZRG1
2024Democratizing statistical computing through AI1R43GM153076-01BURKHALTER, DANIELRTUTOR, LLC, SD$273,987ZRG1
2024A novel and inexpensive multiplex miRNA platform for liver diseases screening1R43AA031448-01BALA, SHASHIKASA BIO, L.L.C., GA$273,974ZRG1
2024Binding free energy predictions for peptide drugs: A novel machine learning-based peptide simulation model for high-throughput computational lead optimization with quantum mechanical accuracy.1R43GM152994-01WHITE, ALECQUANTUM SIMULATION TECHNOLOGIES, INC., MA$272,369ZRG1
2024High Mass MALDI TOF Employing a Novel High-Tc Superconducting Ion Detector1R43GM153742-01BERKOUT, VADYM DZETEO TECH, INC., MD$271,495ZRG1
2024A smart wearable contact microphone patch for extended and remote monitoring of lung functions1R43HL167472-01A1WEN, HAORANSTETH X MICROSYSTEMS, INC., GA$269,922ZRG1
2024Ubiquitin pathway modulators for treating pancreatitis1R43DK138712-01SURESH, KUMARPROGENRA, INC., PA$269,622ZRG1
2024System on Chip for Intraoperative OCT1R43EY035946-01AL-QAISI, MUHAMMADMYRIAD ADVANCED TECHNOLOGIES LLC, CA$269,472ZRG1
2024Single cell tri-omics: High coverage simultaneous profiling of DNA, RNA, and proteins in single cells1R43NS135703-01PRINCE, ROBINFLUID DISCOVERY INC, CA$268,142ZRG1
2024Point-of-care viral load monitoring to support large-scale clinical testing of new HIV cure strategies1R43AI181436-01PRINCE, ROBINFLUID DISCOVERY INC, CA$268,142ZRG1
2024Improving the effectiveness of anti-tuberculosis drugs by developing a point-of-care therapeutic drug monitoring system for areas with limited medical resources1R43AI181155-01LAN, TIANGLUCOSENTIENT, INC., IL$265,773ZRG1
2024Development of POC system for patient condition and treatment monitoring in Sickle Cell Disease through hypoxia-induced sickling1R43HL172384-01HINES, PATRICKFUNCTIONAL FLUIDICS, LLC, MI$265,347ZRG1
2024Developing a Novel Incubator to Increase Cell Culture Reproducibility1R44TR004569-01A1ROTHENBERG, BARRY E.EMBRIENT INC, CA$262,240ZRG1
2024Evolving the standard of care for carbapenem resistant infections, through the development of a phenotypic assay capable of DETECTing and classifying carbapenemases1R43AI181482-01JACKSON, NICOLEBIOAMP DIAGNOSTICS, INC., CA$243,806ZRG1
2024GlyCoSAM: Glycolysis coupled S-adenosyl methionine regeneration for cell-free methylation reactions1R43GM153108-01BRUECKNER, ADRIANINVIZYNE TECHNOLOGIES, INC., CA$243,527ZRG1
2024DNA-optical barcoding technology for spatiotemporal single-cell analysis1R44HG013591-01KWOK, SHELDON J.J.LASE INNOVATION INC., MA$239,680ZRG1
2024An In Chemico Test to Identify Dermal Corrosives1R44ES036065-01LEBRUN, STEWARTLEBRUN LABS, LLC, CA$238,257ZRG1
2024DEVELOPMENT OF A WEARABLE, NON-INVASIVE, TREATMENT DEVICE FOR METASTATIC TRIPLE-NEGATIVE BREAST CANCER (TNBC)1R43CA287836-01SUBRAMANIAM, VISH V.EMBIOSYS INC., MA$211,125ZRG1
2024Synthetic Egg:Sperm Fusion Assay (SEFA): A Diagnostic Test for Male Fertility1R43HD114303-01LYSIAK, JEFFREY JPS-FERTILITY, INC., VA$195,000ZRG1
