Research data · Brain technique and test
Elevated plus maze with ICV injection
From 2021 to 2025, 65 animal research papers mentioned ICV injection and the elevated plus maze in their title or abstract.
That is 8% fewer than the 71 papers of 2011 to 2015. Between the same two periods, the papers that mention ICV injection and any of the 90 tests we count fell 6%. The 2021 to 2025 count may run low because of a dip in PubMed's indexing, explained under the year chart.
Papers by year
Animal research papers that mention ICV injection and the elevated plus maze, by year, 2001 to 2026
The 2026 bar counts papers added to PubMed by November 8, 2026.
- Papers in a full year
- 2026 so far
Show the counts for each year
| Year | Papers |
|---|---|
| 2001 | 14 |
| 2002 | 11 |
| 2003 | 14 |
| 2004 | 8 |
| 2005 | 8 |
| 2006 | 13 |
| 2007 | 13 |
| 2008 | 17 |
| 2009 | 17 |
| 2010 | 13 |
| 2011 | 12 |
| 2012 | 13 |
| 2013 | 21 |
| 2014 | 10 |
| 2015 | 15 |
| 2016 | 15 |
| 2017 | 17 |
| 2018 | 12 |
| 2019 | 10 |
| 2020 | 15 |
| 2021 | 14 |
| 2022 | 17 |
| 2023 | 7 |
| 2024 | 10 |
| 2025 | 17 |
| 2026 (part year) | 16 |
Papers that mention ICV injection and the elevated plus maze fell from 14 in 2021 to 7 in 2023, then rose to 17 in 2025. Part of this dip may come from PubMed's indexing rather than from fewer studies. We take a paper's species from PubMed's indexing when the indexing names one. Otherwise PubTator 3, NCBI's text-mining service, has to find a species in the title or abstract, or the paper is not counted. Papers that PubMed indexed under the subject heading Animals also fell and rose, from 200,221 in 2021 to 156,447 in 2023 and 235,479 in 2025.
Which species the papers used
Each bar is a share of the 65 papers from 2021 to 2025. A paper can use more than one species, so the shares can add to more than 100%.
Species
“Other animals” counts papers that use none of the species this chart names.
Tests mentioned alongside the elevated plus maze
Each bar is one test, with how many of the 65 papers also mention it, and what share that is. Of these papers, 11 (17%) mention no other test.
The 12 tests these papers mention most
Which papers count
A paper counts here when it is animal research and its title or abstract mentions ICV injection and the elevated plus maze.
A paper that mentions either only in its methods is missed, so the count runs low. The search terms are in the list of models and techniques and the test list. The full method, with each source and its terms of use, is on our main page, Behavioral tests in published research.
More pairings
Every pairing of a brain technique and a test with 30 or more papers from 2021 to 2025 has a page like this one.
Other tests with ICV injection
The elevated plus maze with animal models and other brain techniques
- Chronic unpredictable stress 170 papers
- Restraint stress 154 papers
- Lipopolysaccharide (LPS) 85 papers
- Exercise 83 papers
- Maternal separation and early-life stress 83 papers
- High-fat diet 79 papers
- Single prolonged stress 63 papers
- Environmental enrichment 54 papers
- Social defeat stress 54 papers
- Streptozotocin diabetes 54 papers
- Pentylenetetrazole (PTZ) 52 papers
- Chemogenetics (DREADDs) 50 papers
- Social isolation 49 papers
- Sleep deprivation 46 papers
- Scopolamine 43 papers
- Ovariectomy 41 papers
- Predator stress 40 papers
- AAV vectors 38 papers
- Nerve injury 35 papers
- EEG and ECoG 34 papers
- Intranasal delivery 34 papers
- Optogenetics 30 papers
The page on the elevated plus maze counts all the papers that mention it, whatever they study. The page on ICV injection ranks the tests mentioned with it.
How to cite
APA
ConductScience. (2026, November 13). Elevated plus maze with ICV injection [Data set]. https://conductscience.com/resources/data/brain-techniques/icv-injection/elevated-plus-maze
BibTeX
@misc{conductscience_icv_injection_elevated_plus_maze_2026,
author = {{ConductScience}},
title = {Elevated plus maze with ICV injection},
year = {2026},
month = nov,
url = {https://conductscience.com/resources/data/brain-techniques/icv-injection/elevated-plus-maze},
note = {Data set, released November 13, 2026},
}Elevated plus maze apparatus in our store
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