Use when
- Mechanical or thermal hypersensitivity is expected after model induction.
- Baseline and post-model readouts can be measured with consistent timing.
- The page needs to connect model choice to endpoints and companion controls.
Research Models
Model
Neuropathic pain models
Neuropathic pain models are used to study sensory changes after nerve injury, disease, or treatment exposures.
Decision summary
Use this model page when the study starts from a biological injury or disease mechanism and needs behavioral readouts that are plausible, limited, and auditable.
| Common readouts | Mechanical threshold, thermal latency, guarding, gait, or health observations. |
|---|---|
| Timing | Baseline plus model-specific post-induction windows. |
| Controls | Sham, vehicle, contralateral comparison, or naive groups depending on design. |
| Interpretation boundary | Behavioral hypersensitivity is a readout, not proof of subjective pain state. |
Do not use when
- The content would imply that one animal behavior fully represents human neuropathic pain.
- The model does not have a defined time course or endpoint rationale.
Caveats
- Model induction can create motor, wound, or health changes that affect behavioral endpoints.
- Different neuropathic models have different time courses and mechanisms.
- Translation from animal behavior to human pain requires cautious language.
Reporting checklist
- Define model and induction procedure.
- Report baseline and follow-up schedule.
- Name endpoints, apparatus, and calculation methods.
- Report sham or control structure.
- Report welfare and motor observations.
References
Related surfaces
Use these related surfaces to move from the scientific method question to the relevant product page, endpoint definition, analysis tool, or adjacent guide.