2024Advanced Water Treatment System for On-Site PFAS Capture and Destruction1R43ES036038-01WANG, MENGENSPIRED SOLUTIONS INC., MI$179,465ZRG1
2024Development of Microwave Induced Membrane Distillation with Carbon Nanotube Immobilized Membranes: A Sustainable Solution for Solvent Recovery from Aqueous Wastes1R43ES036050-01LI, CHENGNANOSEPEX INC., NJ$168,337ZRG1
2024Stress, Mindfulness, and People with Intellectual Disabilities1R43MH135535-01A1SHEEHAN, MARTIN R.DOUBLE S INSTRUCTIONAL SYSTEMS, OR$135,214ZRG1
2023A youth-specific helmet for preventing traumatic brain injury2R44NS119134-03A1 · under PA-21-259AVERY, GORDONCECCHI, NICHOLAS JAMESSAVIOR BRAIN INC., VA$2,864,855ZRG1
2023Development of an Opioid Sparing Therapeutic to Minimize Opioid Use Disorderand Tolerance in the Treatment of Pain1R44DA059302-01MEYN, MALCOLM AAMALGENT THERAPEUTICS, INC., NC$2,579,875ZRG1
2023Toxicology and Efficacy Studies of Intrathecal VersaMab-101 for spinal cord injury treatment2R44NS120397-02SUN, MIAOVERSAPEUTICS INC, CA$2,380,552ZRG1
2023A Novel Opioid-Free Targeted Pain Control Method for Acute Post-Operative Localized Pain Related to Oral Surgical Procedures2R44DE029369-02JADIA, RAHULKAY, GEORGEREVBIO, INC., MA$2,050,357ZRG1
2023RSK3 Anchoring Disruptor Therapy for Heart Failure1R44HL167349-01A1CIVIDINI, FEDERICOCARDIAC RSK3 INHIBITORS, LLC, CA$1,978,293ZRG1
2023Automated lab identification and sorting (Rapid-IDX) for mosquito surveillance2R44GH002369-02BREY, JEWELL AMANDAVECTECH, LLC, MD$1,962,860ZRG1
2023Targeting galectin-3 to overcome insulin resistance in type 2 diabetes2R44DK125126-02AHMED, HAFIZGLYCOMANTRA, INC., MD$1,810,483ZRG1
2023BRITE-Eye: An integrated discovery engine for CNS therapeutic targets driven by high throughput genetic screens, functional readouts in human neurons, and machine learning1R44MH135521-01LEWARCH, CAITLIN LEIGHWILLIAMS, LUIS ALBERTOQUIVER BIOSCIENCE INC., MA$1,721,943ZRG1
2023Multi-functional anti-thrombotic therapy for coronary microvascular obstruction1R44HL169132-01CHEN, RIDONGAPT THERAPEUTICS, INC., IL$1,582,022ZRG1
2023Using Machine Learning and Blockchain Technology to Reduce Drug Diversion in Hospitals2R44DA051084-02A1GHOLAMI, BEHNOODAUTONOMOUS HEALTHCARE, INC., CA$1,577,231ZRG1
2023Innovative 3D Printed Intravaginal Ring AnelleO-PRO, the first Single Administration of Progesterone for Infertility2R44HD100190-04BENHABBOUR, SOUMYA RAHIMAJANUSZIEWICZ, RIMAANELLEO, INC., NC$1,570,185ZRG1
2023Low-Dose Magneto-Thrombolysis to Expand Stroke Care1R44NS132605-01CREIGHTON, FRANCIS MILTONDERDEYN, COLIN PIETERUNANDUP, LLC, MO$1,523,833ZRG1
2023Gene Therapy that Systemically Produces Brain-penetrating Replacement Enzyme for MPS IIIA (Sanfilippo A Syndrome)1R44NS134453-01CRAMER, CAROLE L.PATTADA, SHIVAKUMAR DEVAIAHBIOSTRATEGIES, LC, AR$1,500,000ZRG1
2023Development of a SYF2 antisense oligonucleotide treatment for ALS and FTD1R44AG085411-01 · under PA-21-259ALWORTH, SAMUEL VFENG, ZHIHUAACURASTEM, INC., CA$1,492,509ZRG1
