ConductVision · Behavioral Analysis

Zebrafish Seizure Detection

Automated detection and staging of seizure-like behavior in zebrafish.

ZebrafishNeurologicalAuto Export
ConductVision / Zebrafish Seizure Detection
Recording / Trial 3fish tracked
Seizure Stagelive
Seizure Frequencyauto
Ictal Duration27%

Key Parameters

Metrics automatically extracted by ConductVision.

Seizure Stage

Baraban scale classification (Stage I–III) based on locomotor pattern

Seizure Frequency

Number of seizure events per recording period

Ictal Duration

Length of each seizure episode from onset to termination

Clonus Events

Rhythmic convulsive movements detected via high-frequency tracking

Whirlpool Swimming

Stage III circular swimming pattern characteristic of severe seizures

Post-Ictal Suppression

Reduced activity period following seizure termination

What is Zebrafish Seizure Detection?

Zebrafish are widely used as a model for epilepsy research due to conserved seizure mechanisms and amenability to high-throughput chemical screening. The Baraban seizure staging system classifies larval zebrafish seizures into Stage I (increased swimming), Stage II (whirlpool swimming), and Stage III (clonus-like convulsions with loss of posture).

ConductVision automatically classifies seizure stages using velocity, trajectory curvature, and posture analysis. The software detects PTZ-induced seizures in 96-well plates, enabling rapid antiepileptic drug screening and genetic modifier identification with quantitative, reproducible seizure metrics.

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