2023Commercial translation of high-density carbon fiber electrode arrays for multi-modal analysis of neural microcircuits1R44NS134432-01BHANDARI, RAJMOHANCHESTEK, CYNTHIA ANNEPOWELL, DANIELSOLZBACHER, FLORIANBLACKROCK MICROSYSTEMS, UT$1,487,586ZRG1
2023Implementing a coupled system of integrative ML modeling and data validation for elucidating microglial therapeutic targets in neurodegenerative disease1R44MH135465-01SACHS, KARENMODULO BIO, INC., CA$1,457,344ZRG1
2023Development of an UNC13A antisense oligonucleotide treatment for ALS and FTD1R44NS132698-01FENG, ZHIHUASAZANI, PETERACURASTEM, INC., CA$1,390,906ZRG1
2023A democratized platform for mapping the spatial epigenome in tissue1R44CA287890-01SABINA, JEFFREYATLASXOMICS INC., CT$1,390,826ZRG1
2023A Disease-Modifying Protein Therapeutic for the Treatment of COPD2R44HL149580-02 · under PA-21-259PRINCE, CHRISTOPHER LUCASVERRA THERAPEUTICS, INC., NY$1,364,498ZRG1
2023Development of a cell-penetrating beta-catenin antagonist peptide as a therapeutic candidate for Wnt-driven breast cancer2R44CA265503-02A1ROTOLO, JIMSAPIENCE THERAPEUTICS, INC., NY$1,362,268ZRG1
2023Multi-modal spatial genomics in the mouse and human brains1R44MH133530-01A1FRIEDA, KIRSTENSPATIAL GENOMICS, INC., CA$1,337,968ZRG1
2023The Alara Imaging Gateway: Linking Electronic Health Records and Radiology Imaging Exams to Report on National Quality Measures to Reduce Cancer Risk from Computed Tomography (Alara Imaging Gateway)1R44CA287536-01MAZONSON, NATHANALARA IMAGING INC., CT$1,316,275ZRG1
2023Ethnically Diverse iPSC-Cardiomyocyte Panel for Pharmacogenomics and Drug Safety Testing1R44HL170756-01AHMED, SYED MUKHTARGREENSTONE BIOSCIENCES, INC., CA$1,294,681ZRG1
2023Development of a novel peptide therapeutic for traumatic brain injury1R44NS130776-01 · under PA-21-259MANN, AMANAIVOCODE, LLP, CA$1,290,957ZRG1
2023Novel recombinant sensors to study histone ubiquitin signaling1R44GM149036-01 · under PA-21-259SUN, ZU-WENEPICYPHER, INC., NC$1,276,822ZRG1
2023Use of Time Series Biomarker and Clinical Data to Construct a Time Trajectory Host Response Map1R44GM149095-01A1REDDY, BOBBYPRENOSIS, INC., IL$1,272,176ZRG1
2023Development of a Novel Bone Adhesive Scaffold to Accelerate Bone Regeneration and Improve Ridge Height Maintenance for the Treatment of Patients with Residual Ridge Resorption1R44DE032564-01 · under PA-21-259JADIA, RAHULKAY, GEORGEREVBIO, INC., MA$1,265,448ZRG1
2023HEALS™: An Active Hydrogen Sulfide Delivery Technique for Accelerated, Effective Wound Healing2R44GM144027-02SHEKARRIZ, REZAEXHALIX, LLC, NM$1,244,870ZRG1
2023IND Enabling Studies for the Development of Pruritus Therapeutic PRA-5232R44AR081768-02PIPPIN, DOUGLAS ANTHONYPRAEVENTIX, LLC, PA$1,244,708ZRG1
2023TempO-LINC high throughput high sensitivity single cell gene expression profiling assay Ph II2R44GM140771-02SELIGMANN, BRUCE E.BIOSPYDER TECHNOLOGIES, INC., CA$1,241,285ZRG1
20233D Printed Silicon Nitride Porous PEEK Composite Spinal Cages for Anti-Infection2R44AR083836-02BOCK, RYANSINTX TECHNOLOGIES, INC., UT$1,227,401ZRG1
2023IL-10NanoCap® for Therapy of Familial Adenomatous Polyposis2R44DK117687-04AUCI, DOMINICKEGILMEZ, NEJAT KTHERAPYX, INC., NY$1,201,534ZRG1
2023Process Development and Preclinical Advancement of a Novel Nanoparticle Formulation for Immune Activation1R44CA281497-01A1JOHNSON, RICHARDSAROS THERAPEUTICS INC, IL$1,196,731ZRG1
2023Ultra-low Fouling and Anti-infective and Anti-thrombotic Nitric Oxide Releasing Intravascular Catheters2R42HL149595-02A1SHEBUSKI, RONALD J.NYTRICX INC., GA$1,193,055ZRG1
2023Expansion and validation of novel mobile app for guiding home modifications for aging in place2R44AG067804-02 · under PA-21-259TENENBAUM, LOUISHOMESRENEWED VENTURES LLC, DC$1,170,977ZRG1
2023ViTrack: Wearable, accurate, continuous blood pressure monitor to improve outcomes in hypertensive diseases of pregnancy1R44HL167356-01 · under PA-21-259THANIKACHALAM, MOHANDYNOCARDIA, INC., MA$1,168,681ZRG1
2023Combined Biomarker and EMR Data for Heterogeneous Treatment Effects and Surrogate Endpoints in Sepsis1R44GM149065-01 · under PA-21-259REDDY, BOBBYPRENOSIS, INC., IL$1,161,624ZRG1
2023Development of Cortical Bone Mechanics Technology for Enhancing the Diagnosis of Osteoporosis2R44AG058312-04CLARK, BRIAN CDICK, ANDREWOSTEODX INC., OH$1,160,485ZRG1
2023Development of CA-IL-12 for Triple Negative Breast Cancer2R44CA250887-02A1FILARDO, EDWARD JCYTONUS THERAPEUTICS, INC., OH$1,148,542ZRG1
2023Commercialization of methods and reagents for high-throughput single cell analysis2R44GM137648-02FONTANEZ, KRISTINAFLUENT BIOSCIENCES INC., MA$1,146,224ZRG1
2023The Point Powered: A Robust Actuated Prosthetic Finger for Partial Hand Amputation2R44EB030895-02SLIKER, LEVINPOINT DESIGNS, LLC, CO$1,142,929ZRG1
2023Treating non-small cell lung tumors with a novel inhaled dry powder chemotherapeutic formulation1R44CA277898-01A1BEVERLIN II, BRYCEQUENCH MEDICAL, INC., MN$1,127,538ZRG1
2023Method for the validation by Western analysis of affinity reagents against post-translationally modified proteins.2R44GM146473-02WEINER, MICHAEL PABBRATECH, INC., CT$1,121,971ZRG1
2023A Novel, Low-Cost, Handheld, 3D Imaging System for Improved Screening of Cervical Neoplasia in Resource Limited Settings2R44CA254586-02CARSON, JOSEPHPENSIEVISION, INC., CA$1,116,921ZRG1
2023Rapid NGS Method for Mapping of the Epitranscriptome2R44HG012534-02STENGEL, GUDRUNALIDA BIOSCIENCES, INC., CA$1,107,445ZRG1
2023Strain-Programmed Bioadhesive Patch for Enhanced Diabetic Wound Healing1R44DK137615-01A1YUK, HYUNWOOSANAHEAL, INC., MA$1,105,432ZRG1
2023Development of a high precision and high order DNA counting platform1R44GM149104-01 · under PA-21-259SHUM, ELEEN YEE LAMENUMERIX, INC., CA$1,080,705ZRG1
2023Platform for the High Throughput Generation and Validation of Affinity Reagents1R44GM148998-01 · under PA-21-259WEINER, MICHAEL PABBRATECH, INC., CT$1,080,240ZRG1
2023Development of An Innovative TEE Technology for Mutation Detection1R44CA284965-01DENG, QIPANGUO, BAOCHUANGLC BIOTECHNOLOGY, INC., OH$1,071,571ZRG1
2023Novel Broad-Spectrum Point-of-Care Coagulometer1R44HL169158-01BAKHRU, SASHA HPEROSPHERE TECHNOLOGIES INC., CT$1,068,783ZRG1
2023ADDITIVE MANUFACTURING OF PDMS MICROFLUIDICS2R44TR003968-02SCHULTZ, JEFFREYPHASE, INC., NC$1,066,595ZRG1
2023A novel monobody-drug conjugate to treat mutant Ras multiple myeloma2R44CA250616-02RAMIREZ, CRAIG PATRICKTEZCAT LABORATORIES LLC, CT$1,062,082ZRG1
2023Development of an innovative neurosurgical planning tool for awake craniotomy1R44MH135726-01SIMS, MAXWELL HARRISONMINDTRACE TECHNOLOGIES, INC., PA$1,050,668ZRG1
2023Diagnostic tool for assessment and tracking of microbial load in bloodstream infections1R44AI174578-01 · under PA-21-259SINGER, ALONHELIXBIND, INC., MA$1,050,000ZRG1
2023Trypanocidal Agents that Kill Multiple Stages of the Trypanosoma cruzi Life Cycle2R44AI152788-03 · under PA-21-259MCDONNELL, MARK EFOX CHASE CHEMICAL DIVERSITY CENTER, INC, PA$1,050,000ZRG1
2023Rapid, Handheld, Point-of-Care Stool Sample-prep Device for the Extraction and Detection of Nucleic Acid from Diarrheal Pathogens2R44AI155367-02 · under PA-21-259KIM, CHANG HEEGODX, INC., WI$1,050,000ZRG1
2023XVIR-110 an ultra-long-acting INSTI for HIV pre-exposure prophylaxis in IND-enabling studies1R44AI179564-01KEARNEY, BRIANEXAVIR THERAPEUTICS INC., CA$1,049,975ZRG1
2023In vivo delivery of Ab-directed CRISPR ribonucleoproteins for anal cancer immunotherapy1R44CA287699-01HAAK-FRENDSCHO, MARYSPOTLIGHT THERAPEUTICS, CA$1,043,843ZRG1
2023Isabl GxT: A clinically actionable whole genome and transcriptome precision medicine platform1R44CA281474-01MEDINA, JUAN SANTIAGOISABL INC., NY$1,041,487ZRG1
2023Mitigation of Radiation Induced Gastrointestinal Syndrome.1R44AI177220-01NORRIS, ANDREW JOHNSAHA, SUBHRAJITBCN BIOSCIENCES, LLC, CA$1,034,934ZRG1
2023Development of a High Throughput Assay for Rapid Screening of Congenital Cytomegalovirus Infection using Dried Blood Spots2R44DC019890-02STOWE, RAYMOND PRESTONMICROGEN, LLC, TX$1,034,453ZRG1
2023Point of Care maternal milk concentration device to optimize neonatal growth with targeted nutrition support1R44HD110306-01A1NELSON, ELIZABETH RANDALLMOTHER'S MILK IS BEST, INC., MA$1,032,045ZRG1
2023A Novel Synthetic Biology-Derived Microbiome Therapeutic to Treat Viral-Induced Acute Respiratory Distress Syndrome (ARDS)1R44AI174332-01 · under PA-21-259FANGER, GARYFURLAN FREGUIA, CHRISTIANRISE THERAPEUTICS, LLC, MD$1,026,596ZRG1
2023Manganese-based Contrast Agent for Cardiovascular MRI2R44HL156713-02HOFFMAN, VERAREVEAL PHARMA, MA$1,026,595ZRG1
2023Hybrid ELISA: Simple and specific one-tier assay for Lyme disease2R44AI142903-03A1LEVIN, ANDREW E.KEPHERA DIAGNOSTICS, LLC, MA$1,025,000ZRG1
2023IND-enabling Preclinical Development of a Sustained-release Pritelivir Intravaginal ring for the Treatment and Prophylaxis of Genital Herpes2R44AI136201-04SHAH, SARJANSMITH, THOMAS J.AURITEC PHARMACEUTICALS, INC., CA$1,025,000ZRG1
2023Arylsulfonamides for the Treatment of Primary and Metastatic Uveal Melanoma2R44CA254756-02A1OFFERMANN, MARGARET KENNYONCOSPHERIX, INC., GA$1,024,999ZRG1

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